研究者業績

今井一洋

イマイカズヒロ (Kazuhiro Imai)

基本情報

所属: 武蔵野大学薬学研究所薬学研究所客員教授,名誉教授（東京大学）

学位: Ph.D.
Master of pharmaceutical Sciences

J-GLOBAL ID: 200901058703864038
researchmap会員ID: 1000013291

研究キーワード

2

研究分野

1

ライフサイエンス / 薬系分析、物理化学 /

経歴

11

2012年 - 現在

武蔵野大学客員教授
2003年 - 現在

- 武蔵野大学教授
2003年 - 2012年

武蔵野大学教授
1993年 - 2003年

東京大学教授
1993年 - 2003年

東京大学

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学歴

4

委員歴

11

1998年 - 1999年

クロマトグラフィー科学会会長
1999年

日本薬理学会評議員、選考委員
1998年

Academia Iberoamericana de Pharmacia 会員
1995年 - 1997年

国際薬学連合薬科学部会代議員
1991年 - 1994年

日本臨床化学会評議員

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受賞

7

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論文

2

Alteration of intracellular secretory acute phase response proteins expressed in human hepatocyte induced by exposure with interleukin-6 Liquid chromatographic separation of proteins derivatized with a fluorogenic reagent at cysteinyl residues on

K. Nakata, R. Saitoh, J. Amano, A. Koshiyama, T. Ichibangase, N. Murao, K. Ohta, Y. Aso, M. Ishigai, K. Imai

Cytokine 2012年9月査読有り
A toxicoproteomic study on cardioproteactive effects of pre-administration of docetaxel in a mouse model of adriamycin-induced cardiotoxicity

Biochem. Pharm. 2010年

MISC

246

Quantification of Norepinephrine and Its Metabolites in the Plasma of Renal Failure Models

Hiroshi Iijima, Yuji Okada, Makoto Tsunoda, Tomoko Takamiya, Kazuhiro Imai

NEPHRON PHYSIOLOGY 116(2) P9-P16 2010年
Synthesis and evaluation of a fluorogenic reagent for proteomic studies: 7-fluoro-N-[2-(dimethylamino)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide (DAABD-F)

Akiyo Koshiyama, Kazuhiro Imai

ANALYST 135(8) 2119-2124 2010年
Limitation of immunoaffinity column for the removal of abundant proteins from plasma in quantitative plasma proteomics

Tomoko Ichibangase, Kyoji Moriya, Kazuhiko Koike, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 23(5) 480-487 2009年5月
Synthesis of benzofurazan derivatization reagents for short chain carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry (LC/ESI-MS/MS)

Tomofumi Santa, Osama Y. Al-Dirbashi, Takashi Yoshikado, Takeshi Fukushima, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 23(4) 443-446 2009年4月
Application of Fluorogenic Derivatization-Liquid Chromatography-Tandem Mass Spectrometric Proteome Method to Skeletal Muscle Proteins in Fast Thoroughbred Horses

Tomoko Ichibangase, Kazuhiro Imai

JOURNAL OF PROTEOME RESEARCH 8(4) 2129-2134 2009年4月
Study of the acute cardiovascular effects of several antihypertensive agents with the measurement of plasma catecholamines in mice

Anal.Bioanal.Chem. 394(4) 947-952 2009年
Screening system for d-Asp-containing proteins using d-aspartyl endopeptidase and two-dimensional gel electrophoresis

Kumiko Sakai-Kato, Tadatoshi Kinouchi, Noriko Fujii, Kazuhiro Imai, Naoko Utsunomiya-Tate

AMINO ACIDS 36(1) 125-129 2009年1月
A proteomics study on human breast cancer cell lines by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry

Kazuhiro Imai, Tomoko Ichibangase, Ryoichi Saitoh, Yutaka Hoshikawa

BIOMEDICAL CHROMATOGRAPHY 22(11) 1304-1314 2008年11月
Application of an improved proteomics method, fluorogenic derivatization-liquid chromatography-tandem mass spectrometry, to differential analysis of proteins in small regions of mouse brain

