ENOMOTO TAKEMI

(榎本武美)

Profile Information

Affiliation: Professor, Musashino University

Degree: 学士(東京大学)
修士(東京大学)
博士(東京大学)

J-GLOBAL ID: 200901056088076439
researchmap Member ID: 1000183964

Research Interests

Research Areas

Life sciences / Molecular biology /

Research History

Education

- 1981

アルバートアインシュタイン医科大学
- 1975

The University of Tokyo
- 1975

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo
- 1972

The University of Tokyo
- 1972

Graduate School, Division of Pharmaceutical Sciences, The University of Tokyo

Misc.

267

WRNIP1 accumulates at laser light irradiated sites rapidly via its ubiquitin-binding zinc finger domain and independently from its ATPase domain

Hironoshin Nomura, Akari Yoshimura, Takato Edo, Shin-ichiro Kanno, Syusuke Tada, Masayuki Seki, Akira Yasui, Takemi Enomoto

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 417(4) 1145-1150, Jan, 2012
Nucleosome surface containing nucleosomal DNA entry/exit site regulates H3-K36me3 via association with RNA polymerase II and Set2

Hirohito Endo, Yu Nakabayashi, Satoshi Kawashima, Takemi Enomoto, Masayuki Seki, Masami Horikoshi

GENES TO CELLS, 17(1) 65-81, Jan, 2012
Embryonic Lethality in Mice Lacking Mismatch-Specific Thymine DNA Glycosylase Is Partially Prevented by DOPS, a Precursor of Noradrenaline

Yusuke Saito, Tetsuya Ono, Naoki Takeda, Takehiko Nohmi, Masayuki Seki, Takemi Enomoto, Tetsuo Noda, Yoshihiko Uehara

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 226(1) 75-83, Jan, 2012
Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication

Katsuyuki Ishikawa, Tatsuya Ohsumi, Shusuke Tada, Ryo Natsume, Lena Rani Kundu, Naohito Nozaki, Toshiya Senda, Takemi Enomoto, Masami Horikoshi, Masayuki Seki

GENES TO CELLS, 16(10) 1050-1062, Oct, 2011
Roles of histone chaperone CIA/Asf1 in nascent DNA elongation during nucleosome replication

Katsuyuki Ishikawa, Tatsuya Ohsumi, Shusuke Tada, Ryo Natsume, Lena Rani Kundu, Naohito Nozaki, Toshiya Senda, Takemi Enomoto, Masami Horikoshi, Masayuki Seki

GENES TO CELLS, 16(10) 1050-1062, Oct, 2011

Books and Other Publications

生物系薬学IV 演習編

東京化学同人, Jun, 2011
生物系薬学II 第２版

東京化学同人, Dec, 2010
生物系薬学II 日本薬学会編

東京化学同人

200500
Molecular mechanism of Werner's syndrome edited by Michel Lebel Kluwer Academic

Plenum Publishers, New York,

200400
廣川タンパク質化学第４巻酵素福井哲也、伊藤正樹編

廣川書店

200300

Presentations

601

Acetylation of histone H3-K56 regulates homologous recombination

2009
The role of FACT in DNA replication

Swiss-Japan joint metting on the molecular mechanisms regulating "Chromosome dynamics and Genome stability" Villars Ollons, Switzerland, 2009
Regulation of DNA replication initiation by Cdc6 and its implication in anti-cancer

2009
Suppression of the initiation of DNA replication by Cdc6, a protein essential for the pre-replicative complex formation

2009
Analysis of functional relationships between Claspin and Rad17

2009
Nuclear superoxide may trigger spontaneous sister chromatid exchanges

2009
Analysis of DNA replication repression by excess Cdt1

2009
A mutant protein of histone chaperone CIA/Asf1 defective in disrupting histone (H3-H4)2 tetramer accelerates rate of DNA replication

2009
Histone chaperone FACT is involved in efficient elongation of nascent DNA chain

2009
Global analysis of mutual interaction surfaces of nucleosomes with comprehensive point mutants

2009
Acetylation of histone H3-K56 regulates homologous recombination

2009
異所的なCdt1活性に伴うDNA複製抑制機構の解析

第19回 DNA 複製・分配ワークショップ・2007 年度組換え・染色体再編ワークショップ合同ワークショップ伊豆市, 2008
ヒストンH2Aのacidic patch領域の解析

日本薬学会第128年会横浜, 2008
RecQL4のDNA二本鎖切断誘発時における挙動の解析

日本薬学会第128年会横浜, 2008
Novel function of Rmi1, a subunit of the Sgs1-Top3 complex, of Saccharomyces cerevisiae in sister chromatid cohesion

2008
DNA組換え修復酵素Rad52のSUMO修飾による制御機構の解析

第19回 DNA 複製・分配ワークショップ・2007 年度組換え・染色体再編ワークショップ合同ワークショップ伊豆市, 2008
Cdc6によるDNA複製開始過程の抑制

