Curriculum Vitaes

ENOMOTO TAKEMI

(榎本武美)

Profile Information

Affiliation: Professor, Musashino University

Degree: 学士(東京大学)
修士(東京大学)
博士(東京大学)

J-GLOBAL ID: 200901056088076439
researchmap Member ID: 1000183964

Research Interests

6

Research Areas

1

Life sciences / Molecular biology /

Research History

18

Education

7

- 1981

アルバートアインシュタイン医科大学
- 1975

The University of Tokyo
- 1975

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 1972

The University of Tokyo
- 1972

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo

Misc.

267

Stimulation of DNA Synthesis by Mouse DNA Helicase B in a DNA Replication System Containing Eukaryotic Replication Origins

Ken Matsumoto, Masayuki Seki, Chikahide Masutani, Shusuke Tada, Takemi Enomoto, Yukio Ishimi

Biochemistry, 34(24) 7913-7922, 1995
MOLECULAR-CLONING OF CDNA-ENCODING HUMAN DNA HELICASE Q1 WHICH HAS HOMOLOGY TO ESCHERICHIA-COLI REC-Q HELICASE AND LOCALIZATION OF THE GENE AT CHROMOSOME-12P12

M SEKI, H MIYAZAWA, S TADA, J YANAGISAWA, T YAMAOKA, S HOSHINO, K OZAWA, T EKI, M NOGAMI, K OKUMURA, H TAGUCHI, F HANAOKA, T ENOMOTO

NUCLEIC ACIDS RESEARCH, 22(22) 4566-4573, Nov, 1994
Identification of the nature of modification that causes the shift of DNA topoisomerase IIβ to apparent higher molecular weight forms in the M phase

Keiji Kimura, Naohito Nozaki, Masafumi Saijo, Akihiko Kikuchi, Michio Ui, Takemi Enomoto

Journal of Biological Chemistry, 269(40) 24523-24526, Oct 7, 1994
GROWTH-STATE AND CELL-CYCLE DEPENDENT PHOSPHORYLATION OF DNA TOPOISOMERASE-II IN SWISS 3T3 CELLS

M SAIJO, M UI, T ENOMOTO

BIOCHEMISTRY, 31(2) 359-363, Jan, 1992
Human ubiquitin-activating enzyme (E1): compensation for heat-labile mouse E1 and its gene localization on the X chromosome.

Kudo, M, Sugasawa, K, Hori, T, nomoto, T, Hanaoka, F, Ui, M

Exp. Cell Res., 192(1) 110-117, 1991

199100
Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication

T. Eki, T. Enomoto, C. Masutani, A. Miyajima, R. Takada, Y. Murakami, T. Ohno, F. Hanaoka, M. Ui

Journal of Virology, 65(9) 4874-4881, 1991
Human ubiquitin-activating enzyme (E1): compensation for heat-labile mouse E1 and its gene localization on the X chromosome.

Exp. Cell Res., 192(1) 110-117, 1991

199100
PURIFICATION AND CHARACTERIZATION OF MOUSE DNA POLYMERASE-ALPHA DEVOID OF PRIMASE ACTIVITY

R TAKADATAKAYAMA, M SUZUKI, T ENOMOTO, F HANAOKA, M UI

FEBS LETTERS, 273(1-2) 27-30, Oct, 1990
PURIFICATION AND CHARACTERIZATION OF MOUSE DNA POLYMERASE-ALPHA DEVOID OF PRIMASE ACTIVITY

R TAKADATAKAYAMA, M SUZUKI, T ENOMOTO, F HANAOKA, M UI

FEBS LETTERS, 273(1-2) 27-30, Oct, 1990
PURIFICATION AND CHARACTERIZATION OF TYPE-II DNA TOPOISOMERASE FROM MOUSE FM3A CELLS - PHOSPHORYLATION OF TOPOISOMERASE-II AND MODIFICATION OF ITS ACTIVITY

