研究者業績

榎本武美

エノモトタケミ (ENOMOTO TAKEMI)

基本情報

所属: 武蔵野大学薬学部薬学部薬学科教授

学位: 学士(東京大学)
修士(東京大学)
博士(東京大学)

J-GLOBAL ID: 200901056088076439
researchmap会員ID: 1000183964

研究キーワード

6

研究分野

1

ライフサイエンス / 分子生物学 /

経歴

18

もっとみる

学歴

7

もっとみる

MISC

267

Stimulation of DNA Synthesis by Mouse DNA Helicase B in a DNA Replication System Containing Eukaryotic Replication Origins

Ken Matsumoto, Masayuki Seki, Chikahide Masutani, Shusuke Tada, Takemi Enomoto, Yukio Ishimi

Biochemistry 34(24) 7913-7922 1995年
MOLECULAR-CLONING OF CDNA-ENCODING HUMAN DNA HELICASE Q1 WHICH HAS HOMOLOGY TO ESCHERICHIA-COLI REC-Q HELICASE AND LOCALIZATION OF THE GENE AT CHROMOSOME-12P12

M SEKI, H MIYAZAWA, S TADA, J YANAGISAWA, T YAMAOKA, S HOSHINO, K OZAWA, T EKI, M NOGAMI, K OKUMURA, H TAGUCHI, F HANAOKA, T ENOMOTO

NUCLEIC ACIDS RESEARCH 22(22) 4566-4573 1994年11月
Identification of the nature of modification that causes the shift of DNA topoisomerase IIβ to apparent higher molecular weight forms in the M phase

Keiji Kimura, Naohito Nozaki, Masafumi Saijo, Akihiko Kikuchi, Michio Ui, Takemi Enomoto

Journal of Biological Chemistry 269(40) 24523-24526 1994年10月7日
GROWTH-STATE AND CELL-CYCLE DEPENDENT PHOSPHORYLATION OF DNA TOPOISOMERASE-II IN SWISS 3T3 CELLS

M SAIJO, M UI, T ENOMOTO

BIOCHEMISTRY 31(2) 359-363 1992年1月
Human ubiquitin-activating enzyme (E1): compensation for heat-labile mouse E1 and its gene localization on the X chromosome.

Kudo, M, Sugasawa, K, Hori, T, nomoto, T, Hanaoka, F, Ui, M

Exp. Cell Res. 192(1) 110-117 1991年

199100
Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication

T. Eki, T. Enomoto, C. Masutani, A. Miyajima, R. Takada, Y. Murakami, T. Ohno, F. Hanaoka, M. Ui

Journal of Virology 65(9) 4874-4881 1991年
Human ubiquitin-activating enzyme (E1): compensation for heat-labile mouse E1 and its gene localization on the X chromosome.

Exp. Cell Res. 192(1) 110-117 1991年

199100
PURIFICATION AND CHARACTERIZATION OF MOUSE DNA POLYMERASE-ALPHA DEVOID OF PRIMASE ACTIVITY

R TAKADATAKAYAMA, M SUZUKI, T ENOMOTO, F HANAOKA, M UI

FEBS LETTERS 273(1-2) 27-30 1990年10月
PURIFICATION AND CHARACTERIZATION OF MOUSE DNA POLYMERASE-ALPHA DEVOID OF PRIMASE ACTIVITY

R TAKADATAKAYAMA, M SUZUKI, T ENOMOTO, F HANAOKA, M UI

FEBS LETTERS 273(1-2) 27-30 1990年10月
PURIFICATION AND CHARACTERIZATION OF TYPE-II DNA TOPOISOMERASE FROM MOUSE FM3A CELLS - PHOSPHORYLATION OF TOPOISOMERASE-II AND MODIFICATION OF ITS ACTIVITY

M SAIJO, T ENOMOTO, F HANAOKA, M UI

BIOCHEMISTRY 29(2) 583-590 1990年1月
Isolation of temperature-sensitive cell cycle mutants from mouse FM3A cells. Characterization of mutants with special reference to DNA replication

