Curriculum Vitaes
Profile Information
- Affiliation
- Professor, Nippon Veterinary and Life Science University学術顧問, 日本臨床獣医学フォーラム
- Degree
- (BLANK)(BLANK)
- J-GLOBAL ID
- 200901046496925929
- researchmap Member ID
- 1000303666
- External link
Research Interests
4Research Areas
1Education
2Committee Memberships
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Apr, 2008 - Present
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Apr, 2008 - Present
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Apr, 2008 - Present
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Apr, 2008 - Present
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Feb, 2001 - Present
Papers
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Journal of Small Animal Practice, Jun 22, 2023
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Open Veterinary Journal, 13(5) 604-604, 2023Background: Plasma N-terminal pro-atrial natriuretic peptide (NT-proANP) and plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations may be affected by the hydration status.Aim: This study aimed to evaluate the effect of dehydration on plasma NT-proANP and NT-proBNP concentrations in healthy dogs. Methods: This prospective study included five clinically healthy dogs. Furosemide was administered intravenously at 2–4 mg/kg every 1–2 h until completion of the dehydration model. The dehydration model was considered complete when weight loss was ≥5% and findings of dehydration on physical examination were observed. Plasma NT-proANP and NT-proBNP concentrations were compared at three time points: before the dehydration model was created (point 1), at the completion of the dehydration model (point 2), and when dehydration was judged to have improved (point 3). Association between plasma NT-proANP and NT-proBNP concentrations, and each clinical variable (physical examination, blood pressure, blood chemistry, blood gases, and echocardiography) was assessed using linear regression analysis. Results: Plasma NT-proANP concentration decreased significantly from point 2 to point 1 (p < 0.05), whereas plasma NT-proBNP concentration showed a decreasing trend but did not differ significantly between points 1 and 2. Plasma NT-proANP concentration correlated significantly with body weight (R2 = 0.178) and plasma NT-proBNP concentration (R2 = 0.284) (p < 0.05, respectively), and plasma NT-proBNP concentration correlated significantly with electrolytes (sodium, R2 = 0.439; potassium, R2 = 0.444; chloride, R2 = 0.419), and echocardiographic parameters (diastolic left ventricular internal diameter [LVIDd], R2 = 0.519; weight-standardised LVIDd, R2 = 0.535) (p < 0.01, respectively). Conclusion: The plasma NT-proANP concentrations decreased with dehydration. However, the plasma NT-proBNP concentration did not change with mild dehydration and reflected left ventricular morphology.
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Veterinary record open, 9(1) e28, Dec, 2022BACKGROUND: Ivabradine is used to treat tachycardia; unlike atenolol, it does not affect blood pressure or myocardial contractility. This study compared the impact of ivabradine and atenolol on heart rate (HR) and HR variability (HRV) during a 24 h period, feeding and sleeping times, via a Holter electrocardiogram in healthy cats. We hypothesised that ivabradine and atenolol would lower the HRs equally well, even at times of excitement and rest, such as during feeding and sleep; that ivabradine, unlike atenolol, would have an effect on HRV. METHODS: Five clinically healthy cats were used in the prospective blinded crossover study receiving 3 days of ivabradine (0.30 mg/kg per os twice daily) followed by atenolol (6.25 mg/cat per os twice daily, range 1.3-2.0 mg/kg) or receiving atenolol followed by ivabradine. A placebo period was initiated before the start of the crossover test, data obtained during that period were used as a baseline (BL). Evaluation parameters included HR and HRV, for the whole 24 h period and for feeding and sleeping times, comparing the effect of ivabradine and atenolol with BL. RESULTS: The HR for the whole 24 h, feeding and sleeping times, were significantly lower with ivabradine and atenolol, compared to BL (p < 0.05). The HRV for the whole 24 h and sleeping time were significantly higher after ivabradine compared with BL and after atenolol. CONCLUSIONS: In healthy cats, ivabradine and atenolol significantly reduced the HR regardless of excitement and rest; their effects were comparable. Ivabradine significantly increased HRV in comparison to BL whereas atenolol did not.
