Structural basis for promotion of duodenal iron absorption by enteric ferric reductase with ascorbate.

Ganasen M, Togashi H, Takeda H, Asakura H, Tosha T, Yamashita K, Hirata K, Nariai Y, Urano T, Yuan X, Hamza I, Mauk AG, Shiro Y, Sugimoto H, Sawai H

Communications biology 1(1) 120 2018年査読有り
Structural basis for binding and transfer of heme in bacterial heme-acquisition systems

Youichi Naoe, Nozomi Nakamura, Md Mahfuzur Rahman, Takehiko Tosha, Satoru Nagatoishi, Kouhei Tsumoto, Yoshitsugu Shiro, Hiroshi Sugimoto

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 85(12) 2217-2230 2017年12月査読有り
Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate

Takehiko Tosha, Takashi Nomura, Takuma Nishida, Naoya Saeki, Kouta Okubayashi, Raika Yamagiwa, Michihiro Sugahara, Takanori Nakane, Keitaro Yamashita, Kunio Hirata, Go Ueno, Tetsunari Kimura, Tamao Hisano, Kazumasa Muramoto, Hitomi Sawai, Hanae Takeda, Eiichi Mizohata, Ayumi Yamashita, Yusuke Kanematsu, Yu Takano, Eriko Nango, Rie Tanaka, Osamu Nureki, Osami Shoji, Yuka Ikemoto, Hironori Murakami, Shigeki Owada, Kensuke Tono, Makina Yabashi, Masaki Yamamoto, Hideo Ago, So Iwata, Hiroshi Sugimoto, Yoshitsugu Shiro, Minoru Kubo

NATURE COMMUNICATIONS 8(1) 1585 2017年11月査読有り
Dynamics of nitric oxide controlled by protein complex in bacterial system

Erina Terasaka, Kenta Yamada, Po-Hung Wang, Kanta Hosokawa, Raika Yamagiwa, Kimi Matsumoto, Shoko Ishii, Takaharu Mori, Kiyoshi Yagi, Hitomi Sawai, Hiroyuki Arai, Hiroshi Sugimoto, Yuji Sugita, Yoshitsugu Shiro, Takehiko Tosha

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 114(37) 9888-9893 2017年9月査読有り
CHAPTER 6: Structure and Function of Nitric Oxide Reductases

Takehiko Tosha, Yoshitsugu Shiro

RSC Metallobiology 2017-(9) 114-140 2017年査読有り
Solving Biology's Iron Chemistry Problem with Ferritin Protein Nanocages

Elizabeth C. Theil, Takehiko Tosha, Rabindra K. Beherat

ACCOUNTS OF CHEMICAL RESEARCH 49(5) 784-791 2016年5月査読有り
A nearly on-axis spectroscopic system for simultaneously measuring UV-visible absorption and X-ray diffraction in the SPring-8 structural genomics beamline

Miyuki Sakaguchi, Tetsunari Kimura, Takuma Nishida, Takehiko Tosha, Hiroshi Sugimoto, Yoshihiro Yamaguchi, Sachiko Yanagisawa, Go Ueno, Hironori Murakami, Hideo Ago, Masaki Yamamoto, Takashi Ogura, Yoshitsugu Shiro, Minoru Kubo

JOURNAL OF SYNCHROTRON RADIATION 23 334-338 2016年1月査読有り
Fe2+ substrate transport through ferritin protein cage ion channels influences enzyme activity and biomineralization

Rabindra K. Behera, Rodrigo Torres, Takehiko Tosha, Justin M. Bradley, Celia W. Goulding, Elizabeth C. Theil

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY 20(6) 957-969 2015年9月査読有り
Oxidation Reactivity of a Structurally and Spectroscopically Well-defined Mononuclear Peroxocarbonato-Iron(III) Complex

Tomohiro Tsugawa, Hideki Furutachi, Megumi Marunaka, Taichi Endo, Koji Hashimoto, Shuhei Fujinami, Shigehisa Akine, Yoko Sakata, Shigenori Nagatomo, Takehiko Tosha, Takashi Nomura, Teizo Kitagawa, Takashi Ogura, Masatatsu Suzuki

CHEMISTRY LETTERS 44(3) 330-332 2015年3月査読有り
Structures of reduced and ligand-bound nitric oxide reductase provide insights into functional differences in respiratory enzymes

Nozomi Sato, Shoko Ishii, Hiroshi Sugimoto, Tomoya Hino, Yoshihiro Fukumori, Yoshihiko Sako, Yoshitsugu Shiro, Takehiko Tosha

