Hiroyuki Tezuka

(手塚裕之)

Profile Information

Affiliation: Research Promotion Headquarters, Fujita Health University

Degree: 博士(医学)(東京医科歯科大学)

Researcher number: 30375258
J-GLOBAL ID: 201601006012155800
researchmap Member ID: B000251084

External link: https://kaken.nii.ac.jp/d/r/30375258.ja.html

Research Interests

Research Areas

Committee Memberships

Committee member, Japanese Society for Endotoxin・LPS

Awards

2022

Research Grant, Aichi Kidney Foundation

Hiroyuki TEZUKA
2013

Research Grant, Kato Memorial Bioscience Foundation

Hiroyuki TEZUKA
2012

Research Grant, The NOVARTIS Foundation

Hiroyuki TEZUKA
2012

TMDU award, TMDU

Hiroyuki TEZUKA
2011

Research Grant, The Sumitomo Foundation

Hiroyuki TEZUKA

Major Papers

Prominent role for plasmacytoid dendritic cells in mucosal T cell-independent IgA induction

Hiroyuki Tezuka, Yukiko Abe, Jumpei Asano, Taku Sato, Jiajia Liu, Makoto Iwata, Toshiaki Ohteki

Immunity, 34(2) 247-257, Feb, 2011 Peer-reviewedLead author
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells

Hiroyuki Tezuka, Yukiko Abe, Makoto Iwata, Hajime Takeuchi, Hiromichi Ishikawa, Masayuki Matsushita, Tetsuo Shiohara, Shizuo Akira, Toshiaki Ohteki

Nature, 448(7156) 929-933, Aug, 2007 Peer-reviewedLead author

Misc.

Dendritic cells maintain intestinal immune homeostasis

Nao Shimoga, Hiroyuki Tezuka

Farumashia, 61(4) 329-334, Apr, 2025 Peer-reviewedInvitedLast authorCorresponding author
Mucosa-associated lymphoid tissue : an organ that controls mucosal immune responses

Yui Shibata, Chikako Hibiya, Hiroyuki Tezuka

Respiratory Medicine, 40(6) 615-621, Dec, 2021 InvitedLast authorCorresponding author
Regulation of IgA production by dendritic cells in the intestine

Hiroyuki Tezuka

臨床免疫・アレルギー科, 62(6) 593-599, Dec, 2014 InvitedLead author
Regulation of immunoglobulin synthesis by dendritic cells

Hiroyuki Tezuka

臨床免疫・アレルギー科, 58(5) 525-533, Nov, 2012 InvitedLead author
Current understandings of intestinal dendritic cells

Hiroyuki Tezuka

21(1) 9, Oct, 2012 InvitedLead author
Regulation of mucosal T cell-independent IgA production by dendritic cells

Hiroyuki Tezuka

臨床免疫・アレルギー科, 58(3) 283-289, Sep, 2012 InvitedLead author
A new mechanism of IgA production in the gut: role of plasmacytoid dendritic cells

Toshiaki Ohteki, Hiroyuki Tezuka

Inflammation & Immunity, 20(2) 70-74, 2012 InvitedLast author
pDCによる新たなIgA産生誘導メカニズム

樗木俊聡, 手塚裕之

医学のあゆみ, 240(2) 182-183, Jan, 2012 InvitedLast author
Regulation of mucosal T cell-independent IgA production by plasmacytoid dendritic cells

Hiroyuki Tezuka

Clinical immunology & allergology, 55(6) 687-692, Jun, 2011 InvitedLead author
Qualitative prominence of plasmacytoid dendritic cells in mucosal T cell-independent IgA induction

Cell technology, 30(4) 376-380, 2011 InvitedLast author
Good old days

Hiroyuki Tezuka

20(2) 9, 2011 InvitedLead author
TNF/iNOS-producing DC and IgA production

234(5) 453-457, Jul 31, 2010 InvitedLast author
T cell-independent IgA class switch recombination in the mucosal-associated lymphoid tissues

Hiroyuki Tezuka

Clinical immunology & allergology, 52(4) 422-430, Oct, 2009 InvitedLead author
Regulation of IgA synthesis in the intestine

Hiroyuki Tezuka

17(2) 86-92, Sep, 2009 InvitedLead author
Regulation of IgA class switch recombination by intestinal dendritic cells: conditioning of dendritic cells by commensals

Hiroyuki Tezuka

医学のあゆみ, 227(5) 326-331, Nov, 2008 InvitedLead author
The regulation of IgA class switch recombination by Peyer's patch dendritic cell subsets

Hiroyuki Tezuka

Clinical immunology & allergology, 50(2) 216-221, Aug, 2008 InvitedLead author
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells

Hiroyuki Tezuka

生体の科学, 59(4) 268-274, Jul, 2008 InvitedLead author
Regulation of IgA class-switch recombination by intestinal dendritic cells