M SAIJO, T ENOMOTO, F HANAOKA, M UI

BIOCHEMISTRY, 29(2) 583-590, Jan, 1990
Isolation of temperature-sensitive cell cycle mutants from mouse FM3A cells. Characterization of mutants with special reference to DNA replication

T. Eki, T. A. Enomoto Miyajima, H. Miyazawa, Y. Murakami, F. Hannaoka, M. Yamada, M. Ui

Journal of Biological Chemistry, 265(1) 26-33, 1990
DNA HELICASE AND NUCLEOSIDE-5'-TRIPHOSPHATASE ACTIVITIES OF POLYOMA-VIRUS LARGE TUMOR-ANTIGEN

M SEKI, T ENOMOTO, T EKI, A MIYAJIMA, Y MURAKAMI, F HANAOKA, M UI

BIOCHEMISTRY, 29(4) 1003-1009, Jan, 1990
PURIFICATION AND CHARACTERIZATION OF TYPE-II DNA TOPOISOMERASE FROM MOUSE FM3A CELLS - PHOSPHORYLATION OF TOPOISOMERASE-II AND MODIFICATION OF ITS ACTIVITY

M SAIJO, T ENOMOTO, F HANAOKA, M UI

BIOCHEMISTRY, 29(2) 583-590, Jan, 1990
DNA HELICASE AND NUCLEOSIDE-5'-TRIPHOSPHATASE ACTIVITIES OF POLYOMA-VIRUS LARGE TUMOR-ANTIGEN

M SEKI, T ENOMOTO, T EKI, A MIYAJIMA, Y MURAKAMI, F HANAOKA, M UI

BIOCHEMISTRY, 29(4) 1003-1009, Jan, 1990
DNA primase-DNA polymerase α assembly from mouse FM3A cells. Purification of constituting enzymes, reconstitution, and analysis of RNA priming as coupled to DNA synthesis

M. Suzuki, T. Enomoto, C. Masutani, F. Hanaoka, M. Yamada, M. Ui

Journal of Biological Chemistry, 264(17) 10065-10071, 1989
A human homologue of the yeast GST1 gene codes for a GTP-binding protein and is expressed in a proliferation-dependent manner in mammalian cells

S. Hoshino, H. Miyazawa, T. Enomoto, F. Hanaoka, Y. Kikuchi, A. Kikuchi, M. Ui

EMBO Journal, 8(12) 3807-3814, 1989
FURTHER CHARACTERIZATION OF DNA HELICASE ACTIVITY OF MOUSE DNA-DEPENDENT ADENOSINETRIPHOSPHATASE-B (DNA HELICASE-B)

M SEKI, T ENOMOTO, J YANAGISAWA, F HANAOKA, M UI

BIOCHEMISTRY, 27(5) 1766-1771, Mar, 1988
FURTHER CHARACTERIZATION OF DNA HELICASE ACTIVITY OF MOUSE DNA-DEPENDENT ADENOSINETRIPHOSPHATASE-B (DNA HELICASE-B)

M SEKI, T ENOMOTO, J YANAGISAWA, F HANAOKA, M UI

BIOCHEMISTRY, 27(5) 1766-1771, Mar, 1988
Characterization of DNA polymerase activity from a mouse DNA temperature-sensitive mutant, strain tsFT20, which shows a defect in DNA polymerase activity at restrictive temperatures.

Eki, T, nomoto, T, Murakami, Y, Hanaoka, F, Yamada, M

Arch. Biochem. Biophys, 260(2) 552-560, 1988

198800
Characterization of DNA polymerase activity from a mouse DNA temperature-sensitive mutant, strain tsFT20, which shows a defect in DNA polymerase activity at restrictive temperatures.