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS 82(7) 1258-1271 2014年7月査読有り
Characterization of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus: Enzymatic activity and active site structure

Erina Terasaka, Norihiro Okada, Nozomi Sato, Yoshihiko Sako, Yoshitsugu Shiro, Takehiko Tosha

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1837(7) 1019-1026 2014年7月査読有り
Spectroscopic Studies of Single and Double Variants of M Ferritin: Lack of Conversion of a Biferrous Substrate Site into a Cofactor Site for O-2 Activation

Yeonju Kwak, Jennifer K. Schwartz, Suranjana Haldar, Rabindra K. Behera, Takehiko Tosha, Elizabeth C. Theil, Edward I. Solomon

BIOCHEMISTRY 53(3) 473-482 2014年1月査読有り
Crystal structures of nitric oxide reductases provide key insights into functional conversion of respiratory enzymes

Takehiko Tosha, Yoshitsugu Shiro

IUBMB LIFE 65(3) 217-226 2013年3月査読有り
Ferritins for chemistry and for life

Elizabeth C. Theil, Rabindra K. Behera, Takehiko Tosha

COORDINATION CHEMISTRY REVIEWS 257(2) 579-586 2013年1月査読有り
Ferritin Ion Channel Disorder Inhibits Fe(II)/O-2 Reactivity at Distant Sites

Takehiko Tosha, Rabindra K. Behera, Elizabeth C. Theil

INORGANIC CHEMISTRY 51(21) 11406-11411 2012年11月査読有り
Proton transfer in the quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus during reduction of oxygen

Lina Salomonsson, Joachim Reimann, Takehiko Tosha, Nils Krause, Nathalie Gonska, Yoshitsugu Shiro, Pia Adelroth

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS 1817(10) 1914-1920 2012年10月査読有り
Structural basis for nitrous oxide generation by bacterial nitric oxide reductases

Yoshitsugu Shiro, Hiroshi Sugimoto, Takehiko Tosha, Shingo Nagano, Tomoya Hino

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES 367(1593) 1195-1203 2012年5月査読有り
Molecular structure and function of bacterial nitric oxide reductase.

Hino T, Nagano S, Sugimoto H, Tosha T, Shiro Y

Biochimica et biophysica acta 1817(4) 680-687 2012年4月査読有り
Ferritin Protein Nanocage Ion Channels GATING BY N-TERMINAL EXTENSIONS

Takehiko Tosha, Rabindra K. Behera, Ho-Leung Ng, Onita Bhattasali, Tom Alber, Elizabeth C. Theil

JOURNAL OF BIOLOGICAL CHEMISTRY 287(16) 13016-13025 2012年4月査読有り
Crystal structure of quinol-dependent nitric oxide reductase from Geobacillus stearothermophilus

Yushi Matsumoto, Takehiko Tosha, Andrei V. Pisliakov, Tomoya Hino, Hiroshi Sugimoto, Shingo Nagano, Yuji Sugita, Yoshitsugu Shiro

NATURE STRUCTURAL & MOLECULAR BIOLOGY 19(2) 238-245 2012年2月査読有り
Moving Iron through ferritin protein nanocages depends on residues throughout each four α-helix bundle subunit.

Haldar S, Bevers LE, Tosha T, Theil EC

The Journal of biological chemistry 286(29) 25620-25627 2011年7月査読有り
Moving iron in ferritin: Leucine 154, a residue near Fe(III) during mineral buildup minimizes mineral dissolution

Suranjana Haldar, Takehiko Tosha, Elizabeth C. Theil

INDIAN JOURNAL OF CHEMISTRY SECTION A-INORGANIC BIO-INORGANIC PHYSICAL THEORETICAL & ANALYTICAL CHEMISTRY 50(3-4) 414-419 2011年3月査読有り
CD and MCD Spectroscopic Studies of the Two Dps Miniferritin Proteins from Bacillus anthracis: Role of O-2 and H2O2 Substrates in Reactivity of the Diiron Catalytic Centers

Jennifer K. Schwartz, Xiaofeng S. Liu, Takehiko Tosha, Adrienne Diebold, Elizabeth C. Theil, Edward I. Solomon

BIOCHEMISTRY 49(49) 10516-10525 2010年12月査読有り
Moving Metal Ions through Ferritin-Protein Nanocages from Three-Fold Pores to Catalytic Sites

