研究者業績
基本情報
研究キーワード
23研究分野
1経歴
6-
2016年4月 - 現在
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2012年4月 - 2015年3月
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2007年4月 - 2012年3月
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2006年4月 - 2007年3月
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2004年4月 - 2006年3月
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2001年4月 - 2004年3月
委員歴
3-
2019年9月 - 現在
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2017年10月 - 現在
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2017年4月 - 現在
受賞
1-
2014年4月
論文
139-
Journal of Comparative Pathology 210 8-14 2024年4月
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The Canadian veterinary journal = La revue veterinaire canadienne 65(3) 227-233 2024年3月A stray cat, an intact female Japanese domestic shorthair cat of unknown age (suspected to be a young adult), was rescued. The cat was lethargic and thin and had marked skin fragility, delayed wound healing without skin hyperextensibility, and hind limb proprioceptive ataxia and paresis. Survey radiography, computed tomography, and magnetic resonance imaging revealed congenital vertebral anomalies, including thoracolumbar transitional vertebrae, scoliosis resulting from a thoracic lateral wedge-shaped vertebra, and a kinked tail, and a dilated spinal cord central canal. Through nutritional support, the cat's general condition normalized, followed by a gradual and complete improvement of skin features. Whole-genome sequencing was completed; however, no pathogenic genetic variant was identified that could have caused this phenotype, including congenital scoliosis. A skin biopsy obtained 7 y after the rescue revealed no remarkable findings on histopathology or transmission electron microscopy. Based on clinical course and microscopic findings, malnutrition-induced reversible feline skin fragility syndrome (FSFS) was suspected, and nutritional support was considered to have improved the skin condition. Key clinical message: This is the second reported case of presumed malnutrition-induced reversible FSFS and was accompanied by long-term follow-up.
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International Journal of Molecular Sciences 2023年12月14日
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Journal of Veterinary Diagnostic Investigation 2023年10月2日A 9-y-old male Boxer dog developed a mandibular skin tumor, which histologically had a locally invasive growth pattern composed of bilayered structures of inner eosinophilic cuboidal tumor cells and outer clear polygonal tumor cells with cytoplasm containing glycogen granules. Both cell populations gradually changed from low-grade morphologic features to highly anaplastic ones. Immunohistochemically, the eosinophilic tumor cells were positive for cytokeratin 8, a useful marker for luminal epithelial cells. In contrast, the clear tumor cells expressed several myoepithelial markers, including α-smooth muscle actin, p63, and cytokeratin 14. Based on these histologic and immunohistochemical characteristics, we diagnosed this apocrine sweat gland tumor as a carcinoma-and-malignant myoepithelioma with high-grade transformation of both luminal and myoepithelial cells. Our case may be a helpful reference for the histogenesis of carcinoma-and-malignant myoepithelioma, in which both the luminal epithelial and myoepithelial components are malignant.
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Frontiers in Veterinary Science 10 2023年4月 査読有り
MISC
38-
日本獣医師会雑誌 = Journal of the Japan Veterinary Medical Association 73(11) 665-668 2020年11月
書籍等出版物
1講演・口頭発表等
44所属学協会
3共同研究・競争的資金等の研究課題
11-
日本学術振興会 科学研究費助成事業 2022年4月 - 2025年3月
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日本学術振興会 科学研究費助成事業 2021年4月 - 2024年3月
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2019年4月 - 2022年3月
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基盤研究(B) 2015年4月 - 2018年3月
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日本学術振興会 科学研究費助成事業 2014年4月 - 2017年3月