研究者業績

幸田光復

コウダコウフク (Kohfuku Kohda)

基本情報

所属: 武蔵野大学薬学研究所教授

学位: 薬学博士
薬学修士

J-GLOBAL ID: 200901008223441849
researchmap会員ID: 1000055199

研究分野

1

ナノテク・材料 / 生体化学 /

学歴

4

受賞

1

1984年

佐藤記念国内賞

MISC

238

Electrophilic amination of adenine. Formation of N-aminoadenines and their characteristics.

Nucleosides & Nucleotides 15 219-233 1996年
Cytotoxicity of antitumor agents toward cultured murine leukemia L1210 cells under a serum-deprived apoptotic condition

T Kasamatsu, K Kohda, Y Kawazoe

ANTICANCER RESEARCH 15(6B) 2597-2600 1995年11月
STRUCTURE-CYTOTOXICITY RELATIONSHIP OF TILIVALLINE DERIVATIVES

T SHIOIRI, T AOYAMA, N YAMAGAMI, N SHIMIZU, N MORI, K KOHDA

ANTI-CANCER DRUG DESIGN 10(2) 167-176 1995年3月
Differential inactivation of O⁶-methylguanine-DNA methyltransferase activity by O⁶-arylmethylguanines. K. Mineura, M. Fukuchi, M. Kowada, I. Terashima, and K. Kohda

Int. J. Cancer 63, 148-151 1995年
Mouse methyltransferase for repair of O⁶-methylguanine and O⁴-methylthymine in DNA. M. Kawate, K. Ihara, K. Kohda, K. Sakumi, and M. Sekiguchi

Carcinogenesis 16, 1595-1602 1995年
Wide difference between the cytotoxicity of the 11-α- and 11-β-cyano analogues of tilivalline and their epimeric conversion. K. Kohda, N. Yamagami, T. Kasamatsu, T. Aoyama, and T. Shioiri

Biochem. Pharmacol. 49, 1063-1068 1995年
Potentiation of the cytotoxicity of chloroethylnitrosourea by O⁶-arylmethylguanines. K. Kohda, I. Terashima, K. Koyama, K. Watanabe, and K. Mineura

Biol. Pharm. Bull. 18, 424-430 1995年
Differential inactivation of O⁶-methylguanine-DNA methyltransferase activity by O⁶-arylmethylguanines. K. Mineura, M. Fukuchi, M. Kowada, I. Terashima, and K. Kohda

Int. J. Cancer 63, 148-151 1995年
Mouse methyltransferase for repair of O⁶-methylguanine and O⁴-methylthymine in DNA. M. Kawate, K. Ihara, K. Kohda, K. Sakumi, and M. Sekiguchi

Carcinogenesis 16, 1595-1602 1995年
Wide difference between the cytotoxicity of the 11-α- and 11-β-cyano analogues of tilivalline and their epimeric conversion. K. Kohda, N. Yamagami, T. Kasamatsu, T. Aoyama, and T. Shioiri

Biochem. Pharmacol. 49, 1063-1068 1995年
Potentiation of the cytotoxicity of chloroethylnitrosourea by O⁶-arylmethylguanines. K. Kohda, I. Terashima, K. Koyama, K. Watanabe, and K. Mineura

Biol. Pharm. Bull. 18, 424-430 1995年
3-AMINOTHYMIDINE INHIBITS GROWTH OF CULTURED HUMAN T-CELL ACUTE LYMPHOBLASTOID LEUKEMIA-CELLS

N ASHIDA, S ASANO, K KOHDA

ANTICANCER RESEARCH 14(5A) 2061-2062 1994年9月
ENHANCING EFFECT OF O-6-ALKYLGUANINE DERIVATIVES ON CHLOROETHYLNITROSOUREA CYTOTOXICITY TOWARD TUMOR-CELLS

K MINEURA, IZUMI, I, K WATANABE, M KOWADA, K KOHDA, K KOYAMA, TERASHIMA, I, M IKENAGA

INTERNATIONAL JOURNAL OF CANCER 58(5) 706-712 1994年9月
Enhanced cytotoxicity caused by increased DNA strand breakage resulting from synergistic potentiation of bleomycin with Bacillus thuringiensis subsp. israelensis δ-endotoxin.

