School of Veterinary Medicine

Kazunori Ike

  (池 和憲)

Profile Information

Affiliation
Professor, Faculty of Veterinary Science, School of Veterinary Medicine, Nippon Veterinary and Life Science University
Degree
Master of Veterinary Science(Nippon Veterinary and Animal Science University)
Ph. D.(Nippon Veterinary and Animal Science University)

J-GLOBAL ID
200901020343407296
researchmap Member ID
1000145506

External link

Committee Memberships

 1

Papers

 31
  • Shyun Chou, Shinichiro Hadano, Atsushi Kojima, Mario Yorisaki, Masaru Yasuda, Kazunori Ike, Toshihiro Tokiwa
    Journal of Microbiology, Immunology and Infection, 55 527-534, Jun, 2022  Peer-reviewed
  • Shyun Chou, Nobumoto Izawa, Kazunori Ike, Toshihiro Tokiwa
    International Journal for Parasitology: Parasites and Wildlife, 14 75-83, Apr 1, 2021  
    The genus Eumonospora Allen, 1933 (Apicomplexa: Sarcocystidae), an avian coccidia, is characterized by monosporocystic and octasporozoic oocysts without Stieda and substieda bodies. Some members of Eumonospora, which infect several raptor species, exhibit high levels of pathogenicity, making eumonosporiosis the leading cause of death in captive-bred raptors. The host specificity of these species appears to be mesostenoxenous, as evidenced by unsuccessful transmission between different orders of avian hosts. However, several studies have detected Eumonospora spp. in taxonomically distant avian hosts, indicating that some of these species may be euryxenous. In the current study, diarrheic fecal examination of a captive-bred juvenile merlin (Falconiformes: Aves) in Tokyo, Japan, was conducted, and a large number of oocysts were morphologically and molecularly identified as E. henryae (Yakimoff and Matschulsky, 1932), a coccidia species reported only in Strigiformes. This is a new recorded host for this coccidia. Phylogenetic analyses via Bayesian inference and maximum likelihood methods using concatenated genomic datasets consisting of nuclear 18S rDNA, nuclear 28S rDNA and mitochondrial cytochrome C oxidase subunit 1 gene, revealed a well-supported monophyletic clade of Eumonospora spp. belonging to the family Sarcocystidae Poche 1913, which largely corresponded to the avian host phylogram. Therefore, based on distinguishable oocyst morphology, a new subfamily, Eumonosporinae, within the family Sarcocystidae, is proposed, and a reconsideration of the definition of Sarcocystidae is suggested. Further molecular characterization of this emerging pathogen, as well as clarification of its complete life cycle, including cyst-forming ability, is required for more appropriate generic assessment.
  • Shyun Chou, Toshihiro Tokiwa, Shinichiro Hadano, Nobumoto Izawa, Michihiro Ueda, Atsushi Kojima, Kazunori Ike
    Parasitology International, 77, Aug 1, 2020  
    The coccidian genus Eumonospora Allen, 1933 is re-established. Despite morphological features and host preference among species, coccidian with octasporozoic and monosporocystic oocysts are traditionally consider to belonging in the genus Caryospora Léger, 1904 (Apicomplexa: Eimeriidae). Recently, the genus Avispora Schuster et al., 2016 was proposed for above caryosporoids parasitizing birds based on combined morphological and phylogenetic analyses. However, diagnostic morphological characters of the genus Avispora, the absence of Stieda and substieda bodies, has already been mentioned in the description of the genus Eumonospora Allen, 1933 (Apicomplexa: Sarcocystidae), and thus Avispora is considered to be a junior synonym of Eumonospora. In this study, caryosporoid coccidians were detected from five owl species Bubo scandiacus, Ptilopsis leucotis, Athene noctua, Strix nebulosa, and Pulsatrix perspicillata (Strigiformes: Strigidae) and identified as Avispora henryae (Yakimoff &amp Matikaschwaili, 1932) described from Bubo bubo (Strigiformes: Strigidae). Eumonospora henryae (Yakimoff &amp Matikaschwili, 1932) comb. nov. is redescribed for this species based not only on morphological features but also on phylogenetical analyses. The key of the genus Eumonospora and a list to the species known at present are also provided.
  • Shyun Chou, Toshihiro Tokiwa*, Shinichiro Hadano, Nobumoto Izawa, Michihiro Ueda, Atsushi Kojima, Kazunori Ike
    Parasitology International, Aug, 2020  Peer-reviewed
  • Rie Kubota, Toshihiro Tokiwa, Katsuki Matsubara, Minoru Okamoto, Kazunori Ike
    International Journal for Parasitology: Parasites and Wildlife, 11 83-87, Apr, 2020  Peer-reviewed
    Uromastyx is a genus of the herbivorous agamid lizards, also known as spiny-tailed lizards or mastigures, which are found in parts of Africa and the Middle East. Currently, several species of this genus are available in the international pet trade in Japan. In this study, two imported wild-caught spiny-tailed lizards (Arabian blue mastigure, Uromastyx ornata philbyi, and Sudan mastigure, Uromastyx dispar flavifasciata) were diagnosed with a Cryptosporidium (Apicomplexa: Cryptosporidiidae) infection based on the presence of the oocysts in the rectal feces using sucrose flotation and light microscopy examination at a local animal hospital in Tokyo, Japan. One of the lizards had died, and histopathological examination revealed enteritis with the Cryptosporidium parasite. Sequence analyses using the small subunit ribosomal RNA, actin, and 70-kDa heat shock protein genes indicated that the lizards had contracted a novel variant of C. avium that commonly infects avian species.

