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戸塚 学

トツカ マナブ  (TOTSUKA MANABU)

基本情報

所属
藤田医科大学 医療科学部　基礎教育 教授
学位
体育学修士(日本体育大学)
博士(医学)(弘前大学)
J-GLOBAL ID
200901041989407542
researchmap会員ID
1000003167

研究キーワード

 4

研究分野

 4

主要な経歴

 14
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学歴

 5

主要な委員歴

 23
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主要な受賞

 1
もっとみる

論文

 56
  • 川端良介, 戸塚学
    日本高専学会誌 22(3) 67-71 2022年7月  査読有り
  • 益川満治, 杉本和那美, 戸塚学, 高橋俊哉, 上野秀人, 三上孝志, 佐藤貴史
    弘前大学教育学部紀要 127(127) 103-108 2022年3月  
    type:Article 小学校低学年児を対象とした運動プログラムを考案及び実践し，それらの効果検証としてセルフエフィカシーと運動に対する好意度から検討することを研究の目的とした．対象は，弘前市内にある２つの小学校の２年生児童運動群37名，対象群36名，計73名とし運動介入前後に調査を行った．その結果，運動群において運動好意度の有意な上昇が認められ，運動プログラムの介入効果の可能性が示唆された．しかし，セルフエフィカシーの上昇は認められず，身体活動量などの視点からの検討も行っていないため，今後，長期的な介入や児童の身体活動量の観点からも検討する必要性がある．
  • 川端良介, 戸塚学, 相馬優樹, 大島義晴
    東北体育・スポーツ科学研究 1 1-11 2021年4月  査読有り
  • 川端 良介, 相馬 優樹, 戸塚 学, 大島 義晴
    八戸工業高等専門学校紀要 55 23-27 2021年2月19日  
  • Ryosuke Kawabata, Yuki Soma, Yutaro Kudo, Junichi Yokoyama, Hiroyasu Shimizu, Arata Akaike, Daisuke Suzuki, Yoshihisa Katsuragi, Manabu Totsuka, Shigeyuki Nakaji
    PLOS ONE 15(11) e0242308-e0242308 2020年11月17日  査読有り
    Pulmonary diseases, including chronic obstructive pulmonary disease (COPD), are major chronic diseases that result in decreased pulmonary function. Relationships between body composition and pulmonary function have been reported. However, few epidemiological studies have used the visceral fat area (VFA) to measure body composition. This study aimed to examine the relationship between body composition and pulmonary function. A cross-sectional study was conducted between 2015 and 2016, using data obtained from 1,287 residents aged between 19 and 91 years living in the Iwaki area of Hirosaki City, a rural region in Aomori Prefecture, Japan. Pulmonary function was evaluated using the forced vital capacity (FVC) as a percentage of the predicted value (predicted FVC%) and the ratio of forced expiratory volume in one second (FEV1) to FVC. The measurements for evaluating body composition included the body fat percentage (BFP) of the whole body and trunk, skeletal muscle index (SMI), body mass index (BMI), VFA, waist circumference (WC) at the navel level, and waist-to-hip ratio (WHR). To adjust for potential confounders, Spearman’s partial correlation analysis was used to examine the relationship between the measurements of body composition and pulmonary function. There were significant correlations between the predicted FVC% and the following parameters: BFP (whole body and trunk) in younger males; SMI in older males; WC, VFA, BMI, and SMI in younger females; and BFP (whole body and trunk) and VFA in older females. Contrastingly, WC and VFA in younger males and WC in younger females were correlated with the FEV1/FVC ratio. VFA was correlated with the FEV1/FVC ratio in younger males and predicted FVC% in older females. These findings suggest that visceral fat accumulation may increase the development of obstructive pulmonary disease in young males and accelerate the decline of pulmonary function (predicted FVC%) in older females.
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MISC

