研究者業績

吉田 優

ヨシダ マサル  (Masaru Yoshida)

基本情報

所属
兵庫県立大学 環境人間学部 食環境栄養課程 教授
学位
博士(医学)(京都大学)

J-GLOBAL ID
200901056277606171
researchmap会員ID
5000088941

経歴
平成 4 (1992) 年 3月 神戸大学医学部卒業
平成 4 (1992) 年 4月 神戸大学附属病院内科研修医
平成 5 (1993) 年 6月 愛仁会高槻病院内科研修医
平成 7 (1995) 年 2月 明石市立市民病院消化器内科医師
平成 8 (1996) 年 4月 京都大学大学院医学研究科入学(消化器病態学講座;千葉勉教授)
平成12 (2000) 年 3月 京都大学大学院医学研究科修了,医学博士取得
平成13 (2001) 年 5月 Research Fellow, Brigham and Women’s Hospital, Harvard Medical School
平成16 (2004) 年 7月 Instructor, Harvard Medical School, Boston, MA
平成17 (2005) 年 8月 神戸大学大学院医学研究科・助手(難治性疾患病態解析分野・消化器内科)
平成19 (2007) 年 4月 同・助教(消化器内科学分野)
平成19 (2007) 年12月 同・助教(脂質生化学分野、併任)
平成20 (2008) 年 4月 同・助教(質量分析総合センター、併任)
平成20 (2008) 年 9月 同・特命准教授(消化器内科学分野)
平成22 (2010) 年 4月 同・准教授(病因病態解析学分野長、消化器内科学分野併任)

令和3(2021)年4月 兵庫県立大学環境人間学部食環境栄養課程・教授
現在に至る

その他
平成18 (2006) 年 4月より 兵庫医科大学・非常勤講師(内科学講座下部消化管科)
平成19 (2007) 年 4月より 独立行政法人理化学横浜研究所免疫アレルギーセンター・客員研究員
平成22 (2010) 年 6月より 国立大学法人北海道大学大学院生命科学研究院 客員准教授


研究キーワード

 3

受賞

 3

論文

 388
  • Yuki Motono, Shin Nishiumi, Masaru Yoshida, Motoko Takaoka
    FERMENTATION-BASEL 9(3) 2023年3月  
    Obesity, along with hypertension and hyperlipidemia, is one of the leading factors of metabolic syndrome, which increases the risk of diabetes. However, controlling obesity is a global challenge. Sake lees, or Japanese rice wine lees, is a by-product of sake fermentation and has been consumed in Japan for a long time. Sake lees contains an abundance of amino acids, peptides, dietary fiber, and micronutrients, which make it highly nutritional. Additionally, sake lees has been reported to have multiple interesting effects when ingested and may aid in combating obesity. In this study, we investigated the effects of sake lees materials on preadipocyte differentiation and fat accumulation in preadipocyte cells (3T3-L1) and analyzed it with a metabolome analysis. We found that compared to the control group, lipid accumulation was suppressed by 80.9% when the 100 C-? extract of indigestible sake lees component (ISLCs) was added to 1 mg/mL. Additionally, the metabolome analysis revealed various other differences between the control group and the group treated with ISLCs, especially in amino acids concentrations. Based on the above findings, we demonstrate that ISLCs affect the amino acid metabolic pathways, which in turn affect differentiation and lipid accumulation in adipocytes. Therefore, we suggest that sake lees may aid in combating obesity and addressing metabolic syndromes, both of which can be considered as global issues. The limitation of this research is sake lee is a general non-direct edible raw material and it is difficult to add as a regular diet.
  • Kazufumi Honda, Takashi Kobayashi, Masaru Yoshida
    CANCER SCIENCE 113 2022年2月  
  • Shin Nishiumi, Yoshihiro Izumi, Akiyoshi Hirayama, Masatomo Takahashi, Motonao Nakao, Kosuke Hata, Daisuke Saigusa, Eiji Hishinuma, Naomi Matsukawa, Suzumi M Tokuoka, Yoshihiro Kita, Fumie Hamano, Nobuyuki Okahashi, Kazutaka Ikeda, Hiroki Nakanishi, Kosuke Saito, Masami Yokota Hirai, Masaru Yoshida, Yoshiya Oda, Fumio Matsuda, Takeshi Bamba
    Metabolites 12(2) 2022年2月1日  
    In mass spectrometry-based metabolomics, the differences in the analytical results from different laboratories/machines are an issue to be considered because various types of machines are used in each laboratory. Moreover, the analytical methods are unique to each laboratory. It is important to understand the reality of inter-laboratory differences in metabolomics. Therefore, we have evaluated whether the differences in analytical methods, with the exception sample pretreatment and including metabolite extraction, are involved in the inter-laboratory differences or not. In this study, nine facilities are evaluated for inter-laboratory comparisons of metabolomic analysis. Identical dried samples prepared from human and mouse plasma are distributed to each laboratory, and the metabolites are measured without the pretreatment that is unique to each laboratory. In these measurements, hydrophilic and hydrophobic metabolites are analyzed using 11 and 7 analytical methods, respectively. The metabolomic data acquired at each laboratory are integrated, and the differences in the metabolomic data from the laboratories are evaluated. No substantial difference in the relative quantitative data (human/mouse) for a little less than 50% of the detected metabolites is observed, and the hydrophilic metabolites have fewer differences between the laboratories compared with hydrophobic metabolites. From evaluating selected quantitatively guaranteed metabolites, the proportion of metabolites without the inter-laboratory differences is observed to be slightly high. It is difficult to resolve the inter-laboratory differences in metabolomics because all laboratories cannot prepare the same analytical environments. However, the results from this study indicate that the inter-laboratory differences in metabolomic data are due to measurement and data analysis rather than sample preparation, which will facilitate the understanding of the problems in metabolomics studies involving multiple laboratories.
  • Koji Yamamoto, Yasuyuki Kondo, Shunsuke Ohnishi, Masaru Yoshida, Toshiro Sugiyama, Naoya Sakamoto
    iScience 24(9) 103064-103064 2021年9月24日  
    Helicobacter suis, a zoonotic infection-related bacterium, can induce gastric mucosa-associated lymphoid tissue (MALT) lymphoma in humans and animals. Recently, we reported that the formation of gastric MALT lymphoma after H. suis infection is induced by interferon (IFN)-γ activation. Here, we revealed that activation of the Toll-like receptor (TLR) 4-Toll/IL-1 receptor domain-containing adapter-inducing interferon-β (TRIF) pathway after H. suis infection is associated with the production of type 1 IFNs (IFN-α, IFN-β) by gastric epithelial cells. Additionally, these type 1 IFNs interact with type 1 IFN receptors on gastric B cells, facilitating the secretion of IFN-γ and the activation of which is enhanced by positive feedback regulation in B cells. These results suggest that the TLR4-TRIF-type 1 IFN-IFN-γ pathway is crucial in the development of gastric MALT lymphoma after H. suis infection and may, therefore, represent a therapeutic target for the prevention of this condition.
  • 本田 一文, 小林 隆, 吉田 優
    日本癌学会総会記事 80回 [J14-5] 2021年9月  

MISC

 170

書籍等出版物

 3

講演・口頭発表等

 218

共同研究・競争的資金等の研究課題

 38