CVClient

服部 祐介

ハットリ ユウスケ  (Yusuke Hattori)

基本情報

所属
武蔵野大学 薬学部 薬学科 講師
学位
学士(東京農工大学)
修士(東京農工大学大学院)
博士(東京農工大学大学院)

J-GLOBAL ID
201701006797102120
researchmap会員ID
B000271129

外部リンク

研究キーワード

 1

論文

 65
  • Makiko Kobayashi, Yusuke Hattori, Tetsuo Sasaki, Jun-ichi Nishizawa, Makoto Otsuka
    Colloids and Surfaces A: Physicochemical and Engineering Aspects 630 2021年12月5日  
    In order to scientifically elucidate the difference in the dissolution characteristics of crystalline atorvastatin calcium (ATCH) and the amorphous ATC solids (ATC30 and ATC120) obtained by the grinding for 30 and 120 min, X-ray powder diffractometry (XRD), infrared (IR) spectroscopy, near-infrared (NIR) spectroscopy, terahertz (THz) spectroscopy and thermal analysis were measured, and compared with the result of dissolution kinetics analysis. ATCH showed characteristic crystalline XRD pattern, but ATC30 and ATC120 showed no XRD peak profiles, meaning that those completely transformed into the amorphous solids. ATCH, ATC30 and ATC120 showed also individual characteristic IR and NIR spectra, respectively. ATCH contained 3 mol of crystal water, but ATC30 and ATC120 contained weakly binding adsorbed water in the amorphous solids, respectively. The result of the dissolution kinetic analysis based on the dissolution model including the phase transition showed that the dissolution behaviors of ATCH, ATC30 and ATC120 were significantly different, respectively, reflecting their intermolecular interaction in the solids. THz was able to indicate a difference between the chemical structure of amorphous solids ATC30 and ATC120, which were not able to discriminate by the XRD.
  • Ryoma Tanaka, Sae Ishihara, Tetsuo Sasaki, Yusuke Hattori, Makoto Otsuka
    Journal of Pharmaceutical Sciences 110(9) 3289-3297 2021年9月  
  • Tomomi Takaku, Yusuke Hattori, Tetsuo Sasaki, Tomoaki Sakamoto, Makoto Otsuka
    JOURNAL OF NEAR INFRARED SPECTROSCOPY 29(2) 92-101 2021年4月  
    The effect of grinding on the pharmaceutical properties of matrix tablets consisting of ground glutinous rice starch (GRS) and theophylline (TH) was predicted by near infrared (NIR) spectroscopy. Ground GRS samples were prepared by grinding GRS in a planetary ball mill for 0-120 min, measured by X-ray diffractometry (XRD) and NIR, and then evaluated for crystallinity (%XRD) based on XRD profiles. Tablets containing TH (5 w/w%), ground GRS (94 w/w%), and magnesium stearate (1 w/w%) were formed by compression. Gel-forming and drug-release processes of the tablets were measured using a dissolution instrument with X-ray computed tomography (XCT). Swelling ratio (SWE) and mean drug-release time (MDT) were evaluated based on XCT and drug-release profiles, respectively. Calibration models for predicting percent %XRD, MDT, and SWE were constructed based on the NIR of ground GRS using partial least-squares. The results indicated the possibility of controlling the pharmaceutical properties of matrix tablets by altering the pre-gelatinization of GRS based on changes in their NIR spectra during the milling process.
  • Yusuke Hattori, Yuka Hoshi, Yasunori Ichimura, Yasuo Sugiura, Makoto Otsuka
    Applied Spectroscopy 2021年  
    The objective of this work is to demonstrate the potential of near-infrared spectroscopy for common screening of falsified medicines in the field by means of a device-independent universal discrimination approach. In order to provide a useful discrimination tool to protect people from low-quality medical products, not only is a low-cost and portable screening device necessary, but a reference library is also essential. The authors believe that a device-dependent reference library inhibits near-infrared spectroscopy from becoming a popular screening tool. In this study, to develop a device-independent method, discrimination performance is evaluated using different devices for training and testing. The training data sets for the reference library were prepared using a bench-top Fourier transform near-infrared spectrophotometer, and predictive discrimination was performed using the spectral data by a low-cost and portable wavelength dispersive near-infrared spectrophotometer. A near-infrared spectrum-based support vector machine was used for these purposes, but the screening resulted in low accuracy thought to be caused by the intrinsically device-dependent features of the spectra data. Thus, principal component analysis was performed to collect the proper components to discriminate low-quality products from standard products. The principal component score-based support vector machine was able to produce highly accurate results, identifying falsified products with no false positive cases.
  • Ryoma Tanaka, Supisara Osotprasit, Jomjai Peerapattana, Kazuhide Ashizawa, Yusuke Hattori, Makoto Otsuka
    PHARMACEUTICS 13(1) 2021年1月  
    The manufacturing of solid pharmaceutical dosage forms composed of cocrystals requires numerous processes during which there is risk of dissociation into parent molecules. Resonant acoustic wet granulation (RAG) was devised in an effort to complete theophylline-citric acid (THPCIT) cocrystal formation during the granulation process, thereby reducing the number of operations. In addition, the influence of granulation liquid was investigated. A mixture of anhydrous THP (drug), anhydrous CIT (coformer), and hydroxypropyl cellulose (granulating agent) was processed by RAG with water or ethanol as a granulation liquid. The purposes were to (i) form granules using RAG as a breakthrough method; (ii) accomplish the cocrystallization during the integrated unit operation; and (iii) characterize the final solid product (i.e., tablet). The RAG procedure achieved complete cocrystal formation (>99%) and adequately sized granules (d50: >250 mu m). The granulation using water (GW) facilitated formation of cocrystal hydrate which were then transformed into anhydrous cocrystal after drying, while the granulation using ethanol (GE) resulted in the formation of anhydrous cocrystal before and after drying. The dissolution of the highly dense GW tablet, which was compressed from granules including fine powder due to the dehydration, was slower than that of the GE tablet.

MISC

 6

講演・口頭発表等

 26

担当経験のある科目(授業)

 4

共同研究・競争的資金等の研究課題

 1

社会貢献活動

 3