Arch. Biochem. Biophys, 260(2) 552-560, 1988

198800
DNA-DEPENDENT ADENOSINE-TRIPHOSPHATASE-B FROM MOUSE FM3A CELLS HAS DNA HELICASE ACTIVITY

M SEKI, T ENOMOTO, F HANAOKA, M YAMADA

BIOCHEMISTRY, 26(10) 2924-2928, May, 1987
DNA-DEPENDENT ADENOSINE-TRIPHOSPHATASE-B FROM MOUSE FM3A CELLS HAS DNA HELICASE ACTIVITY

M SEKI, T ENOMOTO, F HANAOKA, M YAMADA

BIOCHEMISTRY, 26(10) 2924-2928, May, 1987
Characterization of revertants derived from a mouse DNA temperature-sensitive mutant strain, tsFT20, which contains heat-labile DNA polymerase α activity.

Eki, T, nomoto, T, Murakami, Y, Miyazawa, H, Hanaoka, F, Yamada, M

Exp. Cell Res., 171(1) 24-36, 1987

198700
PURIFICATION AND CHARACTERIZATION OF A DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASE FROM MOUSE FM3A CELLS - EFFECTS OF RIBONUCLEOSIDE TRIPHOSPHATES ON THE INTERACTION OF THE ENZYME WITH SINGLE-STRANDED-DNA

M SEKI, T ENOMOTO, Y WATANABE, Y TAWARAGI, K KAWASAKI, F HANAOKA, M YAMADA

BIOCHEMISTRY, 25(11) 3239-3245, Jun, 1986
PURIFICATION AND CHARACTERIZATION OF A DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASE FROM MOUSE FM3A CELLS - EFFECTS OF RIBONUCLEOSIDE TRIPHOSPHATES ON THE INTERACTION OF THE ENZYME WITH SINGLE-STRANDED-DNA

M SEKI, T ENOMOTO, Y WATANABE, Y TAWARAGI, K KAWASAKI, F HANAOKA, M YAMADA

BIOCHEMISTRY, 25(11) 3239-3245, Jun, 1986
DETECTION AND CHARACTERIZATION OF A NOVEL FACTOR THAT STIMULATES DNA POLYMERASE-ALPHA

K KAWASAKI, T ENOMOTO, M SUZUKI, M SEKI, F HANAOKA, MA YAMADA

BIOCHEMISTRY, 25(10) 3044-3050, May, 1986
Further characterization of a murine temperature-sensitive mutant, tsFT20 strain, containing heat-labile DNA polymerase activity.

Murakami, Y, Eki, T, Miyazawa, H, nomoto, T, Hanaoka, F, Yamada

Exp. Cell Res., 163(1) 135-142, 1986

198600
Effect of 3-aminobenzamide on the process of ultraviolet-induced DNA excision repair

Fuminori Otsuka, Kouichi Yamada, Hisako Ohno, Takemi Enomoto, Fumio Hanaoka, Motoyasu Ohsawa, Masa-atsu Yamada

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 161(1) 75-82, 1986
Purification and characterization of two forms of DNA polymerase from mouse FM3A cells: a DNA polymerase-primase complex and a free DNA polymerase α.

Enomoto, T, Suzuki, M, Takahashi, M, Kawasaki, K, Watanabe, Y, Nagata, K, Hanaoka F, Yamada, M

Cell Struct. Funct., 10(2) 161-171, 1985

198500
Isolation and initial characterization of a temperature-sensitive mutant of mouse FM3A cells defective in cytokinesis.

Yasumitsu, H, Hanaoka, F, Yasuda, H, Murakami, Y, nomoto, T, Yamada, M

Cell Struct. Funct., 10(1) 79-88, 1985

198500
DECREASE IN THE REACTION OF DNA-REPAIR SYNTHESIS IN RESPONSE TO NICOTINAMIDE OR 3-AMINOBENZAMIDE IN ULTRAVIOLET IRRADIATED SYSTEMIC LUPUS-ERYTHEMATOSUS LYMPHOCYTES

