医学部
Profile Information
- Affiliation
- Department of Biomedical Molecular Sciences, School of Medicine, Fujita Health University
- Degree
- 博士(理学)(同志社大学)
- ORCID ID
https://orcid.org/0009-0006-7462-2234
- J-GLOBAL ID
- 202101014437516876
- researchmap Member ID
- R000022318
Research Areas
1Papers
1-
Applied Sciences, 11(22) 11038-11038, Nov 22, 2021 Peer-reviewedLead authorMatrix-assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) is increasingly used in a broad range of research due to its ability to visualize the spatial distribution of metabolites in vivo. Here, we have developed a method, named thoracic Mass Spectrometry Imaging (tMSI), as a standard protocol of molecular imaging of whole-animal sectioning in various settings of mice in vivo. Further application of the strategy that involved the systemic administration of dexamethasone (DEX) in mice, enabled a dynamic shift in the energy status of multiple thoracic organs to be visualized, based on tMSI data of purine and pyrimidine metabolites. Furthermore, with the introduction of uniform manifold approximation and projection (UMAP) for tMSI data, metabolic profiles normally localized in the cortex and cortico-medullary junction (CMJ) of the thymus were drastically shifted as minor profiles into the medulla of DEX-treated thymus. As a massive apoptotic cell death in the thymic cortex was noticeable, a single molecule, which was upregulated in the cortex of the thymus, enabled us to predict ongoing immunosuppression by in vivo DEX-administration.
Misc.
10-
JSBMS Letters, 46(Suppl.) 90-90, Aug, 2021
Presentations
30-
Cell Symposium/Translational Immunometabolism, Jun, 2022
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70th American Society for Mass Spectrometry Conference, Jun, 2022
Research Projects
5-
公益財団法人 愛知腎臓財団, Aug, 2024 - Mar, 2025
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研究助成費ー若手研究費, 藤田医科大学, Apr, 2024 - Mar, 2025
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科学研究費助成事業 令和4年度 若手研究, 日本学術振興会, Apr, 2022 - Mar, 2025
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公益財団法人 愛知腎臓財団, Aug, 2023 - Mar, 2024
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公益財団法人 愛知腎臓財団, Aug, 2021 - Mar, 2022