School of Veterinary Medicine

田中 良和

タナカ ヨシカズ  (Yoshikazu Tanaka)

基本情報

所属
日本獣医生命科学大学 獣医学部獣医学科 教授
学位
博士(医学)(大阪大学)

研究者番号
50291159
J-GLOBAL ID
201601010063032190
researchmap会員ID
B000250554

外部リンク

経歴

 1

論文

 31
  • Yukari Asahi, Toshiro Arai, Yoshikazu Tanaka
    Frontiers in Veterinary Science 11 2024年5月31日  
    In older horses, basal metabolic rate decreases, and plasma metabolite and hormone concentrations related to energy metabolism change. The occurrence of age-related diseases, which increases in old animals, may enhance inflammatory reactivity (inflammaging). Finding the appropriate treatment for inflammaging at an early stage may prevent various age-related diseases. Changes in metabolite and hormone concentrations and enzyme activities involved in energy metabolism in the plasma of clinically healthy riding horses of various ages were measured to identify biomarkers of inflammaging (persistent low-grade inflammation that occurs with aging). All horses were clinically healthy, and their body condition scores (BCSs) were 4 or 5 (9-point scale). Plasma triglyceride (TG), total cholesterol (T-Cho), blood urea nitrogen (BUN), insulin concentrations, malondialdehyde (MDA), and serum amyloid A (SAA) concentrations generally increased with age. Adiponectin concentrations, plasma superoxide dismutase (SOD), and leukocyte AMP-activated protein kinase (AMPK) activities decreased, while plasma aspartate aminotransferase (AST), alanine aminotransferase (ALT), and glutathione peroxidase (GPx) remained unchanged as horses aged. Although riding horses that partake in continuous exercise seems to be less likely to develop inflammaging, horses over 17 years of age tend to show proinflammatory signs with disordered lipid metabolism. In riding horses, SAA, in combination with other markers, may be a useful biomarker for inflammaging and dysregulated lipid metabolism in aging horses.
  • Rui Nishijima, Takuro Endo, Enkhjavkhlan Gankhuyag, Shwe Thiri Maung Maung Khin, Sheikhy Mohammad Jafar, Yuta Shinohara, Yoshikazu Tanaka, Kazumi Sawakami, Masafumi Yoda, Tetsuya Furuya
    The Journal of veterinary medical science 2023年2月17日  査読有り
    The geneLEAD VIII is a fully-automated nucleic acid extraction/quantitative PCR equipment developed by Precision System Science Co. Ltd, (PSS). To take advantage of its capability, we developed a quantitative assay system to measure growth of animal viruses. The system was used to assay one of the Chinese herbal extracts whose anti-malarial activities were previously reported and demonstrated its dose-dependent anti-viral activity against feline infectious peritonitis virus (FIPV), a feline coronavirus causing the fatal diseases in cats, and relatively low cell toxicity. The assay developed in this study is useful to screen antiviral drugs and the anti-FIPV activity of the herbal extract identified have a potential to lead to development of new drugs against FIPV and other coronaviruses, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
  • Kei Shimakawa, Kazuhiko Ochiai, Sachi Hirose, Eri Tanabe, Masaki Michishita, Motoharu Sakaue, Yasunaga Yoshikawa, Masami Morimatsu, Tsuyoshi Tajima, Masami Watanabe, Yoshikazu Tanaka
    Veterinary sciences 9(12) 2022年12月17日  査読有り最終著者
    Due to the high incidence of mammary tumors in dogs, it is important to elucidate the pathogenesis of these tumors in veterinary medicine. Radiation therapy is often used to treat mammary tumors that target DNA lesions. RAD51 is a key molecule that repairs DNA damage via homologous recombination. We examined the relationship between RAD51 expression and radiosensitivity in mammary tumor cell lines. CHMp and CHMm from the same individual were selected based on the differences in RAD51 expression. The radiosensitivity of both cell lines was examined using MTT and scratch assays; CHMm, which has high RAD51 expression, showed higher sensitivity to radiation than CHMp. However, the nuclear focus of RAD51 during DNA repair was formed normally in CHMp, but not in most of CHMm. Since irradiation resulted in the suppression of cell cycle progression in CHMp, the expression of p21, a cell cycle regulatory factor, was detected in CHMp after 15 Gy irradiation but not in CHMm. These results indicate that functional expression is more important than the quantitative expression of RAD51 in canine mammary tumor cells in response to DNA damage.
  • Ushine, N, O. Kurata, Y. Tanaka, S. M.M Nakayama, M. Ishizuka, T. Kato, S.-I. Hayama
    Avian Conservation and Ecology 17(2) 40 2022年11月  査読有り
  • 廣瀬 紗千, 落合 和彦, 岩崎 まりか[前田], 道下 正貴, 森松 正美, 田中 良和
    日本獣医学会学術集会講演要旨集 165回 [I1P-01] 2022年9月  

MISC

 22

書籍等出版物

 1

講演・口頭発表等

 2

担当経験のある科目(授業)

 12

共同研究・競争的資金等の研究課題

 11