研究者業績

原 光彦

ハラ ミツヒコ  (Hara Mitsuhiko)

基本情報

所属
和洋女子大学 家政学部 健康栄養学科 教授
学位
医学博士(日本大学)

連絡先
m-harawayo.ac.jp
J-GLOBAL ID
201601007955857753
researchmap会員ID
B000252201

1990年日本大学医学部大学院医学研究科卒
小児科医
資格
日本小児科学会専門医・指導医
日本アレルギー学会専門医
日本肥満学会肥満症専門医・指導医
日本臨床栄養学会認定臨床栄養医・指導医
日本体育協会公認スポーツドクター
産業医


主要な論文

 58
  • Tatsuhiko Urakami, Remi Kuwahara, Junichi Suzuki, Yuriko Abe, Mitsuhiko Hara, Ichiro Morioka
    Endocrine Journal 70(4) 115-452 2023年7月  査読有り
    The aim of the study was to determine the pathogenesis of non-obese children with type 2 diabetes, and its relationship with fat distribution. The study participants included 36 obese children with type 2 diabetes (age: 13.5 years, BMI: 28.3, BMI percentile: 91.9) and 30 non-obese children with type 2 diabetes (age: 13.5 years, BMI: 23.1, BMI percentile: 74.0). The proportion of female participants was significantly higher in non-obese children than in obese children (73.3% vs. 41.7%, p < 0.001). Abdominal fat distribution, evaluated by subcutaneous fat (SF) area, visceral fat (VF) area, and the ratio of VF area to SF area (V/S ratio), measured using computed tomography, and serum lipid levels and liver function were compared between the two groups. Non-obese children with type 2 diabetes had significantly smaller SF area and also smaller VF area than obese children with type 2 diabetes (SF area: 158.3 m2 vs. 295.3 m2, p < 0.001, VF area: 71.0 m2 vs. 94.7 m2, p = 0.032). Whereas non-obese children with type 2 diabetes had significantly greater V/S ratio than obese children with type 2 diabetes (0.41 vs. 0.31, p = 0.007).The prevalence of dyslipidemia and liver dysfunction were similar in the two groups. In conclusion, non-obese children with type 2 diabetes had excess accumulation of VF despite a small amount of SF, which might be associated with glucose intolerance and other metabolic disorders.
  • Katsumi Mizuno, Toshiaki Shimizu, Shinobu Ida, Setsuko Ito, Mikako Inokuchi, Toshihiro Ohura, Akihisa Okumura, Masanobu Kawai, Toru Kikuchi, Motoichiro Sakurai, Shigetaka Sugihara, Mitsuyoshi Suzuki, Kimitaka Takitani, Daisuke Tanaka, Sotaro Mushiake, Nobuo Yoshiike, Hiroko Kodama, Kazuo Okada, Chiharu Tsutsumi, Mitsuhiko Hara, Yoshio Hanawa, Kazue Kawakami, Hiroaki Inomata, Tatsuya Oguni, Yuko Bito, Keiichi Uchida, Akihide Sugiyama
    Pediatrics International 2020年  査読有り
    © 2019 The Authors. Pediatrics International published by John Wiley & Sons Australia, Ltd on behalf of Japan Pediatric Society For preterm and very low birthweight infants, the mother’s own milk is the best nutrition. Based on the latest information for mothers who give birth to preterm and very low birthweight infants, medical staff should encourage and assist mothers to pump or express and provide their own milk whenever possible. If the supply of maternal milk is insufficient even though they receive adequate support, or the mother’s own milk cannot be given to her infant for any reason, donor human milk should be used. Donors who donate their breast milk need to meet the Guideline of the Japan Human Milk Bank Association. Donor human milk should be provided according to the medical needs of preterm and very low birthweight infants, regardless of their family’s financial status. In the future, it will be necessary to create a system to supply an exclusive human milk-based diet (EHMD), consisting of human milk with the addition of a human milk-derived human milk fortifier, to preterm and very low birthweight infants.
  • 原光彦, 斉藤恵美子, 阿部百合子, 朝原 祟, 高橋琢也, 山城雄一郎
    肥満研究 24(3) 158-165 2018年12月  査読有り筆頭著者
  • 原 光彦, 斉藤恵美子, 阿部百合子, 岡田知雄
    肥満研究 23(2) 171-177 2017年1月  査読有り筆頭著者
  • Mitsuhiko Hara
    JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 23(3) 295-296 2016年  査読有り筆頭著者
  • Emiko Saito, Tomoo Okada, Yuriko Abe, Minako Odaka, Yuki Kuromori, Fujihiko Iwata, Mitsuhiko Hara, Hideo Mugishima, Yohei Kitamura
    OBESITY RESEARCH & CLINICAL PRACTICE 8(3) E266-E270 2014年5月  査読有り
