Nephrology

Kyoko Hirano

  (平野 恭子)

Profile Information

Affiliation
Assistant Professor, Nephrology, Fujita Health University
Degree
Ph.D.(Fujita Health Univ.)

J-GLOBAL ID
201501005952740308
researchmap Member ID
7000012801

Papers

 2
  • Midori Hasegawa, Junichi Ishii, Fumihiko Kitagawa, Hiroshi Takahashi, Kazuhiro Sugiyama, Masashi Tada, Kyoko Kanayama, Kazuo Takahashi, Hiroki Hayashi, Shigehisa Koide, Shigeru Nakai, Yukio Ozaki, Yukio Yuzawa
    BIOMED RESEARCH INTERNATIONAL, 2016 8761475, 2016  Peer-reviewed
    Background. Our aim was to assess plasma neutrophil gelatinase-associated lipocalin (NGAL) as a predictor of cardiovascular (CV) events in patients with chronic kidney disease (CKD) and no history of CV events. Methods. This was a prospective observational cohort study of 252 patients with predialysis CKD. CV events were defined as CV death, acute coronary syndrome, and hospitalization for worsening heart failure, stroke, and aortic dissection. Results. During a median follow-up period of 63 months, 36 CV events occurred. On Cox stepwise multivariate analysis, plasma NGAL and B-type natriuretic peptide (BNP) were significant predictors of CV events. Kaplan-Meier incidence rates of CV event-free survival at 5 years were 96.6%, 92.9%, 85.9%, and 61.3%, respectively, among quartiles of plasma NGAL (P < 0.0001). The C-index for the receiver-operating characteristic curves for CV events was greater when plasma NGAL was added to an established risk model (0.801, 95% CI 0.717-0.885), compared to the model without plasma NGAL (0.746, 95% CI 0.653-0.840, P = 0.021). Conclusion. Elevated plasma NGAL could predict future CV events in CKD patients with no history of CV events and add incremental value to the established risk model.
  • Nobuya Kitaguchi, Midori Hasegawa, Shinji Ito, Kazunori Kawaguchi, Yoshiyuki Hiki, Sigeru Nakai, Nobuo Suzuki, Yasunobu Shimano, Osamu Ishida, Hiroko Kushimoto, Masao Kato, Sigehisa Koide, Kyoko Kanayama, Takashi Kato, Kengo Ito, Hiroshi Takahashi, Tatsuro Mutoh, Satoshi Sugiyama, Yukio Yuzawa
    JOURNAL OF NEURAL TRANSMISSION, 122(11) 1593-1607, Nov, 2015  Peer-reviewed
    To obtain the proof of concept of a novel therapy for Alzheimer's disease (AD), we conducted two prospective studies with hemodialysis patients who had amyloid beta protein (A beta) removed from their blood three times a week. One major pathological change in the brain associated with AD is A beta deposition, mainly 40 amino acids A beta(1-40) and 42 amino acids A beta(1-42). Impaired A beta clearance is proposed to be one cause of increased A beta in the AD brain. Thus, we hypothesized that an extracorporeal removal system of A beta from the blood may remove brain A beta and be a useful therapeutic strategy for AD. In the first prospective study, plasma A beta levels and the cognitive function of 30 hemodialysis patients (65-76 years old) were evaluated at baseline as well as 18 or 36 months after. Although plasma A beta(1-40) levels either decreased or remained unchanged, levels of A beta(1-42) either remained unchanged or increased at the second time point. Mini-Mental State Examination scores of most subjects increased or were maintained at the second time point. A beta(1-40) influx into the blood correlated with MMSE at the second time point. In the second prospective study, five patients (51-84 years old) with renal failure were evaluated before and after the initiation of hemodialysis. Plasma A beta levels decreased, while cognitive function improved after initiating blood A beta removal. Therefore, long-term hemodialysis, which effectively removes blood A beta, might alter A beta influx and help maintain cognitive function.

Misc.