Hiromichi Asamoto, Tomoko Ichibangase, Kazuo Uchikura, Kazuhiro Imai

JOURNAL OF CHROMATOGRAPHY A 1208(1-2) 147-155 2008年10月
Oxidative stress increases 6-nitronorepinephrine and 6-nitroepinephrine concentrations in rat brain

Makoto Tsunoda, Erika Uchino, Kazuhiro Imai, Takashi Funatsu

BIOMEDICAL CHROMATOGRAPHY 22(6) 572-574 2008年6月
Proteomics of Caenorhabditis elegans over-expressing human α-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson'・・・

T.Ichibangase, H.Saimaru, N.Takamura, T.Kuwahara, A.Koyama, T.Iwatsubo, K.Imai

Biomed. Chromatogr. 22(3) 232-234 2008年3月
Proteomics of Caenorhabditis elegans over-expressing human alpha-synuclein analyzed by fluorogenic derivatization-liquid chromatography/tandem mass spectrometry: identification of actin and several ribosomal proteins as negative markers at early Parkinson's disease stages

Tomoko Ichibangase, Hiroshi Saimaru, Norio Takamura, Tornoki Kuwahara, Akihiko Koyama, Takeshi Iwatsubo, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 22(3) 232-234 2008年3月
Synthesis of 4-[2-(N,N-dimethylamino)ethylaminosulfonyl]-7-N-methylhydrazino-2,1,3-benzoxadiazole (DAABD-MHz) as a derivatization reagent for aldehydes in liquid chromatography/electrospray ionization-tandem mass spectrometry

Tomofumi Santa, Osama Y. Al-Dirbashi, Tomoko Ichibangase, Mohamed S. Rashed, Takeshi Fukushima, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 22(2) 115-118 2008年2月
Fluorescence determination of N-acetylaspartic acid in the rat cerebrum homogenate using high-performance liquid chromatography with pre-column fluorescence derivatization

Takeshi Fukushima, Kotaro Arai, Masayuki Tomiya, Shogo Mitsuhashi, Tsukasa Sasaki, Tomofumi Santa, Kazuhiro Imai, Toshimasa Toyo'oka

BIOMEDICAL CHROMATOGRAPHY 22(1) 100-105 2008年1月
Synthesis of benzofurazan derivatization reagents for carboxylic acids in liquid chromatography/electrospray ionization-tandem mass spectrometry

Tomofumi Santa, Osama Y. Al-Dirbashi, Tomoko Ichibangase, Takeshi Fukushima, Mohamed S. Rashed, Takashi Funatsu, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 21(11) 1207-1213 2007年11月
Existence of low-molecular-weight thiols in Caenorhabditis elegans demonstrated by HPLC-fluorescene detection utilizing 7-chloro-N-[2-(dimethylamino)ethyl]-2,1,3-benzoxadiazole-4-sulfonamide

Hiromichi Asamoto, Tomoko Ichibangase, Hiroshi Saimaru, Kazuo Uchikura, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 21(10) 999-1004 2007年10月
Determination of nitrocatecholamines in rat brain using high-performance liquid chromatography-peroxyoxalate chemiluminescence reaction detection

Makoto Tsunoda, Erika Uchino, Kazuhiro Imai, Kazuichi Hayakawa, Takashi Funatsu

JOURNAL OF CHROMATOGRAPHY A 1164(1-2) 162-166 2007年9月
Determination of kynurenine levels in rat plasma by high-performance liquid chromatography with pre-column fluorescence derivatization

Shogo Mitsuhashi, Takeshi Fukushima, Masayuki Tomiya, Tomofumi Santa, Kazuhiro Imai, Toshimasa Toyo'oka

ANALYTICA CHIMICA ACTA 584(2) 315-321 2007年2月
A proteomics method revealing disease-related proteins in livers of hepatitis-infected mouse model

