Peng Chen, Keisuke Takenaka, Masahiro Tsukamoto, Maki Ashida, Yusuke Tsutsumi, Hisashi Doi, Takao Hanawa
Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium 40 355 2019年
Introduction: The next generation surface modification on medical and dental implants is coatings of tissue or stem cells on them.1 To promote cellular attachment and formation of tissues on materials, the control of patterned surface topography is necessary, as the surface topography of a material governs its biocompatibility. For example, in the case of titanium (Ti), nanometer scale topographical features influence cell spreading and micrometer scale topography promotes stem cell differentiation in vitro.2-4 To clarify the role of patterned nano topographies on the biocompatibility and osteoconductivity of metal implant, we investigated the adhesion and calcification of mouse preosteoblast (MC3T3-E1) to Ti surfaces with three surface patterned nano-ripples topography fabricated by single-shot femtosecond laser irradiation.