Kiichiro Totani

(戸谷希一郎)

Profile Information

Affiliation: Professor, Faculty of Science and Technology Department of Science and Technology , Seikei University

Degree: Ph.D.(Keio University)

J-GLOBAL ID: 201401094820177323
researchmap Member ID: B000243010

External link: http://www.ml.seikei.ac.jp/totanilab/Totani_Lab/Home.html

Research Interests

Research Areas

Research History

Apr, 2018 - Present

Professor, Faculty of Science and Technology, Seikei University
Apr, 2009 - Mar, 2018

Associate Professor, Faculty of Science and Technology, Seikei University
Apr, 2008 - Mar, 2009

Instructor, Faculty of Science and Technology, Seikei University
Apr, 2005 - Mar, 2008

JST-CREST Researcher, Synthetic Cellular Chemistry Lab., RIKEN
Apr, 2002 - Mar, 2005

Special Postdoctoral Researcher, Synthetic Celluclar Chamistry Lab., RIKEN

Education

Apr, 1999 - Mar, 2002

Doctoral course, Applied Chemistry, Graduate School of Science and Technology, Keio University
Apr, 1997 - Mar, 1999

Master's Program, Applied Chmistry, Graduate School of Science and Technology, Keio University
Apr, 1993 - Mar, 1997

Department of Applied Chemistry, Faculty of Science and Technology, Keio University

Committee Memberships

Apr, 2020 - Present

会長, 東京糖鎖研究会
Apr, 2018 - Present

編集幹事, Trends in Glycoscience and Glycotechnology 誌
Nov, 2010 - Present

幹事会員, 東京糖鎖研究会
Apr, 2009 - Present

評議員, 日本糖質学会

Awards

Papers

Chemical Probe Approach Reveals Endo-α-mannosidase Triages Misfolded Glycoproteins in the Calnexin/Calreticulin Cycle

Akito Taira, Makoto Hirano, Taiki Kuribara, Chie Watanabe, Satoshi Hiraki, Mitsuaki Hirose, Zalihe Hakki, Spencer J. Williams, Yukishige Ito, Kiichiro Totani

ACS Chemical Biology, Nov 21, 2025
Synthesis of N-glycan mimics for investigating the influence of the N-acetyl group in core GlcNAc2 on the folded conformation

Ruchio Usui, Megumi Kabasawa, Naoya Tajima, Akito Taira, Mitsuaki Hirose, Kiichiro Totani

Chemistry Letters, Jul 8, 2025
Development of a Calreticulin-targeting Glycan Ligand Based on a Hybrid Binding Concept

Taiki Kuribara, Taiga Kojima, Yuka Kobayashi, Mitsuaki Hirose, Keita Shibayama, Yoichi Takeda, Kiichiro Totani

Glycobiology, Mar 13, 2025
Stepwise self-organization of hydrogen-bonded fibers in a minimalist glucose-pyrene system via CH–π-stabilized “iotamers”

Mitsuaki Hirose, Keigo Tashiro, Naoya Tajima, Futa Sugiura, Shuhei Shimoda, Yoshiumi Kohno, Yasumasa Tomita, Kiichiro Totani

Chemical Communications, 2025
Chemical Study of High-Mannose-Type Glycan-Related Proteins to Understand Their Functions at the Molecular Level

Taiki Kuribara, Mitsuaki Hirose, Naoya Tajima, Kiichiro Totani

Trends in Glycoscience and Glycotechnology, 36(213) E94-E103, Sep 25, 2024

Misc.

Development of Fluorescent-labeled Glycan Probes towards CRT

栗原大輝, 児島大河, 柴山佳大, 武田陽一, 戸谷希一郎

日本化学会春季年会講演予稿集(Web), 102nd, 2022
Development of calreticulin inhibitor based on hybrid binding concept

栗原大輝, 児島大河, 柴山佳大, 武田陽一, 戸谷希一郎

日本化学会春季年会講演予稿集(Web), 101st, 2021
Development of Hybrid Binding Inhibitor for Calreticulin

栗原大輝, 柴山佳大, 平野真, 足立優花, 武田陽一, 伊藤幸成, 戸谷希一郎

日本化学会春季年会講演予稿集(CD-ROM), 100th, 2020
ハイブリッド結合型カルレティキュリン阻害剤の開発

栗原大輝, 柴山佳大, 平野真, 足立優花, 武田陽一, 伊藤幸成, 戸谷希一郎

日本糖質学会年会要旨集, 38th, 2019
Glycoprotein Quality Control Contributed by Secondary Factors

