研究者業績

Sachiko YANAGISAWA

  (柳澤 幸子)

Profile Information

Affiliation
University of Hyogo
Degree
Doctor of Philosophy(Jul, 2006, Faculty of Science, Agriculture and Engineering University of Newcastle upon Tyne)

J-GLOBAL ID
201801003242745601
researchmap Member ID
B000329623

Papers

 64
  • Sachiko Yanagisawa, Takuto Kamei, Atsuhiro Shimada, Stephanie Gladyck, Siddhesh Aras, Maik Hüttemann, Lawrence I. Grossman, Minoru Kubo
    Journal of Inorganic Biochemistry, 260 112673-112673, Nov, 2024  
  • Kaho Ueda, Wataru Sato, Sachiko Yanagisawa, Minoru Kubo, Masahiko Hada, Hiroshi Fujii
    Journal of Inorganic Biochemistry, 255 112544-112544, Jun, 2024  Peer-reviewed
  • Yoshiaki Kokubo, Kazuki Tsuzuki, Hikari Sugiura, Shunsuke Yomura, Yuko Wasada-Tsutsui, Tomohiro Ozawa, Sachiko Yanagisawa, Minoru Kubo, Tomoyuki Takeyama, Takahide Yamaguchi, Yuichi Shimazaki, Shinichi Kugimiya, Hideki Masuda, Yuji Kajita
    Inorganic Chemistry, 62(14) 5320-5333, Mar 27, 2023  
  • Mohan Zhang, Hulin Tai, Sachiko Yanagisawa, Masaru Yamanaka, Takashi Ogura, Shun Hirota
    The Journal of Physical Chemistry B, 127(11) 2441-2449, Mar 15, 2023  Peer-reviewed
  • Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Satoshi Ogasawara, Ken Shimuta, Takashi Iwamoto, Chisa Nakabayashi, Waka Matsumura, Hisakazu Kato, Chai Gopalasingam, Takemasa Nagao, Tasneem Qaqorh, Yusuke Takahashi, Satoru Yamazaki, Katsumasa Kamiya, Ryuhei Harada, Nobuhiro Mizuno, Hideyuki Takahashi, Yukihiro Akeda, Makoto Ohnishi, Yoshikazu Ishii, Takashi Kumasaka, Takeshi Murata, Kazumasa Muramoto, Takehiko Tosha, Yoshitsugu Shiro, Teruki Honma, Yasuteru Shigeta, Minoru Kubo, Seiji Takashima, Yasunori Shintani
    Nature Communications, 13 7591, Dec 8, 2022  Peer-reviewed
    Abstract Antimicrobial resistance (AMR) is a global health problem. Despite the enormous efforts made in the last decade, threats from some species, including drug-resistant Neisseria gonorrhoeae, continue to rise and would become untreatable. The development of antibiotics with a different mechanism of action is seriously required. Here, we identified an allosteric inhibitory site buried inside eukaryotic mitochondrial heme-copper oxidases (HCOs), the essential respiratory enzymes for life. The steric conformation around the binding pocket of HCOs is highly conserved among bacteria and eukaryotes, yet the latter has an extra helix. This structural difference in the conserved allostery enabled us to rationally identify bacterial HCO-specific inhibitors: an antibiotic compound against ceftriaxone-resistant Neisseria gonorrhoeae. Molecular dynamics combined with resonance Raman spectroscopy and stopped-flow spectroscopy revealed an allosteric obstruction in the substrate accessing channel as a mechanism of inhibition. Our approach opens fresh avenues in modulating protein functions and broadens our options to overcome AMR.

Misc.

 4

Presentations

 10

Research Projects

 4