研究者業績

幸田光復

コウダコウフク (Kohfuku Kohda)

基本情報

所属: 武蔵野大学薬学研究所教授

学位: 薬学博士
薬学修士

J-GLOBAL ID: 200901008223441849
researchmap会員ID: 1000055199

研究分野

1

ナノテク・材料 / 生体化学 /

学歴

4

受賞

1

1984年

佐藤記念国内賞

MISC

238

Inhibitory effect of heavy water on mutability of chemically injured ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB

┣DBMutation Res.(/)-┫DB 180 155-161 1987年
Chemical reactivity of alkylguanines. I. Methylation of O⁶-methylguanine derivatives. K. Kohda, K. Baba, and Y. Kawazoe

Tetrahedron Letters 28, 6285-6288 1987年
SELECTIVE DESILYLATION OF PHENOLIC AND ALCOHOLIC TRIMETHYLSILYL ETHERS

Y KAWAZOE, M NOMURA, Y KONDO, K KOHDA

TETRAHEDRON LETTERS 28(37) 4307-4310 1987年
Temperature-dependence of cytotoxicity of several genotoxicants in Chinese hamster V79 cells : Bleomycin, paraquat, and some N-alkyl-N-nitrosoureas

┣DBBiochem. Biophys. Res. Commun.(/)-┫DB 146(1) 67-72 1987年
Mutagenicity of a series of N-alkyl-, N-hydroxyalkyl-, N-haloalkyl- and N-carboxyalkyl-N-nitrosoureas in Escherichia coli tester strains: Dependence on the uvrA DNA-repair system. K. Kohda, S. Ninomiya, K. Wash・・・

Mutation Res. 177, 219-228 1987年

Mutagenicity of a series of <i>N</i>-alkyl-, <i>N</i>-hydroxyalkyl-, <i>N</i>-haloalkyl- and <i>N</i>-carboxyalkyl-<i>N</i>-nitrosoureas in <i>Escherichia coli</i> tester strains: Dependence on the uvrA DNA-repair system.<br /> K. Kohda, S. Ninomiya, K. Washizu, K. Shiraki, M. Edie, and Y. Kawazoe
ORNITHINE DECARBOXYLASE ACTIVITY AND DNA-SYNTHESIS IN RATS AFTER LONG-TERM TREATMENT WITH BUTYLATED HYDROXYANISOLE, SODIUM SACCHARIN OR PHENOBARBITAL

M TATEMATSU, Y MERA, K KOHDA, Y KAWAZOE, N ITO

CANCER LETTERS 33(2) 119-124 1986年11月
Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N', N'-Dimethyl-N-Nitrosourea

┣DBChem. Pharm. Bull.(/)-┫DB 34 5056-5062 1986年
Studies on Chemical Carcinogens and Mutagens. XL. Chemoselectivity of Acylating Agents toward Aniline in Aqueous Medium

川添豊, 二宮眞一, 安達孝浩, 幸田光復

┣DBChem. Pharm. Bull.(/)-┫DB 34(10) 4103-4108 1986年
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-nitrouracil (2'-deoxy-5-nitrouridine) and its 5-monophosphate

Improved and new synthetic procedures, methods and techniques, Part 3 248-251 1986年
Aminations of Guanosine and Deoxyguanosine with Hydroxylamine-O-Sulfonic Acid and 2, 4-Dinitrophenoxyamine. Dependence on the Reaction Medium

┣DBNucleic Acids Symposium Series(/)-┫DB 17 145-148 1986年
Formation of 8-Hydroxyguanine Residues in Cellular DNA Exposed to the Carcinogen 4-Nitroquinoline 1-Oxide

KOHDA K, TADA M, KASAI H, NISHIMURA S, KAWAZOE Y

┣DBBiochem. Biophys. Res. Commun.(/)-┫DB 139(2) 626-632 1986年
Studies on Chemical Carcinogens and Mutagens. XXXIX. Physico-Chemical Properties and Cytotoxicity of Si- and Ge-containing Nitrosoureas

┣DBChem. Pharm. Bull.(/)-┫DB 34 3273-3278 1986年
Quantitative Structure-Chemoselectivity Relationship among Alkanesulfonates of Primary Alcohols

