Curriculum Vitaes
Profile Information
- Affiliation
- Research Promotion Headquarters, Division of Comprehensive Medical Science, Center for Medical Science, Division of Systems Medical Science, Fujita Health University
- Degree
- bachelor(The University of Tokyo)phD(The Graduate University for Advanced Studies)
- Contact information
- tomoyuki.murano
fujita-hu.ac.jp
- ORCID ID
https://orcid.org/0000-0002-9351-737X
- J-GLOBAL ID
- 202101008576743119
- researchmap Member ID
- B000249228
- External link
神経の過剰な興奮が精神疾患の病態形成に及ぼす影響について研究しています。
Research Interests
8Research Areas
1Research History
3-
Apr, 2017 - Mar, 2019
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Apr, 2015 - Mar, 2017
Awards
4Papers
8-
Frontiers in Psychiatry, 14 1151480, May 2, 2023 Peer-reviewed
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Proceedings of the National Academy of Sciences of the United States of America, 119(32) e2106830119, Aug 9, 2022 Peer-reviewedLead authorThe dentate gyrus (DG) plays critical roles in cognitive functions, such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely unknown how information is represented in this region. Here, we recorded neuronal activity in the DG using Ca2+ imaging in freely moving mice and analyzed this activity using machine learning. The activity patterns of populations of DG neurons enabled us to successfully decode position, speed, and motion direction in an open field, as well as current and future location in a T-maze, and each individual neuron was diversely and independently tuned to these multiple information types. Our data also showed that each type of information is unevenly distributed in groups of DG neurons, and different types of information are independently encoded in overlapping, but different, populations of neurons. In alpha-calcium/calmodulin-dependent kinase II (αCaMKII) heterozygous knockout mice, which present deficits in spatial remote and working memory, the decoding accuracy of position in the open field and future location in the T-maze were selectively reduced. These results suggest that multiple types of information are independently distributed in DG neurons.
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Jun 9, 2020 Lead authorAbstract The dentate gyrus (DG) plays critical roles in cognitive functions such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely unknown how information is represented in this region. Here, we recorded neuronal activity in the DG using Ca2+imaging in freely moving mice and analysed this activity using machine learning. The activity patterns of populations of DG neurons enabled us to successfully decode position, speed, and motion direction in an open field as well as current and future location in a T-maze, and each individual neuron was diversely and independently tuned to these multiple information types. In αCaMKII heterozygous knockout mice, which present deficits in spatial remote and working memory, the decoding accuracy of position in the open field and future location in the T-maze were selectively reduced. These results suggest that multiple types of information are independently distributed in DG neurons.
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Molecular brain, 12(1) 108-108, Dec 10, 2019 Peer-reviewedIt is agreed upon that adult hippocampal neurogenesis (AHN) occurs in the dentate gyrus (DG) in rodents. However, the existence of AHN in humans, particularly in elderly individuals, remains to be determined. Recently, several studies reported that neural progenitor cells, neuroblasts, and immature neurons were detected in the hippocampus of elderly humans, based on the expressions of putative markers for these cells, claiming that this provides evidence of the persistence of AHN in humans. Herein, we briefly overview the phenomenon that we call "dematuration," in which mature neurons dedifferentiate to a pseudo-immature status and re-express the molecular markers of neural progenitor cells and immature neurons. Various conditions can easily induce dematuration, such as inflammation and hyper-excitation of neurons, and therefore, the markers for neural progenitor cells and immature neurons may not necessarily serve as markers for AHN. Thus, the aforementioned studies have not presented definitive evidence for the persistence of hippocampal neurogenesis throughout adult life in humans, and we would like to emphasize that those markers should be used cautiously when presented as evidence for AHN. Increasing AHN has been considered as a therapeutic target for Alzheimer's disease (AD); however, given that immature neuronal markers can be re-expressed in mature adult neurons, independent of AHN, in various disease conditions including AD, strategies to increase the expression of these markers in the DG may be ineffective or may worsen the symptoms of such diseases.
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Communications Biology, 2(1), Jan 22, 2019 Peer-reviewedLead authorAbstract Biomarkers are needed to improve the diagnosis of neuropsychiatric disorders, which are often associated to excitatory/inhibitory imbalances in neural transmission and abnormal maturation. Here, we characterized different disease conditions by mapping changes in the expression patterns of maturation-related genes whose expression was altered by experimental neural hyperexcitation in published studies. This analysis revealed two gene expression patterns: decreases in maturity markers and increases in immaturity markers. These two groups of genes were characterized by the over-representation of genes related to synaptic function and chromosomal modification, respectively. Using these two groups in a transdiagnostic analysis of 87 disease datasets for eight neuropsychiatric disorders and 12 datasets from corresponding animal models, we found that transcriptomic pseudoimmaturity inducible by neural hyperexcitation is shared by multiple neuropsychiatric disorders, such as schizophrenia, Alzheimer disorders, and amyotrophic lateral sclerosis. Our results indicate that this endophenotype serves as a basis for the transdiagnostic characterization of these disorders.
Presentations
19-
American College of Neuropsychopharmacology 2024 Annual Meeting, Dec 12, 2024
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The 47th Annual Meeting of the Japan Neuroscience Society (NEURO2024), Jul 25, 2024
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The Society for Neuroscience 2023 Annual Meeting, Nov 11, 2023
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Annual Meeting of Japanese Society of Neuropsychopharmacology 2023, Sep 7, 2023
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The 51st Annual Meeting of the Japanese Society of Neuropsychopharmacology, Nov 4, 2022
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The 45th Annual Meeting of the Japan Neuroscience Society (NEURO2022), Jul 2, 2022
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Annual Meeting of Japanese Society of Neuropsychopharmacology 2021, Nov 5, 2021
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The 44th Annual Meeting of the Japan Neuroscience Society, Jul 28, 2021
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American College of Neuropsychopharmacology 2020 Annual Meeting, Dec 6, 2020
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Annual Meeting of Japanese Society of Neuropsychopharmacology 2020, Aug 21, 2020
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The 43nd Annual Meeting of Japan Neuroscience Society, Jul 30, 2020
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The 49th Annual Meeting of Japanese Society of Neuropsychopharmacology, Oct 13, 2019
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Multiple Types of Information are distributed in different Ensembles of Dentate Gyrus Neurons (Oral)Molecular and Cellular Cognition Society, 18th, Oct, 2019
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Society for Neuroscience 50th Annual meeting, Chicago, Oct, 2019
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The 42nd Annual Meeting of Japan Neuroscience Society, Jul 25, 2019
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Cold Spring Harbor Asia conference, Sep, 2018
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American College of Neuropsychopharmacology, Dec, 2017
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Society for Neuroscience 46th Annual meeting, SanDiego, Nov, 2016
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30th CINP World Congress of Neuropsychopharmacology, Seoul, Republic of Korea, Jul, 2016
Teaching Experience
1-
Jun, 2024 - Jul, 2024解剖学総論 (浜松医科大学)
Professional Memberships
3Research Projects
2-
Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Apr, 2024 - Mar, 2026
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科学研究費助成事業, 日本学術振興会, Apr, 2022 - Mar, 2025