CVClient

小村 智美

コムラ トモミ  (Tomomi Komura)

基本情報

所属
兵庫県立大学 環境人間学部 食環境栄養課程 助教
学位
学術博士(大阪市立大学)

研究者番号
10736515
J-GLOBAL ID
201601000482165366
researchmap会員ID
B000256325

外部リンク

論文

 18
  • Tomomi Komura, Masaru Yoshida, Yoshikazu Nishikawa
    Exploration of Neuroscience 3 80-102 2024年4月7日  査読有り招待有り筆頭著者責任著者
  • Tomomi Komura, Motoshi Aoki, Yoshikazu Nishikawa
    Letters in Applied Microbiology 2024年2月22日  査読有り筆頭著者責任著者
    Abstract Lactic acid bacteria (LAB) contribute to human health, and LAB functionality has been studied using Caenorhabditis elegans as an alternative host. However, many studies have focused on the efficacy of a single strain of LAB, and few reports have compared various LAB strains. In this study, we examined the effects of 15 strains of LAB isolated from vegetables, meat, and fermented foods on nematode longevity and healthy lifespan. To reduce the frequency of laborious survival observations, we performed a lifespan assay on agar plates containing 2′-deoxy-5-fluorouridine (FUdR), which inhibits egg-hatching and prevents generation mixing. Four beneficial strains showed significant lifespan extension and increased spontaneous nematode mobility, regardless of treatment with or without FUdR and the frequency of survival observation. These results suggested increased longevity and an extended healthy lifespan, which confirming the reliability of our method. The four strains are expected to show anti-ageing effects besides longevity and have effects on age-related degenerative diseases. Our labour-saving method can be used as an alternative to conventional methods and enable simultaneous screening of multiple strains. Future research could explore factors contributing to lifespan regulation by comparing and verifying differential strain effects on lifespan.
  • Tomomi Komura, Motoshi Aoki, Satoshi Kotoura, Yoshikazu Nishikawa
    Biomedicine&Pharmacotherapy 155 113769 2022年11月  査読有り筆頭著者責任著者
  • Tomomi Komura, Asami Takemoto, Hideki Kosaka, Toshio Suzuki, Yoshikazu Nishikawa
    Microbiology Spectrum 10(3) e0045421 2022年5月16日  査読有り筆頭著者
  • Ayano Tsuru, Yumi Hamazaki, Shuta Tomida, Mohammad Shaokat Ali, Tomomi Komura, Yoshikazu Nishikawa, Eriko Kage-Nakadai
    Microbiology Spectrum 9(2) e0056221 2021年10月27日  査読有り
    <named-content content-type="genus-species">Cutibacterium acnes</named-content> is one of the most common bacterial species residing on the human skin. Although the pathogenic properties of <named-content content-type="genus-species">C. acnes</named-content> , such as its association with acne vulgaris, have been widely described, its beneficial aspects have not been well characterized.

書籍等出版物

 5

講演・口頭発表等

 66

共同研究・競争的資金等の研究課題

 23