Hiroyuki Tezuka, Yukiko Abe, Toshiaki Ohteki

Experimental Medicine, 26(20) 114-120, 2008 InvitedLead author
Regulation of IgA Class-Switch Recombination by Mucosal Dendritic Cells

Ykiko Abe, Hiroyuki Tezuka, Toshiaki Ohteki

38(3) 91-94, 2008 InvitedLead author
Regulation of IgA Production by Dendritic Cells

Toshiaki Ohteki, Yukiko Abe, Hiroyuki Tezuka

Inflammation & Immunity, 16(2) 73-78, 2008 InvitedLast author
Dendritic cell trafficking in MALT: its role in IgA synthesis

Hiroyuki Tezuka

Clinical immunology & allergology, 49(1) 10-15, Jan, 2008 InvitedLead author
Regulation of IgA class-switch recombination by dendritic cells

Hiroyuki Tezuka

Clinical immunology & allergology, 48(3) 230-235, Sep, 2007 InvitedLead author
Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells (Tip-DC)

Hiroyuki Tezuka

Clinical immunology & allergology, 47(6) 619-624, Jun, 2007 InvitedLead author
Regulation of B cells by dendritic cell-derived cytokines

Hiroyuki Tezuka

44(1) 109-112, Jul, 2005 InvitedLead author

Books and Other Publications

『免疫の事典』桂義元, 河本宏, 小安重夫, 山本一彦編

手塚裕之, 樗木俊聡 (Role: Contributor, 「腫瘍壊死因子」pp245)

朝倉書店, Dec, 2011 (ISBN: 9784254310931)
『食品免疫・アレルギーの事典』日本食品免疫学会編

手塚裕之, 安部由紀子, 樗木俊聡 (Role: Contributor, 「樹状細胞 (機能)」pp68-69)

朝倉書店, May, 2011 (ISBN: 9784254431100)
『腸内共生系のバイオサイエンス』(財)日本ビフィズス菌センター編

手塚裕之, 樗木俊聡 (Role: Contributor, 「分泌抗体」pp173-182)

丸善出版, May, 2011 (ISBN: 9784621083611)
『臨床粘膜免疫学』清野宏編

手塚裕之, 安部由紀子, 樗木俊聡 (Role: Contributor, 「粘膜系樹状細胞 (誘導組織)」pp266-274)

シナジー, Dec, 2010 (ISBN: 9784916166340)

Presentations

Regulation of antibody production by dendritic cells

Hiroyuki Tezuka

Japanese Association for Food Immunology (JAFI 2025), Oct 2, 2025 Invited
腸管樹状細胞によるIgA生産制御機構

手塚裕之

第28回内毒素・LPS研究会, Jun 29, 2019 Invited
粘膜バリア : 病原体と戦う免疫システム

手塚裕之

東京医科歯科大学難治疾患研究所市民講座 -最先端生命科学講座シリーズ第11回-, Feb 20, 2015 Invited
T細胞非依存性IgA生産誘導における形質細胞様樹状細胞の質的優位性

手塚裕之

第32回富山大学和漢医薬学総合研究所特別セミナー, Dec 9, 2011 Invited
粘膜IgA生産誘導における形質細胞様樹状細胞の質的優位性

手塚裕之

第4回グローバルCOE若手研究者シンポジウム, Nov 16, 2010 Invited

Major Teaching Experience

Immunology (Fujita Health University (Graduate School))
Immunology (Tokyo Medical and Dental University)
Immunology (Tokyo Medical and Dental University)
Immunology (Akita University)

Professional Memberships

Research Projects

腸管樹状細胞によるTGF-β依存性クラススイッチ誘導機構の解明

科学研究費補助金 (基盤研究(C)), 文部科学省, 2019 - 2021

手塚裕之
A conditioning machinery of dendritic cells by epithelial cells in the gut

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2013 - 2015

TEZUKA HIROYUKI
Regulation of gut mucosal homeostasis by autophagy in dendritic cells

Grants-in-Aid for Scientific Research(若手研究(B)), Ministry of Education, Culture, Sports, Science and Technology, 2011 - 2012

Hiroyuki TEZUKA
Regulatory mechanism of IgA production by plasmacytoid dendritic cells and its therapeutic application for IgA nephrophathy

Grants-in-Aid for Scientific Research(若手研究(B)), Ministry of Education, Culture, Sports, Science and Technology, 2009 - 2010

Hiroyuki TEZUKA
Nod1-mediated regulation of immunological homeostasis

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2007 - 2008

SATO Taku, ONAI N. Obuyuki, TEZUKA Hiroyuki, TADA Hiroyuki

Academic Activities

31st Japanese Society for Endotoxin・LPS (chairman)

Planning, Management, etc., Panel moderator, Session chair, etc., Supervision (editorial), Others

Japanese Society for Endotoxin・LPS, Jun 29, 2024
50 Years of the Japanese Society for Immunology (Coordinator)

Panel moderator, Session chair, etc., Review, evaluation, Peer review, Others

Japanese Society for Immunology, Dec 8, 2021 - Dec 10, 2021

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