KAWAZOE Y, NINOMIYA S, KOHDA K, KIMOTO H

┣DBTetrahedron Letters(/)-┫DB 27(25) 2897-2900 1986年
Synthesis of 7-Aminoguanosine and its Conversion to 8-Substituted Derivatives

幸田光復, 馬場邦尚, 川添豊

┣DBChem. Pharm. Bull.(/)-┫DB 34(5) 2298-2301 1986年
Studies on Chemical Carcinogens and Mutagens. XXXVII. A Simple Method to Predict Ultimate Structures of Chemical Mutagens, and Probably Carcinogens

川添豊, 藤浦敏治, 幸田光復

┣DBChem. Pharm. Bull.(/)-┫DB 34(4) 1755-1763 1986年
Studies on Chemical Carcinogens and Mutagens. XXXIII. Mutation Frequencies Induced by Combinations of Methylating and/or Ethylating Mutagens

KAWAZOE Y, HAKURA A, KOHDA K

┣DBChem. Pharm. Bull.(/)-┫DB 34(1) 250-255 1986年
Spontaneous and Enzymatic Activations of Carcinogenic N-Butyl-N', N'-Dimethyl-N-Nitrosourea

┣DBChem. Pharm. Bull.(/)-┫DB 34 5056-5062 1986年
Studies on Chemical Carcinogens and Mutagens. XL. Chemoselectivity of Acylating Agents toward Aniline in Aqueous Medium

YUTAKA KAWAZOE, SHIN-ICHI NINOMIYA, TAKAHIRO ADACHI, KOHFUKU KOHDA

┣DBChem. Pharm. Bull.(/)-┫DB 34(10) 4103-4108 1986年
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-nitrouracil (2'-deoxy-5-nitrouridine) and its 5-monophosphate

Improved and new synthetic procedures, methods and techniques, Part 3 248-251 1986年
Aminations of Guanosine and Deoxyguanosine with Hydroxylamine-O-Sulfonic Acid and 2, 4-Dinitrophenoxyamine. Dependence on the Reaction Medium

┣DBNucleic Acids Symposium Series(/)-┫DB 17 145-148 1986年
Formation of 8-Hydroxyguanine Residues in Cellular DNA Exposed to the Carcinogen 4-Nitroquinoline 1-Oxide

┣DBBiochem. Biophys. Res. Commun.(/)-┫DB 139(2) 626-632 1986年
Studies on Chemical Carcinogens and Mutagens. XXXIX. Physico-Chemical Properties and Cytotoxicity of Si- and Ge-containing Nitrosoureas

┣DBChem. Pharm. Bull.(/)-┫DB 34 3273-3278 1986年
Quantitative Structure-Chemoselectivity Relationship among Alkanesulfonates of Primary Alcohols

┣DBTetrahedron Letters(/)-┫DB 27(25) 2897-2900 1986年
Synthesis of 7-Aminoguanosine and its Conversion to 8-Substituted Derivatives

Kohfuku Kohda, Kunihisa Baba, Yutaka Kawazoe

┣DBChem. Pharm. Bull.(/)-┫DB 34(5) 2298-2301 1986年
Studies on Chemical Carcinogens and Mutagens. XXXVII. A Simple Method to Predict Ultimate Structures of Chemical Mutagens, and Probably Carcinogens

YUTAKA KAWAZOE, TOSHIHARU FUJIURA, KOHFUKU KOHDA

┣DBChem. Pharm. Bull.(/)-┫DB 34(4) 1755-1763 1986年
Studies on Chemical Carcinogens and Mutagens. XXXIII. Mutation Frequencies Induced by Combinations of Methylating and/or Ethylating Mutagens

┣DBChem. Pharm. Bull.(/)-┫DB 34(1) 250-255 1986年
Studies on Chemical Carcinogens and Mutagens. XXIX. Mutagenic N-Trimethylsilylmethyl-N-nitrosourea as A Biological Alkylating Agent Equivalent to N-Methyl-N-nitrosourea(MNU)

┣DBMutation Res.(/)-┫DB 157 87-93 1985年
遺伝子障害性物質の化学特性川添豊、幸田光復

ファルマシアレビュー (16) 83-98 1985年
Studies on Chemical Carcinogens and Mutagens. XXIX. Mutagenic N-Trimethylsilylmethyl-N-nitrosourea as A Biological Alkylating Agent Equivalent to N-Methyl-N-nitrosourea(MNU)