T. Eki, T. A. Enomoto Miyajima, H. Miyazawa, Y. Murakami, F. Hannaoka, M. Yamada, M. Ui

Journal of Biological Chemistry 265(1) 26-33 1990年
DNA HELICASE AND NUCLEOSIDE-5'-TRIPHOSPHATASE ACTIVITIES OF POLYOMA-VIRUS LARGE TUMOR-ANTIGEN

M SEKI, T ENOMOTO, T EKI, A MIYAJIMA, Y MURAKAMI, F HANAOKA, M UI

BIOCHEMISTRY 29(4) 1003-1009 1990年1月
PURIFICATION AND CHARACTERIZATION OF TYPE-II DNA TOPOISOMERASE FROM MOUSE FM3A CELLS - PHOSPHORYLATION OF TOPOISOMERASE-II AND MODIFICATION OF ITS ACTIVITY

M SAIJO, T ENOMOTO, F HANAOKA, M UI

BIOCHEMISTRY 29(2) 583-590 1990年1月
DNA HELICASE AND NUCLEOSIDE-5'-TRIPHOSPHATASE ACTIVITIES OF POLYOMA-VIRUS LARGE TUMOR-ANTIGEN

M SEKI, T ENOMOTO, T EKI, A MIYAJIMA, Y MURAKAMI, F HANAOKA, M UI

BIOCHEMISTRY 29(4) 1003-1009 1990年1月
DNA primase-DNA polymerase α assembly from mouse FM3A cells. Purification of constituting enzymes, reconstitution, and analysis of RNA priming as coupled to DNA synthesis

M. Suzuki, T. Enomoto, C. Masutani, F. Hanaoka, M. Yamada, M. Ui

Journal of Biological Chemistry 264(17) 10065-10071 1989年
A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells

S. Hoshino, H. Miyazawa, T. Enomoto, F. Hanaoka, Y. Kikuchi, A. Kikuchi, M. Ui

EMBO Journal 8(12) 3807-3814 1989年
FURTHER CHARACTERIZATION OF DNA HELICASE ACTIVITY OF MOUSE DNA-DEPENDENT ADENOSINETRIPHOSPHATASE-B (DNA HELICASE-B)

M SEKI, T ENOMOTO, J YANAGISAWA, F HANAOKA, M UI

BIOCHEMISTRY 27(5) 1766-1771 1988年3月
FURTHER CHARACTERIZATION OF DNA HELICASE ACTIVITY OF MOUSE DNA-DEPENDENT ADENOSINETRIPHOSPHATASE-B (DNA HELICASE-B)

M SEKI, T ENOMOTO, J YANAGISAWA, F HANAOKA, M UI

BIOCHEMISTRY 27(5) 1766-1771 1988年3月
Characterization of DNA polymerase activity from a mouse DNA temperature-sensitive mutant, strain tsFT20, which shows a defect in DNA polymerase activity at restrictive temperatures.

Eki, T, nomoto, T, Murakami, Y, Hanaoka, F, Yamada, M

Arch. Biochem. Biophys 260(2) 552-560 1988年

198800
Characterization of DNA polymerase activity from a mouse DNA temperature-sensitive mutant, strain tsFT20, which shows a defect in DNA polymerase activity at restrictive temperatures.

Arch. Biochem. Biophys 260(2) 552-560 1988年

198800
DNA-DEPENDENT ADENOSINE-TRIPHOSPHATASE-B FROM MOUSE FM3A CELLS HAS DNA HELICASE ACTIVITY

M SEKI, T ENOMOTO, F HANAOKA, M YAMADA

BIOCHEMISTRY 26(10) 2924-2928 1987年5月
DNA-DEPENDENT ADENOSINE-TRIPHOSPHATASE-B FROM MOUSE FM3A CELLS HAS DNA HELICASE ACTIVITY

M SEKI, T ENOMOTO, F HANAOKA, M YAMADA

BIOCHEMISTRY 26(10) 2924-2928 1987年5月
Characterization of revertants derived from a mouse DNA temperature-sensitive mutant strain, tsFT20, which contains heat-labile DNA polymerase α activity.