F TAKEUCHI, F OTSUKA, T ENOMOTO, F HANAOKA, MA YAMADA, N KAMATANI, K NAKANO, K MATSUTA, K TANIMOTO, T MORITA, T MIYAMOTO

JOURNAL OF RHEUMATOLOGY, 12(3) 504-507, 1985
CONTAMINATION BY ATP OF COMMERCIAL DATP SAMPLES CAUSING ERRONEOUS RESULTS IN STUDIES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

F HANAOKA, M TAKAHASHI, T ENOMOTO, M YAMADA, S TANAKA, Y WATAYA, H HAYATSU

JOURNAL OF BIOCHEMISTRY, 97(1) 383-386, 1985
Isolation and initial characterization of a temperature-sensitive mutant of mouse FM3A cells defective in cytokinesis.

Hidetaro Yasumitsu, Fumio Hanaoka, Hideyo Yasuda, Yasufumi Murakami, Takemi Enomoto, Masa-atsu Yamada

Cell Struct. Funct., 10(1) 79-88, 1985

198500
DECREASE IN THE REACTION OF DNA-REPAIR SYNTHESIS IN RESPONSE TO NICOTINAMIDE OR 3-AMINOBENZAMIDE IN ULTRAVIOLET IRRADIATED SYSTEMIC LUPUS-ERYTHEMATOSUS LYMPHOCYTES

F TAKEUCHI, F OTSUKA, T ENOMOTO, F HANAOKA, MA YAMADA, N KAMATANI, K NAKANO, K MATSUTA, K TANIMOTO, T MORITA, T MIYAMOTO

JOURNAL OF RHEUMATOLOGY, 12(3) 504-507, 1985
CONTAMINATION BY ATP OF COMMERCIAL DATP SAMPLES CAUSING ERRONEOUS RESULTS IN STUDIES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

F HANAOKA, M TAKAHASHI, T ENOMOTO, M YAMADA, S TANAKA, Y WATAYA, H HAYATSU

JOURNAL OF BIOCHEMISTRY, 97(1) 383-386, 1985
MULTIPLE DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASES IN FM3A CELLS - CHARACTERIZATION OF AN ADENOSINETRIPHOPHATASE THAT PREFERS POLY[D(A-T)] AS COFACTOR

Y TAWARAGI, T ENOMOTO, Y WATANABE, F HANAOKA, MA YAMADA

BIOCHEMISTRY, 23(3) 529-533, 1984
Effect of strandedness of cofactor DNA on the activities of DNA-dependent ATPases B and C3 from mouse FM3A cells.

Enomoto, T, Tawaragi, Y, Watanabe, Y, Seki., M, Kawasaki, K, Hanaoka, F, Yamada, M

Cell Struct. Funct., 9(2) 197-202, 1984

198400
MULTIPLE DEOXYRIBONUCLEIC-ACID DEPENDENT ADENOSINE-TRIPHOSPHATASES IN FM3A CELLS - CHARACTERIZATION OF AN ADENOSINETRIPHOPHATASE THAT PREFERS POLY[D(A-T)] AS COFACTOR

Y TAWARAGI, T ENOMOTO, Y WATANABE, F HANAOKA, MA YAMADA

BIOCHEMISTRY, 23(3) 529-533, 1984
Effect of strandedness of cofactor DNA on the activities of DNA-dependent ATPases B and C3 from mouse FM3A cells.

Takemi Enomoto, Yasunori Tawaragi, Yoshinari Watanabe, Masayuki Seki, Katsumi Kawasaki, Fumio Hanaoka, Masa-atsu Yamada

Cell Struct. Funct., 9(2) 197-202, 1984

198400
Purification and characterization of two forms of DNA polymerase from HeLa cell nuclei.

Enomoto, T, Tanuma, S, Yamada, M

Biochemistry, 22(5) 1134-1138, 1983

198300
CHARACTERIZATION OF DEOXYRIBONUCLEIC-ACID SYNTHESIS IN RECONSTITUTED NUCLEAR SYSTEMS

T ENOMOTO, S TANUMA, M YAMADA

BIOCHEMISTRY, 22(5) 1128-1133, 1983
Purification and characterization of two forms of DNA polymerase from HeLa cell nuclei.

