Curriculum Vitaes

Susumu Hama

  (濱 進)

Profile Information

Affiliation
Faculty of Pharmacy, Department of Pharmaceutical Sciences, Musashino University
Degree
博士(薬学)(北海道大学)

Researcher number
60438041
J-GLOBAL ID
201901007919942126
researchmap Member ID
B000349317

Committee Memberships

 1

Papers

 57
  • Susumu Hama, Takayuki Nishi, Eitaro Isono, Shoko Itakura, Yutaka Yoshikawa, Akinori Nishimoto, Satoko Suzuki, Naoko Kirimura, Hiroaki Todo, Kentaro Kogure
    Cancer science, 113(5) 1779-1788, May, 2022  Peer-reviewedLead authorCorresponding author
    Intraperitoneal administration of anticancer nanoparticles is a rational strategy for preventing peritoneal dissemination of colon cancer due to the prolonged retention of nanoparticles in the abdominal cavity. However, instability of nanoparticles in body fluids causes inefficient retention, reducing its anticancer effects. We have previously developed anticancer nanoparticles containing tocopheryl succinate, which showed high in vivo stability and multifunctional anticancer effects. In the present study, we have demonstrated that peritoneal dissemination derived from colon cancer was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. The biodistribution of tocopheryl succinate nanoparticles was evaluated using inductively coupled plasma mass spectroscopy and imaging analysis in mice administered quantum dot encapsulated tocopheryl succinate nanoparticles. Intraperitoneal administration of tocopheryl succinate nanoparticles showed longer retention in the abdominal cavity than by its intravenous (i.v.) administration. Moreover, due to effective biodistribution, tumor growth was prevented by intraperitoneal administration of tocopheryl succinate nanoparticles. Furthermore, the anticancer effect was attributed to the inhibition of cancer cell proliferation and improvement of the intraperitoneal microenvironment, such as decrease in the levels of vascular endothelial growth factor A, interleukin 10, and M2-like phenotype of tumor-associated macrophages. Collectively, intraperitoneal administration of tocopheryl succinate nanoparticles is expected to have multifaceted antitumor effects against colon cancer with peritoneal dissemination.
  • Susumu Hama, Naoko Kirimura, Aki Obara, Hirokatsu Takatsu, Kentaro Kogure
    Molecules, 27(4) 1425, 2022  Peer-reviewedInvitedLead author
  • Susumu Hama, Mika Sakai, Shoko Itakura, Eiji Majima, Kentaro Kogure
    Biochemistry and Biophysics Reports, 27 101067-101067, Sep, 2021  Peer-reviewedLead authorCorresponding author
  • Susumu Hama, Yuriko Okamura, Kazuho Kamei, Saki Nagao, Mari Hayashi, Shizuka Maeda, Kenji Fukuzawa, Kentaro Kogure
    Biochemical and Biophysical Research Communications, Jan 22, 2020  Peer-reviewedLead authorCorresponding author
    α-Tocopheryl succinate (TS) is a tocopherol derivative and has multifaceted anti-cancer effects; TS not only causes cancer cell-specific apoptosis but also inhibits tumor angiogenesis. Although TS has the potential to be used as a well-tolerated anti-angiogenic drug, it is still unclear which step of the angiogenic process is inhibited by TS. Here, we show that TS inhibits the expression of angiopoietin (Ang)-2, which induces destabilization of vascular structure in the initial steps of the angiogenic process. In mouse melanoma cells, TS treatment decreased mRNA and extracellular protein levels of Ang-2; however, the mRNA level of Ang-1, which stabilizes the vascular structure, remained unchanged. Furthermore, aorta ring and Matrigel plug angiogenesis assays indicated that the conditioned medium from TS-treated cells (CM-TS) inhibited neovascularization and blood leakage from the existing blood vessels, respectively. Following immunohistochemical staining of the vessels treated with CM-TS, imaging studies showed that the vascular endothelial cells were highly packed with pericytes. In conclusion, we found that TS inhibits Ang-2 expression and, consequently, stabilizes the vascular structure during the initial step of tumor angiogenesis.
  • Mahadi Hasan, Susumu Hama, Kentaro Kogure
    Scientific Reports, Vol.9(No.1) 4114-4114, Mar, 2019  Peer-reviewedLead author

Books and Other Publications

 15

Presentations

 12

Research Projects

 9

Media Coverage

 1