Faculty of Applied Life Science
基本情報
研究キーワード
27経歴
6-
2016年 - 現在
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2013年 - 2016年
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2007年 - 2013年
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2004年10月 - 2007年5月
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1999年 - 2007年
学歴
2-
1991年 - 1995年
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1985年 - 1991年
論文
44-
J Virol Methods. 311 114644 2023年1月 査読有り
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Journal of Leukocyte Biology 2021年2月 査読有り
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Immunological investigations 1-19 2019年12月13日 査読有りBackground: Psychological stress affects the immune system. Upon stress occurrence, glucocorticoid is released that binds to the glucocorticoid receptor and regulates gene expression. Thus, we aimed to examine the stress-induced immunomodulatory mechanisms by investigating the expression patterns of stress-inducible genes in murine immune cells.Methods: BALB/c, C57BL/6, glucocorticoid-receptor congenic mice, and corticotropin-releasing hormone (CRH)-deficient mice were exposed to synthetic glucocorticoid, dexamethasone, or placed under a restraint condition. The expression level of stress-related genes, such as Rtp801, Gilz, Mkp-1, Bnip3, and Trp53inp1 was measured in the immune cells in these mice.Results: Short restraint stress induced Rtp801 and Gilz expressions that were higher in the spleen of BALB/c mice than those in C57BL/6 mice. Mkp-1 expression increased equally in these two strains, despite the difference in the glucocorticoid level. These three genes induced by short restraint stress were not induced in the CRH-deficient mice. In contrast, Bnip3 and Trp53inp1 were only upregulated upon longer restraint events. In the thymus, Trp53inp1 expression was induced upon short restraint stress, whereas Gilz expression constantly increased upon short and repetitive restraint stresses.Conclusion: These results suggest that singular and repetitive bouts of stress lead to differential gene expression in mice and stress-induced gene expression in thymocytes is distinct from that observed in splenocytes. Gilz, Rtp801, and Mkp-1 genes induced by short restraint stress are dependent on CRH in the spleen.
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Immunological Investigations 48(3) 303-320 2019年4月 査読有り
MISC
31-
日本分子生物学会年会プログラム・要旨集(Web) 41st ROMBUNNO.2P‐0550 (WEB ONLY) 2018年
講演・口頭発表等
26担当経験のある科目(授業)
11共同研究・競争的資金等の研究課題
5-
文科省 科研費 基盤C 2022年 - 2024年
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文科省 科研費 基盤C 2018年 - 2020年
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日本学術振興会 科学研究費助成事業 2009年 - 2011年
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日本学術振興会 科学研究費助成事業 2004年 - 2005年
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日本学術振興会 科学研究費助成事業 2002年 - 2003年