    Background: Abdominal obesity alters the composition of plasma and tissue long chain fatty acids and thus affects a number of important physiological functions relating to the development of cardiometabolic diseases. The fatty acid composition is modulated by desaturases; stearoyl-CoA desaturase (SCD), delta-6 desaturase (D6D) and delta-5 desaturase (D5D). Therefore, we examined the relationship between the desaturase activities and abdominal adiposity. Methods: One hundred eighty-one children (98 males, 83 females), including 42 children with abdominal obesity having waist to height ratio (WHtR) &gt;0.5, were recruited. Fatty acid composition in plasma phospholipids was analyzed by gas chromatography after overnight fast, and SCD activity was estimated by 18:1/18:0 ratio. Results: In children without abdominal obesity, WHtR correlated positively with D6D activity (r = 0.252, p = 0.0027) and negatively with SCD activity (r = -0.289, p = 0.0006), but not with D5D activity (r = -0.159, p = 0.0607). While in children with abdominal obesity, WHtR had a positive association with SCD activity (r = 0.332, p = 0.0315), but not with D6D (r = 0.267, p = 0.0847) or D5D activity (r = 0.008, p = 0.9600). Conclusion: The relationship between the desaturase activities and abdominal adiposity altered in children with abdominal obesity. Especially, SCD activity demonstrated a U-shaped association with WHtR. (C) 2013 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
  • 高谷 竜三, 片山 博視, 森 保彦, 奥村 謙一, 玉井 浩, 岡田 知雄, 能登 信孝, 原 光彦, 石井 正浩, 稲井 慶, 中西 敏雄, 杉原 茂孝, 伊藤 けい子, 小林 浩司, 長嶺 健次郎, 吉永 正夫, 石川 貴充, 大関 武彦
    肥満研究 : 日本肥満学会誌 = Journal of Japan Society for the Study of Obesity 17(1) 49-53 2011年4月25日  査読有り
  • K Asayama, H Hayashibe, A Endo, T Okada, M Hara, H Masuda, S Sugihara
    PEDIATRICS INTERNATIONAL 47(5) 498-504 2005年10月  査読有り
    Background: In order to define the diagnostic criteria for visceral adipose tissue (VAT) accumulation and abdominal obesity in Japanese youths, a cross-sectional, multicenter study was conducted. Methods: Subjects were 194 boys and 96 girls ranging in age from 6 to 15 years. Obese youths were classified according to the occurrence of abnormal values in serum triglyceride, alanine aminotransferase or insulin level. A threshold value of each criterion was calculated, using the analysis of receiver operating characteristic (ROC) curve. The areas of total abdominal adipose tissue (AT), VAT and subcutaneous adipose tissue (SAT) were estimated by single slice computed tomography at the level of umbilicus. Results: VAT area was greater in boys than it was in girls. The critical values for VAT area and waist circumference in all subjects were 54.8 cm(2) and 83.5 cm, respectively. The values for the area under the ROC curves were VAT area &gt; total AT area &gt; waist circumference &gt; SAT area &gt; percentage overweight &gt; percentage body fat. The sensitivity and specificity for VAT area were 90.5 and 79.5%, respectively. Those for waist circumference were high enough (&gt; 70%) for clinical use. In the linear regression analysis assigning VAT area as an independent variable and waist circumference as a dependent variable, the expected value for the waist circumference was 82 cm. Conclusion: In Japanese obese youths ranging in age from 6 to 15 years, the diagnostic criteria for the waist circumference was 82 cm, and that for VAT area was 55 cm(2).
  • Hara M, Saitou E, Iwata F, Okada T, Harada K
    Journal of atherosclerosis and thrombosis 9(3) 127-132 2002年  査読有り筆頭著者

MISC

 122

主要な書籍等出版物

 14

講演・口頭発表等

 13

担当経験のある科目(授業)

 5

Works(作品等)

 3
  • 原 光彦, 堤ちはる, 太田百合子, 長谷川智子, 岩田富士彦, 花木啓一, 桑田弘美, 岡田知雄
    2021年3月16日 その他
  • 原 光彦, 位田 忍, 清水俊明, 杉原茂孝, 菊池 透, 土橋一重, 猪股弘明, 小國龍也, 岡田知雄, 太田百合子, 花木恵一, 井ノ口美香子, 内田恵一
    2019年3月 その他
  • 原 光彦, 岡田知雄, 杉原茂孝, 花木啓一, 菊池透, 太田百合子, 井ノ口美香子, 松野泰一
    2017年9月12日 その他

共同研究・競争的資金等の研究課題

 3

社会貢献活動

 8