Totani Kiichiro

Trends in Glycoscience and Glycotechnology, 31(181) SJ59-SJ60, 2019

<p>Glycoprotein quality control is regulated by high-mannose glycans on the glycoprotein as signals. We found that the quality control mechanism is complementarily regulated by secondary factors other than glycan recognition through our glycoprobe-based analysis. We revealed that most related glycan-recognizing proteins discriminate the aglycon state difference of the substrate glycoprotein to regulate activity. We also found that the upstream of the glycan processing is accelerated and the downstream is decelerated under the molecular crowding conditions mimicking the inside of the cell. Furthermore, the effect of diseases such as obesity, type 2 diabetes, and osteoporosis on the operation status of glycoprotein quality control was clarified.</p>

Books and Other Publications

糖鎖の新機能開発・応用ハンドブック

岩本将吾, 平野真, 松尾一郎, 戸谷希一郎 (Role: Contributor, 糖タンパク質品質管理の稼働状況を知る〜化学合成基質による糖鎖プロファイルの再構成〜)

NTS, 2015
Carbohydrates: Tools for Stereoselective Synthesis

Kiichiro Totani, Kin-ichi Tadano, Mike Martin, Kwabena Boysen (Role: Contributor, 1,4-Addition of nucleophiles to α,β-unsaturated carbonyl compounds)

Wiley-VCH, Mar, 2013 (ISBN: 3527323791)
第三の生命鎖糖鎖の機能と疾患

武田陽一, 戸谷希一郎, 伊藤幸成 (Role: Contributor, 高マンノース型糖鎖の合成とバイオロジーへの展開)

羊土社, 2013
複合糖質の化学と最新応用技術

戸谷希一郎 (Role: Contributor, N-結合型糖鎖プローブの合成とタンパク質品質管理機構解析への応用)

シーエムシー出版, 2009
Glycoscience-Chemistry and Chemical Biology, 2nd edition

Kiichiro Totani, Kin-ichi Tadano (Role: Contributor, Monosaccharides as chiral auxiliaries and ligands for asymmetric synthesis)

Springer- Berlin Heidelberg, 2008

Presentations

127

糖タンパク質をトリアージする小胞体エンドマンノシダーゼ

HIRANO MAKOTO, WATANABE CHIE, ITO YUKISHIGE, WILLIAMS SPENCER J, TOTANI KIICHIRO

日本化学会講演予稿集, Mar 11, 2015
マンノシダーゼ類の選択的阻害に基づく小胞体糖鎖プロセシングの解析

KURIBARA TAIKI, HIRANO MAKOTO, ITO YUKISHIGE, TOTANI KIICHIRO

日本化学会講演予稿集, Mar 11, 2015
小胞体マンノシダーゼ類に対する選択的阻害剤の探索

栗原大輝, 平野真, WILLIAMS Spencer J, 戸谷希一郎

日本糖質学会年会要旨集, Jul 23, 2014
カルレティキュリンのフォールディング識別能

戸谷希一郎, 平野真, 足立優花, 伊藤幸成

日本糖質学会年会要旨集, Jul 23, 2014
小胞体画分に見出されたエンドマンノシダーゼ活性の解析

平野真, 渡邊千恵, 久保佳蓮, 伊藤幸成, WILLIAMS Spencer J, 戸谷希一郎

日本糖質学会年会要旨集, Jul 23, 2014

Teaching Experience

生体分子化学特論 (成蹊大学大学院)
有機化学基礎 (東京工業大学)
有機立体化学 (成蹊大学)
有機反応機構 (成蹊大学)
有機合成化学 (成蹊大学)

Research Projects

フォールディング病のアクティブセーフティを目指すシグナル糖鎖産生調節分子の開発

科学研究費助成事業, 日本学術振興会, Apr, 2022 - Mar, 2025

戸谷希一郎
小胞体糖就職の統合的ケミカルバイオロジー

科学研究費補助金特別推進研究, 文部科学省, Apr, 2016 - Mar, 2021

伊藤幸成, 谷希一郎
不良糖タンパク質分解に係る小胞体エンドマンノシダーゼの科学的解析

科学研究費補助金(基盤研究(C)), 文部科学省, Apr, 2016 - Mar, 2019

戸谷希一郎
Discovery of ER-endomannosidase and its importance on glycoprotein quality control

Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science, 2013 - 2015

Totani Kiichiro
Chemistry based glycan-processing analysis of ER-stress induced diseases

Grants-in-Aid for Scientific Research(若手研究(A)), Ministry of Education, Culture, Sports, Science and Technology, 2011 - 2013

Kiichiro TOTANI

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