Eki, T, nomoto, T, Murakami, Y, Miyazawa, H, Hanaoka, F, Yamada, M

Exp. Cell Res. 171(1) 24-36 1987年

198700
PURIFICATION AND CHARACTERIZATION OF A DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASE FROM MOUSE FM3A CELLS - EFFECTS OF RIBONUCLEOSIDE TRIPHOSPHATES ON THE INTERACTION OF THE ENZYME WITH SINGLE-STRANDED-DNA

M SEKI, T ENOMOTO, Y WATANABE, Y TAWARAGI, K KAWASAKI, F HANAOKA, M YAMADA

BIOCHEMISTRY 25(11) 3239-3245 1986年6月
PURIFICATION AND CHARACTERIZATION OF A DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASE FROM MOUSE FM3A CELLS - EFFECTS OF RIBONUCLEOSIDE TRIPHOSPHATES ON THE INTERACTION OF THE ENZYME WITH SINGLE-STRANDED-DNA

M SEKI, T ENOMOTO, Y WATANABE, Y TAWARAGI, K KAWASAKI, F HANAOKA, M YAMADA

BIOCHEMISTRY 25(11) 3239-3245 1986年6月
Detection and characterization of a novel factor that stimulates DNA polymerase α.

Kawasaki, K, nomoto, T, Suzuki, M, Seki, M, Hanaoka, F, Yamada, M

Biochemistry 25(10) 3044-3050 1986年5月
Further characterization of a murine temperature-sensitive mutant, tsFT20 strain, containing heat-labile DNA polymerase activity.

Murakami, Y, Eki, T, Miyazawa, H, nomoto, T, Hanaoka, F, Yamada

Exp. Cell Res. 163(1) 135-142 1986年

198600
Effect of 3-aminobenzamide on the process of ultraviolet-induced DNA excision repair

Fuminori Otsuka, Kouichi Yamada, Hisako Ohno, Takemi Enomoto, Fumio Hanaoka, Motoyasu Ohsawa, Masa-atsu Yamada

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 161(1) 75-82 1986年
Purification and characterization of two forms of DNA polymerase from mouse FM3A cells: a DNA polymerase-primase complex and a free DNA polymerase α.

Enomoto, T, Suzuki, M, Takahashi, M, Kawasaki, K, Watanabe, Y, Nagata, K, Hanaoka F, Yamada, M

Cell Struct. Funct. 10(2) 161-171 1985年

198500
Isolation and initial characterization of a temperature-sensitive mutant of mouse FM3A cells defective in cytokinesis.

Yasumitsu, H, Hanaoka, F, Yasuda, H, Murakami, Y, nomoto, T, Yamada, M

Cell Struct. Funct. 10(1) 79-88 1985年

198500
DECREASE IN THE REACTION OF DNA-REPAIR SYNTHESIS IN RESPONSE TO NICOTINAMIDE OR 3-AMINOBENZAMIDE IN ULTRAVIOLET IRRADIATED SYSTEMIC LUPUS-ERYTHEMATOSUS LYMPHOCYTES

F TAKEUCHI, F OTSUKA, T ENOMOTO, F HANAOKA, MA YAMADA, N KAMATANI, K NAKANO, K MATSUTA, K TANIMOTO, T MORITA, T MIYAMOTO

JOURNAL OF RHEUMATOLOGY 12(3) 504-507 1985年
CONTAMINATION BY ATP OF COMMERCIAL DATP SAMPLES CAUSING ERRONEOUS RESULTS IN STUDIES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

F HANAOKA, M TAKAHASHI, T ENOMOTO, M YAMADA, S TANAKA, Y WATAYA, H HAYATSU

JOURNAL OF BIOCHEMISTRY 97(1) 383-386 1985年
Isolation and initial characterization of a temperature-sensitive mutant of mouse FM3A cells defective in cytokinesis.

