研究者業績
基本情報
研究分野
5経歴
4-
2007年7月 - 現在
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2003年6月 - 2007年6月
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1999年4月 - 2003年4月
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1998年7月 - 1999年3月
学歴
1-
1982年4月 - 1988年3月
受賞
1論文
109-
Clinical journal of gastroenterology 2022年5月4日 査読有り責任著者A case of subclinical hepatitis E virus (HEV) infection was detected by nucleic acid amplification test on blood donation. The patient was followed-up until day 220 after the blood donation but showed no symptoms throughout the observation period. Aspartate aminotransferase and alanine aminotransferase levels reached the maximum values on day 37 with a slight increase but remained in normal ranges from day 67 to 220. The quantity of HEV RNA at the initial examination on day 13 was 1.1 × 102 copies/mL, which increased to 2.8 × 103 copies/mL by day 37. It was not detected from day 67 to 220. Immunoglobulin G class antibody to HEV (anti-HEV IgG) was below the cut-off value until day 37 and exceeded the cut-off value to positive on day 67, accompanied by normalization of liver function and negative conversion of HEV RNA. Thereafter, the titer decreased gradually, falling below the cut-off value on day 163, and continuing negative until day 220. Although the persistent duration of anti-HEV IgG positive is believed to be generally long, it was within only 126 days for this subclinical case. Further investigation is needed to determine whether short-term positivity for anti-HEV IgG is typical in subclinical HEV infection.
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肝臓 63(1) 35-38 2022年1月岐阜県近郊で発生したE型肝炎13例のE型肝炎ウイルス(HEV)の感染源・感染経路を、問診と原因HEVの遺伝子配列の解析から推測した。全員孤発例であった。2例は生のブタ内臓肉、1例は調理したブタ内臓肉、7例は調理したブタ肉、2例は調理不十分なブタ肉の喫食歴があった。HEVゲノムのORF2領域の412塩基長の配列をもとに近隣結合法で系統樹を作成した。1例はORF1領域を解析した。原因HEVの遺伝子型は、3aが5例、3bが6例、3fが1例、4iが1例であった。13例中2例は原因HEV株に近縁株の登録はなかったが、11例には97%以上の相同性を持つ株が見つかり、地域内拡散8例、国内広域拡散2例、国際拡散1例の3つのパターンに類別された。
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Acta Hepatologica Japonica 62(6) 384-386 2021年6月1日In Mie Prefecture, autochthonous hepatitis E cases occurred via homologous hepatitis E virus subgenotype 3e (HEV-3e), namely, Mie indigenous HEV-3e, from 2004 through 2014. We experienced three cases of autochthonous hepatitis E in 2020 in Mie Prefecture, and analyzed the partial HEV genomes recovered from them. The three HEV isolates clustered with Mie indigenous HEV-3e in the phylogenetic tree and exhibited high similarities to it. Mie indigenous HEV-3e had thus reemerged for the first time in six years. One affected patient often consumed meat of wild animals, and another ate undercooked pork liver, although the third case had no clear risk factors. Mie indigenous HEV-3e appears to be maintained in wild animals or domestic pigs.
MISC
22-
肝臓 57(Supplement 3) 2016年
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経口感染する肝炎ウイルス(A型、E型)の感染防止、遺伝的多様性、および治療に関する研究 平成23年度 総括・分担研究報告書 53-56 2012年
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日本臨床 69(増刊4 新時代のウイルス性肝炎学) 35-40 2011年5月 招待有り筆頭著者
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肝臓 39(Suppl.2) 238-238 1998年9月
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Hepatology Research 9 135-143 1997年12月1日GB virus C/hepatitis G virus (GBV-C/HGV) was recently cloned from patients with hepatitis and is regarded as transmissible through blood and blood products. However, other modes of transmission, such as intrafamilial transmission, are still unknown. In this study, the prevalence in serum of GBV-C/HGV RNA and antibody to HGV E2 (anti-E2), a newly developed marker to indicate past infection and familial clustering are investigated among the Jewish general population in Uzbekistan, previously reported as a GBV-C/HGV epidemic group. Of 66 subjects, belonging to 28 families, GBV-C/HGV RNA was detected in seven (10.6%) and anti-E2 was detected in six (9.1%). Subjects doubly positive for both GBV-C/HGV RNA and anti-E2 were not observed. The mean age of subjects positive for GBV-C/HGV RNA was 29.1 years. In contrast, the mean age of subjects positive for anti-E2 was 53.2 years and these ages are significantly different (P < 0.05). Familial clustering of persistent and past GBV-C/HGV infection was observed in three families, one married couple and two mother and infant pairs. Our data indicate that: (1) subjects positive for GBV-C/HGV RNA are distributed among the younger generation and subjects positive for anti-E2 among the older generation; and (2) GBV-C/HGV is possibly spread by intrafamilial transmission, both mother to infant and spouse to spouse, in this studied group.
書籍等出版物
8-
Springer-Verlag Tokyo 1999年