Anticancer Res. 14(3A) 837-840 1994年5月
ENHANCED CYTOTOXICITY CAUSED BY INCREASED DNA STRAND BREAKAGE RESULTING FROM SYNERGISTIC POTENTIATION OF BLEOMYCIN WITH BACILLUS-THURINGIENSIS SUBSP ISRAELENSIS DELTA-ENDOTOXIN

Y YOKOYAMA, K KOHDA

ANTICANCER RESEARCH 14(3A) 837-840 1994年5月
Demethylation of O⁶-methylguanine in DNA by O⁶-methylguanine-DNA methyltransferase: Synthesis and characterization of O⁶, 9-dimethylguanine coordinated with cis-platin at the N7-position. I. ・・・

Chem. Pharm. Bull. 42(4) 903-906 1994年4月
DEMETHYLATION OF O-6-METHYLGUANIUE IN DNA BY O-6-METHYLGUANINE-DNA METHYLTRANSFERASE - SYNTHESIS AND CHARACTERIZATION OF O-6,9-DIMETHYLGUANINE COORDINATED WITH CISPLATIN AT THE N7-POSITION

TERASHIMA, I, Y YAMAGATA, N YAMAGAMI, K KOHDA

CHEMICAL & PHARMACEUTICAL BULLETIN 42(4) 903-906 1994年4月
Reactions of 9-substituted 1-aminoadenines with nucleophiles and syntheses of 3-substituted 3H-imidazo[4, 5-e][1, 2, 4]triazolo[1, 5-c][1, 2, 3]triazines. S. Asano, K. Itano, Y. Yamagata, and K. Kohda

Nucleosides & Nucleotides 13, 1453-1465 1994年
Inhibitory effect of fatty acids on 8-hydroxydeoxyguanosine formation in calf thymus DNA treated with bleomycin-Fe(Ⅱ). T. Kasamatsu, T. Nakagawa, and K. Kohda

Biol. Pharm. Bull. 17, 391-394 1994年
POTENTIAL OF O6-METHYLGUANINE OR O6-BENZYLGUANINE IN THE ENHANCEMENT OF CHLOROETHYLNITROSOUREA CYTOTOXICITY ON BRAIN-TUMORS

K MINEURA, IZUMI, I, K WATANABE, M KOWADA, K KOHDA, M KENAGA

ACTA NEUROCHIRURGICA 128(1-4) 13-20 1994年
Reactions of 9-substituted 1-aminoadenines with nucleophiles and syntheses of 3-substituted 3H-imidazo[4, 5-e][1, 2, 4]triazolo[1, 5-c][1, 2, 3]triazines. S. Asano, K. Itano, Y. Yamagata, and K. Kohda

Nucleosides & Nucleotides 13, 1453-1465 1994年
Inhibitory effect of fatty acids on 8-hydroxydeoxyguanosine formation in calf thymus DNA treated with bleomycin-Fe(Ⅱ). T. Kasamatsu, T. Nakagawa, and K. Kohda

Biol. Pharm. Bull. 17, 391-394 1994年
Electrophilic amination of imidazole moieties of 9-ethylguanine and 1-methylbenzimidazole derivatives and reactivities of N-aminated products. T. Kaiya, M. Ohta, and K. Kohda

Tetrahedron 49, 8795-8804 1993年
Chemical characteristics of N-aminated nucleic acid bases. Nitrosation of aromatic N-amino group and accompanying reductive deamination. K. Hasebe, and K. Kohda