 96
  • M Yamada, K Suzuki, S Kudo, M Totsuka, T Simoyama, S Nakaji, K Sugawara
    LUMINESCENCE 15(1) 15-20 2000年1月  
    In order to investigate the effect of exercise on the capacity of neutrophils to produce reactive oxygen species (ROS), eight male cross-country skiers underwent maximal exercise. Peripheral blood samples were taken pre-exercise, 0 h, 1 h, and 2 h after finishing maximal exercise. Leukocyte counts significantly increased (p < 0.05), particularly lymphocytes (p < 0.05), just after the exercise period (0 h) and significantly increased again (p < 0.05), particularly neutrophils (p < 0.05), 2 h after the exercise compared with pre-exercise values. The capacity of isolated neutrophils to produce ROS was assessed by lucigenin (Lg)-dependent chemiluminescence (CL) and luminol (Lm)-dependent CL on stimulation with opsonized zymosan (OZ) and phorbol myristate acetate (PMA). Just after exercise, the LgCL response was not affected, while the response of LmCL mixed with sodium azide, which inhibits catalase and myeloperoxidase (MPO) activity, was significantly enhanced (p < 0.05). In addition, just after exercise, the level of serum growth hormone increased significantly (p < 0.05). The serum cortisol level also increased significantly just after and 1 h after exercise (p < 0.05). These data indicated that maximal exercise not only mobilized neutrophils from marginated pools into the circulation, but also caused increased ROS generation. Copyright (C) 2000 John Wiley & Sons, Ltd.
  • 戸塚 学, 鈴木 克彦, 中川 喜直, 中路 重之, 佐藤 光毅, 菅原 和夫
    体力科學 48(6) 1999年12月1日  
  • Katsuhiko Suzuki, Manabu Totsuka, Shigeyuki Nakaji, Mutsuo Suzuki, Satoru Kudoh, Qiang Liu, Kazuo Sugawara, Kanemitsu Yamaya, Koki Sato
    JOURNAL OF APPLIED PHYSIOLOGY 187(4) 1360-1367 1999年10月  査読有り
    We analyzed adaptation mechanisms regulating systemic inflammatory response of the stressed body by using an experimental challenge of repeated exercise bouts and accompanying muscle inflammation. Eight untrained men bicycled at 90 W for 90 min, 3 days in a row. Exercise induced peripheral neutrophilia with a leftward shift of neutrophil nucleus and neutrophil priming for oxidative activity determined by luminol-dependent chemiluminescence. Plasma growth hormone and interleukin-6 rose significantly after exercise and were closely correlated with the neutrophil responses. Serum creatine kinase and myoglobin levels as muscle damage markers rose after exercise in "delayed onset" and were closely correlated with the preceding neutrophil responses. These exercise-induced responses were strongest on day I, but the magnitude gradually decreased with progressive daily exercise. In contrast, the magnitude of catecholamine responses to exercise sessions gradually rose, possibly suppressing neutrophil oxidative responses. These results indicate that stress-induced systemic release of bioactive substances may determine neutrophil mobilization and functional status, which then may affect local tissue damage of susceptible organs.
  • 中路 重之, 杉田 直人, 劉 強, 鈴樹 亨純, 菅原 和夫, 太田 誠耕, 戸塚 学
    日本衞生學雜誌 54(1) 1999年4月15日  
  • 劉 強, 鈴木 克彦, 工藤 悟, 山田 睦雄, 小渡 健司, 鈴樹 亨純, 戸塚 学, 梅田 孝, 中路 重之, 菅原 和夫
    日本衞生學雜誌 54(1) 1999年4月15日  
  • 山田 睦雄, 工藤 悟, 鈴木 克彦, 小渡 健司, 劉 強, 梅田 孝, 鈴樹 亨純, 中路 重之, 菅原 和夫, 戸塚 学
    日本衞生學雜誌 54(1) 1999年4月15日  
  • Mitsukuni Mochizuki, Katsuhiko Suzuki, Shigeyuki Nakaji, Kazuo Sugawara, Manabu Totsuka, Koki Sato
    Jpn. J. Phys. Fitness Sports Med. 48(1) 147-160 1999年2月1日  査読有り