 11
  • 多田 将士, 伊藤 辰将, 金山 恭子, 杉山 和寛, 小出 滋久, 長谷川 みどり, 湯澤 由紀夫
    腎と透析, 79(別冊 腹膜透析2015) 261-262, Oct, 2015  
    高齢かつ低心機能患者に腹膜透析(PD)を導入し、生活の質(QOL)のみならず心機能が改善した87歳男性の症例を報告した。10年前より腎硬化症による慢性腎不全にて加療中、心エコーでの所見で高度の低心機能を認めていたが、腎機能が不良のため心カテーテル検査による心精査を施行できなかった。うっ血性心不全を発症し入退院を繰り返していた。腎機能は緩徐に増悪したため、PDカテーテルを挿入し、体液量コントロールを目的にPD導入とした。導入後1年の時点で、心機能、SF-36v2によるQOL評価ともに改善を認めた。下腿の浮腫が消失し、経口摂取が改善し体重は増加した。本症例のように重度の低心機能例では、残腎機能が十分に保たれているうちからPD導入が望ましいと考えられた。本症例ではPDによって心機能が改善したが、心機能改善には血液透析(HD)にはない緩徐な除水に加え、さまざまな物質の除去が関与している可能性があり、今後HDと比較した検討が必要であることを指摘した。
  • Mizuguchi Takashi, Hojo Chiharu, Kanayama Kyoko, Takaishi Sachi, Okada Kazumi, Chujo Keiko, Fujiwara Sawako, Yoshikawa Etsuko, Miyake Naomi, Kawashima Shu
    Journal of Japanese Society for Dialysis Therapy, 47(3) 191-197, Mar, 2014  
    Substitution therapy using levocarnitine chloride (L-carnitine 600 mg/day, 12 weeks) was carried out in 13 cases of hemodialysis patients requiring high-capacity (9,000 IU/week or more upon rHuEpo conversion) ESA, and its effect against anemia was investigated along with the ESA requirement. The TC and FC values were very low in all patients before levocarnitine administration, and increased to a normal range 4 weeks after the administration and continued to increase over the following 12 weeks. The hemoglobin value increased by 1.0 g/dL or more in 7 of the 13 cases due to levocarnitine administration, while ESA was reduced by 25% or more in 4 cases, and was effective in a total of 9 cases (2 cases satisfying both standards). There were no significant differences between the effective example and ineffective example regarding the TC, FC, and acylcarnitine (AC) values as well as FC/AC ratio prior to levocarnitine administration. The TC and FC values 4 and 12 weeks after administration in the effective example were significantly higher than those in the ineffective example. The FC/AC ratio significantly increased in the effective example 4 and 8 weeks after administration compared with the prior value. Although red blood cell survival was shortened in 3 effective examples prior to administration, this improved following administration. Red blood cell survival in 2 ineffective examples did not improve, even after administration. As a result, levocarnitine substitution therapy appears to be highly effective in anemic hemodialysis patients without complicated diseases requiring high-quantity ESA, and its mechanism of action is mainly the improvement of shortened red blood cell survival.
  • Kanayama Kyoko, Ohashi Atsushi, Hasegawa Midori, Yuzawa Yukio
    33(1) 31-36, Feb, 2014  
    In this clinical study, the reduction rate of FLCs by hemodiafiltration (HDF) using protein leaking dialyzer and hemodialysis using PMMA membrane were measured. The removal rates of κFLC were 20.8-71.6% by HDF and 54.7% by PMMA hemodialysis (HD). The removal rates of λFLC were 48.5-60.2% by HDF and 39.4% by PMMA HD. In an in vitro study, high cut-off membrane Theralite2100^<TM>, protein leaking dialyzer PES210Dα^<TM>, plasma separator Evacure1A20^<TM> and β2 microglobulin adsorption column LixelleS-35 were compared in their FLC removal rate. Dialysis using Theralite2100^<TM> or Evacure1A20^<TM>, diafiltration using PES210Dα^<TM> and adsorption using LixelleS-35^<TM> were performed in an in vitro circuit. The highest removal rate was obtained by Theralite2100 dialysis among the four blood purification methods. PES210Da^<TM> diafiltration has the second best removal rate. In conclusion, Theralite2100^<TM> dialysis was the best in removal of FLCs. In countries where Theralite2100^<TM> is not available, HDF using protein leaking dialyzer could become an alternative option.
  • 岡田 和美, 水口 隆, 山田 真由美, 中條 恵子, 大橋 照代, 金山 恭子, 水口 潤, 川島 周
    腎と透析, 75(5) 759-763, Nov, 2013  
    通院中の血液透析患者でダルベポエチンα(DA)を週1回投与されている32例を対象とし、静注用鉄剤の投与方法別に、DAと同日に投与する群(9例)、DA投与の次の透析日に投与する群(11例)、DA投与の前の透析日に投与する群(12例)に無作為に分け、「赤血球造血」「鉄代謝」「酸化ストレス」に関わる諸指標の推移を群間比較した。結果、いずれの指標にも有意な群間差は認められなかった。このことから、DA週1回投与下にある透析患者において静注用鉄剤の投与日の違いは赤血球造血や酸化ストレスに影響を及ぼさず、どのタイミングで投与しても問題なく使用できると考えられた。
  • Midori Hasegawa, Junichi Ishii, Fumihiko Kitagawa, Kyoko Kanayama, Hiroshi Takahashi, Yukio Ozaki, Yukio Yuzawa
    HEART AND VESSELS, 28(4) 473-479, Jul, 2013  
    Serum troponin T levels using a highly sensitive assay (hsTnT) in patients with chronic kidney disease (CKD) not on dialysis have not been examined. The aim of this prospective cohort study was to investigate the association of hsTnT with cardiac events in ambulatory CKD patients not on dialysis. The serum hsTnT level was measured in 442 ambulatory CKD patients not on dialysis whose estimated glomerular filtration rate was &lt; 60 ml/min/1.73 m(2). Patients were divided into quartiles according to hsTnT levels, and were followed up for 3 years. Cardiac events were defined as a cardiac death, acute myocardial infarction, unstable angina pectoris that required emergency coronary revascularization, or hospitalization for worsening heart failure. During the follow-up period (median 22 months), 63 cardiac events occurred. Kaplan-Meier incidence rates of cardiac events for 3 years were 0.88 %, 11.5 %, 19.0 %, and 41.4 % among quartiles of hsTnT levels (P &lt; 0.0001). After adjusting for other confounders, elevated hsTnT level was an independent predictor for cardiac events (hazard ratio 6.18, 95 % confidence interval 1.38-27.7, P = 0.0080 for highest quartile vs lowest quartile). In addition, C-index for receiver-operating characteristic curves for cardiac events was greater in an established risks plus hsTnT model than in the established risk alone model (0.857 vs 0.844, P = 0.026). Using a highly sensitive assay, serum hsTnT level was shown to be an independent predictor of cardiac events and a promising risk stratification tool in patients with CKD not on dialysis.

Presentations

 49