Biochemistry, 22(5) 1134-1138, 1983

198300
Independent induction of sister-chromatid exchanges by 3-aminobenzamide and ultraviolet radiation in HeLa cells

Fuminori Otsuka, Hisako Ohno, Takemi Enomoto, Fumio Hanaoka, Masa-atsu Yamada

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 107(2) 289-296, 1983
CHARACTERIZATION OF DEOXYRIBONUCLEIC-ACID SYNTHESIS IN RECONSTITUTED NUCLEAR SYSTEMS

T ENOMOTO, S TANUMA, M YAMADA

BIOCHEMISTRY, 22(5) 1128-1133, 1983
ISOLATION OF PROTEINS INVOLVED IN THE REPLICATION OF ADENOVIRAL DNA INVITRO

JH LICHY, K NAGATA, BR FRIEFELD, T ENOMOTO, J FIELD, RA GUGGENHEIMER, JE IKEDA, MS HORWITZ, J HURWITZ

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 47(Pt2) 731-740, 1982
DNA-DEPENDENT ATPASE-B OF FM3A CELLS - ITS SEPARATION FROM DNA POLYMERASE-ALPHA

Y WATANABE, K NAGATA, Y TAWARAGI, T ENOMOTO, F HANAOKA, M YAMADA

FEBS LETTERS, 149(1) 44-46, 1982
ADENOVIRUS DNA-REPLICATION INVITRO - IDENTIFICATION OF A HOST FACTOR THAT STIMULATES SYNTHESIS OF THE PRE-TERMINAL PROTEIN-DCMP COMPLEX

K NAGATA, RA GUGGENHEIMER, T ENOMOTO, JH LICHY, J HURWITZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 79(21) 6438-6442, 1982
ADENOVIRAL PROTEIN-PRIMED INITIATION OF DNA CHAINS INVITRO

JE IKEDA, T ENOMOTO, J HURWITZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 79(8) 2442-2446, 1982
MULTIPLE FORMS OF DNA-DEPENDENT ATPASE IN CALF THYMUS

Y WATANABE, Y TAWARAGI, T ENOMOTO, F HANAOKA, MA YAMADA

BIOCHEMISTRY INTERNATIONAL, 3(4) 407-413, 1981
ATP REQUIREMENT FOR THE PROCESSES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

T ENOMOTO, S TANUMA, M YAMADA

JOURNAL OF BIOCHEMISTRY, 89(3) 801-807, 1981

Books and Other Publications

14

生物系薬学IV 演習編

東京化学同人, Jun, 2011
生物系薬学II 第２版

東京化学同人, Dec, 2010
生物系薬学II 日本薬学会編

東京化学同人

200500
Molecular mechanism of Werner's syndrome edited by Michel Lebel Kluwer Academic

Plenum Publishers, New York,

200400
廣川タンパク質化学第４巻酵素福井哲也、伊藤正樹編

廣川書店

200300

Presentations

601

Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium, 2012
損傷乗り越え合成におけるWRNIP1とDNA polymerase etaの機能的関連の解析

日本薬学会第132年会北海道大学札幌市, 2012
システムバイオロジーの構築を指向した新戦略：FD-LC-MS/MS法の活用

日本薬学会第132年会北海道大学札幌市, 2012
Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium, 2012
Antioxidant protein, either SOD1, SOD2 or PRDX1 is required for normal cell growth in vertebrate cells.

Gordon Research Conference; Oxidative Stress and Disease Ventura CA USA, 2011

Professional Memberships

7

Works

56

Research Projects

2

新たなDNA修復、組み換え機構及びその発生学的役割

1995 - 1996
Novel mechanism and developmental roles of repair recombination

1995 - 1996

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