研究者業績
基本情報
研究分野
1論文
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Industrial health 57(4) 537-546 2018年12月 査読有り責任著者
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医学と生物学 139(1) 23-28 1999年9月 査読有りベリリウム(Be)による免疫毒性影響を明らかにするため,酸化Be(BeO)と塩化Be(BeCl2)のモルモット腹腔内及び胸腔内の継続投与実験を行った.免疫毒性反応指標としてBe特異的リンパ球幼弱化試験(Be-LT)を用い,Beによる生体感作影響を検討した.Be化合物の生体感作反応の発現において,可溶性のBeCl2投与によりこの種の反応がより加速することが示唆された
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Industrial Health 35(3) 374-379 1997年The relationship between airborne concentration of beryllium in the working environment and workers' beryllium lymphocyte transformation test (Be-LTT) values was examined based on data obtained from a four-year survey (1992-1995) conducted at beryllium-copper alloy manufacturing factories. This study showed that the T cells of workers continuously exposed to beryllium of more than 0.01μg/m3 could be activated and that the cell-mediated immune response of workers could be promoted. On the other hand, the Be-LTT of workers exposed to beryllium levels of less than 0.01μg/m3 was shown to be unaffected by beryllium. These findings suggest that beryllium sensitization is not manifested when level of beryllium in working environment are less than 0.01μg/m3. Therefore, in such cases workers do not develop Chronic beryllium disease (CBD). We concluded that the Be-LTT can be applied as a medical indicator to detect the development of CBD.
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日本衞生學雜誌 49(5) 869-876 1994年12月15日Placental transfer and body distribution of triphenyl tin chloride (TPTC) and tin chloride (SnCl2) were investigated in pregnant rats.<br>Pregnant wistar rats were orally administered TPTC at 0, 1.0 and 2.0mg/rat/day during 6-10 and 14-18 days of gestation, and with SnCl2 at 0 and 20mg/rat/day on 7, 10 and 15 days of gestation (group treated 3 times) or 6-10 and 13-16 days of gestation at 0 and 20mg/rat/day (group treated 9 times).<br>On day 20 of gestation in rats treated with TPTC, and day 17 in rats with SnCl2, fetuses, placentas, maternal blood and organs were obtained for analyses.<br>Mean fetal tin levels from rats treated with 1.0 and 2.0mg TPTC were 0.05 and 0.11μg/g wet weight, respectively, these values being significantly (P<0.01) higher than in the control group. The latter was higher than the former at a significance level of 5%. No significant difference between fetal tin levels from rats treated with SnCl2 and the control group could be detected.<br>Following oral TPTC administration, tin was present in maternal liver, kidney and brain in high concentrations.<br>Following the oral administration of SnCl2, the tin level was highest in bone and kidney, but none could be detected in the brain.
MISC
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Fujita Medical Journal 1(1) 6-8 2015年6月Objectives: We examined whether selected factors were associated with activity limitation used to calculate the healthy life expectancy in accordance with the target of Health Japan 21 (the second term). Methods: Data for 6251 subjects were obtained from the Comprehensive Survey of Living Conditions and the National Health and Nutrition Survey, both of which were conducted by the Ministry of Health, Labour and Welfare of Japan in 2010. The age-adjusted odds ratios (AOR) of limitation of activity for the assessed factors were estimated using a logistic model.Results:, The percentage of persons with activity limitation was 12.1% of men and 15.6% of women. For men, low body mass index (BMI) (AOR: 2.02, p=0.008), high blood pressure (AOR: 1.53, p=0.021), high hemoglobin A1c (HbA1c) (AOR: 1.99, p=0.000), a small number of steps (AOR: 1.68, p=0.002), and high intake of salt (AOR: 0.69, p=0.010) were significantly associated with limitation of activity. For women, high BMI (AOR: 1.49, p=0.003), a small number of steps (AOR: 1.48, p=0.009), and high intake of salt (AOR: 0.77, p=0.017) were significantly associated with activity limitation. Conclusion: We identified several factors that were associated with activity limitation. Our results from cross-sectional data require careful interpretation before concluding whether these relationships are causal
講演・口頭発表等
7所属学協会
1共同研究・競争的資金等の研究課題
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日本学術振興会 科学研究費助成事業 1999年 - 2001年
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日本学術振興会 科学研究費助成事業 1999年 - 2000年
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日本学術振興会 科学研究費助成事業 1997年 - 1998年
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日本学術振興会 科学研究費助成事業 1996年 - 1996年
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日本学術振興会 科学研究費助成事業 1992年 - 1992年
教育内容・方法の工夫（授業評価等を含む）
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件名授業評価結果に対する改善開始年月日2009終了年月日2013概要評価結果を参考に講義資料の作成、講義方法の改善した。
作成した教科書、教材、参考書
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件名「予防医学・公衆衛生学 学生実習提要」終了年月日2013概要「血糖の関連要因に関する疫学研究」の部分を担当した。
その他教育活動上特記すべき事項
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件名藤田保健衛生大学医学部医学教育ワークショップ終了年月日2011/04/10概要「医学教育の改善：ポートフォリオの原理とその応用」に参加した。