Hidetaro Yasumitsu, Fumio Hanaoka, Hideyo Yasuda, Yasufumi Murakami, Takemi Enomoto, Masa-atsu Yamada

Cell Struct. Funct. 10(1) 79-88 1985年

198500
DECREASE IN THE REACTION OF DNA-REPAIR SYNTHESIS IN RESPONSE TO NICOTINAMIDE OR 3-AMINOBENZAMIDE IN ULTRAVIOLET IRRADIATED SYSTEMIC LUPUS-ERYTHEMATOSUS LYMPHOCYTES

F TAKEUCHI, F OTSUKA, T ENOMOTO, F HANAOKA, MA YAMADA, N KAMATANI, K NAKANO, K MATSUTA, K TANIMOTO, T MORITA, T MIYAMOTO

JOURNAL OF RHEUMATOLOGY 12(3) 504-507 1985年
CONTAMINATION BY ATP OF COMMERCIAL DATP SAMPLES CAUSING ERRONEOUS RESULTS IN STUDIES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

F HANAOKA, M TAKAHASHI, T ENOMOTO, M YAMADA, S TANAKA, Y WATAYA, H HAYATSU

JOURNAL OF BIOCHEMISTRY 97(1) 383-386 1985年
MULTIPLE DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASES IN FM3A CELLS - CHARACTERIZATION OF AN ADENOSINETRIPHOPHATASE THAT PREFERS POLY[D(A-T)] AS COFACTOR

Y TAWARAGI, T ENOMOTO, Y WATANABE, F HANAOKA, MA YAMADA

BIOCHEMISTRY 23(3) 529-533 1984年
Effect of strandedness of cofactor DNA on the activities of DNA-dependent ATPases B and C3 from mouse FM3A cells.

Enomoto, T, Tawaragi, Y, Watanabe, Y, Seki., M, Kawasaki, K, Hanaoka, F, Yamada, M

Cell Struct. Funct. 9(2) 197-202 1984年

198400
MULTIPLE DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASES IN FM3A CELLS - CHARACTERIZATION OF AN ADENOSINETRIPHOPHATASE THAT PREFERS POLY[D(A-T)] AS COFACTOR

Y TAWARAGI, T ENOMOTO, Y WATANABE, F HANAOKA, MA YAMADA

BIOCHEMISTRY 23(3) 529-533 1984年
Effect of strandedness of cofactor DNA on the activities of DNA-dependent ATPases B and C3 from mouse FM3A cells.

Takemi Enomoto, Yasunori Tawaragi, Yoshinari Watanabe, Masayuki Seki, Katsumi Kawasaki, Fumio Hanaoka, Masa-atsu Yamada

Cell Struct. Funct. 9(2) 197-202 1984年

198400
Purification and characterization of two forms of DNA polymerase from HeLa cell nuclei.

Enomoto, T, Tanuma, S, Yamada, M

Biochemistry 22(5) 1134-1138 1983年

198300
CHARACTERIZATION OF DEOXYRIBONUCLEIC-ACID SYNTHESIS IN RECONSTITUTED NUCLEAR SYSTEMS

T ENOMOTO, S TANUMA, M YAMADA

BIOCHEMISTRY 22(5) 1128-1133 1983年
Purification and characterization of two forms of DNA polymerase from HeLa cell nuclei.

