Faculty of Veterinary Science
基本情報
研究キーワード
4研究分野
2経歴
4-
2018年4月 - 現在
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2011年4月 - 2018年3月
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2006年4月 - 2011年3月
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2002年4月 - 2006年3月
学歴
2-
1993年4月 - 1997年3月
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1987年4月 - 1993年3月
論文
23-
Open Veterinary Journal 13(12) 1708-1708 2023年Background: We previously reported that myocardial fibrosis may be one of the causes of left ventricular hypertrophy and cardiac dysfunction in dogs with hyperglucocorticism (HGC). The detailed mechanism by which myocardial fibrosis of the left ventricle occurs in dogs with hyperglucocorticism (HGC) remains unclear. Aim: This study investigated the mechanism by which HGC causes fibrosis of the left ventricle.Methods: The impacts of HGC on the heart by comparing samples obtained from high-dose glucocorticoid-treated (P) and untreated (C) dogs. The P group included healthy Beagle dogs (n=6) treated with prednisolone (2 mg/kg, bid, po) for 84 days, and the C group included healthy Beagle dogs (n=6) euthanized for unrelated reasons. In three of the P group dogs, serum was collected before the start of administration (Day 0) and on Day 84 to measure angiotensin II concentrations and oxidative stress markers (8-hydroxy-2’-deoxyguanosine (8OHdG), NADPH oxidase, and superoxide levels). Samples of the left ventricular free wall (LVFW), right ventricular free wall (RVFW), interventricular septum (IVS), and aortic root were harvested from both groups (n = 6 for each group). Using these tissue samples, angiotensin II type 1 receptor (AT1R), 8OHdG, and transforming growth factor β1 (TGFβ1) immunohistochemical stains were performed.Results: The blood NADPH oxidase concentration was significantly higher (P=0.027) in the P group 84 days after initiation of the medication compared to that before prednisolone treatment. By contrast, there was no significant difference in serum angiotensin II (P=0.450), 8OHdG (P=0.068), and superoxide (P=0.057) concentrations. The positive staining rates of AT1R, 8OHdG, and TGFβ1 in the heart (LVFW, RVFW, IVS, and aortic root) were significantly higher in the P group than those in the C group.Conclusion: Angiotensin II and oxidative stress in HGC may cause left ventricular fibrosis in dogs.
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Journal of pharmacological sciences 140(1) 48-53 2019年5月 査読有り責任著者
MISC
38-
JOURNAL OF PHARMACOLOGICAL SCIENCES 128(3) S171-S171 2015年7月
書籍等出版物
7講演・口頭発表等
33共同研究・競争的資金等の研究課題
5-
日本学術振興会 科学研究費助成事業 基盤研究(C) 2021年4月 - 2024年3月
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日本学術振興会 科学研究費助成事業 基盤研究(C) 2020年4月 - 2023年3月
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文部科学省 科学研究費補助金(基盤研究(C)) 2016年10月 - 2019年3月
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文部科学省 科学研究補助金(基盤研究(B)) 2011年4月 - 2014年3月
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動物疾病制御研究拠点プロジェクト(私立大学戦略的研究基盤形成支援事業) 2010年 - 2012年