Shosuke Ito

(伊藤祥輔)

Profile Information

Affiliation: Professor, Institute for Melanin Chemistry, Fujita Health University

Degree: Doctor of Science, Doctor of Medicine
医学博士

J-GLOBAL ID: 200901053326272218
researchmap Member ID: 1000102729

Research Interests

Research Areas

Education

- 1972

Nagoya University
- 1972

Graduate School, Division of Natural Science, Nagoya University
- 1967

School of Science, Osaka University
- 1967

Faculty of Science, Osaka University

Committee Memberships

Awards

Papers

250

A Cell-Based Evaluation of the Tyrosinase-Mediated Metabolic Activation of Leukoderma-Inducing Phenols, II: The Depletion of Nrf2 Augments the Cytotoxic Effect Evoked by Tyrosinase in Melanogenic Cells

Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu, Takumi Akiyama, Norimasa Tamehiro, Norihito Shibata

Biomolecules, Jan 13, 2025
メラノジェネシス標的低分子NPrCAPとナノマグネタイト粒子結合による次世代型低侵襲性メラノーマ化学・温熱・免疫療法(CTI療法)の産学共同開発

神保孝一, 肥田時征, 川上聡経, 伊藤祥輔, 若松一雅, 井藤彰, 本多裕之, 田村保明, 鳥越俊彦

日本皮膚科学会雑誌, 134(12) 3017-3034, Nov, 2024
Pterostilbene, a Dimethyl Derivative of Resveratrol, Exerts Cytotoxic Effects on Melanin-Producing Cells through Metabolic Activation by Tyrosinase

Hitomi Tanaka, Tomoko Nishimaki-Mogami, Norimasa Tamehiro, Norihito Shibata, Hiroki Mandai, Shosuke Ito, Kazumasa Wakamatsu

International Journal of Molecular Sciences, Sep 17, 2024
Sperm Size Decreases With Increasing Pheomelanin Pigmentation but Not With the Amount of Glutathione in the Barn Swallow

Masaru Hasegawa, Emi Arai, Hitomi Tanaka, Shosuke Ito, Kazumasa Wakamatsu

Zoological Science, 41(5), Jul 11, 2024
Genetic insights into Tietz albinism‐deafness syndrome: A new dominant‐negative mutation in MITF

Kohei Yamamoto, Ken Okamura, Kazumasa Wakamatsu, Shosuke Ito, Kozue Akabane, Yosuke Arai, Junnosuke Kawaguchi, Yutaka Hozumi, Tamio Suzuki

Pigment Cell & Melanoma Research, Jul, 2024

Misc.

210

Synthesis and selective in vitro anti-melanoma effect of enantiomeric alpha-methyl- and alpha-ethyl-4-S-cysteaminylphenol

J Yukitake, H Otake, S Inoue, K Wakamatsu, C Olivares, F Solano, K Hasegawa, S Ito

MELANOMA RESEARCH, 13(6) 603-609, Dec, 2003
Quantitative analysis of eumelanin and pheomelanin in humans, mice, and other animals: A comparative review

S Ito, K Wakamatsu

PIGMENT CELL RESEARCH, 16(5) 523-531, Oct, 2003
Cutaneous photobiology. The melanocyte vs. the sun: Who will win the final round?

AL Kadekaro, RJ Kavanagh, K Wakamatsu, S Ito, MA Pipitone, ZA Abdel-Malek

PIGMENT CELL RESEARCH, 16(5) 434-447, Oct, 2003
Rate constants for the first two chemical steps of eumelanogenesis

EJ Land, S Ito, K Wakamatsu, PA Riley

PIGMENT CELL RESEARCH, 16(5) 487-493, Oct, 2003
HPLC analysis of pheomelanin degradation products in human urine

A Takasaki, E Nezirevic, K Arstrand, K Wakamatsu, S Ito, B Kagedal

PIGMENT CELL RESEARCH, 16(5) 480-486, Oct, 2003
Eumelanin and phaeomelanin contents of depigmented and repigmented skin in vitiligo patients