    We investigated both the acute effects of maximal exercise and the chronic effects of training on nonspecific immunity in 15 winter-sports athletes during different periods of training: (a) before the athletic season, in summer, when the athletes were undertaking extensive endurance training to enhance aerobic capacity, (b) during the winter sports season, in early winter, when endurance and athletic training were being undertaken, and (c) after the winter sports season, in spring, when the athletes were resting (detraining for a month). The mean value of the maximal oxygen uptake in each training period was (a) 65.4 (SD 4.6) mL . kg(-1) . min(-1), (b) 63.1 (SD 5.5) mL . kg(-1) . min(-1) and (c) 58.3 (SD 5.8) mL . kg(-1) . min(-1), respectively. Following maximal exercise, acute peripheral leukocytosis due to lymphocytosis and neutrophila was observed in every period. The capacity of isolated neutrophils to produce reactive oxygen species upon stimulation with opsonized zymosan measure by luminol-dependent chemiluminescence (LDCL) was significantly enhanced after maximal exercise before and during the athletic season. However, the degree of enhancement was smaller during after-season detraining, suggesting that the conditioning state affected the exercise-induced changes in neutophil functional status. Serum opsonic activity also showed a similar pattern. As for the chronic effects of training, the resting values of the neutrophil count, especially the segmented neutrophil count, the neutrophil LDCL response and the serum IgG level, declined significantly in the pre-season training period. Since the subjects were engaged in exhaustive endurance training under heat exposure at that time, the nonspecific immune status might have been partially compromised due to chronic overload.
  • M Mochizuki, K Suzuki, S Nakaji, K Sugawara, M Totsuka, K Sato
    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE 48(1) 147-159 1999年2月  
    We investigated both the acute effects of maximal exercise and the chronic effects of training on nonspecific immunity in 15 winter-sports athletes during different periods of training: (a) before the athletic season, in summer, when the athletes were undertaking extensive endurance training to enhance aerobic capacity, (b) during the winter sports season, in early winter, when endurance and athletic training were being undertaken, and (c) after the winter sports season, in spring, when the athletes were resting (detraining for a month). The mean value of the maximal oxygen uptake in each training period was (a) 65.4 (SD 4.6) mL . kg(-1) . min(-1), (b) 63.1 (SD 5.5) mL . kg(-1) . min(-1) and (c) 58.3 (SD 5.8) mL . kg(-1) . min(-1), respectively. Following maximal exercise, acute peripheral leukocytosis due to lymphocytosis and neutrophila was observed in every period. The capacity of isolated neutrophils to produce reactive oxygen species upon stimulation with opsonized zymosan measure by luminol-dependent chemiluminescence (LDCL) was significantly enhanced after maximal exercise before and during the athletic season. However, the degree of enhancement was smaller during after-season detraining, suggesting that the conditioning state affected the exercise-induced changes in neutophil functional status. Serum opsonic activity also showed a similar pattern. As for the chronic effects of training, the resting values of the neutrophil count, especially the segmented neutrophil count, the neutrophil LDCL response and the serum IgG level, declined significantly in the pre-season training period. Since the subjects were engaged in exhaustive endurance training under heat exposure at that time, the nonspecific immune status might have been partially compromised due to chronic overload.
  • M Mochizuki, K Suzuki, S Nakaji, K Sugawara, M Totsuka, K Sato
    JAPANESE JOURNAL OF PHYSICAL FITNESS AND SPORTS MEDICINE 48(1) 147-159 1999年2月  
