Ryo Okamoto

(岡本亮)

Profile Information

Affiliation: Associate Professor, Faculty of Science and Technology Department of Science and Technology , Seikei University

Degree: 博士(理学)(Mar, 2009, 横浜市立大学)

J-GLOBAL ID: 201901015947934026
researchmap Member ID: B000349289

Research Interests

Research Areas

Research History

Apr, 2024 - Present

Associate Professor, Faculty of Science and Technology, Department of Science and Technology, Seikei University
Aug, 2023 - Mar, 2024

Associate Professor, Graduate School of Science, Osaka University
Jul, 2017 - Jul, 2023

Associate Professor, Department of Chemistry, Graduate School of Science, Osaka University
Sep, 2010 - Jun, 2017

Assistant Professor, Department of Chemistry, Graduate of School, Osaka University
Aug, 2009 - Aug, 2010

Postdoctoral Fellow for Research Abroad, JSPS

Education

Apr, 2006 - Mar, 2009

Yokoham City University
Apr, 2004 - Mar, 2006

Yokohama City University
Apr, 2000 - Mar, 2004

School of Science, Yokohama City University

Committee Memberships

Jun, 2024 - Present

評議員, 日本糖質学会
Jun, 2022 - Present

Frontiers Review Editor (Chemical Biology section of Frontiers in Chemistry and Frontiers in Molecular Biosciences)
2018 - Present

Editorial board, International Journal of Peptide Research and Therapeutics
Apr, 2023 - Mar, 2024

幹事, 日本化学会近畿支部

Awards

2015

Incentive Award of Japanese Society of Carbohydrate Research, Japanese Society of Carbohydrate Research

Ryo Okamoto
2012

Chemical Society of Japan Presentation Award 2012, Chemical Society of Japan

Ryo Okamoto
2009

日本糖質学会第１２回ポスター賞, 日本糖質学会

岡本亮

Papers

Expanding the Scope of Native Chemical Ligation in Glycopeptide Synthesis

Ryo Okamoto, Masayuki Izumi, Yasuhiro Kajihara

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, 16(3) 191-198, Sep, 2010 Peer-reviewed
Chemical Synthesis of Homogeneous Glycopeptides and Glycoproteins

Yasuhiro Kajihara, Naoki Yamamoto, Ryo Okamoto, Kiriko Hirano, Takefumi Murase

CHEMICAL RECORD, 10(2) 80-100, 2010 Peer-reviewed
Protein Cysteine Modifications: (2) Reactivity Specificity and Topics of Medicinal Chemistry and Protein Engineering

N. Nagahara, T. Matsumura, R. Okamoto, Y. Kajihara

CURRENT MEDICINAL CHEMISTRY, 16(34) 4490-4501, Dec, 2009 Peer-reviewed
Efficient Substitution Reaction from Cysteine to the Serine Residue of Glycosylated Polypeptide: Repetitive Peptide Segment Ligation Strategy and the Synthesis of Glycosylated Tetracontapeptide Having Acid Labile Sialyl-T-N Antigens

Ryo Okamoto, Shingo Souma, Yasuhiro Kajihara

JOURNAL OF ORGANIC CHEMISTRY, 74(6) 2494-2501, Mar, 2009 Peer-reviewedLead author
The study of glycopeptide syntheses: exploring concise O-linked sialylglycopeptide synthesis and glycopeptide coupling reaction

Ryo Okamoto, Yasuhiro Kajihara

TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, 20(114) 203-217, Sep, 2008 Peer-reviewedLead author
Semisynthesis of human complex type oligosaccharide library and chemical synthesis of glycopeptides and glycoprotein

Ryo Okamoto, Yasuhiro Kajihara

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 66(9) 893-905, Sep, 2008 Peer-reviewed
Efficient synthesis of MUC4 sialylglycopeptide through the new sialylation using 5-acetamido-neuraminamide donors

Ryo Okamoto, Shingo Souma, Yasuhiro Kajihara

JOURNAL OF ORGANIC CHEMISTRY, 73(9) 3460-3466, May, 2008 Peer-reviewedLead author
Chemical synthesis of a glycoprotein having an intact human complex-type sialyloligosaccharide under the Boc and Fmoc synthetic strategies

Naoki Yamamoto, Yasutaka Tanabe, Ryo Okamoto, Philip E. Dawson, Yasuhiro Kajihara

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(2) 501-510, Jan, 2008 Peer-reviewed
Uncovering a latent ligation site for glycopeptide synthesis

Ryo Okamoto, Yasuhiro Kajihara

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(29) 5402-5406, 2008 Peer-reviewedLead author
Synthesis of CMP-9"-modified-sialic acids as donor substrate analogues for mammalian and bacterial sialyltransferases

Yasuhiro Kajihara, Toshimi Kamitani, Reiko Sato, Naoki Kamei, Tatsuo Miyazaki, Ryo Okamoto, Thoru Sakakibara, Takashi Tsuji, Takeshi Yamamoto

CARBOHYDRATE RESEARCH, 342(12-13) 1680-1688, Sep, 2007 Peer-reviewed

Misc.