Tomoko Ichibangase, Kyoji Moriya, Kazuhiko Koike, Kazuhiro Imai

JOURNAL OF PROTEOME RESEARCH 6(7) 2841-2849 2007年
A further study on the combined use of internal standard and isotope-labeled derivatization reagent for expansion of linear dynamic ranges in liquid chromatography-electrospray mass spectrometry

Yuhki Tsukamoto, Tomofumi Santa, Hiroo Yoshida, Hiroshi Miyano, Takeshi Fukushima, Kazuo Hirayama, Kazuhiro Imai, Takashi Funatsu

BIOMEDICAL CHROMATOGRAPHY 20(10) 1049-1055 2006年10月
Synthesis and evaluation of fluorogenic reagents for simultaneous detection of peptides and proteins by HPLC in two different samples

Hiroshi Saimaru, Eiko Yasui, Norio Takamura, Kazuhiro Imai

BIOMEDICAL CHROMATOGRAPHY 20(6-7) 576-584 2006年6月
Synthesis and evaluation of fluorogenic reagents for simultaneous detection of peptides and proteins by HPLC in two different samples

Hiroshi Saimaru, Eiko Yasui, Norio Takamura, Kazuhiro Imai

Biomedical Chromatography 20(6-7) 576-584 2006年6月
Catecholamine analysis with microcolurnn LC-peroxyoxalate chemiluminescence reaction detection

M Tsunoda, M Nagayama, T Funatsu, S Hosoda, K Imai

CLINICA CHIMICA ACTA 366(1-2) 168-173 2006年4月
Improved method for the determination of kynurenic acid in rat plasma by column-switching HPLC with post-column fluorescence detection

S Mitsuhashi, T Fukushima, J Kawai, M Tomiya, T Santa, K Imai, T Toyo'oka

ANALYTICA CHIMICA ACTA 562(1) 36-43 2006年3月
Low Catechol-O-methyltransferase Activity in the Brain and Blood Pressure Regulation.

M.Masuda, M.Tsunoda, K.Imai

Biol. Pharm. Bull. 29(2) 202-205 2006年
Synthesis of the isotope-labeled derivatization reagent for carboxylic acids, 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperazino-2,1,3-benzoxadiazole (d6) [DBD-PZ-NH2(D)], and its application to the quantification and the determination of relative ・・・

Y.Tsukamoto, T.Santa, H.Yoshida, H.Miyano, T.Fukushima, K.Hirayama, K.Imai, T.Funatsu

Biomed.Chromatogr. 20 358-364 2006年

Synthesis of the isotope-labeled derivatization reagent for carboxylic acids, 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperazino-2,1,3-benzoxadiazole (d6) [DBD-PZ-NH2(D)], and its application to the quantification and the determination of relative amount of fatty acidsin rat plasma samples by high-performance liquid choromatography/mass spectrometry.
Low Catechol-O-methyltransferase Activity in the Brain and Blood Pressure Regulation.

M.Masuda, M.Tsunoda, K.Imai

Biol. Pharm. Bull. 29(2) 202-205 2006年
Synthesis of the isotope-labeled derivatization reagent for carboxylic acids, 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperazino-2,1,3-benzoxadiazole (d6) [DBD-PZ-NH2(D)], and its application to the quantification and the determination of relative ・・・

Y.Tsukamoto, T.Santa, H.Yoshida, H.Miyano, T.Fukushima, K.Hirayama, K.Imai, T.Funatsu

Biomed.Chromatogr. 20 358-364 2006年

Synthesis of the isotope-labeled derivatization reagent for carboxylic acids, 7-(N,N-dimethylaminosulfonyl)-4-(aminoethyl)piperazino-2,1,3-benzoxadiazole (d6) [DBD-PZ-NH2(D)], and its application to the quantification and the determination of relative amount of fatty acidsin rat plasma samples by high-performance liquid choromatography/mass spectrometry.
Fluorescence characteristics of ionic benzofurazans, 7-substituted-2, 1,3-benzoxadiazole-4-sulfonates

