Curriculum Vitaes
Profile Information
- Affiliation
- Professor, Faculty of Veterinary ScienceSchool of Veterinary Medicine, Nippon Veterinary and Life Science University
- Degree
- 博士(獣医学)(日本獣医生命科学大学)
- J-GLOBAL ID
- 201601000466127500
- researchmap Member ID
- B000251047
Committee Memberships
8-
Jun, 2023 - Present
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Jul, 2019 - Present
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Apr, 2019 - Present
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2014 - Present
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Apr, 2012 - Present
Awards
2Papers
88-
Biology, Apr 30, 2024 Peer-reviewed
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Journal of Veterinary Internal Medicine, Apr 25, 2024 Peer-reviewed
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International Journal of Molecular Sciences, Dec 14, 2023 Peer-reviewed
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Journal of veterinary internal medicine, Aug 18, 2023 Peer-reviewedBACKGROUND: Pulmonary hypertension (PH) secondary to respiratory disease is caused by pulmonary vascular remodeling and hypoxia. Severe PH can induce various clinical signs, including syncope and right-sided heart failure. HYPOTHESIS/OBJECTIVES: To investigate the echocardiographic characteristics in dogs with PH secondary to respiratory diseases. ANIMALS: Thirty-one dogs with respiratory diseases with or without PH and 15 healthy dogs. METHODS: Prospective cross-sectional study. Dogs were classified according to respiratory disease (obstructive airway/lung disease [OALD] or restrictive lung disease [RLD]) and PH-relevant signs. The association between echocardiographic variables and PH (classified by respiratory disease and PH-relevant signs) was investigated. RESULTS: Twenty-one dogs were diagnosed with PH; of these, 11 showed PH-related signs (OALD, n = 2; RLD, n = 9), 14 had right ventricular hypertrophy, and 19 had pulmonary arterial enlargement. Right ventricular dysfunction and dilatation were observed only in dogs with PH-related signs (n = 10). Left and right ventricular stroke volumes were significantly lower in dogs with PH (median [interquartile range]: 17.2 [12.4-20.8] and 16.8 [15.3-29.5] mL/m2 , respectively). Dogs with RLD had higher echocardiography-estimated pulmonary vascular resistance than those with OALD (median [interquartile range]: 3.1 [1.9-3.3] and 1.6 [1.3-2.2], respectively). CONCLUSIONS AND CLINICAL IMPORTANCE: Pulmonary arterial enlargement was the most common echocardiographic finding in dogs with PH secondary to respiratory diseases. Right ventricular dysfunction, dilatation, and decreased left and right ventricular stroke volume were significantly associated with the PH-related signs, indicating that comprehensive echocardiography is recommended in dogs with respiratory disease. Restricted lung disease might induce more severe PH than OALD.
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Veterinary sciences, 10(4), Apr 19, 2023 Peer-reviewedPulmonary hypertension (PH) is a life-threatening complication in dogs with cardiopulmonary disease. Epoprostenol is an intravenous pulmonary vasodilator used to treat PH in humans; however, its efficacy in dogs remains unknown. We investigated the cardiovascular effects of epoprostenol and several cardiac agents for acute heart failure in canine models of chronic PH. Six dogs with chronic PH were anesthetized and underwent right heart catheterization and echocardiography before and after infusion of epoprostenol, dobutamine, dopamine and pimobendane. (The drug administration order was the same for all dogs). High-dose epoprostenol (15-20 ng/kg/min) tended to decrease pulmonary arterial pressure (PAP) while significantly decreasing pulmonary and systemic vascular resistance and increasing left and right ventricular (LV and RV, respectively) function. Pimobendan significantly increased LV and RV functions without increasing PAP. Conversely, dobutamine and dopamine significantly increased LV and RV function as well as PAP. This study revealed the efficacy of epoprostenol in treating canine PH through its pulmonary and systemic vasodilating effects. Although catecholamines improve LV and RV function, they might worsen PH pathophysiology, and careful monitoring may be necessary when using these drugs. Pimobendan improved LV and RV function without increasing PAP; however, a stronger vasodilating effect was observed with epoprostenol.
Misc.
86-
Small Anim Dermatol, 10(1) 58-64, Jan 15, 2014
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Small Anim Dermatol, 10(1) 65-71, Jan 15, 2014
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Small animal dermatology : 小動物皮膚科専門誌, 25 58-64, Jan, 2014
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Small animal dermatology : 小動物皮膚科専門誌, 25 65-71, Jan, 2014
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獣医麻酔外科学雑誌, 44(Suppl.2) 247-247, Dec, 2013
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獣医麻酔外科学雑誌, 44(Suppl.1) 259-259, Jun, 2013
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獣医麻酔外科学雑誌, 44(Suppl.1) 260-260, Jun, 2013
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Clinic note : journal of clinical daily treatment for small animals, 9(2) 100-106, Feb, 2013
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日本獣医生命科学大学研究報告, (61) 42-50, Dec, 2012 Peer-reviewed早期離乳により成熟後のラットの不安傾向が増加することが知られている。本研究では,早期離乳に関わる様々な要因の中でも栄養的側面に着目し,早期離乳に伴いn-3不飽和脂肪酸が低下するのか,さらにn-3不飽和脂肪酸を補うことで不安傾向が軽減されるのかについて検討した。対象は63頭のWistar-Imamichiラットであり,通常離乳群(CT群),早期離乳群(EW群),サプリメント群(SP群)の3群から成る。CT群のラットは21日齢,EW群とSP群のラットは15日齢で離乳,さらにSP群のラットには離乳後の5日間にn-3不飽和脂肪酸を主成分とするサプリメントを餌に混ぜて与えた。3群ともに10週齢に達した時点で驚愕反応を指標として用い不安傾向を測定し,同時にロータロッド・テストにより協調運動機能について検討した。血中脂肪酸濃度は3週齢,5週齢,10週齢の時点で測定した。実験の結果,EW群,SP群のラットは,CT群のラットよりも不安傾向が増大し,EW群のオスにおいては協調運動機能の低下が確認された。また,血中脂肪酸の解析結果からは,早期離乳したラットのn-3不飽和脂肪酸が成熟後に至るまで低下することが明らかになった。一方,EW群とSP群との間に,不安傾向の顕著な差は認められなかった。今後はn-3不飽和脂肪酸の投与量や投与期間を増加させて検討を重ねる必要がある。
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小動物臨床, 26(4) 250-255, Jul 1, 2007
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日本獣医学会学術集会講演要旨集, 126th 236, Aug, 1998
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日本獣医学会学術集会講演要旨集, 125th 274, Mar, 1998
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日本獣医学会学術集会講演要旨集, 121st 232, Mar, 1996