Curriculum Vitaes
Profile Information
- Affiliation
- Faculty of Applied Life Science School of Animal Science, Nippon Veterinary and Life Science University
- J-GLOBAL ID
- 201501004715879753
- researchmap Member ID
- B000250402
Research Interests
27Research Areas
4Research History
6-
Oct, 2004 - May, 2007
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1995 - 1999
Education
2-
1991 - 1995
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1985 - 1991
Papers
44-
J Virol Methods., 311 114644, Jan, 2023 Peer-reviewed
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Journal of Leukocyte Biology, Feb, 2021 Peer-reviewed
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Immunological investigations, 1-19, Dec 13, 2019 Peer-reviewedBackground: Psychological stress affects the immune system. Upon stress occurrence, glucocorticoid is released that binds to the glucocorticoid receptor and regulates gene expression. Thus, we aimed to examine the stress-induced immunomodulatory mechanisms by investigating the expression patterns of stress-inducible genes in murine immune cells.Methods: BALB/c, C57BL/6, glucocorticoid-receptor congenic mice, and corticotropin-releasing hormone (CRH)-deficient mice were exposed to synthetic glucocorticoid, dexamethasone, or placed under a restraint condition. The expression level of stress-related genes, such as Rtp801, Gilz, Mkp-1, Bnip3, and Trp53inp1 was measured in the immune cells in these mice.Results: Short restraint stress induced Rtp801 and Gilz expressions that were higher in the spleen of BALB/c mice than those in C57BL/6 mice. Mkp-1 expression increased equally in these two strains, despite the difference in the glucocorticoid level. These three genes induced by short restraint stress were not induced in the CRH-deficient mice. In contrast, Bnip3 and Trp53inp1 were only upregulated upon longer restraint events. In the thymus, Trp53inp1 expression was induced upon short restraint stress, whereas Gilz expression constantly increased upon short and repetitive restraint stresses.Conclusion: These results suggest that singular and repetitive bouts of stress lead to differential gene expression in mice and stress-induced gene expression in thymocytes is distinct from that observed in splenocytes. Gilz, Rtp801, and Mkp-1 genes induced by short restraint stress are dependent on CRH in the spleen.
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Immunological investigations, 48(3) 303-320, Apr, 2019 Peer-reviewed
Misc.
31-
日本分子生物学会年会プログラム・要旨集(Web), 41st ROMBUNNO.2P‐0550 (WEB ONLY), 2018
Presentations
26Teaching Experience
11Professional Memberships
2Research Projects
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科研費 基盤C, 文科省, 2022 - 2024
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科研費 基盤C, 文科省, 2018 - 2020
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Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2009 - 2011
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Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2004 - 2005
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科学研究費助成事業, 日本学術振興会, 2002 - 2003