CVClient

加藤 陽二

カトウ ヨウジ  (Yoji Kato)

基本情報

所属
兵庫県立大学 環境人間学部 教授
先端食科学研究センター 兼任教員
学位
博士(農学)(名古屋大学)

ORCID ID
 https://orcid.org/0000-0002-8295-7337
J-GLOBAL ID
200901064302201702
researchmap会員ID
1000254227

外部リンク

経歴

 2

論文

 133
  • Maki Takami, Wataru Aoi, Chinatsu Ando, Yoji Kato, Yukiko Kobayashi, Masashi Kuwahata
    Advances in Redox Research 9 100076-100076 2023年12月  査読有り
  • Maki Takami, Wataru Aoi, Karin Matsumoto, Yoji Kato, Yukiko Kobayashi, Masashi Kuwahata
    Journal of Clinical Biochemistry and Nutrition 74(2) 136-140 2023年11月  査読有り
  • Yoji Kato, Asahi Sakanishi, Kaoru Matsuda, Mai Hattori, Ichiro Kaneko, Miyu Nishikawa, Shinichi Ikushiro
    Free Radical Biology and Medicine 206 74-82 2023年9月  査読有り筆頭著者責任著者
  • Toshio Niwa, Yoji Kato, Toshihiko Osawa
    Bioscience, Biotechnology, and Biochemistry 87(3) 303-307 2022年12月15日  査読有り
    ABSTRACT The PtO2-catalyzed hydrogenation of curcumin produced slightly predominant meso-octahydrocurcumin than raceme octahydrocurcumin. Similar result was found in the product obtained from tetrahydrocurcumin and NaBH4, whereas using palladium carbon as a catalyst increased the meso-octahydrocurcumin ratio. Compared with chemical methods, baker's yeast produced 3S,5S-octahydrocurcumin and meso-octahydrocurcumin from tetrahydrocurcumin. The different activity between raceme and meso-octahydrocurcumin was not found in our experiments.
  • Toshiyuki Nakamura, Chiharu Tsutsui, Yu Okuda, Naomi Abe-Kanoh, Saori Okazawa, Shintaro Munemasa, Yoshiyuki Murata, Yoji Kato, Yoshimasa Nakamura
    Journal of biochemical and molecular toxicology 36(11) e23184 2022年8月3日  査読有り
    Benzyl isothiocyanate (BITC), derived from cruciferous vegetables, is an organosulfur compound exerting antiproliferative effects in several human cancer cells. In this study, we assessed BITC as a potential osteoclastogenesis inhibitor and investigated its underlying mechanism. BITC at 5 μM significantly decreased the viability of the osteoclast-like differentiating RAW264.7 cells, coinciding with the downregulation of the primary biomarkers for osteoclast differentiation, such as the tartrate-resistant acid phosphatase activity and nuclear factor of activated T-cells gene expression. Not only BITC but also its metabolites, inhibited cell proliferation in the normal RAW264.7 cells, suggesting that BITC shows an anti-osteoclastogenesis effect in vivo after its ingestion and metabolism, possibly through an antiproliferative action. Both BITC and its metabolites also enhanced the DNA fragmentation and the caspase-3 activity, whereas their higher concentrations tended to suppress these effects. BITC was intracellularly accumulated when the cells were treated with its metabolites via their degradation into the free form. A quantitative experiment using the proteolysis/high performance liquid chromatography technique showed that the amount of BITC-lysine thiourea in the cells was also increased in a time-dependent manner, suggesting that lysine modification of the cellular proteins actually took place in the cells treated by BITC. Among the cellular proteins, the cleaved caspase-3 was identified as a potential target for lysine modification by BITC. Taken together, BITC dissociated from its metabolites as well as its free form might modulate osteoclastogenesis, possibly through inhibition of cell proliferation by protein modification.

MISC

 1

書籍等出版物

 7

講演・口頭発表等

 14

共同研究・競争的資金等の研究課題

 26

学術貢献活動

 4

社会貢献活動

 2