    We investigated both the acute effects of maximal exercise and the chronic effects of training on nonspecific immunity in 15 winter-sports athletes during different periods of training: (a) before the athletic season, in summer, when the athletes were undertaking extensive endurance training to enhance aerobic capacity, (b) during the winter sports season, in early winter, when endurance and athletic training were being undertaken, and (c) after the winter sports season, in spring, when the athletes were resting (detraining for a month). The mean value of the maximal oxygen uptake in each training period was (a) 65.4 (SD 4.6) mL . kg(-1) . min(-1), (b) 63.1 (SD 5.5) mL . kg(-1) . min(-1) and (c) 58.3 (SD 5.8) mL . kg(-1) . min(-1), respectively. Following maximal exercise, acute peripheral leukocytosis due to lymphocytosis and neutrophila was observed in every period. The capacity of isolated neutrophils to produce reactive oxygen species upon stimulation with opsonized zymosan measure by luminol-dependent chemiluminescence (LDCL) was significantly enhanced after maximal exercise before and during the athletic season. However, the degree of enhancement was smaller during after-season detraining, suggesting that the conditioning state affected the exercise-induced changes in neutophil functional status. Serum opsonic activity also showed a similar pattern. As for the chronic effects of training, the resting values of the neutrophil count, especially the segmented neutrophil count, the neutrophil LDCL response and the serum IgG level, declined significantly in the pre-season training period. Since the subjects were engaged in exhaustive endurance training under heat exposure at that time, the nonspecific immune status might have been partially compromised due to chronic overload.
  • Takashi Umeda, Shigeyuki Nakaji, Kazuo Sugawara, Yousuke Yamamoto, Kazuo Saito, Satoshi Honjo, Yutaka Sakurai, Manabu Totsuka
    Environmental Health and Preventive Medicine 4(3) 146-150 1999年  
    Gender-related differences in anthropometry, blood biochemistry, psychological parameters, and energy intake during prematch weight reduction were studied in 22 men and 7 women college judoists who lost weight by combining judo training, restricting food and fluid, and sweating. Body weight (BW) decreased significantly by 2.2 ± 1.4 kg in men and 2.0 ± 1.4 kg in women 2 weeks after weight reduction started - not significantly different. Body fat, relative body fat and total energy intake also decreased significantly in both groups 2 weeks after weight reduction started. Lean body mass decreased significantly 2 weeks after weight reduction started only in men. Men had significantly decreased blood lipids, immunoglobulins, complements, hematocrit, white blood cell count, and serum electrolytes, and significant increases in blood uric nitrogen, creatinine, and hemoglobin, while women showed no such changes. The score for vigor in the Profile of Mood States (POMS) decreased in both groups 2 weeks after weight reduction started, but with no statistically gender difference. In women, scores for anxiety in the State-Trait Anxiety Inventory (STAI) and confusion in POMS increased significantly. Although the men and women had the same BW reduction, significant physical stress response was seen only in men, and psychological stress due to weight reduction and mental pressure of an upcoming competition were seen more in women.
  • Takashi Umeda, Shigeyuki Nakaji, Kazuo Sugawara, Yousuke Yamamoto, Kazuo Saito, Satoshi Honjo, Yutaka Sakurai, Manabu Totsuka
    Environmental Health and Preventive Medicine 4(3) 146-150 1999年  
