Hiroya Kou

(廣谷功)

Profile Information

Affiliation: Professor, Faculty of Pharmacy Department of Pharmaceutical Sciences, Musashino University

Degree: 薬学士(東北大学)
薬学修士(東北大学)
薬学博士(東北大学)

J-GLOBAL ID: 201701020116661251
researchmap Member ID: B000270515

External link: http://www.musashino-u.ac.jp/facilities/pharmacy/yakka.html

●趣味
日曜大工，映画・海外ドラマ鑑賞，野球観戦．
●モットー
やる時はやる．一心不乱．
●授業方針
基礎から応用までを丁寧に解説します．
記憶より考えて答えを出す方法を解説します．

Research Interests

Research Areas

Research History

Apr, 2011 - Present

of Pharmaceutical Sciences, Graduate School, Musashino University
Apr, 2011 - Present

Faculty of Pharmacy, Department of Pharmaceutical Sciences, Musashino University
Apr, 2011 - Present

of Pharmaceutical Sciences, Graduate School, Musashino University
Apr, 1999 - Mar, 2011

Tohoku University Graduate School of Pharmaceutical Sciences Associate Professor
Feb, 1996 - Mar, 1999

Tohoku University Associate Professor

Education

Apr, 1985 - Mar, 1988

Graduate School, Division of Pharmaceutical Sciences, Tohoku University
Apr, 1983 - Mar, 1985

Graduate School, Division of Pharmaceutical Sciences, Tohoku University
Mar, 1979 - Mar, 1983

Faculty of Pharmaceutical Science, Tohoku University

Awards

May, 1997

有機合成化学協会研究企画賞
Dec, 1992

日本薬学会東北支部奨励賞

Papers

102

Catalytic Direct Cyclization of Alkenyl Thioester

Shiori Date, Kensei Hamasaki, Karen Sunagawa, Hiroki Koyama, Chikayoshi Sebe, Kou Hiroya, Hiroki Shigehisa

ACS Catalysis, 10(3) 2039-2045, Feb 7, 2020
SIMULTANEOUS FUNCTIONALIZATION AND CYCLIZATION OF 2-ETHYNYLANILINE DERIVATIVES TO INDOLES

Kou Hiroya, Shin Itoh, Kiyofumi Inamoto, Hiroki Shigehisa, Takao Sakamoto

HETEROCYCLES, 95(2) 920-933, Jan, 2017 Peer-reviewed
Co-Catalyzed Hydroarylation of Unactivated Olefins

Hiroki Shigehisa, Takuya Ano, Hiroshi Honma, Kousuke Ebisawa, Kou Hiroya

ORGANIC LETTERS, 18(15) 3622-3625, Aug, 2016 Peer-reviewed
Catalytic Synthesis of Saturated Oxygen Heterocycles by Hydrofunctionalization of Unactivated Olefins: Unprotected and Protected Strategies

Hiroki Shigehisa, Miki Hayashi, Haruna Ohkawa, Tsuyoshi Suzuki, Hiroki Okayasu, Mayumi Mukai, Ayaka Yamazaki, Ryohei Kawai, Harue Kikuchi, Yui Satoh, Akane Fukuyama, Kou Hiroya

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 138(33) 10597-10604, Aug, 2016 Peer-reviewed
Markovnikov-Selective Addition of Fluorous Solvents to Unactivated Olefins Using a Co Catalyst

Hiroki Shigehisa, Harue Kikuchi, Kou Hiroya

CHEMICAL & PHARMACEUTICAL BULLETIN, 64(4) 371-374, Apr, 2016 Peer-reviewed

Misc.

SYNTHESIS OF 4,4-DISUBSTITUTED ISOCHROMAN-3-ONE BY A TANDEM ELECTROCYCLIC-SIGMATROPIC REACTION AND ITS APPLICATION TO THE SYNTHESIS OF NATURAL-PRODUCTS

K SHISHIDO, E SHITARA, H KOMATSU, K HIROYA, K FUKUMOTO, T KAMETANI

HETEROCYCLES, 24(1) 250-250, Jan, 1986 Peer-reviewed

Books and Other Publications

薬学演習 II. 基礎科学

廣谷功 (Role: Contributor, 第II編化学系薬学)

東京化学同人, Oct 22, 2021
現場で役に立つ！臨床医薬品化学

廣谷功 (Role: Contributor, 10章免疫・アレルギー疾患とその治療薬および抗炎症薬)

化学同人, Apr 10, 2021
化学系薬学 I. 化学物質の性質と反応

廣谷功 (Role: Contributor, 第６章芳香族化合物 SBO29 代表的な芳香族複素間化合物の性質を芳香属性と関連づけて説明できる．)