Nucleic Acids Symp. Ser. (29) 27-28 1993年
Identification of N⁴-(guanosin-7-yl)-4-aminoquinoline 1-oxide and its possible role in guanine C8 adducation. M. Tada, and K. Kohda

Nucleic Acids Symp. Ser. 29(25-26) 1993年
Chemical characteristics of complexes of O⁶, 9-dimethylguanine with cis-platin and debenzylation rates of O⁶-benzylguanines. I. Terashima, K. Koyama, and K. Kohda

Nucleic Acids Symp. Ser. (29) 23-24 1993年
Syntheses and properties of N-aminopyrimidines. K. Kohda, I. Kobayashi, K. Itano, S. Asano, and Y. Kawazoe

Tetrahedron 49, 3947-3958 1993年
Electrophilic amination of imidazole moieties of 9-ethylguanine and 1-methylbenzimidazole derivatives and reactivities of N-aminated products. T. Kaiya, M. Ohta, and K. Kohda

Tetrahedron 49, 8795-8804 1993年
Chemical characteristics of N-aminated nucleic acid bases. Nitrosation of aromatic N-amino group and accompanying reductive deamination. K. Hasebe, and K. Kohda

Nucleic Acids Symp. Ser. (29) 27-28 1993年
Identification of N⁴-(guanosin-7-yl)-4-aminoquinoline 1-oxide and its possible role in guanine C8 adducation. M. Tada, and K. Kohda

Nucleic Acids Symp. Ser. 29(25-26) 1993年
Chemical characteristics of complexes of O⁶, 9-dimethylguanine with cis-platin and debenzylation rates of O⁶-benzylguanines. I. Terashima, K. Koyama, and K. Kohda

Nucleic Acids Symp. Ser. (29) 23-24 1993年
Syntheses and properties of N-aminopyrimidines. K. Kohda, I. Kobayashi, K. Itano, S. Asano, and Y. Kawazoe

Tetrahedron 49, 3947-3958 1993年
Hyperthermic potentiation of bleomycin cytotoxicity in the presence of ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBisraelensis(/)-┫DB d-endotoxin

┣DBAnticancer Res.(/)-┫DB 12 1079-1082 1992年
Structures of N-aminoguanine hydrochloride salts. Y. Yamagata, K. Tomita, K. Kohda, and Y. Kawazoe

Acta Crystallogr., Sect.C 48, 318-320 1992年
Hyperthermic potentiation of bleomycin cytotoxicity in the presence of ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBisraelensis(/)-┫DB d-endotoxin

┣DBAnticancer Res.(/)-┫DB 12 1079-1082 1992年
Structures of N-aminoguanine hydrochloride salts. Y. Yamagata, K. Tomita, K. Kohda, and Y. Kawazoe

Acta Crystallogr., Sect.C 48, 318-320 1992年
SPIN-SPIN COUPLING BETWEEN FLUORINE AND AROMATIC PROTONS OF 3-FLUOROQUINOLINE - DEPENDENCE ON THE ELECTRONIC-STRUCTURE OF THE RING NITROGEN

K SAEKI, K KOHDA, Y KAWAZOE, Y SAKAMOTO

HETEROCYCLES 33(1) 35-38 1992年1月
Potentiation of antitumor activity of bleomycin towards solid tumors in mice by ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBIsraelensis(/)-┫DB toxin

┣DBAnticancer Res.(/)-┫DB 11 1625-1628 1991年
Syntheses and properties of N-aminated purines and pyrimidines

┣DBNucleic Acids, Symposium Series(/)-┫DB 25 3-4 1991年
Potentiation of bleomycin cytotoxicity in cultured mammalian cells by polyacrylic acid. III. Induction of DNA strand breakage and suppression of cellular heat production

┣DBAnticancer Res.(/)-┫DB 11 957-960 1991年
Potentiation of bleomycin cytotoxicity by higy molecular weight polyacrylic acid. II. Involvement of rapid conformational change of polyacrylate