D Parsad, K Wakamatsu, AJ Kanwar, B Kumar, S Ito

BRITISH JOURNAL OF DERMATOLOGY, 149(3) 624-626, Sep, 2003
Comparison of the structural and physical properties of human hair eumelanin following enzymatic or acid/base extraction

Y Liu, VR Kempf, JB Nofsinger, EE Weinert, M Rudnicki, K Wakamatsu, S Ito, JD Simon

PIGMENT CELL RESEARCH, 16(4) 355-365, Aug, 2003
The structure of neuromelanin as studied by chemical degradative methods

K Wakamatsu, K Fujikawa, FA Zucca, L Zecca, S Ito

JOURNAL OF NEUROCHEMISTRY, 86(4) 1015-1023, Aug, 2003
Comparison of phaeomelanin and its precursor 5-S-cysteinyldopa in the serum of melanoma patients

K Wakamatsu, M Yokochi, A Naito, T Kageshita, S Ito

MELANOMA RESEARCH, 13(4) 357-363, Aug, 2003
A chemist's view of melanogenesis

S Ito

PIGMENT CELL RESEARCH, 16(3) 230-236, Jun, 2003
Effects of melanogenesis-inducing nitric oxide and histamine on the production of eumelanin and pheomelanin in cultured human melanocytes

MW Lassalle, S Igarashi, M Sasaki, K Wakamatsu, S Ito, T Horikoshi

PIGMENT CELL RESEARCH, 16(1) 81-84, Feb, 2003
Changes in the proliferation and differentiation of neonetal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine

Pigment Cell Research, 16, 619-628, 2003
The neuromelanin of human substantia nigra: structure, synthesis and molecular behaviour

L Zecca, FA Zucca, P Costi, D Tampellini, A Gatti, M Gerlach, P Riederer, RG Fariello, S Ito, M Gallorini, D Sulzer

ADVANCES IN RESEARCH ON NEURODEGENERATION, 10 145-155, 2003
DNA damage and melanin content following ultraviolet radiation of human skin from different racial/ethic and photosensitive groups

FASEB Journal, 17, 1177-1179, 2003
gamma-Glutamyl transpeptidase and its role in melanogenesis: Redox reactions and regulation of tyrosinase

VA Chaubal, SS Nair, S Ito, K Wakamatsu, MV Mojamdar

PIGMENT CELL RESEARCH, 15(6) 420-425, Dec, 2002
Melanocortin 1 receptor accounts for 50% of variation in hair melanin eumelanin and phaemelanin in a northern European dataset

L Naysmith, T Ha, K Waterston, Y Bisset, A Ray, NF Ianagan, S Ito, K Wakamatsu, JL Rees

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 119(3) 758-758, Sep, 2002
Advanced chemical methods in melanin determination

K Wakamatsu, S Ito

PIGMENT CELL RESEARCH, 15(3) 174-183, Jun, 2002
The usefulness of 4-amino-3-hydroxyphenylalanine as a specific marker of pheomelanin

K Wakamatsu, S Ito, JL Rees

PIGMENT CELL RESEARCH, 15(3) 225-232, Jun, 2002
Evaluation of 5-S-cysteinyidopa as a marker of melanoma progression: 10 years' experience

K Wakamatsu, T Kageshita, M Furue, N Hatta, Y Kiyohara, J Nakayama, T Ono, T Saida, M Takata, T Tsuchida, H Uhara, A Yamamoto, N Yamazaki, A Naito, S Ito

MELANOMA RESEARCH, 12(3) 245-253, Jun, 2002
Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation

MC Scott, K Wakamatsu, S Ito, AL Kadekaro, N Kobayashi, J Groden, R Kavanagh, T Takakuwa, Virador, V, VJ Hearing, ZA Abdel-Malek

JOURNAL OF CELL SCIENCE, 115(11) 2349-2355, Jun, 2002
Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture

T Hirobe, K Wakamatsu, S Ito, H Abe, Y Kawa, M Mizoguchi

JOURNAL OF CELLULAR PHYSIOLOGY, 191(2) 162-172, May, 2002
Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro

T Hirobe, Y Kawa, M Mizoguchi, S Ito, K Wakamatsu

JOURNAL OF EXPERIMENTAL ZOOLOGY, 292(4) 351-366, Mar, 2002
Molecular and phenotypic analysis of 25 recessive, homozygous-viable alleles at the mouse agouti locus