    Gender-related differences in anthropometry, blood biochemistry, psychological parameters, and energy intake during prematch weight reduction were studied in 22 men and 7 women college judoists who lost weight by combining judo training, restricting food and fluid, and sweating. Body weight (BW) decreased significantly by 2.2 ± 1.4 kg in men and 2.0 ± 1.4 kg in women 2 weeks after weight reduction started - not significantly different. Body fat, relative body fat and total energy intake also decreased significantly in both groups 2 weeks after weight reduction started. Lean body mass decreased significantly 2 weeks after weight reduction started only in men. Men had significantly decreased blood lipids, immunoglobulins, complements, hematocrit, white blood cell count, and serum electrolytes, and significant increases in blood uric nitrogen, creatinine, and hemoglobin, while women showed no such changes. The score for vigor in the Profile of Mood States (POMS) decreased in both groups 2 weeks after weight reduction started, but with no statistically gender difference. In women, scores for anxiety in the State-Trait Anxiety Inventory (STAI) and confusion in POMS increased significantly. Although the men and women had the same BW reduction, significant physical stress response was seen only in men, and psychological stress due to weight reduction and mental pressure of an upcoming competition were seen more in women.
  • 戸塚 学, 佐藤 光毅, 中路 重之, 菅原 和夫, 倉掛 重精, 三浦 照幸
    体力科學 47(6) 1998年12月1日  
  • 板井 美浩, 戸塚 学, 阿部 徳之助
    体力科學 47(6) 754-754 1998年12月1日  
  • J. Phys. Fit. Nutr. Immunol. 6(2), 187-190 1997年  
  • 中路 重之, 菅原 和夫, 持田 典子, 斎藤 一雄, 梅田 孝, 佐藤 光毅, 戸塚 学
    体力科學 45(6) 1996年12月1日  
  • K Suzuki, H Sato, T Kikuchi, T Abe, S Nakaji, K Sugawara, M Totsuka, K Sato, K Yamaya
    JOURNAL OF APPLIED PHYSIOLOGY 81(3) 1213-1222 1996年9月  
    To investigate the cause of disagreement within the large body of literature concerning the effect of exercise on the capacity of circulating neutrophils to produce reactive oxygen species (ROS), 10 male endurance-trained athletes underwent maximal exercise. The generation of superoxide radical (O-2(-).) by neutrophils was first detected on a cell-by-cell basis by using histochemical nitro blue tetrazolium tests performed directly on fresh unseparated blood, which showed that responsive neutrophils under several stimulatory conditions relatively decreased after exercise. Similarly, O--(2). detected with bis-N-methylacridinium nitrate (lucigenin)-dependent chemiluminescence (CL) of a fixed number of purified neutrophils on stimulation with opsonized zymosan was decreased slightly after exercise. In contrast, the 5-amino-2,3-dihydro-1,4-phthalazinedione (luminol)dependent CL response of the neutrophils indicative of the myeloperoxidase (MPO)-mediated formation of highly reactive oxidants was significantly enhanced after exercise. It therefore suggests that the pathway of neutrophil ROS metabolism might be forwarded from the precursor O-2(-). production to the stages of more reactive oxidant formation due to the facilitation of MPO degranulation. In addition, these phenomena were closely associated with the exercise-induced mobilization of neutrophils from the marginated pool into the circulation, which was mediated by the overshooting of catecholamines during exercise. These findings indicate that the use of different techniques for detecting ROS or the different stages of neutrophil ROS metabolism could explain some of the disparate findings of the previous studies.
  • Katsuhiko Suzuki, Shinji Naganuma, Manabu Totsuka, Kojun Suzuki, Mitsukuni Mochizuki, Masahiko Shiraishi, Shigeyuki Nakaji, Kazuo Sugawara
    Int. J. Sports Med. 17(3) 205-212 1996年3月  査読有り
