医学部 歯科・口腔外科学
Profile Information
- Affiliation
- Assistant Professor, Dentistry & Oral-Maxillofacial Surgery, School of Medicine, Fujita Health University
- Degree
- DDS, Ph.D.(Mar, 2018, Hiroshima University)
- J-GLOBAL ID
- 202401004513882379
- researchmap Member ID
- R000069752
Research Areas
1Papers
6-
Oral Diseases, 29(7) 2907-2916, Oct 5, 2022 Peer-reviewedAbstract Objective This study aims to investigate how experimental tooth loss affected learning, memory function, and brain pathophysiology in mice. Materials and Methods The mice (C57BL/6 J, 2‐month‐old, male) were divided into tooth loss and control groups. The behavioral test battery was performed at 6 and 12 months after tooth extraction. The protein levels of the tight junctions in the brains of the mice were analyzed. Hippocampal astrocyte was measured using immunohistochemical staining. Results The results of behavioral tests and biochemical analysis performed during the 6 months observation period did not show significant differences between the groups. However, the escape latency in the tooth loss group was significantly longer than that in the control group at the 12 months after tooth extraction. The level of claudin‐5 decreased in the tooth loss group. Additionally, hippocampal astrogliosis was found in the tooth loss group. Conclusions Experimental tooth loss reduced the level of claudin‐5 and caused astrogliosis in the brains of mice, which was accompanied by deterioration of learning functions. This study may provide a new insight about the association between tooth loss and cognitive dysfunction.
-
Journal of Molecular Histology, 50(4) 389-404, Jun 18, 2019 Peer-reviewed
-
CRANIO®, 39(1) 24-28, Feb 19, 2019 Peer-reviewed
-
In Vitro Cellular & Developmental Biology - Animal, 55(3) 211-219, Feb 12, 2019 Peer-reviewedLead author
-
RSC Advances, 9(3) 1625-1631, 2019 Peer-reviewed<p>The purpose of this study was to evaluate the characteristic structures and osteoconduction ability of porous titanium structures using a resin-impregnated titanium substitution fabrication technique.</p>