RJ Miltenberger, K Wakamatsu, S Ito, RP Woychik, LB Russell, EJ Michaud

GENETICS, 160(2) 659-674, Feb, 2002
The neuromelanin of human substantia nigra and its interaction with metals

L Zecca, D Tampellini, A Gatti, R Crippa, M Eisner, D Sulzer, S Ito, R Fariello, M Gallorini

JOURNAL OF NEURAL TRANSMISSION, 109(5-6) 663-672, 2002
Influence of alpha-melanocyte-stimulating hormone and of ultraviolet radiation on the transfer of melanosomes to keratinocytes

VM Virador, J Muller, XF Wu, ZA Abdel-Malek, ZX Yu, VJ Ferrans, N Kobayashi, K Wakamatsu, S Ito, JA Hammer, VJ Hearing

FASEB JOURNAL, 15(13) 105-+, Nov, 2001
5-S-cysteinyldopa as diagnostic tumor marker for uveal malignant melanoma

H Goto, M Usui, K Wakamatsu, S Ito

JAPANESE JOURNAL OF OPHTHALMOLOGY, 45(5) 538-542, Sep, 2001
Effect of increased intracellular melanin concentration on survival of human melanoma cells exposed to different wavelengths of UV radiation

C Kowalczuk, M Priestner, C Baller, A Pearson, N Cridland, R Saunders, K Wakamatsu, S Ito

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 77(8) 883-889, Aug, 2001
Molecular and phenotypic analysis of Attractin mutant mice

TM Gunn, T Inui, K Kitada, S Ito, K Wakamatsu, L He, DM Bouley, T Serikawa, GS Barsh

GENETICS, 158(4) 1683-1695, Aug, 2001
DNA damage and melanin production induced by ultraviolet radiation in human skin within various racial/ethnic groups

T Tadokoro, N Kobayashi, J Beer, B Zmudzka, Hearing, V, K Korossy, S Ito, K Wakamatsu

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 117(2) 498-498, Aug, 2001
Tissue factor expression and serum level in patients with melanoma does not correlate with disease progression

T Kageshita, Y Funasaka, M Ichihashi, K Wakamatsu, S Ito, T Ono

PIGMENT CELL RESEARCH, 14(3) 195-200, Jun, 2001
Cyclic oscillations in melanin composition within hairs of baboons

S Ito, K Wakamatsu, N Matsunaga, VJ Hearing, KD Carey, S Anderson, TP Dooley

PIGMENT CELL RESEARCH, 14(3) 180-184, Jun, 2001
Noise-induced hearing loss: the effect of melanin in the stria vascularis

S Bartels, S Ito, DR Trune, AL Nuttall

HEARING RESEARCH, 154(1-2) 116-123, Apr, 2001
Interaction of major coat color gene functions in mice as studied by chemical analysis of eumelanin and pheomelanin

ML Lamoreux, K Wakamatsu, S Ito

PIGMENT CELL RESEARCH, 14(1) 23-31, Feb, 2001
Structural characteristics of human substantia nigra neuromelanin and synthetic dopamine melanins

KL Double, L Zecca, P Costi, M Mauer, C Griesinger, S Ito, D Ben-Shachar, G Bringmann, RG Fariello, P Riederer, M Gerlach

JOURNAL OF NEUROCHEMISTRY, 75(6) 2583-2589, Dec, 2000
The underwhite (uw) locus acts autonomously and reduces the production of melanin

AL Lehman, WK Silvers, N Puri, K Wakamatsu, S Ito, MH Brilliant

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 115(4) 601-606, Oct, 2000
Heterozygous HPS1 mutations in a case of Hermansky-Pudlak syndrome with giant melanosomes

T Horikawa, K Araki, K Fukai, M Ueda, T Ueda, S Ito, M Ichihashi

BRITISH JOURNAL OF DERMATOLOGY, 143(3) 635-640, Sep, 2000
Quantitative trait loci that modify the sootiness of yellow pigmentation in KK-A(y)/a mice