第19回 DNA 複製・分配ワークショップ・2007 年度組換え・染色体再編ワークショップ合同ワークショップ伊豆市, 2008
KU70 and DNA-PKcs are essential for the rapid induction of apoptosis after massive DSB formation

Ataxia-telangiectasia workshop 2008, 2008
Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion

2008 EMBO conference on DNA recombination Il Cioccol, Italy, 2008
SOD1条件欠損細胞の作製とその性状解析

第5回東北大学バイオサイエンスシンポジウム仙台, 2008
Rad52がSUMO修飾を受けるための必要条件とその修飾の意義

第5回東北大学バイオサイエンスシンポジウム仙台, 2008
DNA複製開始過程におけるCdc6の活性制御の意義

第5回東北大学バイオサイエンスシンポジウム仙台, 2008
Inhibition of DNA Replication by the Replication Licensing Factor Cdc6

Second JCA-AACR Special Joint Conference, 2008
Significance of regulating Cdc6 during the initiation of DNA replication

NCRI Cancer Conference 2008 Birmingham, England, 2008
Repression of nascent strand elongation of DNA replication by deregulated Cdt1 in Xenopus egg extracts.

The 6th 3R Symposium Tsumagoi, 2008
Functional analysis of RecQL4 using RecQL4 mutated cells.

The 6th 3R Symposium Tsumagoi, 2008
Effects of deregulating Cdc6 during the initiation of DNA replication.

The 6th 3R Symposium Tsumagoi, 2008
Analyses of the role of budding yeast Rmi1, a member of the Sgs1-Top3 complex, in sister chromatid cohesion

The 6th 3R Symposium Tsumagoi, 2008
Accumulation of sumoylated Rad52 in checkpoint mutants

The 6th 3R Symposium Tsumagoi, 2008
染色体分配に必要なヒストンH4の機能領域の解析

第４７回日本薬学会東北支部大会岩手, 2008
高等動物細胞におけるチェックポイント因子Claspinの機能の解析

第４７回日本薬学会東北支部大会岩手, 2008
ヒストンH2Aの分子表面の解析

第４７回日本薬学会東北支部大会岩手, 2008
DNA傷害に応じたRecQL4の機能の解析

第４７回日本薬学会東北支部大会岩手, 2008
高等動物細胞におけるチェックポイント因子Claspinの機能の解析

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
ブルーム症候群原因遺伝子産物BLMのDNA複製及び姉妹染色分体接着における役割

日本環境変異原学会第３７回大会宜野湾市, 2008
ヒストンH2Aの分子表面の解析

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
ヌクレオソーム表面上のコアヒストン網羅的点変異体株による染色体分配における機能解析

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
ＤＮＡ複製開始調節におけるＣｄｃ６の機能の解析

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
WRNIP1はRAD18-RAD6に結合し、RAD18-RAD6のもつ複製フォーク様構造への結合を阻害する

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
SOD1枯渇によるゲノムの不安定化と細胞死はアスコルビン酸で抑制される

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
Requisite conditions for sumoylation of Rad52 and enhancement of the modification in checkpoint mutants

BMB2008, 2008
Nascent DNA elongation is repressed by deregulated Cdt1 in Xenopus egg extracts.

BMB2008, 2008
DNA傷害に応じたRecQL4の動態と相互作用タンパク質の機能解明

BMB2008（第31回日本分子生物学会年会・第81回日本生化学会大会合同大会）神戸, 2008
Budding yeast Rmi1 (a member of the Sgs1-Top3 complex) and sister chromatid cohesion: what's the connection?

BMB2008, 2008
Novel function of Rmi1, a subunit of the Sgs1-Top3 complex, of Saccharomyces cerevisiae in sister chromatid cohesion

2008
KU70 and DNA-PKcs are essential for the rapid induction of apoptosis after massive DSB formation

Ataxia-telangiectasia workshop 2008, 2008
Rmi1, a member of the Sgs1-Top3 complex in budding yeast, contributes to sister chromatid cohesion

2008 EMBO conference on DNA recombination Il Cioccol, Italy, 2008
Inhibition of DNA Replication by the Replication Licensing Factor Cdc6

Second JCA-AACR Special Joint Conference, 2008
Significance of regulating Cdc6 during the initiation of DNA replication

NCRI Cancer Conference 2008 Birmingham, England, 2008
Repression of nascent strand elongation of DNA replication by deregulated Cdt1 in Xenopus egg extracts.

The 6th 3R Symposium Tsumagoi, 2008

Professional Memberships

Works

Research Projects

新たなDNA修復、組み換え機構及びその発生学的役割

1995 - 1996
Novel mechanism and developmental roles of repair recombination

1995 - 1996

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