Insight into behavior and effect of a free sulfate group for glycosylation

満保章泰, 真木勇太, 真木勇太, 阿部純平, 信藤紘樹, 岡本亮, 和泉雅之, 山中秀介, 奥村光隆, 梶原康宏, 梶原康宏

日本糖質学会年会要旨集, 43rd, 2024
Revisiting the function of glycans on glycoproteins in protein-protein interaction

岡本亮, 岡本亮, 真木勇太, 真木勇太, 佐藤あやの, 梶原康宏, 梶原康宏

日本糖質学会年会要旨集, 41st, 2022
糖タンパク質の細胞内逆行輸送の定量化

佐藤あやの, 真木勇太, 川田一稀, 岡本亮, 梶原康宏

日本生化学会大会(Web), 95th, 2022
Glycopeptide synthesis for construction of quaternary structure of IgG antibody Fc region

西川晴美, 上田南, 真木勇太, 真木勇太, 岡本亮, 岡本亮, 和泉雅之, 梶原康宏, 梶原康宏

日本糖質学会年会要旨集, 41st, 2022
Chemical synthesis of glycosylated Cholera toxin B-subunit and its delivering into living cells

真木勇太, 佐藤あやの, 川田一希, 岡本亮, 梶原康宏

日本糖質学会年会要旨集, 40th, 2021

Presentations

化学合成糖タンパク質を利用し糖鎖の水和機能を探る

大阪大学蛋白質研究所セミナー、蛋白質に挑戦する化学, Mar 2, 2023 Invited
Dissecting the hydration of glycans on proteins by using total chemical synthesis of glycoproteins

International Congress on Pure & Applied Chemistry, Nov 25, 2022 Invited
非天然型糖タンパク質を合成し天然型糖鎖の機能を探る

第８回慶應有機化学若手シンポジウム, May 8, 2021 Invited
化学合成不凍糖タンパク質を利用したタンパク質糖鎖修飾機能の解明研究

岡本亮;折井亮;芝田大之;満保章泰;深見大地;津田栄;真木勇太;梶原康宏

第６１回天然有機化合物討論会, Sep, 2019
化学合成不凍糖タンパク質を利用したタンパク質糖鎖修飾機能の解明研究

岡本亮, 折井亮, 芝田大之, 満保章泰, 深見大地, 津田栄, 真木勇太, 梶原康宏

第38回日本糖質学会, Aug, 2019

Professional Memberships

Research Projects

New Synthetic Methods for Glycoproteins and the Integrated Approaches to Elucidate the Functions of Post-translational Modifications

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, Jul, 2021 - Mar, 2026
糖改変型複合糖質の迅速な系統合成法の開発と水を介した糖の複合糖質活性調節能の解明

科学研究費助成事業基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

岡本亮
Development of the new convergent one-pot peptide ligations for the synthesis of glycoproteins and crystallography

Grants-in-Aid for Scientific Research, JSPS, Apr, 2016 - Mar, 2019

Ryo Okamoto
化学合成糖タンパク質を利用したシアリル糖鎖構造と糖タンパク質活性相関の解明研究

第２７回加藤記念バイオサイエンス振興財団研究助成, 公益財団法人加藤記念バイオサイエンス振興財団, 2016 - 2017

岡本亮
Development of a high-speed peptide synthesis in aqueous solution by using guanidides and thioesters

Grants-in-Aid for Scientific Research, JSPS, Apr, 2014 - Mar, 2016

Ryo Okamoto

Industrial Property Rights

特許第6186278号 NCL法に適した、ポリペプチド断片の効率的な製造方法

梶原康宏, 岡本亮, 木村元春, 石井一之
特許第5730197号ペプチドチオエステル体の製造方法

梶原康宏, 岡本亮, 坂本泉, 石井一之
WO2013-047372 NCL法に適した、ポリペプチド断片の効率的な製造方法

梶原康宏, 岡本亮, 木村元春, 石井一之
WO2010-150730 ペプチドチオエステル体の製造方法

梶原康宏, 岡本亮, 坂本泉, 石井一之

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