Misc.

 36
  • 常盤 俊大, 池 和憲
    病原微生物検出情報, 38(4) 4, Apr, 2017  
  • NATAAMI KEI, ITO AKIRA, IKE KAZUNORI, MORITA TATSUSHI, IMAI SOICHI
    原生動物学雑誌, 44(1) 68-69, Apr 30, 2011  
  • ISHIHARA MIKI, ITO AKIRA, MORITA TATSUSHI, IKE KAZUNORI, IMAI SOICHI
    原生動物学雑誌, 44(1) 67-68, Apr 30, 2011  
  • K Ike, T Komatsu, T Murakami, Y Kato, M Takahashi, Y Uchida, S Imai
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 67(5) 515-520, May, 2005  
    As the comparative study was carried out on the susceptibility by the pursuit of parasitemia among the Djungarian, Syrian, and Chinese hamsters as well as BALB/c mice infected with the Syrian hamster-adapted Babesia microti strain, and Djungarian hamsters showed the highest parasitemia among them. Then, the other hematological parameters were pursued in the Djungarian hamsters infected with the hamster-adapted B. micron strain. Remarkable symptoms observed were hemoglobinuria clinically, anemia hematologically, and splenomegaly macroscopically during all over the observation period for 24 weeks post infection (PI). Parasitemia began to rise at 2 weeks and peaked at 4 weeks PI. After that, parasitemia decreased gradually but was maintained with a level of about 10% on average until 24 weeks PI at the end of the experiment. A decrease in the RBC count, Hb, and PCV, and an increase in the reticulocyte and WBC counts due to the development of immature neutrophils, lymphocytes and monocytes were recognized together with a rise of parasitemia. The hamsters had macrocytic hypochromic anemia due to the increase of MCV and the decrease of MCHC in the growth phase of the parasite. It was considered that the Djungarian hamsters will be useful for the infection examination, isolation, maintenance, and passage of B. microti in laboratory.
  • K Ike, Y Uchida, T Nakamura, S Imai
    JOURNAL OF VETERINARY MEDICAL SCIENCE, 67(5) 521-524, May, 2005  
    Mice were inoculated intraperitoneally wih 34 different types of vegetable juices, and interferon-gamma (IFN-gamma) and interleukin-4 (IL-4) were measured as markers for the induction of Th1 and Th2 cells, respectively. Serum IFN-gamma level was markedly increased in mice inoculated with bitter gourd (Momordica charantia) juice, but IL-4 levels were not increased with any of the 34 vegetable juices. Testing of the various components of bitter gourd, including peel, pulp, and seed, showed that the pulp induced the highest levels of IFN-gamma. Trial immunogen including the heat extract of the pulp induced specific IgG(2a) antibody of the mice serum inoculated with this immunogen. These results demonstrate that bitter gourd pulp induced IFN-gamma production and show its promise as a means of effective imnunostimulatory therapy specific for Th1 cells and IFN-gamma production.

Books and Other Publications

 5

Presentations

 2

Professional Memberships

 4

Research Projects

 10