研究者業績

横井 美有希

ヨコイ ミユキ  (miyuki yokoi)

基本情報

所属
藤田医科大学 医学部 歯科 口腔外科学 助教
学位
博士(歯)(2018年3月 広島大学)

J-GLOBAL ID
202401004513882379
researchmap会員ID
R000069752

論文

 6
  • Hiroshi Oue, Rie Hatakeyama, Eri Ishida, Miyuki Yokoi, Kazuhiro Tsuga
    Oral Diseases 29(7) 2907-2916 2022年10月5日  査読有り
    Abstract Objective This study aims to investigate how experimental tooth loss affected learning, memory function, and brain pathophysiology in mice. Materials and Methods The mice (C57BL/6 J, 2‐month‐old, male) were divided into tooth loss and control groups. The behavioral test battery was performed at 6 and 12 months after tooth extraction. The protein levels of the tight junctions in the brains of the mice were analyzed. Hippocampal astrocyte was measured using immunohistochemical staining. Results The results of behavioral tests and biochemical analysis performed during the 6 months observation period did not show significant differences between the groups. However, the escape latency in the tooth loss group was significantly longer than that in the control group at the 12 months after tooth extraction. The level of claudin‐5 decreased in the tooth loss group. Additionally, hippocampal astrogliosis was found in the tooth loss group. Conclusions Experimental tooth loss reduced the level of claudin‐5 and caused astrogliosis in the brains of mice, which was accompanied by deterioration of learning functions. This study may provide a new insight about the association between tooth loss and cognitive dysfunction.
  • Shinji Hiyama, Miyuki Yokoi, Yuichi Akagi, Yumiko Kadoyama, Kiichi Nakamori, Kazuhiro Tsuga, Takashi Uchida, Ryuji Terayama
    Journal of Molecular Histology 50(4) 389-404 2019年6月18日  査読有り
  • Koji Morita, Hiroki Tsuka, Ko-Ichi Kuremoto, Hitomi Kimura, Hiromichi Kawano, Miyuki Yokoi, Keisuke Yasuda, Mitsuyoshi Yoshida, Kazuhiro Tsuga
    CRANIO® 39(1) 24-28 2019年2月19日  査読有り
  • Miyuki Yokoi, Koh-ichi Kuremoto, Shinsuke Okada, Miwa Sasaki, Kazuhiro Tsuga
    In Vitro Cellular & Developmental Biology - Animal 55(3) 211-219 2019年2月12日  査読有り筆頭著者
  • Reiko Kobatake, Kazuya Doi, Takayasu Kubo, Yusuke Makihara, Yoshifumi Oki, Miyuki Yokoi, Hanako Umehara, Kazuhiro Tsuga
    RSC Advances 9(3) 1625-1631 2019年  査読有り
    <p>The purpose of this study was to evaluate the characteristic structures and osteoconduction ability of porous titanium structures using a resin-impregnated titanium substitution fabrication technique.</p>
  • Shinsuke Okada, Akira Kawano, Hiroshi Oue, Yosuke Takeda, Miyuki Yokoi, Katsunori Koretake, Kazuhiro Tsuga
    Clinical and Experimental Dental Research 3(3) 81-86 2017年6月9日  査読有り
    Abstract This study investigated the clinical utility of an ultrasound axial transmission device in preoperative evaluation of bone quality for dental implantation, by clarifying the relationship between cortical bone speed of sound (cSOS), insertion torque values (ITV), and implant stability quotient (ISQ) in porcine femur bone. Eleven fresh porcine femurs, without soft tissue, were prepared. The cSOS of these bones were measured using the axial transmission device. Bone mineral density (BMD) and porosity (Po) were measured in cortical bone samples obtained from the region of ultrasound measurements by X‐ray microcomputed tomography. Thirty‐three implants were inserted into these samples (three implants per bone sample), and ITV and ISQ were measured for all implants. Then, cortical bone thickness (CbTh) of the area for implantation was measured for all implants using a micrometer. The mean cSOS was 3962 m/s; mean BMD and Po were 0.822 g/cm2 and 0.185%, respectively. cSOS and BMD values were positively correlated, and cSOS values and Po values were negatively correlated. Mean ITV, ISQ, and CbTh were 37.95 Ncm, 71.172, and 2.869 mm, respectively. There was a positive correlation between cSOS values and ISQ values. The cSOS of each bone did not correlate with ITV for all of the bone samples. However, when the CbTh ranges from 3.0 to 3.5 mm, ITV are correlated with cSOS. These findings suggest that cSOS, which reflects the cortical bone quality, may be clinical utility as a preoperative diagnosis of the implant.