研究者業績

梅澤喜夫

ウメザワヨシオ (Yoshio Umezawa)

基本情報

所属: 武蔵野大学薬学研究所客員教授

学位: 理学博士

J-GLOBAL ID: 200901096118618594
researchmap会員ID: 1000013807

研究キーワード

2

研究分野

1

ナノテク・材料 / 分析化学 /

学歴

4

受賞

3

MISC

212

Selective observation of hydroxy and carboxylate moieties by scanning tunneling microscopy using chemically modified tips with differing extents of hydrogen bond acidity or basicity

T Nishino, T Ito, Y Umezawa

JOURNAL OF ELECTROANALYTICAL CHEMISTRY 550 125-129 2003年7月
Noninvasive imaging of protein-protein interactions in living subjects by using reporter protein complementation and reconstitution strategies

R Paulmurugan, Y Umezawa, SS Gambhir

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 99(24) 15608-15613 2002年11月
High sensitive ion-channel sensors for detection of oligonucleotides using PNA modified gold electrodes

Hiroshi Aoki, Yoshio Umezawa

Electroanalysis 14(19-20) 1405-1410 2002年11月
Carbon nanotube scanning tunneling microscopy tips for chemically selective imaging

T Nishino, T Ito, Y Umezawa

ANALYTICAL CHEMISTRY 74(16) 4275-4278 2002年8月
Probing chemical processes in living cells: Applications for assay and screening of chemicals that disrupt cellular signaling pathways

Yoshio Umezawa, Takeaki Ozawa, Moritoshi Sato

Bulletin of the Chemical Society of Japan 75(7) 1423-1433 2002年7月
Peptide assemblies in living cells. Methods for detecting protein-protein interactions

T Ozawa, Y Umezawa

SUPRAMOLECULAR CHEMISTRY 14(2-3) 271-280 2002年4月
Voltammetric detection of inorganic phosphate using ion-channel sensing with self-assembled monolayers of a hydrogen bond-forming receptor

Hiroshi Aoki, Katsuyuki Hasegawa, Koji Tohda, Yoshio Umezawa

Biosensors and Bioelectronics 18(2-3) 261-267 2002年3月1日
Assay and Screening Methods for Bioactive Substances Based on Cellular Signaling Pathways.

Y.Umezawa, Reviews in Molecular Biotechnology 82, 357-370 2002年
Assay and Screening Methods for Chemicals that Disrupt Cellular Signaling Pathways. Risk Assessment for Potential Endocrine Disruptors.

Y.Umezawa, T.Ozawa and M.Sato,Environmental Sciences 9(1), 23-35 2002年
Fluorescent Indicators for Imaging Protein Phosphorylation in Single Living Cells.

M.Sato, T.Ozawa, K.Inukai, T.Asano, and Y.Umezawa, Nature Biotech. 20, 287-294 2002年
Methods of Analysis for Chemicals that Promote/Disrupt Cellular Signaling.

Y.Umezawa, T.Ozawa and M.Sato, Anal.Sci. 18, 503-516 2002年
Probing Chemical Processes in Living Cells : Application for Assay and Screening of Chemicals that Disrupt Cellular Signaling Pathways.

Y.Umezawa, T.Ozawa and M.Sato, Bull.Chem.Soc.Jpn.(Accounts) 75(7), 1423-1433 2002年
Peptide Assemblies in Living Cells. Methods for Detectiong Protein-Protein Interactions.

T.Ozawa and Y.Umezawa, special issue of Supramolecular Chemistry 14(2-3), 271-280 2002年
Potentiometric Selectivity Coefficients of on-Selective Electrodes. Part Ⅱ. Inorganic Anions.

Y.Umezawa, K.Umezawa, P.Buhlmann, N.Hamada, J.Nakanishi, H.Aoki, M.Sato, Y.Nishimura and K.P.Xiao, Pure Appl.Chem. 74(6), 923-994 2002年
Potentiometric Selectivity Coefficients of Ion-Selective Electrodes. Part Ⅲ. Organic Ions.

Y.Umezawa, P.Buhlmann, K.Umezawa and N.Hamada, Pure Appl. 74(6), 995-1099 2002年
High Sensitive Ion-Channel Sensors for Detectin of Oligonucleotides Using PNA Modified Gold Electrodes.

H.Aoki and Y.Umezawa, Electroanalysis 14(19-20), 1405-1410 2002年
Design and Application of Ion-Channel Sensors Based on Biological and Artificial Receptors.

