研究者業績

榎本武美

エノモトタケミ (ENOMOTO TAKEMI)

基本情報

所属: 武蔵野大学薬学部薬学部薬学科教授

学位: 学士(東京大学)
修士(東京大学)
博士(東京大学)

J-GLOBAL ID: 200901056088076439
researchmap会員ID: 1000183964

研究キーワード

6

研究分野

1

ライフサイエンス / 分子生物学 /

経歴

18

もっとみる

学歴

7

もっとみる

MISC

267

ADENOVIRUS DNA-REPLICATION INVITRO - PURIFICATION OF THE TERMINAL PROTEIN IN A FUNCTIONAL FORM

T ENOMOTO, JH LICHY, JE IKEDA, J HURWITZ

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES 78(11) 6779-6783 1981年
ACCUMULATION OF S-PHASE POPULATIONS OF FM3A CELLS GROWING IN THE MOUSE DUE TO ADMINISTRATION OF 5-FLUORO-2'-DEOXYURIDINE

F HANAOKA, K NAGATA, Y WATANABE, T ENOMOTO, MA YAMADA

CELL STRUCTURE AND FUNCTION 6(4) 357-365 1981年
MULTIPLE FORMS OF DNA-DEPENDENT ATPASE IN CALF THYMUS

Y WATANABE, Y TAWARAGI, T ENOMOTO, F HANAOKA, MA YAMADA

BIOCHEMISTRY INTERNATIONAL 3(4) 407-413 1981年
ATP REQUIREMENT FOR THE PROCESSES OF DNA-REPLICATION IN ISOLATED HELA-CELL NUCLEI

T ENOMOTO, S TANUMA, M YAMADA

JOURNAL OF BIOCHEMISTRY 89(3) 801-807 1981年
ACCUMULATION OF S-PHASE POPULATIONS OF FM3A CELLS GROWING IN THE MOUSE DUE TO ADMINISTRATION OF 5-FLUORO-2'-DEOXYURIDINE

F HANAOKA, K NAGATA, Y WATANABE, T ENOMOTO, MA YAMADA

CELL STRUCTURE AND FUNCTION 6(4) 357-365 1981年
HYDROGEN-EXCHANGE STUDY OF A NUCLEOSOME

Y MITANE, M NAKANISHI, M TSUBOI, T KOHWISHIGEMATSU, T ENOMOTO, MA YAMADA

FEBS LETTERS 121(1) 130-132 1980年
CHARACTERIZATION OF DNA-SYNTHESIS IN SALT-TREATED HELA-CELL NUCLEI

SI TANUMA, T ENOMOTO, MA YAMADA

CELL STRUCTURE AND FUNCTION 5(1) 27-37 1980年
HYDROGEN-EXCHANGE STUDY OF A NUCLEOSOME

Y MITANE, M NAKANISHI, M TSUBOI, T KOHWISHIGEMATSU, T ENOMOTO, MA YAMADA

FEBS LETTERS 121(1) 130-132 1980年
CHARACTERIZATION OF DNA-SYNTHESIS IN SALT-TREATED HELA-CELL NUCLEI

SI TANUMA, T ENOMOTO, MA YAMADA

CELL STRUCTURE AND FUNCTION 5(1) 27-37 1980年
Distribution of poly(ADP-ribose) in histones of HeLa cell nuclei.

Tanuma, S, nomoto, T, d Yamada, M. HeLa

Biochem Biophys Res Commun 74(2) 599-605 1977年

197700
Distribution of poly(ADP-ribose) in histones of HeLa cell nuclei.

Biochem Biophys Res Commun 74(2) 599-605 1977年

197700
Binding specificity of a HeLa DNA-binding protein to DNA and homopolymers.

Enomoto, T, d Yamada, M. HeLa

Biochem. Biophys. Res. Commun. 71(1) 122-127 1976年

197600
Binding specificity of a HeLa DNA-binding protein to DNA and homopolymers.

Biochem. Biophys. Res. Commun. 71(1) 122-127 1976年

197600
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.

Kobayashi, T, Tada, S, Tsuyama, T, Murofushi, H, Seki, M, nomoto, T

J. Cell Sci. 115 3159-3169

200200
Efficient replication of polyomavirus DNA in a cell-free system supplemented with Escherichia coli single-stranded DNA binding protein, which exhibits species-specificity in the requirement for DNA polymerase α-primase.

Eki, T, Hanaoka, F, Kohda, T, Seki, M, Ui, M, nomoto, T

J. Biochem. 118 435-441

199500
Characterization of DNA synthesis and DNA-dependent ATPase activity at a restrictive temperature in temperature-sensitive tsFT848 cells with thermolabile DNA helicase B.

Seki, M, Kohda, T, Yano, T, Tada, S, Yanagisawa, J, Eki, T, Ui, M, nomoto, T

Mol. Cell. Biol. 15 165-172

199500
Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.