Takehiko Tosha, Ho-Leung Ng, Onita Bhattasali, Tom Alber, Elizabeth C. Theil

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 132(41) 14562-14569 2010年10月査読有り
Oxidation Reactivity of Bis(mu-oxo) Dinickel(III) Complexes: Arene Hydroxylation of the Supporting Ligand

Kaoru Honda, Jaeheung Cho, Takahiro Matsumoto, Jungyun Roh, Hideki Furutachi, Takehiko Tosha, Minoru Kubo, Shuhei Fujinami, Takashi Ogura, Teizo Kitagawa, Masatatsu Suzuki

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 48(18) 3304-3307 2009年査読有り
Formation of a Bridged Butterfly-Type mu-eta(2):eta(2)-Peroxo Dicopper Core Structure with a Carboxylate

Yasuhiro Funahashi, Tomohide Nishikawa, Yuko Wasada-Tsutsui, Yuji Kajita, Syuhei Yamaguchi, Hidekazu Arii, Tomohiro Ozawa, Koichiro Jitsukawa, Takehiko Tosha, Shun Hirota, Teizo Kitagawa, Hideki Masuda

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130(49) 16444-+ 2008年12月査読有り
Ferritin Contains Less Iron (Fe-59) in Cells When the Protein Pores Are Unfolded by Mutation

Mohammad R. Hasan, Takehiko Tosha, Elizabeth C. Theil

JOURNAL OF BIOLOGICAL CHEMISTRY 283(46) 31394-31400 2008年11月査読有り
The ferritin Fe2 site at the diiron catalytic center controls the reaction with O-2 in the rapid mineralization pathway

Takehiko Tosha, Mohammad R. Hasan, Elizabeth C. Theil

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 105(47) 18182-18187 2008年11月査読有り
Spectroscopic definition of the ferroxidase site in M ferritin: Comparison of binuclear substrate vs cofactor active sites

Jennifer K. Schwartz, Xiaofeng S. Liu, Takehiko Tosha, Elizabeth C. Theil, Edward I. Solomon

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 130(29) 9441-9450 2008年7月査読有り
Transient intermediates from Mn(salen) with sterically hindered mesityl groups: Interconversion between Mn-IV-phenolate and Mn-III-phenoxyl radicals as an origin for unique reactivity

Takuya Kurahashi, Akihiro Kikuchi, Takehiko Tosha, Yoshitsugu Shiro, Teizo Kitagawa, Hiroshi Fujii

INORGANIC CHEMISTRY 47(5) 1674-1686 2008年3月査読有り
Gated pores in the ferritin protein nanocage

Elizabeth C. Theil, Xiaofeng S. Liu, Takehiko Tosha

INORGANICA CHIMICA ACTA 361(4) 868-874 2008年3月査読有り
Interaction between substrate and oxygen ligand responsible for effective O-O bond cleavage in bovine cytochrome P450 steroid 21-hydroxylase proved by Raman spectroscopy

Takehiko Tosha, Norio Kagawa, Miharu Arase, Michael R. Waterman, Teizo Kitagawa

JOURNAL OF BIOLOGICAL CHEMISTRY 283(7) 3708-3717 2008年2月査読有り
Unique peroxidase reaction mechanism in prostaglandin endoperoxide H synthase-2 - Compound I in prostaglandin endoperoxide H synthase-2 can be formed without assistance by distal glutamine residue

Shizuo Ichimura, Takeshi Uchida, Shuhei Taniguchi, Shusuke Hira, Takehiko Tosha, Isao Morishima, Teizo Kitagawa, Koichiro Ishimori

JOURNAL OF BIOLOGICAL CHEMISTRY 282(22) 16681-16690 2007年6月査読有り
Synthesis, characterization, and reactivities of manganese(V)-oxo porphyrin complexes

Woon Ju Song, Mi Sook Seo, Serena DeBeer George, Takehiro Ohta, Rita Song, Min-Jung Kang, Takehiko Tosha, Teizo Kitagawa, Edward I. Solomon, Wonwoo Nam

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(5) 1268-1277 2007年2月査読有り
Regioselective arene hydroxylation mediated by a (mu-peroxo)diiron(III) complex: A functional model for toluene monooxygenase

Mai Yamashita, Hideki Furutachi, Takehiko Tosha, Shuhei Fujinami, Wataru Saito, Yonezo Maeda, Kenji Takahashi, Koji Tanaka, Teizo Kitagawa, Masatatsu Suzuki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129(1) 2-3 2007年1月
Identification of an "end-on" nickel-superoxo adduct, [Ni(tmc)(O-2)](+)

