理工学部 教員紹介
Profile Information
- Affiliation
- Assistant Professor, Faculty of Science and Technology Department of Science and Technology , Seikei University
- Degree
- 博士（理学）(Mar, 2023, 立命館大学)
- ORCID ID
https://orcid.org/0000-0001-9996-4544- J-GLOBAL ID
- 202301013063538852
- researchmap Member ID
- R000046680
Research Areas
5Research History
3-
Apr, 2023 - Present
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Apr, 2021 - Mar, 2023
Education
3-
Apr, 2021 - Mar, 2023
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Apr, 2019 - Mar, 2021
Awards
3-
Oct, 2025
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Jun, 2023
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Dec, 2020
Papers
23-
Bioorganic & Medicinal Chemistry Letters, 135 130584, Jun, 2026 Peer-reviewed
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Bioorganic & Medicinal Chemistry, 134 118547, Mar, 2026 Peer-reviewed
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ACS Chemical Biology, 20(11) 2671-2680, Oct 16, 2025 Peer-reviewed
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Chemical Communications, 61(64) 11939-11942, Aug, 2025 Peer-reviewedLead authorCorresponding authorA kinetically controlled self-organization system was realized using the synthetically simple molecule 4,6-O-pyrenylidene glucose (Py-Glc).
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Chemistry Letters, 54(7) upaf120, Jun 24, 2025 Peer-reviewedAbstract The N-acetyl (NAc) group of N-acetyl glucosamine (GlcNAc) in the core structure of N-glycans is believed to stabilize their folded conformation. In this study, we synthesized Man3GlcNAc2, the common structural motif of N-glycan, bearing NAc groups and Man3Glc2 having no NAc group to understand the differences in their folded conformations due to the presence or absence of NAc group using 2D-NMR analysis. In Man3GlcNAc2, the branched α1-6Man was found to be positioned closer to the core sugar residue compared to Man3Glc2.
Misc.
4-
立命館大学 プレスリリース, Apr, 2023
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成蹊大学理工学研究報告, 60 1-6, 2023 Lead author
Books and Other Publications
2Presentations
106-
Pacifichem 2025, Dec, 2025
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Pacifichem 2025, Dec, 2025
Teaching Experience
8Research Projects
5-
科学研究費助成事業, 日本学術振興会, Apr, 2024 - Mar, 2027
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天野工業技術研究所, 公益財団法人, Apr, 2025 - Mar, 2026
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藤森科学技術振興財団, 公益財団法人, Apr, 2024 - Mar, 2025
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2024年度笹川科学研究助成, 公益財団法人 日本科学協会, Apr, 2024 - Feb, 2025
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Grants-in-Aid for Scientific Research Grant-in-Aid for JSPS Fellows, Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Other
6-
Oct, 2025A. Taira, M. Hirano, T. Kuribara, C. Watanabe, S. Hiraki, M. Hirose, Z. Hakki, S. J. Williams, Y. Ito, K. Totani, Endomannosidase Chemical probe approach reveals endo-α-mannosidase triages misfolded glycoproteins in the Calnexin/Calreticulin cycle, ACS Chemical Biology 20 (2025) 2671-2680.
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Jul, 2025M. Hirose, K. Tashiro, N. Tajima, F. Sugiura, S. Shimoda, Y. Kohno, Y. Tomita, K. Totani, Stepwise self-organization of hydrogen-bonded fibers in a minimalist glucose-pyrene system via CH–π-stabilized “iotamers”, Chemical Communications 61 (2025) 11939-11942.
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Apr, 2025M. Hirose, J. Harada, Y. kashiyama, H. Tamiaki, Predicted Structure of the BciC Enzyme Catalyzing the Removal of the C132-Methoxycarbonyl Group for Biosynthesis of Chlorosomal Chlorophylls: A Mechanism for Dual Catalytic Functions of Hydrolysis and Decarboxylation inside Its Active Site, Biochemistry 62 (2023) 1443–1451.
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Apr, 2025M. Hirose, J. Harada, H. Tamiaki, In Vitro Hydrolysis of Zinc Chlorophyllide a Homologues by a BciC Enzyme, Biochemistry 59 (2020) 4622–4626.
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Mar, 2025T. Kuribara, T. Kojima, Y. Kobayashi, M. Hirose, K. Shibayama, Y. Takeda, K. Totani, Development of a calreticulin-targeting glycan ligand based on a hybrid binding concept, Glycobiology 35 (2025) cwaf015.
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