Seki, M, Yanagisawa, J, Kohda, T, Sonoyama, T, Ui, M, nomoto, T

J. Biochem. 115 523-531

199400
Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

Masutani, C, Sugasawa, K, Yanagisawa, J, Sonoyama, T, Ui, M, nomoto, T, Takio, K, Tanaka, K, van der Spek, P.J, Bootsma, D, Hoeijimakers, J. H. J, Hanaoka, F

EMBO J. 13 1831-1843

199400
Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.

Kimura, K, Saijo, M, Ui, M, nomoto, T

J. Biol. Chem. 269 1173-1176

199400
Characterization of DNA synthesis at a restrictive temperature in the temperature-sensitive mutants, tsFT5 cells, that belong to the complementation group of ts85 cells containing a thermolabile ubiquitin-activating enzyme E1. Involvement of the ubiqui・・・

Mori, M, Eki, T, Takahashi-Kudo, M, Hanaoka, F, Ui, M, nomoto, T

J. Biol. Chem. 268 16803-16809

Characterization of DNA synthesis at a restrictive temperature in the temperature-sensitive mutants, tsFT5 cells, that belong to the complementation group of ts85 cells containing a thermolabile ubiquitin-activating enzyme E1. Involvement of the ubiquitin-conjugating system in DNA replication.<br /> 199300
Termination complex in Escherichia coli inhibits SV40 DNA replication in vitro by impeding the action of T antigen helicase.

Hidaka, M, Kobayashi, T, Ishimi, Y, Seki, M, nomoto, T, Abdel-Monem, M, Horiuchi, T

J. Biol. Chem. 267 5361-5365

199200
DNA-dependent adenosinetriphosphatase C1 from mouse FM3A cells has DNA helicase activity.

Yanagisawa, J, Seki, M, Kohda, T, nomoto, T, Ui, M

J. Biol. Chem. 267 3644-3649

199200
Alteration of a DNA-dependent ATPase activity in xeroderma pigmentosum complementation group C cells.

Yanagisawa, J, Seki, M, Ui, M, nomoto, T

J. Biol. Chem. 267 3585-3588

199200
DNA primase stimulatory factor from mouse FM3A cells has an RNase H activity. Purification of the factor and analysis of the stimulation.

Masutani, C, nomoto, T, Suzuki, M, Hanaoka, F, Ui, M

J. Biol. Chem. 256 10210-10216

199000
Characterization of chromosome aberrations induced by incubation at a restrictive temperature in the mouse temperature-sensitive mutant tsFT20 strain containing heat-labile DNA polymerase α.

Eki, T, nomoto, T, Murakami, Y, Hanaoka, F, Yamada, M

Cancer Res 47 5162-5170

198700
Characterization of DNA replication at a restrictive temperature in a mouse DNA temperature-sensitive mutant, tsFT20 strain, containing heat-labile DNA polymerase activity.

Eki, T, Murakami, Y, nomoto, T, Hanaoka, F, Yamada, M

J. Biol. Chem. 261 8888-8893

198600
Dissociation and reconstitution of a DNA polymerase-primase complex.

Suzuki M, nomoto, T, Hanaoka, F, Yamada, M

J. Biochem. 98 581-584

198500
Purification and characterization of a factor stimulating DNA polymerase activity from mouse FM3A cells.

Kawasaki, K, Nagata, K, nomoto, T, Hanaoka, F, Yamada, M

J. Biochem. 95 485-493

198400
Detection of two factors stimulating DNA polymerase activity on heat-denatured DNA from mouse FM3A cells.

Kawasaki, K, Nagata, K, nomoto, T, Hanaoka, F, Yamada, M

Biochem. Intl. 5 121-128

198200
Replication of adenovirus DNA-protein complex with purified proteins.

Ikeda, J-E, nomoto, T, Hurwitz, J

Proc. Natl. Acad. Sci. 78 884-888

198100
A system of DNA replication in HeLa nuclei treated with inhibitors of protein synthesis.

Nagata, K, nomoto, T, Yamada, M

Biochim. Biophys. Acta 653 316-30

198100
Recognition of heterologous cells by macrophages. II The mechanism of phagocytosis of chicken thymocytes by mouse and guinea pig macrophages.

Sugimoto, M, Sano, K, nomoto, T, Yamada, M, Egashira, Y

Microbiol. Immunol. 24 969-979

198000
Variation of two forms of DNA polymerase during a HeLa cell cycle.

Ono, Y, nomoto, T, d Yamada, M. HeLa

Gann 70 527-532

197900
Effect of thymidine on poly ADP-ribosylation in vivo.

Tanuma, S, nomoto, T, Yamada, M

J. Biol. Chem. 254 4960-4962

197900
Separation of two forms of HeLa DNA polymerase with different binding affinity to DNA.

Ono, Y, nomoto, T, Hanaoka, F, Yamada, M. HeLa

Gann 69 207-212

197800
Exposure of DNA bases induced by the interaction of DNA and calf thymus DNA helix-destabilizing protein.

Kohwi-Shigematsu, T, nomoto, T, Yamada, M, Nakanishi, M, Tsuboi, M

Proc. Natl. Acad. Sci. 75 4689-4693

197800
Changes in the level of poly ADP-ribosylation during a HeLa cell cycle.

Tanuma, S, nomoto, T, Yamada, M

Exp. Cell Res. 117 421-430

197800
Focus-formation of replication protein A, activation of checkpoint system and DNA repair synthesis induced by DNA double-strand breaks in Xenopus egg extract.