東京化学同人, Feb 20, 2015
新編ヘテロ環化合物展開編

坂本尚夫, 廣谷功 (Role: Joint author)

講談社, Nov, 2010 (ISBN: 9784061543331)

ヘテロ小員環化合物，含窒素飽和5～7員環化合物，および4級塩化合物の反応性と合成について記述した．また，芳香ヘテロ環化合物の環変換と遷移金属触媒を用いる芳香ヘテロ環への官能基導入法と閉環反応に関しても記述した．
芳香族ヘテロ環化合物の化学－反応性と環合成－

坂本尚夫, 廣谷功 (Role: Joint author)

講談社, Oct, 2008 (ISBN: 9784061536838)

芳香族ヘテロ環化合物の性質，反応性，官能基導入部，環合成方法などに関して記述した著書．

Presentations

温和な条件下でのチオエーテル含有オキサゾリン合成法の開発

長尾芳大, 廣谷功

第64回日本薬学会関東支部大会, Sep, 2020
ベンジル位不斉第四級炭素構築法の開発と合成化学的応用

三嶽香穂, 天野智喬, 村田いぶき, 重久浩樹, 長尾芳大, 廣谷功

第64回日本薬学会関東支部大会, Sep, 2020
アルケニルチオエステルの分子内ヒドロチオ化反応 (2)：基質適用範囲の拡大

館志織, 小山寛貴, 瀬部謹儀, 廣谷功, 重久浩樹

日本薬学会第140年会（京都）, Mar, 2020
アルケニルチオエステルの分子内ヒドロチオ化反応 (1)：チオエステルの求核性

濱崎健生, 砂川夏蓮, 館志織, 廣谷功, 重久浩樹

日本薬学会第140年会（京都）, Mar, 2020
TM-HAT/RPC 機構を基盤にした環状ウレアおよびイソウレア合成

三股奈央, 長井拓哉, 寺田吉宏, 廣谷功, 重久浩樹

日本薬学会第140年会（京都）, Mar, 2020
アルケニルチオエステルの分子内ヒドロチオ化反応

重久浩樹, 濱崎健生, 砂川夏蓮, 館志織, 廣谷功

第45回反応と合成の進歩シンポジウム（倉敷）, Oct, 2019
コバルト触媒を用いたオレフィンのヒドロ官能基化反応による含酸素複素環合成法

重久浩樹, 林美希, 大川陽菜, 鈴木毅史, 岡安弘樹, 向真由実, 山崎彩香, 川井涼平, 佐藤優衣, 福山茜, 廣谷功

第46回複素環化学討論会, Sep 28, 2016
キラルPHOX–パラジウム錯体を用いる動的速度論的光学分割反応の開発

坂貴穂, 松崎里紗, 岡部苑香, 山田啓介, 三宅裕美, 重久浩樹, 廣谷功

第46回複素環化学討論会, Sep 27, 2016
Stracture Revision of Marine Polyketide Trichodermatide A

Mar 28, 2016
Intramolecular Hydroalkoxyl and Hydroacyloxy Reactions of Unactivated Olefin Using Cobalt Complex

Mar 28, 2016
Intramolecular Hydroaryl Reaction of Unactivated Olefin Using Cobalt Complex

Mar 28, 2016
海洋性天然物 Trichodermatide A の構造改訂

菊池陽媛, 鈴木毅史, 重久浩樹, 廣谷功

第59回日本薬学会関東支部大会, Sep 12, 2015, 日本薬学会関東支部
コバルト触媒を用いたオレフィンの分子内ヒドロアルコキシル化反応とヒドロアシルオキシ化反応

林美希, 大川陽菜, 重久浩樹, 廣谷功

第59回日本薬学会関東支部大会, Sep 12, 2015, 日本薬学会関東支部
Hydroxylation Reaction of Olefin Utilizing Cobalt Catalyst

Sep 12, 2015
Intramolecular Hydroamination Reaction of Olefin Utilizing Cobolt Catalyst

Mar 27, 2015
Intramolecular Hydroamination of Olefin Using Co Catalyst

Nao Shimizu, Natsumi Koseki, Mayu Fujisawa, Makoto Niitsu, Hiroki Shigehisa, Kou Hiroya

Oct 4, 2014
Hydrofluorination of Olefin Using Co Catalyst

Eriko Nishi, Mayu Fujisawa, Hiroki Shigehisa, Kou Hiroya

Oct 4, 2014
Catalytic Intramolecular Hydroamination of Olefin Using Co Complex, F⁺ Reagent and SiH Reagent

Hiroki Shigehisa, Natsumi Koseki, Nao Shimizu, Mayu Fujisawa, Makoto Niitsu, Kou Hiroya