J Suto, K Wakamatsu, H Yamanaka, S Ito, K Sekikawa

MAMMALIAN GENOME, 11(8) 639-644, Aug, 2000
The melanocortin-1 receptor is a key regulator of human cutaneous pigmentation

Z Abdel-Malek, MC Scott, Suzuki, I, A Tada, S Im, L Lamoreux, S Ito, G Barsh, VJ Hearing

PIGMENT CELL RESEARCH, 13(Supplement 8) 156-162, 2000
Chemical analysis of melanins and its application to the study of the regulation of melanogenesis

S Ito, K Wakamatsu, H Ozeki

PIGMENT CELL RESEARCH, 13(Supplement 8) 103-109, 2000
Interaction of human substantia nigra neuromelanin with lipids and peptides

Luigi Zecca, Patrizia Costi, Claudio Mecacci, Shosuke Ito, Mariarosa Terreni, Sandro Sonnino

Journal of Neurochemistry, 74(4) 1758-1765, 2000
Chemical analysis of melanin pigments in feather germs of Japanese quail Bh (black at hatch) mutants

N Shiojiri, T Niwa, K Wakamatsu, S Ito, A Nakamura

PIGMENT CELL RESEARCH, 12(4) 259-265, Aug, 1999
Insect melanogenesis. II. Inability of Manduca phenoloxidase to act on 5,6-dihydroxyindole-2-carboxylic acid

M Sugumaran, R Duggaraju, F Generozova, S Ito

PIGMENT CELL RESEARCH, 12(2) 118-125, Apr, 1999
Cysteine transport in melanosomes from murine melanocytes

SB Potterf, Virador, V, K Wakamatsu, M Furumura, C Santis, S Ito, VJ Hearing

PIGMENT CELL RESEARCH, 12(1) 4-12, Feb, 1999
Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice

L Liu, K Wakamatsu, S Ito, PR Williamson

INFECTION AND IMMUNITY, 67(1) 108-112, Jan, 1999
Does tyrosinase exist in neuromelanin-pigmented neurons in the human substantia nigra?

K Ikemoto, Nagatsu, I, S Ito, RA King, A Nishimura, T Nagatsu

NEUROSCIENCE LETTERS, 253(3) 198-200, Sep, 1998
Pigment cells representing polychromatic colony color in Botrylloides simodensis (Ascidiacea, Urochordata): Cell morphology and pigment substances

E Hirose, T Yoshida, T Akiyama, S Ito, Y Iwanami

ZOOLOGICAL SCIENCE, 15(4) 489-497, Aug, 1998
Comparison of high performance liquid chromatography and stereological image analysis for the quantitation of eumelanins and pheomelanins in melanoma cells

E Donois, Del Marmol, V, K Wakamatsu, S Ito, G Ghanem, JE Surleve-Bazeille

PIGMENT CELL RESEARCH, 11(2) 86-93, Apr, 1998
Chemical degradation of melanins: Application to identification of dopamine-melanin

S Ito, K Wakamatsu

PIGMENT CELL RESEARCH, 11(2) 120-126, Apr, 1998
Comparison of antimelanoma effects of 4-S-cysteaminylphenol and its homologues

S Inoue, K Hasegawa, K Wakamatsu, S Ito

MELANOMA RESEARCH, 8(2) 105-112, Apr, 1998
Melanin biosynthesis in Cryptococcus neoformans

PR Williamson, K Wakamatsu, S Ito

JOURNAL OF BACTERIOLOGY, 180(6) 1570-1572, Mar, 1998

Books and Other Publications

Chemistry of Melanins. In "The Pigmentary System. Sec Ed. "

Blackwell Publishing, 2006
Advances in chemical analysis of melanins. In"The Pigmentary System and Its Disorders"(共著)

Oxford University Press, New York, 1998
Spectrophotometric and HPLC characterization of hair melanins(共著)

Excerpta Medica International Congress Series 1096. International Symposium on Melanogenesis and Malignant Melanoma, 1996
Biochemistry and Physiology of Melanin in "Pigmentation and Pigmentary Disorders" (共著)

CRC Press, Inc., 1993

Professional Memberships

Works

Research Projects

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