Curriculum Vitaes
Profile Information
- Affiliation
- professor, Fujita medial innovation center Tokyo, Fujita Health University
- Degree
- PhD(Jul, 2002, Keio University)
- Researcher number
- 10276298
- J-GLOBAL ID
- 200901051691546332
- researchmap Member ID
- 5000105016
Research Areas
1Research History
7-
Jul, 2017
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2015
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Jul, 2012
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Oct, 2005
Awards
7Papers
464-
J Arthroplasty 2025;8:S0883-5403(25)00344-4., Aug, 2025
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Cell Transplant 2025 Jan-Dec;34:9636897251341781. doi: 10.1177/09636897251341781. Epub 2025 Jun 19., Jan, 2025
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Clinical biomechanics (Bristol, Avon), 122 106404-106404, Dec 3, 2024BACKGROUND: Implant design is important for achieving proper knee biomechanics during gait following knee arthroplasty. Bicruciate-stabilized total knee arthroplasty attempts to replicate anterior stability and rotational facilitation. However, its detailed gait biomechanics compared with other implant designs have not been analyzed. The purpose of this study is to compare knee kinematics and kinetics between bicruciate-stabilized total knee arthroplasty, posterior-stabilized total knee arthroplasty, unicompartmental knee arthroplasty, and normal knees. METHODS: Ten healthy subjects, 16 who underwent posterior stabilized total knee arthroplasty, 12 who underwent bicruciate-stabilized total knee arthroplasty, and 13 who underwent unicompartmental knee arthroplasty were recruited. The mean follow-up period after arthroplasty was 11.0 months. Three-dimensional kinematics and kinetics were assessed using a motion capture system with subjects walking on a 5-m walkway. Comparisons between groups were conducted using the Kruskal-Wallis test, and post hoc analysis was performed for those parameters that differed significantly. FINDINGS: The bicruciate-stabilized total knee arthroplasty group showed decreased internal rotation compared to the unicompartmental knee arthroplasty group. Compared to the control group, the posterior-stabilized total knee arthroplasty group exhibited reduced knee extension and internal rotation moment. INTERPRETATION: Bicruciate-stabilized total knee arthroplasties exhibited different biomechanical characteristics compared to unicompartmental knee arthroplasties during terminal stance. Postoperative total knee arthroplasty rehabilitation should focus on relieving stiffness owing to insufficient knee flexion-extension motion observed in both bicruciate-stabilized and posterior-stabilized total knee arthroplasties compared with unicompartmental knee arthroplasty, which may be due to a lack of knee rotational motion during gait.
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Knee. 2024;12;48:14-21. doi: 10.1016/j. knee. 2024.02.015. Online ahead of print.PMID: 38479077, Dec, 2024
Misc.
30-
Scientific reports, 9(1) 18741-18741, Dec 10, 2019The number of osteoarthritis patients is increasing with the rise in the number of elderly people in developed countries. Osteoarthritis, which causes joint pain and deformity leading to loss of activities of daily living, is often treated surgically. Here we show that mechanical stress promotes accumulation of reactive oxygen species (ROS) in chondrocytes in vivo, resulting in chondrocyte apoptosis and leading to osteoarthritis development in a rat model. We demonstrate that mechanical stress induces ROS accumulation and inflammatory cytokine expression in cultured chondrocytes in vitro and that both are inhibited by treatment with the anti-oxidant N-acetyl cysteine (NAC). In vivo, osteoarthritis development in a rat osteoarthritis model was also significantly inhibited by oral administration of NAC. MMP13 expression and down-regulation of type II collagen in chondrocytes, both of which indicate osteoarthritis, as well as chondrocyte apoptosis in osteoarthritis rats were inhibited by NAC. Interestingly, osteoarthritis development in sham-operated control sides, likely due to disruption of normal weight-bearing activity on the control side, was also significantly inhibited by NAC. We conclude that osteoarthritis development in rats is significantly antagonized by oral NAC administration. Currently, no oral medication is available to prevent osteoarthritis development. Our work suggests that NAC may represent such a reagent and serve as osteoarthritis treatment.
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日本リウマチ学会総会・学術集会プログラム・抄録集, 62回 519-519, Mar, 2018
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日本リウマチ学会総会・学術集会プログラム・抄録集, 61回 439-439, Mar, 2017
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整形外科最小侵襲手術ジャーナル, (80) 46-50, Sep, 2016
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日本整形外科学会雑誌, 90(2) S133-S133, Mar, 2016
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日本整形外科学会雑誌, 89(3) S563-S563, Mar, 2015
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日本リウマチ学会総会・学術集会プログラム・抄録集, 59回 427-427, Mar, 2015
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日本リウマチ学会総会・学術集会プログラム・抄録集, 58回 189-189, Mar, 2014
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日本整形外科学会雑誌, 72(8) s1314-s1314, Aug, 1998
Books and Other Publications
33Presentations
462Teaching Experience
4-
Apr, 2020 - Mar, 2021CLINICAL CLERKSHIP IN ORTHOPAEDICS (Keio University)
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Apr, 2020 - Mar, 2021LECTURE SERIES, ORTHOPAEDICS (Keio University)
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Apr, 2019 - Mar, 2020CLINICAL CLERKSHIP IN ORTHOPAEDICS (Keio University)
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Apr, 2019 - Mar, 2020LECTURE SERIES, ORTHOPAEDICS (Keio University)
Research Projects
4-
厚生労働科学研究費補助金, 2022
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Grant-in-Aid for Scientific Research, MEXT,JSPS, Apr, 2018 - Mar, 2021
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Grant-in-Aid for Scientific Research, MEXT,JSPS, Apr, 2015 - Mar, 2018