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Veterinary World, 2072-2083, Aug 27, 2022Background and Aim: Electrocardiography (ECG) is an adjunct for cardiac enlargement diagnosis. However, its efficacy in assessing left cardiac remodeling (left atrial and left ventricular enlargement) in dogs with myxomatous mitral valve disease (MMVD) remains unclear. This study aimed to evaluate the association between ECG parameters and left cardiac remodeling and to investigate whether the rate of change in ECG waveforms in the same individual reflected left cardiac remodeling in dogs with MMVD.Materials and Methods: This retrospective study included 20 healthy dogs and 140 dogs with MMVD. Data on clinical variables were obtained through physical examination, thoracic radiography, and echocardiography. The ECG parameters were the P-wave duration, PR interval, QRS complex duration, P-wave amplitude, R-wave amplitude, and mean electrical axis. Dogs with examination data that could be obtained multiple times during the study period were classified into the non-progressive and progressive groups.Results: Only the P-wave and QRS complex durations were selected as significant variables associated with imaging test parameters (p < 0.05); they had a relatively higher discriminatory ability for the left cardiac remodeling than other ECG parameters. The rates of change in the PR interval and R-wave amplitude were significantly higher in the progressive group than in the non-progressive group.Conclusion: In dogs with MMVD, the P-wave and QRS complex durations were significantly correlated with the left cardiac remodeling indicators. Furthermore, an increased rate of change in the PR interval and R-wave amplitude in the same individual may indicate left cardiac remodeling.
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Journal of feline medicine and surgery, 24(6) 1098612X221089856, Apr 26, 2022OBJECTIVES: This study aimed to define the prevalence of upper urolithiasis in cats with chronic kidney disease (CKD) in a referral population, and to compare urinary calcium:creatinine ratio (UCa:Cr), and total and ionised calcium between cats with CKD with and without upper urolithiasis. METHODS: The medical records of cats diagnosed with CKD were reviewed for signalment, body weight, diet and prevalence of upper urolithiasis. Cats with preserved urine samples were further classified into two groups: urolithiasis group (upper urolithiasis identified by abdominal ultrasonography) and control group (CKD of unknown origin). Serum biochemical analysis, CKD stage, blood gas analysis, urine specific gravity and UCa:Cr were compared between groups using a two-sample t-test or Mann-Whitney U-test for continuous variable and a χ2 test or Fisher's exact test for categorical variables. Multivariable binary logistic regression analysis was used to identify risk factors. RESULTS: Among the 140 cats with CKD, the prevalence of upper urolithiasis was 73%. Fifty cats (5, 29 and 16 cats with CKD stages 1, 2 and 3, respectively) with urine samples met the inclusion criteria and were included in the analysis. Among cats with CKD, being purebred (odds ratio [OR] = 81.56; P = 0.03) and being fed dry food only (OR = 25.06; P = 0.001) were identified as independent upper urolithiasis risk factors; those with upper urolithiasis were more likely to be exclusively fed with urine-acidifying food (P <0.001) and have increased serum ionised calcium (iCa) (P = 0.044), fractional excretion of calcium (P = 0.45) and UCa:Cr (P = 0.005) than cats with CKD without upper urolithiasis. CONCLUSIONS AND RELEVANCE: Cats with CKD that were purebred, fed dry food and fed urine-acidifying food only often had upper urolithiasis. A higher UCa:Cr may be a result of increased serum iCa and may cause upper urolithiasis.
Misc.