Matthew T. Kieber-Emmons, Jamespandi Annaraj, Mi Sook Seo, Katherine M. Van Heuvelen, Takehiko Tosha, Teizo Kitagawa, Thomas C. Brunold, Wonwoo Nam, Charles G. Riordan

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 128(44) 14230-14231 2006年11月査読有り
On the relationship of coral allene oxide synthase to catalase - A single active site mutation that induces catalase activity in coral allene oxide synthase

T Tosha, T Uchida, AR Brash, T Kitagawa

JOURNAL OF BIOLOGICAL CHEMISTRY 281(18) 12610-12617 2006年5月査読有り
Raman evidence for specific substrate-induced structural changes in the heme pocket of human cytochrome P450 aromatase during the three consecutive oxygen activation steps

T Tosha, N Kagawa, T Ohta, S Yoshioka, MR Waterman, T Kitagawa

BIOCHEMISTRY 45(17) 5631-5640 2006年5月査読有り
Nonheme iron(II) complexes of macrocyclic ligands in the generation of oxoiron(IV) complexes and the catalytic epoxidation of olefins

Y Suh, MS Seo, KM Kim, YS Kim, HG Jang, T Tosha, T Kitagawa, J Kim, W Nam

JOURNAL OF INORGANIC BIOCHEMISTRY 100(4) 627-633 2006年4月査読有り
O-17 NMR study of oxo metalloporphyrin complexes: Correlation with electronic structure of M=O moiety

H Fujii, T Kurahashi, T Tosha, T Yoshimura, T Kitagawa

JOURNAL OF INORGANIC BIOCHEMISTRY 100(4) 533-541 2006年4月査読有り
Sequential reaction intermediates in aliphatic C-H bond functionalization initiated by a bis(μ-oxo)dinickel(III) complex

Cho J, Furutachi H, Fujinami S, Tosha T, Ohtsu H, Ikeda O, Suzuki A, Nomura M, Uruga T, Tanida H, Kawai T, Tanaka K, Kitagawa T, Suzuki M

Inorganic Chemistry 45(7) 2873-2885 2006年4月査読有り
Intramolecular arene hydroxylation versus intermolecular olefin epoxidation by (mu-eta(2):eta(2-)peroxo)dicopper(II) complex supported by dinucleating ligand

T Matsumoto, H Furutachi, M Kobino, M Tomii, S Nagatomo, T Tosha, T Osako, S Fujinami, S Itoh, T Kitagawa, M Suzuki

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 128(12) 3874-3875 2006年3月査読有り
A mononuclear alkylperoxocopper(II) complex as a reaction intermediate in the oxidation of the methyl group of the supporting ligand

Masayasu Mizuno, Kaoru Honda, Jaeheung Cho, Hideki Furutachi, Takehiko Tosha, Takahiro Matsumoto, Shuhei Fujinami, Teizo Kitagawa, Masatatsu Suzuki

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 45(41) 6911-6914 2006年査読有り
Mononuclear copper(II)-hydroperoxo complex derived from reaction of copper(I) complex with dioxygen as a model of D beta M and PHM

Tatsuya Fujii, Syuhei Yamaguchi, Yasuhiro Funahashi, Tomohiro Ozawa, Takehiko Tosha, Teizo Kitagawa, Hideki Masuda

CHEMICAL COMMUNICATIONS (42) 4428-4430 2006年査読有り
Oxidizing intermediates from the sterically hindered iron salen complexes related to the oxygen activation by nonheme iron enzymes

T Kurahashi, Y Kobayashi, S Nagatomo, T Tosha, T Kitagawa, H Fujii

INORGANIC CHEMISTRY 44(22) 8156-8166 2005年10月査読有り
Synthesis and reactivity of a (mu-1,1-hydroperoxo)(mu-hydroxo)dicopper(II) complex: Ligand hydroxylation by a bridging hydroperoxo ligand

K Itoh, H Hayashi, H Furutachi, T Matsumoto, S Nagatomo, T Tosha, S Terada, S Fujinami, M Suzuki, T Kitagawa

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 127(14) 5212-5223 2005年4月査読有り
Structural diversities of active site in clinical azole-bound forms between sterol 14 alpha-demethylases ( CYP51s) from human and Mycobacterium tuberculosis

K Matsuura, S Yoshioka, T Tosha, H Hori, K Ishimori, T Kitagawa, Morishima, I, N Kagawa, MR Waterman