Biochemistry 22(5) 1134-1138 1983年

198300
Independent induction of sister-chromatid exchanges by 3-aminobenzamide and ultraviolet radiation in HeLa cells

Fuminori Otsuka, Hisako Ohno, Takemi Enomoto, Fumio Hanaoka, Masa-atsu Yamada

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis 107(2) 289-296 1983年
CHARACTERIZATION OF DEOXYRIBONUCLEIC-ACID SYNTHESIS IN RECONSTITUTED NUCLEAR SYSTEMS

T ENOMOTO, S TANUMA, M YAMADA

BIOCHEMISTRY 22(5) 1128-1133 1983年
ISOLATION OF PROTEINS INVOLVED IN THE REPLICATION OF ADENOVIRAL DNA INVITRO

JH LICHY, K NAGATA, BR FRIEFELD, T ENOMOTO, J FIELD, RA GUGGENHEIMER, JE IKEDA, MS HORWITZ, J HURWITZ

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY 47(Pt2) 731-740 1982年
DNA-dependent ATPase B of FM3A cells. Its separation from DNA polymerase α.

Watanabe, Y, Nagata, K, Tawaragi, Y, nomoto, T, Hanaoka, F, Yamada, M

FEBS Lett. 149(1) 44-46 1982年
ADENOVIRUS DNA-REPLICATION INVITRO - IDENTIFICATION OF A HOST FACTOR THAT STIMULATES SYNTHESIS OF THE PRE-TERMINAL PROTEIN-DCMP COMPLEX

K NAGATA, RA GUGGENHEIMER, T ENOMOTO, JH LICHY, J HURWITZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79(21) 6438-6442 1982年
ADENOVIRAL PROTEIN-PRIMED INITIATION OF DNA CHAINS INVITRO

JE IKEDA, T ENOMOTO, J HURWITZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 79(8) 2442-2446 1982年
MULTIPLE FORMS OF DNA-DEPENDENT ATPASE IN CALF THYMUS

Y WATANABE, Y TAWARAGI, T ENOMOTO, F HANAOKA, MA YAMADA

BIOCHEMISTRY INTERNATIONAL 3(4) 407-413 1981年
ATP REQUIREMENT FOR THE PROCESSES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

T ENOMOTO, S TANUMA, M YAMADA

JOURNAL OF BIOCHEMISTRY 89(3) 801-807 1981年

書籍等出版物

14

生物系薬学IV 演習編

東京化学同人 2011年6月
生物系薬学II 第２版

東京化学同人 2010年12月
生物系薬学II 日本薬学会編

東京化学同人

200500
Molecular mechanism of Werner's syndrome edited by Michel Lebel Kluwer Academic

Plenum Publishers, New York,

200400
廣川タンパク質化学第４巻酵素福井哲也、伊藤正樹編

廣川書店

200300

もっとみる

講演・口頭発表等

601

Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium 2012年
損傷乗り越え合成におけるWRNIP1とDNA polymerase etaの機能的関連の解析

日本薬学会第132年会北海道大学札幌市 2012年
システムバイオロジーの構築を指向した新戦略：FD-LC-MS/MS法の活用

日本薬学会第132年会北海道大学札幌市 2012年
Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium 2012年
Antioxidant protein, either SOD1, SOD2 or PRDX1 is required for normal cell growth in vertebrate cells.

Gordon Research Conference; Oxidative Stress and Disease Ventura CA USA 2011年

もっとみる

所属学協会

7

もっとみる

Works(作品等)

56

ゲノム安定化に寄与するRECQL1とRECQL5の機能の解析文部科学省基盤研究（B）

2011年4月 - 2014年3月
ウェルナー症候群原因遺伝子産物ＷＲＮとＷＲＮに結合するＷＲＮＩＰ１の機能の解析文部科学省基盤研究（B）

2008年4月 - 2011年3月
DNA複製フォークの傷害回避とRecQファミリーヘリカーゼの機能文部科学省特定領域研究（がん）

2005年4月 - 2010年3月
姉妹染色分体接着機構と複製フォーク再生機構との関連(蛋白質・核酸・酵素)

2009年3月
RecQ family helicases in genome stability: Lessons from gene disrupted DT40 cells.(Cell Cycle)

2008年8月

もっとみる

共同研究・競争的資金等の研究課題

2

新たなDNA修復、組み換え機構及びその発生学的役割

1995年 - 1996年
Novel mechanism and developmental roles of repair recombination

1995年 - 1996年

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