研究者業績
基本情報
- 所属
- 藤田医科大学 先端医療研究センター 教授
- 学位
- 博士(医学)(2002年7月 慶應義塾大学)
- 研究者番号
- 10276298
- J-GLOBAL ID
- 200901051691546332
- researchmap会員ID
- 5000105016
研究分野
1経歴
7-
2023年10月 - 現在
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2017年7月
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2015年
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2012年7月
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2005年10月
受賞
7論文
464-
J Arthroplasty 2025;8:S0883-5403(25)00344-4. 2025年8月
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Cell Transplant 2025 Jan-Dec;34:9636897251341781. doi: 10.1177/09636897251341781. Epub 2025 Jun 19. 2025年1月
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Clinical biomechanics (Bristol, Avon) 122 106404-106404 2024年12月3日BACKGROUND: Implant design is important for achieving proper knee biomechanics during gait following knee arthroplasty. Bicruciate-stabilized total knee arthroplasty attempts to replicate anterior stability and rotational facilitation. However, its detailed gait biomechanics compared with other implant designs have not been analyzed. The purpose of this study is to compare knee kinematics and kinetics between bicruciate-stabilized total knee arthroplasty, posterior-stabilized total knee arthroplasty, unicompartmental knee arthroplasty, and normal knees. METHODS: Ten healthy subjects, 16 who underwent posterior stabilized total knee arthroplasty, 12 who underwent bicruciate-stabilized total knee arthroplasty, and 13 who underwent unicompartmental knee arthroplasty were recruited. The mean follow-up period after arthroplasty was 11.0 months. Three-dimensional kinematics and kinetics were assessed using a motion capture system with subjects walking on a 5-m walkway. Comparisons between groups were conducted using the Kruskal-Wallis test, and post hoc analysis was performed for those parameters that differed significantly. FINDINGS: The bicruciate-stabilized total knee arthroplasty group showed decreased internal rotation compared to the unicompartmental knee arthroplasty group. Compared to the control group, the posterior-stabilized total knee arthroplasty group exhibited reduced knee extension and internal rotation moment. INTERPRETATION: Bicruciate-stabilized total knee arthroplasties exhibited different biomechanical characteristics compared to unicompartmental knee arthroplasties during terminal stance. Postoperative total knee arthroplasty rehabilitation should focus on relieving stiffness owing to insufficient knee flexion-extension motion observed in both bicruciate-stabilized and posterior-stabilized total knee arthroplasties compared with unicompartmental knee arthroplasty, which may be due to a lack of knee rotational motion during gait.
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Knee. 2024;12;48:14-21. doi: 10.1016/j. knee. 2024.02.015. Online ahead of print.PMID: 38479077 2024年12月
MISC
30-
Scientific reports 9(1) 18741-18741 2019年12月10日The number of osteoarthritis patients is increasing with the rise in the number of elderly people in developed countries. Osteoarthritis, which causes joint pain and deformity leading to loss of activities of daily living, is often treated surgically. Here we show that mechanical stress promotes accumulation of reactive oxygen species (ROS) in chondrocytes in vivo, resulting in chondrocyte apoptosis and leading to osteoarthritis development in a rat model. We demonstrate that mechanical stress induces ROS accumulation and inflammatory cytokine expression in cultured chondrocytes in vitro and that both are inhibited by treatment with the anti-oxidant N-acetyl cysteine (NAC). In vivo, osteoarthritis development in a rat osteoarthritis model was also significantly inhibited by oral administration of NAC. MMP13 expression and down-regulation of type II collagen in chondrocytes, both of which indicate osteoarthritis, as well as chondrocyte apoptosis in osteoarthritis rats were inhibited by NAC. Interestingly, osteoarthritis development in sham-operated control sides, likely due to disruption of normal weight-bearing activity on the control side, was also significantly inhibited by NAC. We conclude that osteoarthritis development in rats is significantly antagonized by oral NAC administration. Currently, no oral medication is available to prevent osteoarthritis development. Our work suggests that NAC may represent such a reagent and serve as osteoarthritis treatment.
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日本リウマチ学会総会・学術集会プログラム・抄録集 62回 519-519 2018年3月
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日本リウマチ学会総会・学術集会プログラム・抄録集 61回 439-439 2017年3月
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整形外科最小侵襲手術ジャーナル (80) 46-50 2016年9月
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日本整形外科学会雑誌 89(3) S563-S563 2015年3月
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日本リウマチ学会総会・学術集会プログラム・抄録集 59回 427-427 2015年3月
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日本リウマチ学会総会・学術集会プログラム・抄録集 58回 189-189 2014年3月
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日本整形外科学会雑誌 72(8) s1314-s1314 1998年8月
書籍等出版物
33講演・口頭発表等
462担当経験のある科目(授業)
4共同研究・競争的資金等の研究課題
4-
厚生労働科学研究費補助金 2022年
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文部科学省・日本学術振興会 科学研究費助成事業 2018年4月 - 2021年3月
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文部科学省・日本学術振興会 科学研究費助成事業 2015年4月 - 2018年3月