総合医科学研究所 システム医科学

Tomoyuki Murano

  (村野 友幸)

Profile Information

Affiliation
総合医科学研究所, 藤田医科大学
Degree
学士(医学)
phD(The Graduate University for Advanced Studies)

ORCID ID
 https://orcid.org/0000-0002-9351-737X
J-GLOBAL ID
202101008576743119
researchmap Member ID
B000249228

脳の擬似未成熟化現象について研究しています

Research Interests

 2

Papers

 7
  • Hideo Hagihara, Tomoyuki Murano, Tsuyoshi Miyakawa
    Frontiers in Psychiatry, 14 1151480, May 2, 2023  Peer-reviewed
  • Tomoyuki Murano, Ryuichi Nakajima, Akito Nakao, Nao Hirata, Satoko Amemori, Akira Murakami, Yukiyasu Kamitani, Jun Yamamoto, Tsuyoshi Miyakawa
    Proceedings of the National Academy of Sciences of the United States of America, 119(32) e2106830119, Aug 9, 2022  
    The dentate gyrus (DG) plays critical roles in cognitive functions, such as learning, memory, and spatial coding, and its dysfunction is implicated in various neuropsychiatric disorders. However, it remains largely unknown how information is represented in this region. Here, we recorded neuronal activity in the DG using Ca2+ imaging in freely moving mice and analyzed this activity using machine learning. The activity patterns of populations of DG neurons enabled us to successfully decode position, speed, and motion direction in an open field, as well as current and future location in a T-maze, and each individual neuron was diversely and independently tuned to these multiple information types. Our data also showed that each type of information is unevenly distributed in groups of DG neurons, and different types of information are independently encoded in overlapping, but different, populations of neurons. In alpha-calcium/calmodulin-dependent kinase II (αCaMKII) heterozygous knockout mice, which present deficits in spatial remote and working memory, the decoding accuracy of position in the open field and future location in the T-maze were selectively reduced. These results suggest that multiple types of information are independently distributed in DG neurons.
  • Hideo Hagihara, Tomoyuki Murano, Koji Ohira, Miki Miwa, Katsuki Nakamura, Tsuyoshi Miyakawa
    Molecular brain, 12(1) 108-108, Dec 10, 2019  Peer-reviewed
    It is agreed upon that adult hippocampal neurogenesis (AHN) occurs in the dentate gyrus (DG) in rodents. However, the existence of AHN in humans, particularly in elderly individuals, remains to be determined. Recently, several studies reported that neural progenitor cells, neuroblasts, and immature neurons were detected in the hippocampus of elderly humans, based on the expressions of putative markers for these cells, claiming that this provides evidence of the persistence of AHN in humans. Herein, we briefly overview the phenomenon that we call "dematuration," in which mature neurons dedifferentiate to a pseudo-immature status and re-express the molecular markers of neural progenitor cells and immature neurons. Various conditions can easily induce dematuration, such as inflammation and hyper-excitation of neurons, and therefore, the markers for neural progenitor cells and immature neurons may not necessarily serve as markers for AHN. Thus, the aforementioned studies have not presented definitive evidence for the persistence of hippocampal neurogenesis throughout adult life in humans, and we would like to emphasize that those markers should be used cautiously when presented as evidence for AHN. Increasing AHN has been considered as a therapeutic target for Alzheimer's disease (AD); however, given that immature neuronal markers can be re-expressed in mature adult neurons, independent of AHN, in various disease conditions including AD, strategies to increase the expression of these markers in the DG may be ineffective or may worsen the symptoms of such diseases.
  • Tomoyuki Murano
    Communications Biology, 2 32, Jan 22, 2019  Peer-reviewed
  • Tomoyuki Murano, Hideo Hagihara, Katsunori Tajinda, Mitsuyuki Matsumoto, Tsuyoshi Miyakawa
    Communications biology, 2 94, 2019  
    [This corrects the article DOI: 10.1038/s42003-018-0277-2.].

Misc.

 2

Presentations

 10

Research Projects

 1