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獣医麻酔外科学雑誌, 40(Supplement 1) 216, Jun 20, 2009
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獣医麻酔外科学雑誌 = Japanese journal of veterinary anesthesia & surgery, 40, Jun 20, 2009
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Advances in animal cardiology, 42(1) 8-15, Jun 1, 2009目的-高齢犬の血圧、心拍数(HR)および心拍変動解析(HRV)の日内変動は、降圧剤などの循環器作用薬を処方する場合に考慮すべき事項である。しかし、高齢犬ではこれらの報告はない。そのため、本研究では高齢犬の血圧、HRおよびHRVの日内変動を観察し、併せて若齢犬のそれと比較した。方法-雌の正常ビーグル犬が高齢群(10-11歳、n=5)または若齢群(1-3歳、n=6)に振り分けられた。テレメトリーシステムを用い、収縮期血圧(SBP)、拡張期血圧(DBP)、脈圧(PP)およびHRが、無麻酔無拘束下で7日間連続記録された。HRVの高周波成分(HF)および低周波成分(LF)とHFの比 (LF/HF)も記録された。結果-高齢群では、SBP、DBP、HFおよびLF/HFは二峰性の日内変動を示し、HFは単峰性だった。若齢群では、HRおよびLF/HFの日内変動は二峰性だったが、SBP、DBPおよびHFは単峰性だった。PPの日内変動は、両群ともあまり変動しなかった。高齢群では、SBPが有意に上昇し(P=0.0002)、DBPが有意に低下した(P<0.0001)。その結果、PPは有意に増大した(P<0.0001)。HRおよびHFには両群間に有意差はなかった。LF/HFは若齢群で有意に高値を示した(P<0.0001)。結論-本研究の結果は、高齢犬の心血管パラメータの日内変動は若齢犬と異なることを示した。高齢犬の変動は、摂食などの刺激に若齢犬よりも容易に影響されるようだった。さらに、高齢犬ではPPが有意に増大した。高齢犬で観察されたSBPの増加およびDBPの低下は人で観察される変化に類似した。
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動物の循環器, 42(1) 8-15 (J-STAGE), 2009
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ペット栄養学会誌, 12 17-18, 2009慢性心臓弁膜症(ISACHCクラスIa~II)罹患犬12頭に対し心臓病用療法食(療法食)を12週間にわたり給与した。開始時、そして開始後4、8および12週間後にNa、血漿アルドステロン(Aldo)、心房性ナトリウム利尿ペプチド(ANP)およびN末端プロB型ナトリウム利尿ペプチド(NT-proBNP)濃度を測定し、さらに胸部X線検査および心エコー検査を実施した。その結果、療法食開始後のAldoは開始前に比べて上昇傾向を示したが有意な変動ではなかった。NaおよびANPに有意な変動は認められなかった。加えて、胸部X線検査および心エコー検査所見も同様であった。以上の結果から、療法食開始後にAldoが上昇するが、心臓の形態および機能には影響しないと考えられた。
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Advances in Animal Electrocardiography, 42(1) 8-15, 2009Objective—The circadian rhythms of blood pressure (BP), heart rate (HR) and heart rate variability (HRV) in aged dogs are important considerations in the prescription of cardiovascular agents, especially antihypertensives. However, currently there are limited data in the literature concerning this topic. Therefore, this study determined the circadian rhythms of BP, HR and HRV in aged dogs and compared the data to those of young dogs.Procedure—Healthy female beagles were assigned to the "aged group" (10-11 y; n=5) or "young group" (1-3 y; n=6). The systolic BP (SBP), Diastolic BP (DBP), pulse pressure (PP) and HR were continuously recorded in non-anesthetized and unrestrained dogs over seven days using a telemetry system. The high-frequency (HF) and low-frequency/high-frequency (LF/HF) data of HR variability (HRV) were also determined.Results—In the aged group, the circadian rhythms of SBP, DBP, HR and LF/HF were bimodal, while HF was unimodal. In the young group, the circadian rhythms of HR and LF/HF were bimodal and SBP, DBP and HF were unimodal. The amplitudes of the circadian rhythms of PP were small in both groups. A unique finding in the aged group was that the average value of SBP rose (p=0.0002) and that of DBP fell (p<0.0001), resulting in a significant increase in the value of PP (p<0.0001). There were no significant differences in the average values of HR and HF in the groups. The average values of LF/HF were significantly higher in the young group (p<0.0001).Conclusion—The findings of this study suggest that the circadian rhythms of cardiac parameters in aged dogs are different from those of young dogs. Aged dogs' variations may be more easily affected by environmental stimulations such as feeding. Additionally, in aged dogs, PP increased significantly. The observed rise in SBP and fall in DBP in the aged dogs is similar to the changes observed in humans.