M.Sugawara, A.Hirano, P.Buhlmann and Y.Umezawa, Bull.Chem.Soc.Jpn(Accounts) 75(2), 187-201 2002年
Detection of phosphate ion and protein phosphorylation - Crystal surfaces, ionophore monolayers, and protein interactions

Yoshio Umezawa

Journal of Supramolecular Chemistry 2(1-3) 233-245 2002年1月
Assay and screening methods for bioactive substances based on cellular signaling pathways

Yoshio Umezawa

Reviews in Molecular Biotechnology 82(4) 357-370 2002年
Assay and Screening Methods for Chemicals that Disrupt Cellular Signaling Pathways. Risk Assessment for Potential Endocrine Disruptors.

Y.Umezawa, T.Ozawa and M.Sato,Environmental Sciences 9(1), 23-35 2002年
Fluorescent Indicators for Imaging Protein Phosphorylation in Single Living Cells.

M.Sato, T.Ozawa, K.Inukai, T.Asano, and Y.Umezawa, Nature Biotech. 20, 287-294 2002年
Methods of analysis for chemicals that promote/disrupt cellular signaling

Yoshio Umezawa, Takeaki Ozawa, Moritoshi Sato

Analytical Sciences 18(5) 503-516 2002年
Potentiometric Selectivity Coefficients of on-Selective Electrodes. Part Ⅱ. Inorganic Anions.

Y.Umezawa, K.Umezawa, P.Buhlmann, N.Hamada, J.Nakanishi, H.Aoki, M.Sato, Y.Nishimura and K.P.Xiao, Pure Appl.Chem. 74(6), 923-994 2002年
Potentiometric Selectivity Coefficients of Ion-Selective Electrodes. Part Ⅲ. Organic Ions.

Y.Umezawa, P.Buhlmann, K.Umezawa and N.Hamada,Pure Appl. 74(6), 995-1099 2002年
Design and Application of Ion-Channel Sensors Based on Biological and Artificial Receptors.

M.Sugawara, A.Hirano, P.Buhlmann and Y.Umezawa, Bull.Chem.Soc.Jpn(Accounts) 75(2), 187-201 2002年
Protein splicing-based reconstitution of split green fluorescent protein for monitoring protein-protein interactions in bacteria: Improved sensitivity and reduced screening time

T Ozawa, M Takeuchi, A Kaihara, M Sato, Y Umezawa

ANALYTICAL CHEMISTRY 73(24) 5866-5874 2001年12月
Influence of natural, electrically neutral lipids on the potentiometric responses of cation-selective polymeric membrane electrodes

P Buhlmann, M Hayakawa, T Ohshiro, S Amemiya, Y Umezawa

ANALYTICAL CHEMISTRY 73(14) 3199-3205 2001年7月
Split luciferase as an optical probe for detecting protein-protein interactions in mammalian cells based on protein splicing

T Ozawa, A Kaihara, M Sato, K Tachihara, Y Umezawa

ANALYTICAL CHEMISTRY 73(11) 2516-2521 2001年6月
Scanning tunneling microscopy with chemically modified tips: Discrimination of porphyrin centers based on metal coordination and hydrogen bond interactions

T Ohshiro, T Ito, P Buhlmann, Y Umezawa

ANALYTICAL CHEMISTRY 73(5) 878-883 2001年3月
Detection of Protein-Protein Interactions in Vivo Based on Protein Splicing.

T.Ozawa and Y,Umezawa, Current Opinion in Chemical Biology ; Section Andytical Techniques 5, 578-583 2001年
Optimum Concentration of Anionic Sites in Lipophilic Macrocyclic Pentaamine-Based Liquid Membranes for Potentiometric Responses to Anionic Analytes.

H.Radecka, K.Tohda, Y.Umezawa, Anal.Sci. 17(10), 1221-1224 2001年
A Screening Method for Antagonists that Inhibit the Binding of Calmodulin to a Target Peptide Using Surface Plasmon Resonance.

K.Sasaki, T.Ozawa and Y.Umezawa, Anal.Chim.Acta 447, 63-74 2001年
Scanning tunneling microscopy with chemically modified tips : orientation-sensitive observation of ether oxygens.

T.Nishino, P.Buhlmann, T.Ito and Y.Umezawa, Surface Science 490(1-2), L579-L584 2001年
Detection of Protein-Protein Interactions in Vivo Based on Protein Splicing.