JOURNAL OF BIOLOGICAL CHEMISTRY 280(10) 9088-9096 2005年3月査読有り
Structure and dioxygen-reactivity of copper(I) complexes supported by bis(6-methylpyridin-2-ylmethyl)amine tridentate ligands

T Osako, S Terada, T Tosha, S Nagatomo, H Furutachi, S Fujinami, T Kitagawa, M Suzuki, S Itoh

DALTON TRANSACTIONS (21) 3514-3521 2005年査読有り
Crystal structure of the cytochrome P450cam mutant that exhibits the same spectral perturbations induced by putidaredoxin binding

S Nagano, T Tosha, K Ishimori, Morishima, I, TL Poulos

JOURNAL OF BIOLOGICAL CHEMISTRY 279(41) 42844-42849 2004年10月査読有り
L358P mutation on cytochrome P450cam simulates structural changes upon putidaredoxin binding - The structural changes trigger electron transfer to oxy-P450cam from electron donors

T Tosha, S Yoshioka, K Ishimori, Morishima, I

JOURNAL OF BIOLOGICAL CHEMISTRY 279(41) 42836-42843 2004年10月査読有り

MISC

ニトリルヒドラターゼの反応中間体の観測に向けた時間分割固定型シリアルフェムト秒X線結晶構造解析

鷲谷真平, 松村洋寿, 當舎武彦, 杉本宏, 矢野直峰, 馬場清喜, 長谷川和也, 尾高雅文

量子ビームサイエンスフェスタ(Web) 2024 2025年
鉄シャペロンPCBPは鉄イオンをフェリチンのH鎖に輸送する

浦敦人, 浦敦人, 佐藤渚, 簗取いずみ, 城宜嗣, 當舎武彦, 澤井仁美, 澤井仁美

日本鉄バイオサイエンス学会学術集会プログラム・抄録集 48th (CD-ROM) 2024年
膜貫通型鉄還元酵素Dcytbから二価金属輸送体DMT1へのFe²⁺授受機構の解析

坂上正虎, 柴田晃利, 藤宇将吾, 高原教代, 簗取いずみ, 城宜嗣, 當舎武彦, 澤井仁美, 澤井仁美

日本生化学会大会(Web) 97th 2024年
鉄イオンの吸収に関与する二価金属輸送体DMT1の構造解析に向けた精製法の検討

大谷豪, 柴田晃利, 藤宇将吾, 高原教代, 簗取いずみ, 當舎武彦, 城宜嗣, 澤井仁美, 澤井仁美

日本生化学会大会(Web) 97th 2024年
鉄還元機能を持つ6回膜貫通型タンパク質101F6の大腸菌での発現と機能解析

阪口智哉, 澤井仁美, 城宜嗣, 鍔木基成, 當舎武彦, 木村哲就, 杉本宏

日本生化学会大会(Web) 96th 2023年

もっとみる

担当経験のある科目(授業)

2023年10月 - 現在

生体金属分子科学 (兵庫県立大学大学院理学研究科)
2023年10月 - 現在

生物化学5（脂質） (兵庫県立大学理学部)
2023年4月 - 現在

生物化学2（酵素） (兵庫県立大学理学部)
2017年10月 - 2023年3月

放射光構造生命科学 (兵庫県立大学大学院理学研究科)

所属学協会

共同研究・競争的資金等の研究課題

固定ターゲット型チップを用いた時間分解構造解析による金属酵素反応の分子動画撮影

日本学術振興会科学研究費助成事業 2024年9月 - 2028年3月

當舎武彦
合成ヘムモデル化合物による生理活性ガスの系統的機能探索

日本学術振興会科学研究費助成事業 2024年4月 - 2027年3月

北岸宏亮, 當舎武彦, 小寺政人
酵素を誤作動させる分子による酸化反応の遷移状態設計

日本学術振興会科学研究費助成事業学術変革領域研究(A) 2022年6月 - 2027年3月

荘司長三, 當舎武彦, 有安真也
光解離性ケージド化合物を用いた膜結合型NO還元酵素の反応中間体の構造解析

公益財団法人ひょうご科学技術協会学術研究助成 2025年4月 - 2026年3月
高速分子動画が明らかにする光感受性タンパク質の作用機序

JSPS 学術国際交流事業、二国間交流事業 2023年4月 - 2025年3月

もっとみる

一覧へ戻る

當舎 武彦

基本情報

研究キーワード

研究分野

経歴

学歴

委員歴

受賞

論文

MISC

担当経験のある科目(授業)

所属学協会

共同研究・競争的資金等の研究課題

當舎武彦