┣DBMutation Res.(/)-┫DB 157 87-93 1985年
Studies on Chemical Carcinogens and Mutagens. XXVII, Alkylating Property of Mutagenic N-Trimethylsilylmethyl-N-Nitrosourea, A Silicon-Analogue of N-Neopentyl-N-Nitrosourea, in Aqueous Media

NINOMIYA S, EBIE M, HAKURA A, KOHDA K, KAWAZOE Y, SHIOIRI T

┣DBTetrahedron Letter(/)-┫DB 25(50) 5785-5788 1984年
Studies on Chemical Carcinogens and Mutagens. XXVI. Chemical Properties and Mutagenicity of Alkyl Alkanesulfonates on Salmonella typhimurium TA 100

羽倉昌志, 二宮真一, 幸田光復, 川添豊

┣DBChem. Pharm. Bull.(/)-┫DB 32(9) 3626-3635 1984年
Studies on Chemical Carcinogens and Mutagens. XXV. Chemoselectivity of Alkyl Sulfonates toward 4-(p-nitrobenzyl)pyridine (NBP) in Phosphate Buffer

二宮真一, 幸田光復, 川添豊

┣DBChem. Pharm. Bull.(/)-┫DB 32(4) 1326-1332 1984年
Studies on Chemical Carcinogens and Mutagens. XXVII, Alkylating Property of Mutagenic N-Trimethylsilylmethyl-N-Nitrosourea, A Silicon-Analogue of N-Neopentyl-N-Nitrosourea, in Aqueous Media

┣DBTetrahedron Letter(/)-┫DB 25(50) 5785-5788 1984年
BIOMIMETIC PREPARATION AND STRUCTURE DETERMINATION OF QGI, ONE OF THE QUINOLINE-DNA BASE ADDUCTS FORMED IN CELLS TREATED WITH 4-NITROQUINOLINE 1-OXIDE

M TADA, KH KOHDA, Y KAWAZOE

GANN 75(11) 976-985 1984年
PROPOSED STRUCTURE OF THE CYCLIC PEPTIDE DOLASTATIN-3, A POWERFUL CELL-GROWTH INHIBITOR, SHOULD BE REVISED

Y HAMADA, K KOHDA, T SHIOIRI

TETRAHEDRON LETTERS 25(46) 5303-5306 1984年
Studies on Chemical Carcinogens and Mutagens. XXVI. Chemical Properties and Mutagenicity of Alkyl Alkanesulfonates on Salmonella typhimurium TA 100

ATSUSHI HAKURA, SHINICHI NINOMIYA, KOHFUKU KOHDA, YUTAKA KAWAZOE

┣DBChem. Pharm. Bull.(/)-┫DB 32(9) 3626-3635 1984年
Studies on Chemical Carcinogens and Mutagens. XXV. Chemoselectivity of Alkyl Sulfonates toward 4-(p-nitrobenzyl)pyridine (NBP) in Phosphate Buffer

SHINICHI NINOMIYA, KOHFUKU KOHDA, YUTAKA KAWAZOE

┣DBChem. Pharm. Bull.(/)-┫DB 32(4) 1326-1332 1984年
Studies on Chemical Carcinogens. XXIV. Mutagenic Potency of Alkylated 4-Nitroquinoline 1-Oxides : Its Dependence on the Rate of Metabolic Activation

高橋和彦, 幸田光復, 川添豊

┣DBChem. Pharm. Bull.(/)-┫DB 31(3) 959-965 1983年
Studies on Chemical Carcinogens. XXIV. Mutagenic Potency of Alkylated 4-Nitroquinoline 1-Oxides : Its Dependence on the Rate of Metabolic Activation

KAZUHIKO TAKAHASHI, KOHFUKU HUANG KOHDA, YUTAKA KAWAZOE

┣DBChem. Pharm. Bull.(/)-┫DB 31(3) 959-965 1983年
Mutagenicity of N-Alkyl-N-(α-Hydroperoxyalkyl)nitrosamines in V79 Chinese Hamster Cells in Relation to Alkylating Activity

┣DBGANN(/)-┫DB 73(4) 522-530 1982年
Mutagenicity of α-Acetoxy Derivatives of N-Methyl-N-Benzyl-nitrosamine and N, N-Dibenzylnitrosamine in V79 Cells : A Comparison Between Methylating and Benzylating Mutagens