┣DBAnticancer Res.(/)-┫DB 11 953-956 1991年
Separation and identification of N⁴-(guanosin-7-yl)-4-aminoquinoline l-oxide, a novel nucleic acid adduct of arcinogenic 4-nitroquinoline 1-oxide. K. Kohda, Y. Kawazoe, Y. Minoura, and M. Tada

Carcinoenesis 12, 1523-1525 1991年
Detection of 8-hydroxy-2'-deoxyguanosine in DNA by the 32p-postlabeling method

田坂文代, 幸田光復

┣DBChem. Pharm. Bull.(/)-┫DB 39(7) 1880-1882 1991年
Some cytotoxicological aspects of ethyl and fluoroethyl alkanesulfonates in ┣DBEscherichia(/)-┫DB ┣DBcoli(/)-┫DB : Role of fluorine substitution

┣DBChem. Pharm. Bull.(/)-┫DB 39 1510-1512 1991年
Lignified materials as a potential medicinal resource. IV. Dehydrogenation polymers of some phenylpropenids and their capacity to stimulate polymorphonuclear cell iodination

坂上宏, 大原利成, 幸田光復, 川添豊

┣DBChem. Pharm. Bull.(/)-┫DB 39(4) 950-955 1991年
Differential inhibition of retroviral reverse transcriptase by poly(2-fluoroadenylic acid), a template analogue

┣DBAIDS(/)-┫DB 5 341-341 1991年
Dealkylation rates of O⁶-alkyldeoxyguanosine, O⁴-alkylthymidine and related compounds under an alkyl-transfer system. K. Kohda, M. Yasuda, N. Sawada, K. Itano, and Y. Kawazoe

Chemico-Biol. Interactions 78, 23-32 1991年
Formation of ┣DBO⁶(/)-┫DB, 7-dimethylguanine residues in calf thymus DNA treated with carcinogenic ┣D5N-┫D5-methyl-┣D5N-┫D5-nitrosourea ┣DBin vitro(/)-┫DB

┣DBChem. Pharm. Bull.(/)-┫DB 39 801-802 1991年
Potentiation of antitumor activity of bleomycin towards solid tumors in mice by ┣DBBacillus(/)-┫DB ┣DBthuringiensis(/)-┫DB subsp. ┣DBIsraelensis(/)-┫DB toxin

┣DBAnticancer Res.(/)-┫DB 11 1625-1628 1991年
Syntheses and properties of N-aminated purines and pyrimidines

┣DBNucleic Acids, Symposium Series(/)-┫DB 25 3-4 1991年

書籍等出版物

14

Miscoding potential of the ┣DBN(/)-┫DB²-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of ┣DBEscherichia coli(/)-┫DB DNA polymerase (]G0001[)(共著)

┣DBBiochemistry(/)-┫DB 2001年
Miscoding potential of the ┣DBN(/)-┫DB²-ethyl-2'-deoxyguanosine DNA adduct by the exonuclease-free Klenow fragment of ┣DBEscherichia coli(/)-┫DB DNA polymerase (]G0001[)(共著)

┣DBBiochemistry(/)-┫DB 2001年
Syntheses and properties of 1-methyl-3-phenylaminobenzimidazolium salts, models of DNA adducts of N7-arylaminodeoxyguanosinium salt.(共著)

┣DBChem. Res. Toxicol.(/)-┫DB 2000年
┣DBO(/)-┫DB⁶-(Fluorobenzyl)guanine and chloroethylnitrosourea in xenografted rat brain tumor in vivo.(共著)

┣DBActa Oncol.(/)-┫DB 2000年
Reactions of a series of ┣DBN(/)-┫DB-aminobenzimidazoles and ┣DBN(/)-┫DB-aminobenzimidazolium salts with 2, 4-pentanedione.(共著)

┣DBBioorg. Med. Chem.(/)-┫DB 2000年

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3

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2

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