医学部 内科

Tatsunori Nakano

  (中野 達徳)

Profile Information

Affiliation
School of Medicine Faculty of Medicine, Fujita Health University
Degree
博士(医学)

J-GLOBAL ID
201501001377709775
researchmap Member ID
7000012827

Education

 1

Papers

 109
  • Izumi Hasegawa, Tatsunori Nakano, Hiroki Koguchi, Naruomi Jinno, Noboru Hirashima, Shigeo Nagashima, Masaharu Takahashi, Kazumoto Murata, Hiroaki Okamoto
    Clinical journal of gastroenterology, May 4, 2022  Peer-reviewedCorresponding author
    A case of subclinical hepatitis E virus (HEV) infection was detected by nucleic acid amplification test on blood donation. The patient was followed-up until day 220 after the blood donation but showed no symptoms throughout the observation period. Aspartate aminotransferase and alanine aminotransferase levels reached the maximum values on day 37 with a slight increase but remained in normal ranges from day 67 to 220. The quantity of HEV RNA at the initial examination on day 13 was 1.1 × 102 copies/mL, which increased to 2.8 × 103 copies/mL by day 37. It was not detected from day 67 to 220. Immunoglobulin G class antibody to HEV (anti-HEV IgG) was below the cut-off value until day 37 and exceeded the cut-off value to positive on day 67, accompanied by normalization of liver function and negative conversion of HEV RNA. Thereafter, the titer decreased gradually, falling below the cut-off value on day 163, and continuing negative until day 220. Although the persistent duration of anti-HEV IgG positive is believed to be generally long, it was within only 126 days for this subclinical case. Further investigation is needed to determine whether short-term positivity for anti-HEV IgG is typical in subclinical HEV infection.
  • 中野 達徳, 西垣 洋一, 林 秀樹, 田尻下 聡子, 岩佐 太誠, 冨田 栄一, 鈴木 祐介, 清水 省吾, 杉原 潤一, 長嶋 茂雄, 高橋 雅春, 岡本 宏明, 村田 一素
    肝臓, 63(1) 35-38, Jan, 2022  
    岐阜県近郊で発生したE型肝炎13例のE型肝炎ウイルス(HEV)の感染源・感染経路を、問診と原因HEVの遺伝子配列の解析から推測した。全員孤発例であった。2例は生のブタ内臓肉、1例は調理したブタ内臓肉、7例は調理したブタ肉、2例は調理不十分なブタ肉の喫食歴があった。HEVゲノムのORF2領域の412塩基長の配列をもとに近隣結合法で系統樹を作成した。1例はORF1領域を解析した。原因HEVの遺伝子型は、3aが5例、3bが6例、3fが1例、4iが1例であった。13例中2例は原因HEV株に近縁株の登録はなかったが、11例には97%以上の相同性を持つ株が見つかり、地域内拡散8例、国内広域拡散2例、国際拡散1例の3つのパターンに類別された。
  • Naohito Urawa, Naohiko Yoshizawa, Yuji Kojima, Akira Hashimoto, Atsuya Shimizu, Takamitsu Tanaka, Shima Hamaoka, Soichiro Kobayashi, Tatsunori Nakano, Hiroshi Okano, Shigeo Nagashima, Masaharu Takahashi, Hiroaki Okamoto, Kazumoto Murata
    Acta Hepatologica Japonica, 62(6) 384-386, Jun 1, 2021  
    In Mie Prefecture, autochthonous hepatitis E cases occurred via homologous hepatitis E virus subgenotype 3e (HEV-3e), namely, Mie indigenous HEV-3e, from 2004 through 2014. We experienced three cases of autochthonous hepatitis E in 2020 in Mie Prefecture, and analyzed the partial HEV genomes recovered from them. The three HEV isolates clustered with Mie indigenous HEV-3e in the phylogenetic tree and exhibited high similarities to it. Mie indigenous HEV-3e had thus reemerged for the first time in six years. One affected patient often consumed meat of wild animals, and another ate undercooked pork liver, although the third case had no clear risk factors. Mie indigenous HEV-3e appears to be maintained in wild animals or domestic pigs.
  • 浦和 尚史, 吉澤 尚彦, 小島 裕治, 橋本 章, 清水 敦哉, 田中 隆光, 濱岡 志麻, 小林 壮一朗, 中野 達徳, 岡野 宏, 長嶋 茂雄, 高橋 雅春, 岡本 宏明, 村田 一素
    肝臓, 62(6) 384-386, Jun, 2021  Peer-reviewedCorresponding author
  • 中川 直樹, 中野 達徳, 阪口 亮平, 福井 淑崇, 樋口 国博, 中島 滋人, 高司 智史, 三好 美穂, 長嶋 茂雄, 高橋 雅春, 渡邉 省三, 竹井 謙之, 岡本 宏明
    肝臓, 61(5) 270-272, May, 2020  Peer-reviewedCorresponding author

Misc.

 22

Books and Other Publications

 8

Presentations

 76