Faculty of Veterinary Science
基本情報
- 所属
- 日本獣医生命科学大学 獣医学部 獣医学科 獣医寄生虫学研究室 教授
- 学位
- 獣医学修士(日本獣医畜産大学)博士(獣医学)(日本獣医畜産大学)
- J-GLOBAL ID
- 200901020343407296
- researchmap会員ID
- 1000145506
- 外部リンク
研究キーワード
5研究分野
1経歴
3-
1999年4月 - 現在
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1983年 - 1999年
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1983年 - 1999年
学歴
4-
- 1983年
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- 1983年
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- 1981年
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- 1981年
委員歴
1-
2017年9月 - 2020年8月
論文
29-
Journal of Microbiology, Immunology and Infection 55 527-534 2022年6月 査読有り
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Parasitology International 2020年8月 査読有り
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International Journal for Parasitology: Parasites and Wildlife 11 83-87 2020年4月 査読有り
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Vaccine 37 6426-6434 2019年9月 査読有り
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International Journal for Parasitology: Parasites and Wildlife 9 244-247 2019年8月 査読有り
MISC
36-
JOURNAL OF VETERINARY MEDICAL SCIENCE 67(5) 515-520 2005年5月As the comparative study was carried out on the susceptibility by the pursuit of parasitemia among the Djungarian, Syrian, and Chinese hamsters as well as BALB/c mice infected with the Syrian hamster-adapted Babesia microti strain, and Djungarian hamsters showed the highest parasitemia among them. Then, the other hematological parameters were pursued in the Djungarian hamsters infected with the hamster-adapted B. micron strain. Remarkable symptoms observed were hemoglobinuria clinically, anemia hematologically, and splenomegaly macroscopically during all over the observation period for 24 weeks post infection (PI). Parasitemia began to rise at 2 weeks and peaked at 4 weeks PI. After that, parasitemia decreased gradually but was maintained with a level of about 10% on average until 24 weeks PI at the end of the experiment. A decrease in the RBC count, Hb, and PCV, and an increase in the reticulocyte and WBC counts due to the development of immature neutrophils, lymphocytes and monocytes were recognized together with a rise of parasitemia. The hamsters had macrocytic hypochromic anemia due to the increase of MCV and the decrease of MCHC in the growth phase of the parasite. It was considered that the Djungarian hamsters will be useful for the infection examination, isolation, maintenance, and passage of B. microti in laboratory.
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JOURNAL OF VETERINARY MEDICAL SCIENCE 67(5) 521-524 2005年5月Mice were inoculated intraperitoneally wih 34 different types of vegetable juices, and interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) were measured as markers for the induction of Th1 and Th2 cells, respectively. Serum IFN-gamma level was markedly increased in mice inoculated with bitter gourd (Momordica charantia) juice, but IL-4 levels were not increased with any of the 34 vegetable juices. Testing of the various components of bitter gourd, including peel, pulp, and seed, showed that the pulp induced the highest levels of IFN-gamma. Trial immunogen including the heat extract of the pulp induced specific IgG(2a) antibody of the mice serum inoculated with this immunogen. These results demonstrate that bitter gourd pulp induced IFN-gamma production and show its promise as a means of effective imnunostimulatory therapy specific for Th1 cells and IFN-gamma production.
書籍等出版物
5講演・口頭発表等
2共同研究・競争的資金等の研究課題
10-
日本学術振興会 科学研究費助成事業 2016年4月 - 2020年3月
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日本学術振興会 科学研究費助成事業 2016年4月 - 2019年3月
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日本学術振興会 科学研究費助成事業 2013年4月 - 2016年3月
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日本学術振興会 科学研究費助成事業 2010年 - 2012年
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日本学術振興会 科学研究費助成事業 2007年 - 2009年