医療科学部

atsushi ohashi

  (大橋 篤)

Profile Information

Affiliation
Associate Professor, Clinical Science for biological monitoring, Fujita Health University
Degree
博士(医学)

J-GLOBAL ID
200901015597186474
researchmap Member ID
1000265002

Research Interests

 2

Awards

 1

Papers

 35
  • Atsushi Ohashi, Masashi Nakatani, Hideo Hori, Shigeru Nakai, Kunihiro Tsuchida, Midori Hasegawa, Naotake Tsuboi
    Therapeutic Apheresis and Dialysis, Aug 19, 2023  Peer-reviewedLead author
    Abstract Introduction Indoxyl sulfate (IS) is a protein‐bound uremic toxin that causes uremic sarcopenia. IS has poor dialysis clearance; however, the addition of a binding competitor improves its removal efficiency. Methods Dialysis experiments were performed using N‐acetyl‐l‐tryptophan (L‐NAT) instead of l‐tryptophan (Trp) using pooled sera obtained from dialysis patients. The molecular structures of L‐NAT and Trp were similar to that of IS. Therefore, we examined whether Trp and L‐NAT were involved in muscle atrophy in the same manner as IS by performing culture experiments using a human myotube cell line. Results The removal efficiency of L‐NAT was the same as that of Trp. However, L‐NAT concentrations in the pooled sera increased at the end of the experiment. Trp (1 mM) decreased the area of human myocytes, similar to IS, whereas L‐NAT did not. Conclusion L‐NAT is a binding competitor with the ability to remove protein‐bound IS while preventing sarcopenia.
  • Hideo Hori, Kazuyoshi Sakai, Atsushi Ohashi, Shigeru Nakai
    Journal of Artificial Organs, Aug 17, 2022  Peer-reviewed
  • Midori Hasegawa, Nobuya Kitaguchi, Hajime Takechi, Kazunori Kawaguchi, Kengo Ito, Takashi Kato, Masao Kato, Norio Nii, Sachie Yamada, Atsushi Ohashi, Shigehisa Koide, Hiroki Hayashi, Kazuo Takahashi, Daijo Inaguma, Yukio Yuzawa, Naotake Tsuboi
    Therapeutic Apheresis and Dialysis, 26(3) 529-536, Jun, 2022  Peer-reviewed
  • Midori Hasegawa, Hiromichi Matsushita, Kensei Yahata, Akira Sugawara, Yoshitaka Ishibashi, Ryoko Kawahara, Yoshifumi Hamasaki, Hitoshi Kanno, Sachie Yamada, Norio Nii, Masao Kato, Atsushi Ohashi, Shigehisa Koide, Hiroki Hayashi, Yukio Yuzawa, Naotake Tsuboi
    Therapeutic Apheresis and Dialysis, 25(4) 407-414, Aug, 2021  Peer-reviewed
    Cell-free and concentrated ascites reinfusion therapy (CART) is performed by collecting the ascites from the patient, followed by filtration and concentration. Thereafter, concentrated cell-free ascites is reinfused into the patient intravenously. The new type of machine, Plasauto μ, for managing the process of CART was launched onto the market. We have evaluated the machine through postmarketing clinical study in 17 patients with malignant ascites. The amounts of original and concentrated ascites were 3673 ± 1920 g and 439 ± 228 g, respectively. Recovery rates were acceptable regarding values of total protein, albumin, and IgG that were 55.6% ± 17.3%, 60.2% ± 20.8%, and 58.2% ± 20.5%, respectively. Recovery rates were positively associated with amounts of original ascites and negatively associated with total protein concentration. No adverse events related to the machine were observed. The new type of machine showed preferable performance in processing malignant ascites.
  • Atsushi Ohashi, Shigeru Nakai, Hideo Hori, Sachie Yamada, Masao Kato, Shigehisa Koide, Hiroki Hayashi, Naotake Tsuboi, Daijo Inaguma, Midori Hasegawa, Yukio Yuzawa
    Therapeutic Apheresis and Dialysis, 24(5) 511-515, Jun 11, 2020  Peer-reviewedLead author

Misc.

 121

Books and Other Publications

 4

Presentations

 36

Teaching Experience

 7

Research Projects

 8

教育内容・方法の工夫(授業評価等を含む)

 1
  • 件名(英語)
    -
    開始年月日(英語)
    2009/04
    概要(英語)
    代謝機能代行技術学は血液浄化業務に関する専門的分野であり、臨地実習や就職試験の際に十分な基礎知識が要求される。よって、臨床現場で要求される知識や事例を盛り込む実践的な講義構成とした。

作成した教科書、教材、参考書

 2
  • 件名(英語)
    「代謝機能代行技術学実習実習書」
    開始年月日(英語)
    2009/10
    概要(英語)
    臨地実習(血液浄化部)で要求される実践的内容を体得すべく学内実習書を作製した。
  • 件名(英語)
    「臨床工学入門」
    開始年月日(英語)
    2011/09
    概要(英語)
    臨床工学技士国家試験対策で使用する参考書(解説書)を分担執筆した。

その他教育活動上特記すべき事項

 1
  • 件名(英語)
    平成23年度より3年生の専門基礎科目「臨床生化学実習」の分担を担当
    開始年月日(英語)
    2013/04
    概要(英語)
    臨床工学の血液浄化療法は臨床生化学検査のデータを正しく把握する事が必要であり、さらに臨床現場では血液や透析液の濃度や細菌培養など測定技術が必要とされるため、本実習を通じて、血清成分の正確かつ精密な分析技術に関する生化学実習を分担で担当した。