┣DBGANN(/)-┫DB 73(4) 517-521 1982年
Chemistry and Mutagenicity of α-Hydroxy Nitrosamines

”N-Nitroso Compounds : Occurrence and Biological Effects”, Lyon(IARC Scientific Publications No. 41) (41) 553-559 1982年
CYTO-TOXICITY AND DNA DAMAGE AND REPAIR IN MOUSE L-CELLS TREATED WITH A SERIES OF N-ALKYL-N-(ACETOXYMETHYL)NITROSAMINES

KH KOHDA, M MOCHIZUKI, T ANJO, M OKADA

GANN 73(4) 565-573 1982年
MUTAGENICITY OF N-ALKYL-N-(ALPHA-HYDROPEROXYALKYL)NITROSAMINES IN V79-CHINESE HAMSTER-CELLS IN RELATION TO ALKYLATING ACTIVITY

KH KOHDA, M MOCHIZUKI, T ANJO, M OKADA

GANN 73(4) 522-530 1982年
MUTAGENICITY OF A-ACETOXY DERIVATIVES OF N-METHYL-N-BENZYLNITROSAMINE AND N,N-DIBENZYLNITROSAMINE IN V79-CELLS - A COMPARISON BETWEEN METHYLATING AND BENZYLATING MUTAGENS

KH KOHDA, T ANJO, M MOCHIZUKI, Y KAWAZOE, M OKADA

GANN 73(4) 517-521 1982年
CHEMISTRY AND MUTAGENICITY OF ALPHA-HYDROXY NITROSAMINES

M MOCHIZUKI, T ANJO, K TAKEDA, E SUZUKI, N SEKIGUCHI, GF HUANG, M OKADA

IARC PUBLICATIONS (41) 553-559 1982年
ANTIVIRAL, ANTIMETABOLIC, AND CYTO-TOXIC ACTIVITIES OF 5-SUBSTITUTED 2'-DEOXYCYTIDINES

E DECLERCQ, J BALZARINI, J DESCAMPS, GF HUANG, PF TORRENCE, DE BERGSTROM, AS JONES, P SERAFINOWSKI, G VERHELST, RT WALKER

MOLECULAR PHARMACOLOGY 21(1) 217-223 1982年
Mutagenicity of N-Alkyl-N-(α-acetoxyalkyl)Nitrosamines in V79 Chinese Hamster Cells in Relation to their Alkylating Activity

┣DBGann(/)-┫DB 72(4) 531-538 1981年
MUTAGENICITY OF N-ALKYL-N-(ALPHA-ACETOXYALKYL)NITROSAMINES IN V79 CHINESE-HAMSTER CELLS IN RELATION TO ALKYLATING ACTIVITY

GF HUANG, M MOCHIZUKI, T ANJO, M OKADA

GANN 72(4) 531-538 1981年
SYNTHESIS AND ANTI-VIRAL ACTIVITY OF 5-[(CYANOMETHYLENE)OXY]-2'-DEOXYURIDINE

GF HUANG, M OKADA, E DECLERCQ, PF TORRENCE

JOURNAL OF MEDICINAL CHEMISTRY 24(4) 390-393 1981年

書籍等出版物

14

Miscoding potential of the ┣DBN(/)-┫DB²-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of ┣DBEscherichia coli(/)-┫DB DNA polymerase (]G0001[)(共著)

┣DBBiochemistry(/)-┫DB 2001年
Miscoding potential of the ┣DBN(/)-┫DB²-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of ┣DBEscherichia coli(/)-┫DB DNA polymerase (]G0001[)(共著)

┣DBBiochemistry(/)-┫DB 2001年
Syntheses and properties of 1-methyl-3-phenylaminobenzimidazolium salts, models of DNA adducts of N7-arylaminodeoxyguanosinium salt.(共著)

┣DBChem. Res. Toxicol.(/)-┫DB 2000年
┣DBO(/)-┫DB⁶-(Fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo.(共著)

┣DBActa Oncol.(/)-┫DB 2000年
Reactions of a series of ┣DBN(/)-┫DB-aminobenzimidazoles and ┣DBN(/)-┫DB-aminobenzimidazolium salts with 2, 4-pentanedione.(共著)

┣DBBioorg. Med. Chem.(/)-┫DB 2000年

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3

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2

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