    Whereas endurance exercise is known to induce marked neutrophilia, it remains to be fully understood as to whether the cell functions are altered as well as whether the adaptability of the responses to training occurs. To address both of these issues, we undertook the present longitudinal investigation in ten healthy untrained men (20-24 years, VO(2)max 39.1 +/- 4.2 ml/kg/min). The exercise protocol was 7 consecutive sessions of the same workload performed each day for 1.5 h at an intensity of 70 % of VO(2)max. Peripheral blood samples were obtained before, immediately after, and 1 h after exercise on Days 1, 4, and 7, and served for determination of total and differential leukocyte counts, chemotaxis and chemiluminescence of neutrophils. Acute endurance exercise caused marked peripheral neutrophilia with significant increase in both absolute number and relative proportion of band neutrophils (p < 0.01, respectively), indicating partial recruitment of bone marrow neutrophils. While chemotaxis remained unaltered following exercise, reactive oxygen species generation of neutrophils, measured by luminol-dependent chemiluminescence upon stimulation with opsonized zymosan, was not only significantly enhanced following exercise (p < 0.01), but also associated with the proportional increase in band neutrophils (r = 0.727, p < 0.05), suggesting that neutrophils mobilized from the bone marrow following endurance exercise may possess higher responsiveness. On the other hand, the magnitude of the exercise-induced changes was reduced gradually by daily repeated exposure to endurance exercise, but none of the trends were significant except the decline in resting segmented neutrophil counts (p < 0.05) at least during a 1-wk period of repeated exercise sessions.
  • 山本 洋祐, 古賀 稔彦, 斎藤 一雄, 梅田 孝, 菅原 和夫, 戸塚 学, 太田 誠耕
    体力科學 44(6) 775-775 1995年12月1日  
  • 佐藤 英樹, 阿部 達也, 菊地 隆, 中路 重之, 菅原 和夫, 太田 誠耕, 戸塚 学, 佐藤 光毅
    体力科學 44(6) 1995年12月1日  
  • 鈴木 克彦, 佐藤 英樹, 遠藤 哲, 中路 重之, 長谷川 裕子, 菅原 和夫, 戸塚 学, 佐藤 光毅
    体力科學 44(6) 1995年12月1日  
  • J. Phys. Fit. Nutr. Immunol. 5(1), 40-44 1995年  
  • 鈴木 克彦, 長沼 慎二, 望月 充邦, 白石 正彦, 管原 和夫, 戸塚 学, 佐藤 光毅
    体力科學 43(6) 541-541 1994年12月1日  
  • 山本 洋祐, 倉掛 重精, 戸塚 学, 梅田 孝, 中路 重之, 菅原 和夫
    体力科學 43(6) 1994年12月1日  
  • 望月 充邦, 鈴木 克彦, 黒田 祐子, 中路 重之, 菅原 和夫, 戸塚 学, 佐藤 光毅
    体力科學 43(6) 1994年12月1日  
  • 戸塚 学, 佐藤 光毅, 黒田 裕子, 中路 重之, 菅原 和夫
    体力科學 43(6) 1994年12月1日  
  • J. Phys. Fit. , Nutr. Immunol. 4(1), 18-24 1994年  
  • 古賀 稔彦, 山本 洋祐, 笹渕 五夫, 菊地 隆, 中路 重之, 菅原 和夫, 戸塚 学, 太田 誠耕
    武道学研究 27(Supplement) 29-29 1994年  査読有り
  • 戸塚 学, 佐藤 光毅, 長沼 慎二, 坂本 十一, 中路 重之, 菅原 和夫
    体力科學 42(6) 1993年12月1日  
  • 中路 重之, 白石 正彦, 坂本 十一, 長沼 慎二, 菅原 和夫, 戸塚 学, 太田 誠耕
    体力科學 42(6) 1993年12月1日  
  • 板井 美浩, 戸塚 学, 阿部 徳之助, 堀居 昭, 広田 公一
    体力科學 42(6) 575-575 1993年12月1日  
  • 桐谷乃 宇奈, 大橋 令子, 戸塚 学, 木村 直人, 堀居 昭
    体力科學 41(6) 792-792 1992年12月1日  
  • 大橋 令子, 桐谷乃 宇奈, 戸塚 学, 木村 直人, 堀居 昭
    体力科學 41(6) 792-792 1992年12月1日  
  • 加藤 徳也, 戸塚 学
    体力科學 41(6) 871-871 1992年12月1日  
  • 戸塚 学, 冨岡 徹, 井上 辰樹, 板井 美浩, 広田 公一
    体力科學 40(6) 692-692 1991年12月1日  
  • 冨岡 徹, 戸塚 学, 広田 公一
    体力科學 40(6) 693-693 1991年12月1日  
  • 佐藤 智明, 小楠 和典, 坂元 晃史, 安納 弘道, 戸塚 学, 広田 公一
    体力科學 40(6) 900-900 1991年12月1日  
  • 小楠 和典, 坂元 晃史, 安部 孝, 戸塚 学, 圓 吉夫, 広田 公一
    体力科學 39(6) 824-824 1990年12月1日  
  • 芳田 哲也, 戸塚 学, 井上 辰樹, 菅原 勳, 広田 公一
    日本体育学会大会号 (41) 321-321 1990年9月10日  
  • 安部 孝, 福永 哲夫, 石田 良恵, 戸塚 学, 木崎 美至
    日本体育学会大会号 (41) 453-453 1990年9月10日  
  • The Annals of Physiological Anthropology 9(1), 15-20 1990年  
  • 中川 喜直, 池川 繁樹, 安部 孝, 福永 哲夫, 井上 辰樹, 戸塚 学, 関口 脩, 広田 公一
    体力科學 38(6) 424-424 1989年12月1日  
  • 板井 美浩, 戸塚 学, 堀居 昭, 広田 公一
    体力科學 38(6) 393-393 1989年12月1日  
  • 井上 辰樹, 戸塚 学, 富岡 徹, 丹羽 哲次, 村田 清晃, 広田 公一
    体力科學 38(6) 261-261 1989年12月1日  
  • Y NAKAGAWA, M TOTSUKA, T SATO, Y FUKUDA, K HIROTA
    EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY 59(3) 239-242 1989年10月  
  • 安部 孝, 坂元 晃史, 戸塚 学, 広田 公一, 東 悳彦
    体力科學 37(2) 219-220 1988年4月1日  
  • 戸塚 学, 安部 孝, 松尾 彰文, 広田 公一
    体力科學 36(6) 486-486 1987年12月1日  

講演・口頭発表等

 54
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担当経験のある科目(授業)

 1

所属学協会

 8
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共同研究・競争的資金等の研究課題

 4

主要な社会貢献活動

 8
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