Y Numasawa, K Okabe, S Uchiyama, T Santa, K Imai

DYES AND PIGMENTS 67(3) 189-195 2005年12月
High performance liquid chromatography post-column chemiluminescence determination of sulfonamide residues in milk at low concentration levels using bis[4-nitro-2-(3,6,9-trioxadecyloxycarbonyl)phenyl] oxalate as chemiluminescent reagent

JJ Soto-Chinchilla, L Gamiz-Gracia, AM Garcia-Campana, K Imai, LE Garcia-Ayuso

JOURNAL OF CHROMATOGRAPHY A 1095(1-2) 60-67 2005年11月
High performance liquid chromatography post-column chemiluminescence determination of sulfonamide residues in milk at low concentration levels using bis[4-nitro-2-(3,6,9-trioxadecyloxycarbonyl)phenyl] oxalate as chemiluminescent reagent

JJ Soto-Chinchilla, L Gamiz-Gracia, AM Garcia-Campana, K Imai, LE Garcia-Ayuso

JOURNAL OF CHROMATOGRAPHY A 1095(1-2) 60-67 2005年11月
An improved method for proteomics studies in C. elegans by fluorogenic derivatization, HPLC isolation, enzymatic digestion and liquid chromatography-tandem mass spectrometric identification

M Masuda, H Saimaru, N Takamura, K Imai

BIOMEDICAL CHROMATOGRAPHY 19(7) 556-560 2005年9月
Analytical applications of peroxyoxalate chemiluminescence

M Tsunoda, K Imai

ANALYTICA CHIMICA ACTA 541(1-2) 13-23 2005年6月
Improved assay for catechol-O-methyltransferase activity utilizing norepinephrine as an enzymatic substrate and reversed-phase high-performance liquid chromatography with fluorescence detection

N Aoyama, M Tsunoda, K Imai

JOURNAL OF CHROMATOGRAPHY A 1074(1-2) 47-51 2005年5月
Rapid assay for catechol-O-methyltransferase activity by high-performance liquid chromatography-fluorescence detection

Y Hirano, M Tsunoda, T Funatsu, K Imai

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES 819(1) 41-46 2005年5月
Fluorimetric determination of D-lactate in urine of normal and diabetic rats by column-switching high-performance liquid chromatography

JA Lee, YC Tsai, HY Chen, CC Wang, SM Chen, T Fukushima, K Imai

ANALYTICA CHIMICA ACTA 534(2) 185-191 2005年4月
High-performance liquid chromatographic assay of N^G-monomethyl-L-arginine, N^G,N^G-dimethyl-L-arginine, and N^G,N^G’-dimethyl-L-arginine using 4-fluoro-7-nitro-2,1,3-benzoxadiazole as a fluorescent rea・・・

NONAKA S, TSUNODA M, IMAI K, FUNATSU T

J.Chromatogr. A, 1066(1-2) 41-45 2005年2月
High-performance liquid chromatographic assay of N-G-monomethyl-L-arginine, N-G-dimethyl-L-arginine, and (NNG)-N-G-dimethyl-L-arginine using 4-fluoro-7-nitro-2,1,3-benzoxaldiazole as a fluorescent reagent

S Nonaka, M Tsunoda, K Imai, T Funatsu

JOURNAL OF CHROMATOGRAPHY A 1066(1-2) 41-45 2005年2月
化学発光反応による脳脊髄液物質の測定

眞重文子, 西丸宏, 角田誠, 今井一洋

臨床検査 49(4) 387-392 2005年
Detection Limit Estimated from Slope of Calibration Curve: An Application to Comopetitive ELISA.