J. Cell Sci. 115 3159-3169

200200
Elevation of sister chromatid exchange in Saccharomyces cerevisiae sgs1 disruptants and the relevance of the disruptants as a system to evaluate mutations in Bloom's syndrome gene.

Mutat. Res. 459 203-209

200000
Characterization of DNA synthesis and DNA-dependent ATPase activity at a restrictive temperature in temperature-sensitive tsFT848 cells with thermolabile DNA helicase B.

Mol. Cell. Biol. 15 165-172

199500
Purification of two DNA-dependent adenosinetriphosphatases having DNA helicase activity from HeLa cells and comparison of the properties of the two enzymes.

J. Biochem. 115 523-531

199400
Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.

EMBO J. 13 1831-1843

199400
Identification of the nature of modification that causes the shift of DNA topoisomerase II to apparent higher molecular weight forms in the M phase.

J. Biol. Chem. 269 24523-24526

199400
Growth state- and cell cycle-dependent fluctuation in the expression of two forms of DNA topoisomerase II and possible specific modification of the higher molecular weight form in the M phase.

J. Biol. Chem. 269 1173-1176

199400
Characterization of DNA synthesis at a restrictive temperature in the temperature-sensitive mutants, tsFT5 cells, that belong to the complementation group of ts85 cells containing a thermolabile ubiquitin-activating enzyme E1. Involvement of the ubiqui・・・

J. Biol. Chem. 268 16803-16809

Characterization of DNA synthesis at a restrictive temperature in the temperature-sensitive mutants, tsFT5 cells, that belong to the complementation group of ts85 cells containing a thermolabile ubiquitin-activating enzyme E1. Involvement of the ubiquitin-conjugating system in DNA replication.<br /> 199300
Termination complex in Escherichia coli inhibits SV40 DNA replication in vitro by impeding the action of T antigen helicase.

J. Biol. Chem. 267 5361-5365

199200
DNA-dependent adenosinetriphosphatase C1 from mouse FM3A cells has DNA helicase activity.

J. Biol. Chem. 267 3644-3649

199200
Alteration of a DNA-dependent ATPase activity in xeroderma pigmentosum complementation group C cells.

J. Biol. Chem. 267 3585-3588

199200
Isolation of temperature-sensitive cell cycle mutants from mouse FM3A cells. Characterization of mutants with special reference to DNA replication.

J. Biol. Chem. 265 26-33

199000
DNA primase stimulatory factor from mouse FM3A cells has an RNase H activity. Purification of the factor and analysis of the stimulation.

J. Biol. Chem. 256 10210-10216

199000

書籍等出版物

14

生物系薬学IV 演習編

東京化学同人 2011年6月
生物系薬学II 第２版

東京化学同人 2010年12月
生物系薬学II 日本薬学会編

東京化学同人

200500
Molecular mechanism of Werner's syndrome edited by Michel Lebel Kluwer Academic

Plenum Publishers, New York,

200400
廣川タンパク質化学第４巻酵素福井哲也、伊藤正樹編

廣川書店

200300

もっとみる

講演・口頭発表等

601

Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium 2012年
損傷乗り越え合成におけるWRNIP1とDNA polymerase etaの機能的関連の解析

日本薬学会第132年会北海道大学札幌市 2012年
システムバイオロジーの構築を指向した新戦略：FD-LC-MS/MS法の活用

日本薬学会第132年会北海道大学札幌市 2012年
Optimization of intracellular reactive oxygen species levels by antioxidant proteins in vertebrate cells

Sugahara Memorial International Symposium 2012年
Antioxidant protein, either SOD1, SOD2 or PRDX1 is required for normal cell growth in vertebrate cells.

Gordon Research Conference; Oxidative Stress and Disease Ventura CA USA 2011年

もっとみる

所属学協会

7

もっとみる

Works(作品等)

56

ゲノム安定化に寄与するRECQL1とRECQL5の機能の解析文部科学省基盤研究（B）

2011年4月 - 2014年3月
ウェルナー症候群原因遺伝子産物ＷＲＮとＷＲＮに結合するＷＲＮＩＰ１の機能の解析文部科学省基盤研究（B）

2008年4月 - 2011年3月
DNA複製フォークの傷害回避とRecQファミリーヘリカーゼの機能文部科学省特定領域研究（がん）

2005年4月 - 2010年3月
姉妹染色分体接着機構と複製フォーク再生機構との関連(蛋白質・核酸・酵素)

2009年3月
RecQ family helicases in genome stability: Lessons from gene disrupted DT40 cells.(Cell Cycle)

2008年8月

もっとみる

共同研究・競争的資金等の研究課題

2

新たなDNA修復、組み換え機構及びその発生学的役割

1995年 - 1996年
Novel mechanism and developmental roles of repair recombination

1995年 - 1996年

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