Jun Mada, Keisuke Matsuya, Takafumi Yura, Hiroki Kurihara, Tetsuji Tokihiro
Transactions of the Japan Society for Industrial and Applied Mathematics, 26(1) 105-123, Mar, 2016 Peer-reviewed
We investigate a simple mathematical model for angiogenesis. From recent<br />
time-lapse imaging experiments on the dynamics of endothelial cells (ECs) in angiogenesis, we suppose that elongation and bifurcation of neogenetic vessel is determined by only the density of ECs near the tip, and introduce a model described by nonlinear simultaneous differential equations. We also incorporate proliferation of ECs and activation factor such as VEGF and show the exact solutions to that model and numerical simulations.