44nd Congress of Heterocyclic Chemistry, Sep 12, 2014
Catalytic Hydroalkoxylation of Unactivated Olefin via Radical and Cation

Tatsuya Aoki, Sumiko Yamaguchi, Nao Shimizu, Hiroki Shigehisa, Kou Hiroya

Oct 26, 2013
Addition Reaction for Olefin with Functional Group Tolerance Using Co-Complex and Electrophilic Fluorination Reagent

Hiroki Shigehisa, Tatsuya Aoki, Sumiko Yamaguchi, Nao Shimizu, Eriko Nishi, Mayu Fujisawa, Kou Hiroya

Sep 13, 2013
Synthesis of 3-Substituted Indole Derivatives by Sequential Cyclization-functionalization Reaction

42nd Congress of Heterocyclic Chemistry, Oct 12, 2012
Construction of Chiral Quaternary Carbon Centers at Benzylic Position by Catalytic Asymmetric Induction

42nd Congress of Heterocyclic Chemistry, Oct 12, 2012
Synthesis of 2-Quinolinones throuth a Palladium-Catalyzed C-H Amination Process

42nd Congress of Heterocyclic Chemistry, Oct 12, 2012
Total Synthesis of (-)-Trichodermatide A

42nd Congress of Heterocyclic Chemistry, Oct 11, 2012
Construction of Chiral Quaternary Carbon Centers at Benzylic Position by Catalytic Asymmetric Induction

Oct 7, 2012
Synthetic Studies of (-)-Cepharamine Using a Desymmetrization Reaction Based on Diastereoselective Ketalization

Oct 30, 2011
Development of Desymmetrization Reaction of 2,2-Disubstituted-1,3-cyclopentanedione Derivatives

Oct 30, 2011
Synthetic Studies of (-)-Cepharamine Using a Desymmetrization Reaction Based on Diastereoselective Ketalization

Sep 18, 2011
ジアステレオ選択的なケタール化反応による不斉第四級炭素構築法の開発と(−)-Cepharamineの全合成研究

廣谷功, 市橋佑介, 関岡竜一, 稲本浄文, 土井隆行

第98回有機合成協会シンポジウム, Nov 5, 2010
非対称化反応を用いた (+)‒Lycopladine A の全合成

廣谷功, 諏訪好泰, 市橋佑介, 稲本浄文, 土井隆行

第40回複素環化学討論会, Oct 15, 2010
パラジウム触媒を用いた分子内Tsujiアリル化反応によるβ-アルケニル-α-アリールシクロペンタノン誘導体の不斉合成とその応用

廣谷功, 星野恒文, 高橋絵里菜, 中村優子, 稲本浄文, 土井隆行

第97回有機合成協会シンポジウム, Jun 18, 2010
非対称化反応を用いた(－)-Cepharamine の不斉全合成研究

廣谷功, 市橋佑介, 猪飼哲朗, 関岡竜一, 稲本浄文, 土井隆行

第35回反応と合成の進歩シンポジウム, Nov 17, 2009
パラジウム触媒を用いた分子内Tsujiアリル化反応によるβ-アルケニル-α-アリールシクロペンタノン誘導体の不斉合成とその応用

廣谷功, 星野恒文, 中村優子, 稲本浄文, 土井隆行

第35回反応と合成の進歩シンポジウム, Nov 17, 2009
非対称化反応を基盤とする不斉第四級炭素構築法の開発

廣谷功, 市橋佑介, 諏訪好泰, 猪飼哲朗, 稲本浄文, 土井隆行

第35回反応と合成の進歩シンポジウム, Nov 16, 2009
パラジウム触媒を用いる分子内 Tsuji-Trost 反応によるβ-アルケニル-α -アリールシクロペンタノン誘導体の不斉合成研究

廣谷功, 星野恒文, 中村優子, 稲本浄文, 土井隆行

平成21年度化学系学協会東北大会, Sep 21, 2009
Development of a Novel Synthetic Method for Asymmetric Quaternary Carbon Center and Its Application.

Kou Hiroya, Yusuke Ichihashi, Tetsuro Ikai, Ryuichi Sekioka, Kiyofumi Inamoto, Takayuki Doi

The 50th Anniversary Meeting of the American Society of Pharmacognosy, Jun 27, 2009
Synthesis and Catalytic Activity of N-Heterocyclic Carbene-Derived Pincer-Type Nickel(II) Complexes.

Kiyofumi Inamoto, Jun-ichi Kuroda, Kou Hiroya, Takayuki Doi

17th International Conference on Organic Synthesis (ICOS-17), Jun 25, 2008
Michael Addition of Silyl Ketene Acetal to 2-Pyridinone Derivatives: Reactivity and Application to Synthetic Study of Awajanomycin.