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Journal of Japanese Association of Veterinary Nephrology and Urology, 1(1) 46-54, Nov, 2008
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日本獣医師会雑誌, 61(5) 386-389, May 20, 2008
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Journal of the Japan Veterinary Medical Association, 61(5) 386-389, May 20, 2008約1カ月前からの運動不耐性に加え、1週間前からの断続的な発咳を主訴にフェレット(去勢雄、5歳、体重1.25kg)が日本獣医生命科学大学付属動物医療センターに来院した。身体検査では、頻脈および不整脈が聴取された。心電図検査では心室副収縮が記録された。胸部X線検査では、心陰影の拡大は軽度であったが、Mモード心エコー法により、拡張期左室内径の拡大および左室短径短縮率の低下がみられた。テモカプリルおよびアテノロールの経口投与を開始したが、第192病日に突然死した。
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ペット栄養学会誌, 11 5-6, 2008当初,肝硬変と診断・管理されていたヨークシャー・テリア(去勢雄,8歳)がその後に腎機能不全,さらに糖尿病を併発した。これらの疾患ではいずれも方針の異なる食事療法が推奨されている.現在,本症例は薬剤による腎保護療法およびインスリン療法,そして,それぞれの疾患に適した食事療法を実施することで,良好に管理できたと判断された。
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Journal of the Japan Veterinary Medical Association, 61(5) 386-389, 2008five-year-old castrated male ferret weighing 1.25 kg was presented to the Animal Medical Center of the Nippon Veterinary and Life Science University with a one-month history of exercise intolerance and one week ofintermittent coughing. A physical examination revealed that tachycardia and arrhythmia were ausclutated.Electrocardiography revealed ventricular parasystole. Although mild cardiac enlargement was observed bythoracic radiography, a reduced diastolic internal diameter of the left ventricle and fractional shortening wereconfirmed by echocardiography. Oral temocapril and atenolol were initiated, however the ferret died suddenlyafter 192 hospital days.
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Journal of Veterinary Medical Science, 69(9) 939-944, Sep, 2007Preemptive analgesia is recommended in small animal medicine. However, many studies have evaluated the response to analgesic treatment by behavioral observation. Therefore, the influence of preemptive analgesia with meloxicam on postoperative cardiovascular and renal parameters remains to be clarified. The present study examined the changes in blood pressure, heart rate, double product and heart rate variability for 14 days and the changes in glomerular filtration rate (GFR) and serum cortisol level for 24 hr after resection of the unilateral mammary gland in meloxicam and control groups consisting of 5 healthy dogs. All data were collected under unanesthetized and unrestrained conditions using a radio telemetry system. Blood pressure, heart rate and double product were significantly lower in the meloxicam compared with the control group, and the meloxicam group's diurnal changes became stable more than 36 hr earlier than those of the control group. The systolic, diastolic and mean blood pressure values of the meloxicam group were 5- to 20-mm Hg lower than those of the control group until 5 days after surgery. The maximum difference between the two groups in terms of the double product values 14 days after surgery was 2,000 bpm x mmHg. Autonomic activity inhibition was prolonged in the control group. There were no significant differences in the 24-hr changes in GFR or serum cortisol level. This study showed that perioperative administration of meloxicam reduced unfavorable postoperative changes in the cardiovascular system without influencing renal function.
Books and Other Publications
15Presentations
14Research Projects
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科学研究費助成事業, 日本学術振興会, 1994 - 1994
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科学研究費助成事業, 日本学術振興会, 1993 - 1993