T.Ozawa and Y,Umezawa, Current Opinion in Chemical Biology ; Section Andytical Techniques 5, 578-583 2001年
Optimum Concentration of Anionic Sites in Lipophilic Macrocyclic Pentaamine-Based Liquid Membranes for Potentiometric Responses to Anionic Analytes.

H.Radecka, K.Tohda, Y.Umezawa, Anal.Sci. 17(10), 1221-1224 2001年
A Screening Method for Antagonists that Inhibit the Binding of Calmodulin to a Target Peptide Using Surface Plasmon Resonance.

K.Sasaki, T.Ozawa and Y.Umezawa, Anal.Chim.Acta 447, 63-74 2001年
Scanning tunneling microscopy with chemically modified tips : orientation-sensitive observation of ether oxygens.

T.Nishino, P.Buhlmann, T.Ito and Y.Umezawa, Surface Science 490(1-2), L579-L584 2001年
Imaging of Conformational Changes of Proteins with a New Environment-Sensitive Fluorescent Probe Designed for Site-Specific Labeling of Recombinant Proteins in Live Cells.(共著)

┣DBAnal. Chem.(/)-┫DB 73(13) 2920-2928 2001年
Threshold Ionic Site Concentrations Required for Nernstian Potentiometric Responses of Neutral Ionophore-Incorporated Ion-Selective Liquid Membranes.(共著)

┣DBAnal. Sci.(/)-┫DB 17(7) 833-839 2001年
Optical Detection in Microscopic Domains. 2. Inner Filter Effects for Monitoring nonfluorescent Molecules with Fluorescence.(共著)

┣DBAnal. Chem.(/)-┫DB 73(9) 2070-2077 2001年
Studies on the Matched Potential Method for Determining the Selectivity Coefficients of Ion-Selective Electrodes Based on Neutral Ionophores : Experimental and Theoretical Verification.(共著)

┣DBAnal. Sci.(/)-┫DB 17(6) 733-743 2001年
Potentiometric Responses of Polymeric Liquid Membranes Based on Hydrophobic Chelating Agents to Metal Ions.(共著)

┣DBAnal. Sci.(/)-┫DB 17(5) 621-627 2001年
Correlation between cytosolic calcium concentration and degranulation in RBL-2H3 cells in the presence of various concentrations of antigen-specific IgEs

S Aketani, R Teshima, Y Umezawa, J Sawada

IMMUNOLOGY LETTERS 75(3) 185-189 2001年1月
Discrimination of Functional Groups with Scanning Tunneling Microscopy Using Chemically Modified Tips : Recognition of Ether Oxygens Through Hydrogen Bond Interactions.(共著)

┣DBPhys. Chem. Chem. Phys.(/)-┫DB 3(10) 1867-1869 2001年
Expanded porphyrin incorporated solvent polymeric membrane electrodes : Protonation and interaction with an analyte anion at organic/water interface as studied by optical second harmonic generation and Fourier transform infrared attenuated total reflec・・・

┣DBAnal. Chim. Acta(/)-┫DB 426(1) 19-32 2001年

Expanded porphyrin incorporated solvent polymeric membrane electrodes : Protonation and interaction with an analyte anion at organic/water interface as studied by optical second harmonic generation and Fourier transform infrared attenuated total reflectance spectrometry.(共著)
Fluorescent indicators for cyclic GMP based on cyclic GMP-dependent protein kinase I alpha and green fluorescent proteins

M Sato, N Hida, T Ozawa, Y Umezawa

ANALYTICAL CHEMISTRY 72(24) 5918-5924 2000年12月
A fluorescent indicator for detecting protein-protein interactions in vivo based on protein splicing

T Ozawa, S Nogami, M Sato, Y Ohya, Y Umezawa

ANALYTICAL CHEMISTRY 72(21) 5151-5157 2000年11月
Evaluation of agonist selectivity for the NMDA receptor ion channel in bilayer lipid membranes based on integrated single-channel currents

A Hirano, M Sugawara, Y Umezawa, S Uchino, S Nakajima-Iijima

BIOSENSORS & BIOELECTRONICS 15(3-4) 173-181 2000年6月
Electrostatically-induced inclusion of anions in cyclodextrin monolayers on electrodes

RV Chamberlain, K Slowinska, M Majda, P Buhlmann, H Aoki, Y Umezawa

LANGMUIR 16(3) 1388-1396 2000年2月
Potentiometric Selectivity Coefficients of Ion-Selective Electrodes. Part (]G0001[). Inorganic Cations.(共著)

┣DBPure Appl. Chem.(/)-┫DB 72(10) 1851-2082 2000年

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