研究者業績

藤原 亜紀

フジワラ アキ  (Aki Fujiwara)

基本情報

所属
日本獣医生命科学大学 獣医学部 獣医学科 准教授 (アジア獣医内科学専門医(内科), 博士(獣医学), 獣医師)
獣医放射線学
学位
博士(獣医学)(東京大学)

通称等の別名
Fujiwara-Igarashi Aki
J-GLOBAL ID
201601014930538617
researchmap会員ID
B000251295

外部リンク

大学院指導紹介

https://www.nvlu.ac.jp/graduate/002-012.html

 

Vet X Talks Vol.6 にて臨床研究・女性獣医師/研究者に関するインタビュー

https://note.com/vet_x_talks/

 


論文

 47
  • Aki Fujiwara-Igarashi, Takafumi Ohshima, Ryusei Kojima, Michio Fujita, Yuta Nakazawa
    Veterinary medicine and science 10(3) e1456 2024年5月  筆頭著者責任著者
    BACKGROUND: Few epidemiological studies on respiratory medicine and the relationship between clinical signs and various respiratory diseases in cats have been reported. OBJECTIVES: This retrospective study aimed to investigate the prevalence and breed predisposition to feline respiratory diseases in Japan and determine the association between clinical signs, duration and type of respiratory diseases. METHODS: The medical records of cats with feline respiratory diseases were examined to obtain information on age, sex, breed, final diagnosis, clinical signs and duration. The odds ratios (ORs) and 95% confidence intervals were calculated to evaluate breed predispositions. Mann-Whitney U, Kruskal-Wallis and Dunn's tests were used to assess the duration of clinical signs. RESULTS: This study included 540 cats with 615 respiratory diagnoses. The American Shorthair breed was predisposed to bronchopneumonia (BP; OR: 5.0) and pulmonary tumour (PT; OR: 3.6), while the Russian Blue breed exhibited a predisposition to inflammatory lower airway diseases (OR: 3.4), BP (OR: 6.1) and interstitial lung diseases (OR: 11.1). Similarly, the Scottish Fold breed displayed predisposition to PTs (OR: 5.8). The duration of clinical signs among nasal diseases, nasopharyngeal diseases and lower tracheal/bronchial and pulmonary diseases differed significantly (p = 0.001, p = 0.012, p < 0.0001, respectively). CONCLUSIONS: The results suggest that some popular breeds in Japan are predisposed to feline respiratory diseases, especially the American Shorthair, Russian Blue and Scottish Fold breeds. The characteristics of occurrence, clinical signs and duration of each disease will aid in diagnosing, treating, preventing and elucidating the pathophysiology of feline respiratory disease.
  • Yuta Nakazawa, Takafumi Ohshima, Mami Kitagawa, Takaomi Nuruki, Aki Fujiwara-Igarashi
    Veterinary sciences 11(1) 2024年1月10日  査読有り最終著者責任著者
    This study aimed to investigate the association of respiratory rate (RR), oxygen saturation (SpO2), and blood findings with respiratory disease in dogs and to compare the examination findings in the chronic and acute phases. Dogs that visited a veterinary referral hospital with respiratory symptoms were classified into the chronic disease group (GC), and those that visited the emergency veterinary hospital were classified into the acute disease group (GA). In total, 704 and 682 dogs were included in GC and GA, respectively. The RR and SpO2 were significantly higher and lower, respectively, in patients with lung disease compared to other disease sites in both groups. White blood cell counts were significantly increased in patients with lung and pleural diseases