医学部

yu kato

  (加藤 由布)

Profile Information

Affiliation
Fujita Health University
Degree
修士(保建学)(藤田保健衛生大学大学院)

Researcher number
50773412
J-GLOBAL ID
201801005012134614
researchmap Member ID
B000313065

Research Interests

 3

Papers

 6
  • Yamashita C, Moriyama K, Hasegawa D, Kato Y, Sakai T, Kawaji T, Shimomura Y, Kurimoto Y, Nagata M, Nishida O
    Blood purification, 46(4) 269-273, Jul, 2018  Peer-reviewed
  • Takahiro Kawaji, Toshikazu Sakai, Kazuhiro Moriyama, Yoshitaka Hara, Tomoyuki Nakamura, Naohide Kuriyama, Yasuyo Shimomura, Yu Kato, Hidefumi Komura, Chizuru Yamashita, Yasuyoshi Kurimoto, Daisuke Hasegawa, Osamu Nishida
    Therapeutic Apheresis and Dialysis, 22(3) 290-294, Jun 1, 2018  Peer-reviewed
    We aimed to investigate the effects of blood purification and cold saline injection sites on the transpulmonary thermodilution values. We measured the cardiac output of eight pigs in every combination of cold saline injection (left jugular and femoral veins) and blood purification sites (right jugular and femoral veins), with or without blood purification. We examined the influence of the difference between the presence and absence of blood purification, vascular sites for blood purification, and sites for cold saline injection on the transpulmonary thermodilution values. Cardiac output measured during blood purification using transpulmonary thermodilution was underestimated however, there was no difference between vascular sites. Cardiac output measured via injection of cold saline into the femoral vein was higher than that obtained through injection of cold saline into the jugular vein, with or without blood purification.
  • Yasuyo Shimomura, Mika Suga, Naohide Kuriyama, Tomoyuki Nakamura, Toshikazu Sakai, Yu Kato, Yoshitaka Hara, Chizuru Yamashita, Hiroshi Nagasaki, Masao Kaneki, Osamu Nishida
    Journal of Intensive Care, 4(1) 48, Jul 22, 2016  Peer-reviewed
    The aim of this study was to investigate the effects of recombinant human-soluble thrombomodulin (rTM) on lipopolysaccharide (LPS)-induced, platelet-dependent neutrophil extracellular trap (NET) formation (NETosis). Human peripheral blood neutrophils and platelets were co-incubated with or without LPS (0.2 μg/ml) in the presence and absence of rTM (2 μg/ml). NETosis was confirmed by immunostaining and confocal microscopy. In the absence of platelets, LPS did not induce NETosis in the neutrophils. NETosis, however, was induced by LPS when neutrophils were co-cultured with platelets (64 % of neutrophils). Notably, rTM was able to fully inhibit NETosis in neutrophils cultured with platelets and in the presence of LPS. rTM did not induce NETosis in this co-culture system (p &lt 0.01 versus LPS in the absence of rTM). These results show that rTM can suppress LPS-induced platelet-dependent NETosis in vitro.
  • Yoshitaka Hara, Yasuyo Shimomura, Tomoyuki Nakamura, Naohide Kuriyama, Chizuru Yamashita, Yu Kato, Taku Miyasho, Toshikazu Sakai, Shingo Yamada, Kazuhiro Moriyama, Osamu Nishida
    THERAPEUTIC APHERESIS AND DIALYSIS, 19(4) 308-315, Aug, 2015  Peer-reviewed
    Promising results have been reported with blood purification as adjuvant treatment; however, the immunological mechanisms remain unclear. We have been developing a new blood purification system for regulating excessive immune reactions in severe sepsis and septic shock using a granulocyte adsorbing column (Adacolumn [Ada]), and a cytokine-adsorbing hemofilter (AN69ST hemofilter [AN69]). Fresh porcine blood was circulated for 6 h in five experimental groups including Ada and AN69 to assess the effects of leukocyte adsorption, phagocytic activity and adhesiveness of granulocytes. In the present study, we found that Ada mainly adsorbed granulocytes and monocytes, but not lymphocytes. The phagocytic activity level of granulocytes decreased, and adhesiveness increased, but the number of CD11b-positive cells markedly decreased in the current system. Elevated cytokine levels (IL-1 beta, IL-8 and IL-10) at the outlet of Ada were significantly lower than at the outlet of AN69 due to cytokine adsorption. Further studies are needed to better understand cellular interactions.
  • 西田修, 湯本美穂, 森山和広, 加藤由布, 下村泰代, 中村智之, 栗山英直, 原嘉孝, 伊藤舞, 野田昌宏, 秋山正慶, 早川聖子, 小松聖史, 山田晋吾, 宮庄拓
    日本アフェレシス学会雑誌, 31(2) 148-155, May 31, 2012  

Presentations

 40

Research Projects

 1