Curriculum Vitaes

Shoji SERA

  (世良 庄司)

Profile Information

Affiliation
講師, 薬学部 薬学科, 武蔵野大学
Degree
博士(薬学)(Mar, 1998, 福山大学)

Researcher number
20268676
J-GLOBAL ID
202001009686687159
researchmap Member ID
R000002974

Awards

 12

Major Papers

 16
  • Daichi Yaguchi, Shoji Sera, Akira Okada, Yuki Nishimura, Satoshi Tamaru, Naomi Nagai
    Pharmaceutics, 16(12) 1515, Nov, 2024  Peer-reviewedCorresponding author
    Background/Objectives: Anticoagulant therapy, particularly the use of direct oral anticoagulant agents (DOACs), is recommended for patients with nonvalvular atrial fibrillation (NVAF). This multicenter observational retrospective cohort study aimed to assess the efficacy and safety of DOACs compared to warfarin in Japanese patients aged 75 years and older with NVAF. Methods: Data from the Mie-Life Innovation Promotion Center Database were used to collect medical information on the patients. The cumulative incidences of clinically significant bleeding events and systemic embolic events (SEEs) were analyzed. Results: This study included 1787 older adult patients, of whom 1321 received DOACs (edoxaban: 428; apixaban: 586; dabigatran: 105; rivaroxaban: 202) and 466 receiving warfarin. There were no statistically significant differences in the cumulative incidence of bleeding events between the DOAC- and warfarin-treated groups. However, a statistically significant difference was observed for SEEs, with dabigatran showing a significantly lower incidence compared to warfarin. Conclusions: The incidence rates of bleeding events for individual DOACs were comparable to those for warfarin. Additionally, a history of vascular disorders was identified as a risk factor for bleeding events in the DOAC-treated group (hazard ratio (HR): 1.83, 95% confidence interval (CI): 1.16–2.88, p < 0.01) and warfarin-treated group (HR: 1.80, 95% CI: 1.15–2.84, p < 0.01). Based on real-world data, the overall efficacy and safety of DOACs were generally comparable to warfarin.

Misc.

 7
  • 矢口 大地, 西村 有起, 田丸 智巳, 岡田 章, 世良 庄司, 永井 尚美
    日本医薬品情報学会総会・学術大会講演要旨集, 24回 82-82, Jun, 2022  
  • Sera Shoji, Hata Toshiyuki, Inoue Hirofumi, Goromaru Tsuyoshi
    Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University, 19 94-94, 2001  
  • Sera Shoji, Goromaru Tsuyoshi, Sameshima Teruko, Oda Toshiyuki
    Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University, 19 93-93, 2001  
  • Sera Shoji, Goromaru Tsuyoshi, Sameshima Teruko, Kawasaki Koichi, Oda Toshiyuki
    Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University, 17 96-96, 1999  
    Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID). Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-2H19) , as an internal standard. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-^2H_<10>). No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism.
  • Sera Shoji, Goromaru Tsuyoshi, Sameshima Teruko, Kawasaki Koichi, Oda Toshiyuki
    Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University, 17 95-95, 1999  
    The quantitative determination of fentanyl (FT) in serum was examined by isotope dilution analysis using a capillary gas chromatograph equipped with a surface ionization detector. The separation of FT and its deuterated analogue, FT-21119, was achieved within 15 min a column temperature of 260t by using a 25 m column. The present method was used to determine the serum level of FT in surgical patients after iv administration. No endogenous compounds and concomitant drugs interfered with the detection of FT or FT-2H19.

Books and Other Publications

 7

Major Presentations

 76

Social Activities

 3