研究者業績

松田 勇紀

マツダ ユウキ  (Yuki Matsuda)

基本情報

所属
藤田医科大学 臨床研究・開発教育学 講師
(兼任)医学教育企画室 室員
東京慈恵会医科大学 精神医学講座 非常勤講師
国立研究開発法人国立精神・神経医療研究センター 精神診療部 研究生
学位
学士(医学)(2010年3月 藤田医科大学)
博士(医学)(2016年3月 藤田医科大学大学院)
社会健康医学修士(専門職)(2024年3月 京都大学大学院)

researchmap会員ID
B000247656

外部リンク

受賞

 5

論文

 74
  • Daisuke Hayashi, Ryuichi Yamazaki, Yuki Matsuda, Shun Igarashi, Nanase Taruishi, Fumitoshi Kodaka, Masahiro Shigeta, Shinsuke Kito
    Neuropsychobiology 1-8 2024年6月18日  査読有り
    INTRODUCTION: The clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression (TRD) in Japan has not been adequately investigated. Furthermore, the relationship between stimulation-site pain and the antidepressant effects of rTMS has not been thoroughly examined. Therefore, this study aimed to clarify (1) the real-world efficacy and safety of rTMS for TRD in Japan and (2) the relationship between stimulation-site pain and clinical improvement of depressive symptoms. METHODS: We conducted a retrospective observational study involving 50 right-handed patients with TRD. All patients received high-frequency rTMS for up to 6 weeks. Depressive symptoms were assessed using the Montgomery-Åsberg depression rating scale (MADRS). Pain at the stimulation site was reported by the patients using a visual analog scale (VAS) after each session. Remission and response rates at 3 and 6 weeks were calculated based on the MADRS scores. The correlation between changes in the MADRS and VAS scores was examined. RESULTS: Remission and response rates were 36% and 46%, respectively, at the end of 3 weeks, and 60% and 70%, respectively, at 6 weeks. At the end of the treatment, there was significant correlation between the reduction of MADRS and VAS scores (r = 0.42, p = 0.003). CONCLUSION: This study demonstrates the clinical efficacy of rTMS in Japan and the correlation between its antidepressant effects and stimulation-site pain.
  • Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Masakazu Hatano, Yuki Matsuda, Jonas Wilkening, Roberto Goya-Maldonado, Martin Tik, Nolan R Williams, Shinsuke Kito, Nakao Iwata
    Molecular psychiatry 2024年6月6日  査読有り
    In clinical practice, theta burst stimulation (TBS) presents as a more efficient and potentially more effective therapeutic modality than conventional repetitive transcranial magnetic stimulation (rTMS), as it allows for the delivery of more stimuli in less time and at similar intensities. To date, accelerated treatment plans according to various continuous (cTBS) and intermittent TBS (iTBS) protocols for depression have been proposed. To investigate which of the TBS protocols provided a favorable risk-benefit balance for individuals with depression, this systematic review and random-effects model network meta-analysis was conducted. The study outcomes included response rate (primary), depression symptom improvement, remission rate, all-cause discontinuation rate, incidence of switch to mania, and incidence of headache/discomfort at treatment site. In this meta-analysis, a total of 23 randomized controlled trials (n = 960, mean age = 41.88 years, with 60.78% females) were included. Approximately 69.57% of the trials included individuals with an exclusive diagnosis of major depressive disorder. The following six TBS protocols (target) were evaluated: cTBS (right-dorsolateral prefrontal cortex [R-DLPFC]), cTBS (R-DLPFC) + iTBS (left-DLPFC [L-DLPFC]), iTBS (L-DLPFC), iTBS (L-DLPFC) + iTBS (R-DLPFC), iTBS (left-dorsomedial prefrontal cortex) + iTBS (right-dorsomedial prefrontal cortex), and iTBS (occipital lobe). Compared to sham, cTBS (R-DLPFC) + iTBS (L-DLPFC), iTBS (L-DLPFC), and iTBS (occipital lobe) had a higher response rate (k = 23); cTBS (R-DLPFC) + iTBS (L-DLPFC) and iTBS (L-DLPFC) dominated in the depression symptom improvement (k = 23); and iTBS (L-DLPFC) had a higher remission rate (k = 15). No significant differences were found for all-cause discontinuation rate (k = 17), incidence of switch to mania (k = 7), and incidence of headache/discomfort at treatment site (k = 10) between any TBS protocols and sham. Thus, cTBS (R-DLPFC) + iTBS (L-DLPFC) and iTBS (L-DLPFC) demonstrate favorable risk-benefit balance for the treatment of depression.
  • Shun Igarashi, Kyoji Okita, Daisuke Hayashi, Ryuichi Yamazaki, Yuki Matsuda, Takamasa Noda, Koichiro Watanabe, Shinsuke Kito
    Psychiatric research and clinical practice 6(2) 63-64 2024年  査読有り
  • Daisuke Hayashi, Shun Igarashi, Ryuichi Yamazaki, Yuki Matsuda, Takuma Inagawa, Yutaka Kawakami, Kyoji Okita, Takamasa Noda, Tomiki Sumiyoshi, Shinsuke Kito
    Asian Journal of Psychiatry 90 103806-103806 2023年12月  査読有り
  • Taro Kishi, Toshikazu Ikuta, Kenji Sakuma, Masakazu Hatano, Yuki Matsuda, Satoru Esumi, Nobumi Miyake, Itaru Miura, Masaki Kato, Nakao Iwata
    Psychiatry and clinical neurosciences 2023年11月20日  査読有り

MISC

 94

書籍等出版物

 3

講演・口頭発表等

 123

担当経験のある科目(授業)

 7

共同研究・競争的資金等の研究課題

 6

主要な社会貢献活動

 14

メディア報道

 4