研究者業績

川口 和紀

カワグチ カズノリ  (Kazunori Kawaguchi)

基本情報

所属
藤田医科大学 医療科学部 医療検査学科 臨床医工学分野 講師
学位
博士(医学)

J-GLOBAL ID
201501002916890019
researchmap会員ID
7000013058

論文

 14
  • 蔦村 琴子, 大橋 篤, 細江 眞生, 高須 立平, 石田 大賀, 新 典雄, 堀 秀生, 井平 勝, 川口 和紀, 中井 滋, 長谷川 みどり, 坪井 直毅
    日本透析医学会雑誌 56(Suppl.1) 475-475 2023年5月  
  • Midori Hasegawa, Nobuya Kitaguchi, Hajime Takechi, Kazunori Kawaguchi, Kengo Ito, Takashi Kato, Masao Kato, Norio Nii, Sachie Yamada, Atsushi Ohashi, Shigehisa Koide, Hiroki Hayashi, Kazuo Takahashi, Daijo Inaguma, Yukio Yuzawa, Naotake Tsuboi
    Therapeutic Apheresis and Dialysis 26(3) 529-536 2022年6月  
  • Yuta Saito, Miwa Sakata, Moe Kobayakawa, Hiroshi Kawachi, Kazunori Kawaguchi, Yoshiyuki Hiki, Masao Kato, Mayuko Mori, Midori Hasegawa, Norimi Ohashi, Yukio Yuzawa, Nobuya Kitaguchi
    Neuropsychiatric Disease and Treatment 16 607-627 2020年  
    Purpose: Amyloid-β protein (Aβ) is one of the causative proteins of Alzheimer’s disease. We have been developing extracorporeal blood Aβ-removal systems as a method for enhancing Aβ clearance from the brain. We reported previously that medical adsorbents and hemodialyzers removed Aβ monomers from peripheral blood, which was associated with influx of Aβ monomers from the brain into the bloodstream. Our intent here was to develop a method to promote clearance of Aβ oligomers and to provide an estimate of the molecular size of intact Aβ oligomers in plasma. Methods: Two hollow-fiber devices with different pore sizes (Membranes A and B) were evaluated as removers of Aβ oligomers with human plasma in vitro. The concomitant removal of Aβ oligomers and monomers was investigated by using Membrane B and hexadecyl alkylated cellulose beads or polysulfone hemodialyzers. Double-filtration plasma-pheresis with Membrane A was investigated as an approach for the removal of plasma Aβ oligomers in humans. Results: Aβ oligomers were effectively removed by both Membranes A and B. The increase of Aβ oligomers in plasma was observed just after the removal of plasma Aβ oligomers in humans. The intact molecular size of major Aβ oligomers in the plasma was estimated to be larger than albumin at approximately 60 kDa or more. Additionally, the concomitant removal of Aβ monomers and oligomers evoked dissociation of larger Aβ oligomers into smaller ones and monomers. Conclusion: Aβ oligomers were cleared from plasma both in vitro and in human subjects by using hollow-fiber membranes with large pores, indicating that their intact sizes were mostly larger than 60 kDa. Aβ oligomers in peripheral circulation were increased after some clearances in human. Further investigation will determine whether the Aβ oligomers detected in circulation after clearance were via influx from the brain.
  • Kitaguchi N, Tatebe H, Sakai K, Kawaguchi K, Matsunaga S, Kitajima T, Tomizawa H, Kato M, Sugiyama S, Suzuki N, Mizuno M, Takechi H, Nakai S, Hiki Y, Kushimoto H, Hasegawa M, Yuzawa Y, Tokuda T
    Journal of Alzheimer's disease : JAD 69(3) 687-707 2019年  査読有り
  • Kitaguchi N, Kawaguchi K, Yamazaki K, Kawachi H, Sakata M, Kaneko M, Kato M, Sakai K, Ohashi N, Hasegawa M, Hiki Y, Yuzawa Y
    Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs 21(2) 220-229 2018年6月  査読有り

MISC

 45

共同研究・競争的資金等の研究課題

 6