in both groups. Respiratory alkalosis and respiratory acidosis were most common in GC and GA, respectively. The C-reactive protein levels were elevated in both groups, primarily in patients with lung disease. Associations between the results of several tests for understanding and diagnosing respiratory conditions and diseases were recognized, and differences in the trends of the chronic and acute phases were clarified. These tools may be used as adjuncts to other tests for the diagnosis and monitoring of treatment responses.
  • Yuta Nakazawa, Takafumi Ohshima, Hideyuki Kanemoto, Aki Fujiwara-Igarashi
    The Journal of veterinary medical science 85(10) 1083-1093 2023年10月19日  査読有り最終著者責任著者
    Advanced imaging techniques under general anesthesia are frequently employed to achieve a definitive diagnosis of canine nasal diseases. However, these examinations may not be performed immediately in all cases. This study aimed to construct prediction models for canine nasal diseases using less-invasive examinations such as clinical signs and radiography. Dogs diagnosed with nasal disease between 2010 and 2020 were retrospectively investigated to construct a prediction model (Group M; GM), and dogs diagnosed between 2020 and 2021 were prospectively investigated to validate the efficacy (Group V; GV). Prediction models were created using two methods: manual (Model 1) and LASSO logistic regression analysis (Model 2). In total, 103 and 86 dogs were included in GM and GV, respectively. In Model 1, the sensitivity and specificity of neoplasia (NP) and sino-nasal aspergillosis (SNA) were 0.88 and 0.81 in GM and 0.92 and 0.78 in GV, respectively. Those of non-infectious rhinitis (NIR) and rhinitis secondary to dental disease (DD) were 0.78 and 0.88 in GM and 0.64 and 0.80 in GV, respectively. In Model 2, the sensitivity and specificity of NP and SNA were 0.93 and 1 in GM and 0.93 and 0.75 in GV, respectively. Those of NIR and DD were 0.96 and 0.89 in GM and 0.80 and 0.79 in GV, respectively. This study suggest that it is possible to create a prediction model using less-invasive examinations. Utilizing these predictive models may lead to appropriate general anesthesia examinations and treatment referrals.
  • Hideyuki Kanemoto, Aki Fujiwara-Igarashi, Tetsuya Kobayashi, Kei Harada, Masanao Ichimata, Sangho Kim, Kenji Hosoya, Hirotaka Tomiyasu, Aki Ohmi, Hajime Tsujimoto
    Journal of feline medicine and surgery 25(5) 1098612X231164611 2023年5月  査読有り責任著者
    OBJECTIVES: This multicentre, retrospective observational study aimed to describe the clinical presentation, diagnostic methods, treatment and outcomes of cats with tracheal masses. METHODS: Eighteen cats from five academic or secondary/tertiary animal hospitals were included. RESULTS: The median age at diagnosis was 10.7 years (mean 9.5; range 1-17). There were nine castrated males, seven spayed females, one intact male and one intact female. Fourteen (78%) were domestic shorthairs, one (6%) was an Abyssinian, one (6%) was an American Shorthair, one (6%) was a Bengal and one (6%) was a Scottish Fold. The most common presenting complaints included chronic respiratory distress or dyspnoea (n = 14), followed by wheezing/gagging (n = 12), coughing (n = 5) and voice changes (n = 5). There was cervical tracheal involvement in 16/18, and two showed involvement of the intrathoracic trachea. The following methods were used for diagnosis: ultrasound-guided fine-needle biopsy (UG-FNB) and cytology (n = 8), bronchoscopic forceps biopsy and histopathology (n = 5), surgical resection and histopathology (n = 3), forceps biopsy via an endotracheal tube (n = 1) and histology of tissue sputtered from a cough (n = 1). Lymphoma was most often diagnosed (n = 15), followed by adenocarcinoma (n = 2) and squamous cell carcinoma (n = 1). Most lymphoma cases received chemotherapy with or without radiation according to various protocols, and partial (n = 5) or complete responses (n = 8) were noted. Kaplan-Meier survival data for cats with lymphoma revealed a median survival time of 214 days (95% confidence interval >149 days), which was significantly longer than that of other types of tumours (21 days). CONCLUSIONS AND RELEVANCE: Lymphoma was the most prevalent diagnosis, and showed a good response to chemotherapy with or without radiation therapy. Various diagnostic procedures were performed, and UG-FNB and cytology are good diagnostic procedures for cervical tracheal lesions. Owing to the variety of treatment protocols at different centres, it was impossible to compare outcomes.
  • Yuta Nakazawa, Takafumi Ohshima, Michio Fujita, Aki Fujiwara-Igarashi
    Veterinary medicine and science 9(2) 638-644 2023年3月  査読有り最終著者責任著者
    BACKGROUND: Few studies have investigated the incidence of respiratory diseases based on anatomical sites or the relationship between breed and these diseases. OBJECTIVE: The objective of this study was to investigate the prevalence of canine respiratory diseases among dogs in Japan, with relationship to the breed. METHODS: We retrospectively reviewed the medical records of dogs with respiratory symptoms and calculated the odds ratio (OR) to evaluate the relationship between breed and disease. RESULTS: A total of 1050 dogs with respiratory symptoms were included in this study. Miniature dachshunds were the most common breed affected by respiratory diseases. Among tracheobronchial diseases, there was a significant association between some small breeds and tracheobronchial collapse, miniature dachshunds (OR: 4.44, 8.43, 95% confidence interval [CI]: 3.17-6.22, 4.33-16.0) and chronic bronchitis and bronchiectasis. Among nasal diseases, miniature dachshunds (OR: 27.2, 95% CI: 16.8-44.8) and golden retrievers (OR: 21.0, 95% CI: 6.43-69.3) were the most affected by non-infectious rhinitis and nasal aspergillosis, respectively. Brachycephalic obstructive airway syndrome was the most common disease among pharyngeal and laryngeal diseases, with a relationship with breed being found in some brachycephalic breeds, and Pomeranians (OR: 2.7, 95% CI: 1.42-5.17). CONCLUSIONS: Respiratory diseases in dogs are strongly correlated with popular breeds in Japan. Miniature dachshunds, in particular, are associated with many respiratory diseases, which may differ from international reports. Thus, this result may help in the early detection, prevention, treatment, and elucidation of the pathophysiology of canine respiratory diseases.