Kou Hiroya, Kei Kawamoto, Kiyofumi Inamoto, Takayuki Doi

17th International Conference on Organic Synthesis (ICOS-17), Jun 25, 2008
Synthesis of Indoles and Benzothiophenes via Palladium-Catalyzed C-H Activation.

Kiyofumi Inamoto, Yukari Arai, Tadataka Saito, Kou Hiroya, Takayuki Doi

The 12th Japan-Korea Joint Symposium on Drug Design and Development, May 14, 2008
Synthesis and Catalytic Activities of Pincer-type Bis(imidazolin-2-ylidene) Nickel(II) Complexes.

Kiyofumi Inamoto, Jun-ichi Kuroda, Kou Hiroya, Takayuki Doi

The 12th Japan-Korea Joint Symposium on Drug Design and Development, May 14, 2008
Platinum-Catalyzed Regioselective Hydration of Acetylenic Compounds.

Kou Hiroya, Kentaro Ogiwara, Kiyofumi Inamoto, Takayuki Doi

The 12th Japan-Korea Joint Symposium on Drug Design and Development, May 14, 2008
Michael Addition of Silyl Ketene Acetal to 2-Pyridinone Derivatives: Reactivity and Application to Synthetic Study of Awajanomycin.

Kou Hiroya, Kei Kawamoto, Kiyofumi Inamoto, Takayuki Doi

The 12th Japan-Korea Joint Symposium on Drug Design and Development, May 14, 2008
Development of the Synthetic Method for the Asymmetric Quaternary Carbon Center Utilizing Desymmetric Reaction: Application to the Synthesis of (-)-Cepharamine.

Kou Hiroya, Ryuichi Sekioka, Kouki Fuchino, Kiyohumi Inamoto, Takayuki Doi

The 12th Japan-Korea Joint Symposium on Drug Design and Development, May 14, 2008
Asymmetric Synthetic Studies of Novel Poliketide Isolated from Peperomia Duclouxii.

Kou Hiroya, Yusuke Ichihashi, Kiyofumi Inamoto, Takayuki Doi

The 12th Japan-Korea Joint Symposium on Drug Design and Development, May 14, 2008
Pd(II)-Catalyzed C-H Activation/Intramolecular Amination Reaction: A New Route to 3-Substituted Indazole.

Kiyofumi Inamoto, Tadataka Saito, Mika Katsuno, Takao Sakamoto, Kou Hiroya

14th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS14), Aug 5, 2007
Catalytic Activities of a Pincer-Type Bis(imidazolin-2-ylidene) Nickel(II) Complex in Cross-Coupling Reactions of Aryl Halides.

Kiyofumi Inamoto, Jun-ichi Kuroda, Takao Sakamoto, Kou Hiroya

14th International Symposium on Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS14), Aug 5, 2007
アルキンを用いる含窒素ヘテロ環化合物構築法の開発と生理活性化合物合成への応用

廣谷功

平成18年度化学系学協会東北大会有機化学コロキウム（特別企画）, Sep 22, 2006
Regioselective Cyclization Reaction of 5-Substituted Pent-2Z-en-4-ynoic Acid Derivatives and Its Application to Natural Product Synthesis.

Kazuya Takuma, Kou Hiroya, Masanobu Uchiyama, Takao Sakamoto

2005 International Chemical Congress of Pacific Basin Societies, Dec 17, 2005
アルキンを用いるヘテロ環化合物構築法の開発と生理活性化合物合成への応用

廣谷功

平成16年度化学系学協会東北大会, Sep 18, 2004
Development of Stereoselective Synthetic Method for Polyfunctionalized Piperidine Compounds and Its Applications.

Kou Hiroya, Osamu Katoh, Rumi Jouka, Takashi Sakuma, Takao Sakamoto

The 10th Japan-Korea Join Symposium on Drug Design and Development, Apr 22, 2004

Teaching Experience

構造解析学 (東北大学薬学部)
有機化学 (武蔵野大学，東北大学薬学部)

Professional Memberships

Research Projects

Study of the Mechanism for Diastereoselective Ketal Formation Reaction and Its Application to the Synthetic Organic Chemistry.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025

Kou Hiroya
Development of Chiral Ligand Containing Indazole Ring and Its Application to Dynamic Kinetic Resolution

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2022

Hiroya Kou
Elucidation of drug interaction mechanism by metronidazole and investigation of possibility of unknown interactions.

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

KUDO Toshiyuki, ITO Kiyomi, HIROYA Kou
Development and Application of Diastereoselective Ketal Formation Reaction.

Apr, 2015 - Mar, 2018

Kou Hiroya
Development and Application of Dynamic Kinetic Resolution Catalyzed by Chiral Pai-allyl Complex

Apr, 2012 - Mar, 2015

Kou Hiroya

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