HAYASHI Y, MATSUDA R, ITO K, NISHIMURA W, IMAI K, MAEDA M

Anal.Sci., 21(2) 167-169 2005年
A new fluorogenic reagent aimed at simultaneous determination of peptides or proteins in two different samples

H Saimaru, M Masuda, C Toriumi, T Santa, E Ichikawa, TA Norio, K Imai

JOURNAL OF MATERIALS CHEMISTRY 15(27-28) 2865-2872 2005年
Fluorescence enhancement by hydroperoxides based on a change in the intramolecular charge transfer character of benzofurazan

M Onoda, H Tokuyama, S Uchiyama, K Mawatari, T Santa, K Kaneko, K Imai, K Nakagomi

CHEMICAL COMMUNICATIONS 1848-1850(14) 1848-1850 2005年
Detection Limit Estimated from Slope of Calibration Curve: An Application to Comopetitive ELISA.

Anal.Sci. 21(2) 167-169 2005年
Simultaneous determination of D- and L-serine in rat brain microdialysis sample using a column-switching HPLC with fluorimetric detection

T Fukushima, J Kawai, K Imai, T Toyo'oka

BIOMEDICAL CHROMATOGRAPHY 18(10) 813-819 2004年12月
Intravenous administration of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman(γ-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion.

Bioned.Chromatogr. 18(9) 727-734 2004年11月
A fully automated amino acid analyzer using NBD-F as a fluorescent derivatization reagent

C Aoyama, T Santa, M Tsunoda, T Fukushima, C Kitada, K Imai

BIOMEDICAL CHROMATOGRAPHY 18(9) 630-636 2004年11月
Intravenous administration of 2,7,8-trimethyl-2-(beta-carboxyethyl)-6-hydroxy chroman (gamma-CEHC) to rats and determination of its plasma concentration and urinary sodium excretion

M Tanabe, T Fukushima, N Usui, N Aoyama, M Tsunoda, K Imai

BIOMEDICAL CHROMATOGRAPHY 18(9) 727-734 2004年11月
An expression of within-plate uncertainty in sandwich ELISA

Y Hayashi, R Matsuda, T Maitani, K Ito, W Nishimura, K Imai, M Maeda

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 36(1) 225-229 2004年9月
An HPLC assay of hydroxyl radicals by the hydroxylation reaction of terephthalic acid

LX Li, Y Abe, Y Nagasawa, R Kudo, N Usui, K Imai, T Mashino, M Mochizuki, N Miyata

BIOMEDICAL CHROMATOGRAPHY 18(7) 470-474 2004年9月
Determination of fluoxetine and norfluoxetine in rat brain microdialysis samples following intraperitoneal fluoxetine administration

T Fukushima, E Naka-aki, XJ Guo, FM Li, T Vankeirsbilck, WRG Baeyens, K Imai, T Toyo'oka

ANALYTICA CHIMICA ACTA 522(1) 99-104 2004年9月

書籍等出版物

17

バイオ・ケミルミネセンスハンドブック（共著）

丸善 2006年
FUNCTIONAL GROUP ANALYSIS.

Elsevier Ltd. 2005年
FUNCTIONAL GROUP ANALYSIS.

Elsevier Ltd. 2005年
スタンダード薬学シリーズ物理系薬学 Ⅱ.化学物質の分析第1章酸と塩基“酸塩基平衡を説明できる”（共著）

東京化学同人 2004年
機器分析化学（共著）

丸善 2002年

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講演・口頭発表等

60

FD-LC-MS/MS法を用いた乳癌細胞株のプロテオーム解析

第48回日本臨床学会年次学術集会 2008年
乳癌細胞株７種のFD-LC-MS/MSプロテオーム解析による転移性乳癌のバイオマーカー探索

第69回分析化学討論会 2008年
紫外線により惹起される皮膚障害に対するユビキノール-10水溶性プロドラッグの効果

日本薬学会第128年会 2008年
ユビキノール-10水溶性プロドラッグの発毛促進効果

日本薬学会第128年会 2008年
FD-LC-MS/MS法によるマウス肝臓タンパク質の加齢変動解析

日本薬学会第128年会 2008年

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所属学協会

11

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共同研究・競争的資金等の研究課題

2

生体成分の分析化学的研究

ライフサイエンス基礎科学研究 1977年 - 2006年
Analytical Chemical Studies on Biological Substances

Basic Science Research on Life Science 1977年 - 2006年

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