下垣 実央

Three contiguous stereocenters were constructed by an amino acid-catalyzed asymmetric aldol reaction of α-siloxyketones with racemizable α-haloaldehydes via dynamic kinetic resolution. One-pot catalytic asymmetric synthesis of the highly functionalized products...

Chiral tandem modifiers linking two or three cinchonidine molecules at the 2′-position of the quinoline ring are highly effective at low concentrations for the enantioselective hydrogenation of PCA over Pd/C.

An oxetane intermediate during a direct aldol reaction was trapped with an internal aryl group to yield trans-tetraline products. The contribution of the oxetane intermediate was confirmed by 18O-isotope labeling experiments.