MISC

 143

書籍等出版物

 21
  • 藤原亜紀 (担当:共著, 範囲:リンパ腫の診断・治療法 猫のリンパ腫 鼻腔/鼻咽頭リンパ腫の治療)
    緑書房 2024年10月
  • 藤原亜紀 (担当:監修, 範囲:第2章:くしゃみ・鼻水/慢性鼻炎・慢性副鼻腔炎、付録典型的な症状に対する疾患のフローチャート:咳)
    Eduward Press 2024年9月
  • 藤原亜紀 (担当:共著, 範囲:鼻炎・副鼻腔炎、慢性気管支炎、猫喘息・慢性気管支炎(下気道炎症性疾患)、肺炎)
    EDUWARD Press 2023年8月 (ISBN: 9784866712017)
  • 藤原亜紀 (担当:分担執筆, 範囲:「くしゃみをしています」「鼻水が出ています」「咳をしています」)
    学窓社 2023年6月 (ISBN: 9784873627885)
  • 藤原亜紀 (担当:共著, 範囲:超音波検査(喉頭・肺)、内視鏡検査(鼻腔・咽頭および喉頭))
    緑書房 2023年4月 (ISBN: 9784895318792)
  • 藤原亜紀 (担当:監修, 範囲:監修:全章 執筆:頭部X線検査画像の撮影・読影ポイント、鼻炎、猫の鼻咽頭腫瘤、猫の喉頭腫瘤、短頭種気道症候群、喉頭超音波検査、咽喉頭〜食道透視X線検査、胸部X線検査画像の撮影・読影ポイント、読影できるようになりたい・胸部X線検査基本の3パターン、巨大食道症、犬の慢性気管支炎/気管支拡張症、気管・気管支腫瘍、犬の肺炎、猫の肺炎、間質性肺疾患、肺気腫、縦隔腫瘍、気胸/縦隔気腫、犬の肺腫瘍、猫の肺腫瘍、肺葉捻転、肺のミネラル化、肺超音波検査、腹部X線検査画像の撮影・読影ポイント、腹腔結石)
    EDUWARD Press 2022年12月 (ISBN: 9784866711843)
  • 藤原亜紀 (担当:共著, 範囲:鼻咽頭狭窄、鼻腔腫瘤、喉頭の炎症・腫瘍、猫の気管・気管支疾患、肺気腫、肺葉捻転、縦隔気腫・気胸、縦隔腫瘍・胸膜腫瘍)
    緑書房 2022年9月 (ISBN: 9784895317863)
  • 藤原亜紀 (担当:監修, 範囲:執筆:鼻腔腫瘍、肺腫瘍、スコティッシュフォールドの骨軟骨異形成症、若齢猫・高齢猫における気管挿管に伴う縦隔気腫、高齢の純血種に多くみられる鼻腔腫瘍(非リンパ腫)、国内人気品種の起源・特徴(スコティッシュフォールド) 監修:呼吸器・胸腔疾患、骨・関節疾患、腫瘍)
    EDUWARD Press 2022年7月 (ISBN: 9784866711522)
  • 藤原亜紀 (担当:監修, 範囲:監修:X線検査、透視X線検査、CT検査、MRI検査 執筆:X線検査[鼻腔・咽頭(犬猫)、喉頭(猫)、気管・気管支(猫)、肺、縦隔]、透視X線検査[咽喉頭、気管・気管支(猫)]、内視鏡検査[鼻腔・咽頭、喉頭(猫)]、MRI検査[鼻腔・咽頭])
    ファームプレス 2022年4月 (ISBN: 9784863821149)
  • 藤原亜紀 (担当:分担執筆, 範囲:第3章呼吸器・胸腔疾患(鼻腔の疾患、咽頭と喉頭の疾患、縦隔気腫))
    文永堂出版 2022年3月
  • 藤原亜紀 (担当:共著, 範囲:スコティッシュ・フォールドの骨軟骨異形成症)
    緑書房 2021年10月
  • 藤原亜紀 (担当:共著, 範囲:第2章呼吸器 1鼻腔・咽頭鼻部 2喉頭)
    緑書房 2021年3月
  • 藤原亜紀 (担当:単訳, 範囲:鼻腺癌、鼻リンパ腫、鼻腔異物、鼻咽頭ポリープ、スコティッシュフォールドの骨軟骨異形成症)
    株式会社エデュワードプレス 2020年8月
  • 藤原亜紀 (担当:共著, 範囲:鼻腺癌、鼻腔異物、リンパ球形質細胞性鼻炎)
    株式会社エデュワードプレス 2020年8月
  • 藤原亜紀 (担当:共著, 範囲:鼻腔腫瘍、喉頭麻痺、縦隔(洞)気腫)
    緑書房 2020年2月
  • 藤原亜紀 (担当:共著, 範囲:呼吸器(鼻・喉頭))
    インターズー 2019年4月
  • 藤原亜紀 (担当:共著, 範囲:縦隔気腫、鼻炎・鼻腔内腫瘍、鼻咽頭狭窄、喉頭炎・喉頭腫瘍)
    緑書房 2017年8月
  • 藤原亜紀 (担当:共訳, 範囲:Section4 胸部)
    緑書房 2016年11月
  • 藤原亜紀 (担当:共著)
    誠文堂新光社 2016年7月
  • 藤原亜紀 (担当:共訳)
    インターズー 2016年2月
  • 藤原亜紀 (担当:共著, 範囲:アスペルギルス性鼻炎、短頭種気道症候群、鼻腺癌、鼻リンパ腫)
    インターズー 2015年9月

講演・口頭発表等

 145

担当経験のある科目(授業)

 12

共同研究・競争的資金等の研究課題

 5

社会貢献活動

 6

メディア報道

 7